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71. 发明申请

US20050124583A1 Prodrugs of phosphonate nucleotide analogues 审中-公开
标题翻译：膦酸酯核苷酸类似物的前药
公开(公告)号：US20050124583A1
公开(公告)日：2005-06-09
申请号：US11031250
申请日：2005-01-06
申请人： Mark Becker , Harlan Chapman , Tomas Clhlar , Eugene Elsenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
发明人： Mark Becker , Harlan Chapman , Tomas Clhlar , Eugene Elsenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
IPC分类号： A61K31/664 , A61K31/675 , A61P31/12 , A61P31/18 , A61P35/00 , C07F9/6561 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
摘要翻译：一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。

72. 发明申请

US20050064510A1 Ligand analysis 审中-公开
标题翻译：配体分析
公开(公告)号：US20050064510A1
公开(公告)日：2005-03-24
申请号：US10797551
申请日：2004-03-10
申请人： Can Akyuz , D. Annis , William Lee , Gergely Makara , Ciamac Moallemi , Huw Nash , Zhongli Zheng
发明人： Can Akyuz , D. Annis , William Lee , Gergely Makara , Ciamac Moallemi , Huw Nash , Zhongli Zheng
IPC分类号： C12Q1/68 , G01N20060101 , G01N33/53 , G01N33/566
CPC分类号： G01N33/6848 , C07D307/68 , C07D401/12 , C07D405/14 , C07D413/10
摘要： Methods for the analysis of receptor-ligand pairs are herein described. The methods can provide information about the binding affinity of a ligand to a receptor or can provide information about the binding kinetics of a ligand to a receptor. In some instances, the methods provide a very general system for evaluating and/or optimizing receptor-ligand interactions, which can be applied to a variety of types of receptor-ligand interactions, for example protein-small molecule interactions.
摘要翻译：本文描述了受体 - 配体对分析方法。该方法可以提供关于配体对受体的结合亲和力的信息，或者可以提供关于配体与受体的结合动力学的信息。在某些情况下，该方法提供了用于评估和/或优化受体 - 配体相互作用的非常通用的系统，其可以应用于多种类型的受体 - 配体相互作用，例如蛋白质 - 小分子相互作用。

73. 发明申请

US20050009043A1 Prodrugs of phosphonate nucleotide analogues 有权
公开(公告)号：US20050009043A1
公开(公告)日：2005-01-13
申请号：US10798692
申请日：2004-03-11
申请人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
发明人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
IPC分类号： A61K31/664 , A61K31/675 , A61P31/12 , A61P31/18 , A61P35/00 , C07F9/6561 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/15 , G01N33/50 , G01N33/53 , C12Q1/68 , A61K38/16 , C07F9/6512
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.

74. 发明授权

US06540585B1 Ventilated padded lingerie 失效
标题翻译：通风衬垫内衣
公开(公告)号：US06540585B1
公开(公告)日：2003-04-01
申请号：US09715507
申请日：2000-11-17
申请人： William Lee
发明人： William Lee
IPC分类号： A41C300
CPC分类号： A41C3/10 , A41B2400/20 , A41C3/0085
摘要： A ventilated padded material suitable for providing air circulation in padded lingerie is disclosed. Padded lingerie, for example, bras, typically are made from man-made materials that prevent perspiration from evaporating and then accumulates in the breast cup area. The retained perspiration causes discomfort to the wearer, as the surrounding breast area remains moist and damp. The ventilation channels or perforations in the padding material, in accordance with the principles of the present invention, enable air circulation to occur through the padding material. Increased air circulation through the padding material allows for perspiration evaporation and less accumulated perspiration.
摘要翻译：公开了一种适合于在内衬内衣中提供空气循环的通风衬垫材料。填充内衣，例如胸罩，通常由人造材料制成，防止汗液蒸发，然后积聚在胸杯区域。由于周围的乳房区域保持湿润和潮湿，保留的汗水引起佩戴者的不适。根据本发明的原理，衬垫材料中的通风通道或穿孔能够通过衬垫材料发生空气循环。通过填充材料增加空气循环可以使汗液蒸发并减少排汗。

75. 外观设计

USD468979S1 Can opener 失效
公开(公告)号：USD468979S1
公开(公告)日：2003-01-21
申请号：US29142603
申请日：2001-05-29
申请人： Augusto A. Picozza , William Lee
设计人： Augusto A. Picozza , William Lee

