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    • 73. 发明申请
    • ORGANIC LIGHT EMITTING DEVICE AND MATERIALS FOR USE IN SAME
    • US20130306961A1
    • 2013-11-21
    • US13995216
    • 2011-02-11
    • Hitoshi YamamotoMichael S. WeaverJulia J. BrownKazuki NishimuraToshihiro IwakumaTomoki KatoMitsunori Ito
    • Hitoshi YamamotoMichael S. WeaverJulia J. BrownKazuki NishimuraToshihiro IwakumaTomoki KatoMitsunori Ito
    • H01L51/50
    • H01L51/5028H01L51/0059H01L51/0067H01L51/0072H01L51/0085H01L51/5016
    • The present invention provides an OLED in which an organic thin film emissive layer comprising a single layer or plural layers between a cathode and an anode, wherein the organic thin film layer comprises at least one organic light emitting layer, wherein at least one light emitting layer comprises at least one host material and at least one phosphorescent emitter material, wherein the host material comprises a substituted or unsubstituted hydrocarbon compound having the chemical structure represented by the following formula: wherein at least one of Ar1 to Ar3 is represented by the following formula: wherein at least X1 to X3 are independently a nitrogen atom or CR2, provided that two of X1 to X3 are a nitrogen atom, R1 is a linear or branched alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 ring carbon atoms, a substituted or unsubstituted silyl group, an aryl group having 6 to 50 ring carbon atoms, a heteroaryl group having 5 to 50 ring atoms, a halogen atom or a cyano group, R2 is a hydrogen atom or a group represented by R1, a is an integer of 1 to 2 and n is an integer of 0 to 3, L1 is a substituted or unsubstituted arylene group having 6 to 50 ring carbon atoms, L2 is a substituted or unsubstituted arylene group having 6 to 50 ring carbon atoms, or a substituted or unsubstituted heteroarylene group having 5 to 50 ring atoms, at most two of Ar1 to Ar3 that are not the group of formula (2) are independently a substituted or unsubstituted aryl group having 6 to 50 ring carbon atoms, when L1, L2 and/or at most two of Ar1 to Ar3 that are not the group of formula (2) are a substituted group, the substitutes are independently a linear or branched alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 ring carbon atoms, a substituted or unsubstituted silyl group, an aryl group having 6 to 14 ring carbon atoms, a heteroaryl group having 5 to 20 ring atoms, a halogen atom or a cyano group, when two or more of Ar1 to Ar3 are the groups of formula (2), the groups of formula (2) may be the same or different, when a is 2, R1s may be the same or different, and when n is 2 or more, L2s may be the same or different; and the phosphorescent emitter material comprises a phosphorescent organometallic complex having a substituted chemical structure represented by one of the following partial chemical structures represented by the following formulas: wherein each R is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, CN, CF3, CnF2n+1, trifluorovinyl, CO2R, C(O)R, NR2, NO2, OR, halo, aryl, heteroaryl, substituted heteroaryl or a heterocyclic group.
    • 75. 发明授权
    • 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-HT4 receptor agonistic activity
    • 具有5-HT 4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
    • US08362038B2
    • 2013-01-29
    • US12708012
    • 2010-02-18
    • Tomoki KatoKiyoshi KawamuraChikara Uchida
    • Tomoki KatoKiyoshi KawamuraChikara Uchida
    • A61K31/4545C07D401/12
    • C07D401/12C07D405/14
    • This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
    • 本发明提供式(I)化合物:其中R 1表示具有1至4个碳原子的烷基或卤原子,R 2表示具有1至4个碳原子的烷基,R 3表示氢原子或羟基 基团,A表示氧原子或式-C(R4)(R5) - (其中R4表示氢原子或具有1至4个碳原子的烷基,R5表示羟基或式 具有1至4个碳原子的烷氧基)或其药学上可接受的盐。 这些化合物具有5-HT 4受体激动活性,因此可用于治疗哺乳动物特别是人类的胃食管反流病,非溃疡性消化不良,功能性消化不良,肠易激综合征等。