76. 发明授权

US5766701A Foldable model 失效
标题翻译：可折叠模型
公开(公告)号：US5766701A
公开(公告)日：1998-06-16
申请号：US691364
申请日：1996-08-02
申请人： William Lee
发明人： William Lee
IPC分类号： A63H3/16 , B44C3/06
CPC分类号： A63H3/16
摘要： A foldable model made out of a number of wire materials through deformation, assembling and welding to form a main body portion and several accessory portions, characterized in that the joining of the accessory portions with the main body portion are carried out by means of hinges and pivotal fastening latches so that those portions needing to be folded can be folded into or towards said main body portion to reduce the overall packing dimension of said model. The foldable animal model according to the present invention after being folded occupies a volume much smaller than that of a prior art animal model of corresponding dimension after being dismantled and the folding process before packing and the unfolding process after transportation are very simple and easy. Therefore, the foldable model of the present invention is not only convenient for transportation but also the relevant cost thereof have evidently been reduced, so that the selling prices of various models can thus be reduced.
摘要翻译：一种由许多线材通过变形，组装和焊接制成的可折叠模型，以形成主体部分和若干附件部分，其特征在于，附件部分与主体部分的接合通过铰链和枢转紧固闩锁，使得需要折叠的部分可以折叠到或朝向所述主体部分，以减小所述模型的整体包装尺寸。折叠后的本发明的折叠动物模型在分解后占据相当尺寸的现有技术动物模型的体积，比包装前的折叠处理和运输后的展开处理非常简单易行。因此，本发明的折叠模型不仅方便运输，而且相关成本明显降低，从而可以降低各种型号的售价。

77. 发明授权

US5651782A Method and apparatus for implanting an artificial meshwork in glaucoma surgery 失效
标题翻译：用于在青光眼手术中植入人造网的方法和装置
公开(公告)号：US5651782A
公开(公告)日：1997-07-29
申请号：US663404
申请日：1996-06-13
申请人： Gabriel Simon , Jean-Marc Legeais , William Lee , Jean-Marie Parel
发明人： Gabriel Simon , Jean-Marc Legeais , William Lee , Jean-Marie Parel
IPC分类号： A61B17/32 , A61B19/00 , A61F9/00 , A61F9/007 , A61F9/009 , A61F9/013 , B29C53/02
CPC分类号： A61F9/008 , A61F9/00781 , A61B17/3213 , A61B2090/3616 , A61B90/361 , A61F2009/00865 , A61F2009/00868 , A61F2009/00891 , A61F9/00 , A61F9/009 , A61F9/0133
摘要： A method and device which is used to insert an implant in order for treating an eye with glaucoma in order to lower the intraocular pressure of the eye. The implant is an artificial meshwork. The implant is attached to a guide knife which is inserted into the anterior chamber of the eye. The knife is then removed leaving the implant in place. During the operation, a prismatic lens with c-shaped vacuum ring is used to help assist the surgeon in viewing the anterior chamber of the eye and stabilizing the eye.
摘要翻译：一种用于插入植入物以便治疗眼睛与青光眼以降低眼睛眼内压的方法和装置。植入物是人造网。植入物附接到插入眼睛前房的导向刀上。然后取下刀，留下植入物就位。在操作期间，使用具有c形真空环的棱镜透镜来帮助外科医生观察眼前房并稳定眼睛。

78. 发明授权

US5573544A Artificial meshwork filter for glaucoma surgery 失效
标题翻译：用于青光眼手术的人造网状过滤器
公开(公告)号：US5573544A
公开(公告)日：1996-11-12
申请号：US253696
申请日：1994-06-03
申请人： Gabriel Simon , Jean-Marc Legeais , William Lee , Jean-Marie Parel
发明人： Gabriel Simon , Jean-Marc Legeais , William Lee , Jean-Marie Parel
IPC分类号： A61B17/32 , A61B19/00 , A61F9/00 , A61F9/007 , A61F9/009 , A61F9/013 , B29C53/02 , A61B17/08
CPC分类号： A61F9/008 , A61F9/00781 , A61B17/3213 , A61B2090/3616 , A61B90/361 , A61F2009/00865 , A61F2009/00868 , A61F2009/00891 , A61F9/00 , A61F9/009 , A61F9/0133
摘要： A method and device which is used to insert an implant in order for treating an eye with glaucoma in order to lower the intraocular pressure of the eye. The implant is an artificial meshwork formed into a pocket configuration. The implant is attached to a guide knife which is inserted into the anterior chamber of the eye. The knife is then removed leaving the implant in place. During the operation, a prismatic lens with c-shaped vacuum ring is used to help assist the surgeon in viewing the anterior chamber of the eye and stabilizing the eye.
摘要翻译：一种用于插入植入物以便治疗眼睛与青光眼以降低眼睛眼内压的方法和装置。植入物是形成为口袋构型的人造网。植入物附接到插入眼睛前房的导向刀上。然后取下刀，留下植入物就位。在操作期间，使用具有c形真空环的棱镜透镜来帮助外科医生观察眼前房并稳定眼睛。

79. 发明申请

US20190026641A1 GENOMIC SERVICES PLATFORM SUPPORTING MULTIPLE APPLICATION PROVIDERS 审中-公开
公开(公告)号：US20190026641A1
公开(公告)日：2019-01-24
申请号：US15872731
申请日：2018-01-16
申请人： James Lu , Jim Chou , William Lee , Chris Williams , James Warren , Ruomu Jiang
发明人： James Lu , Jim Chou , William Lee , Chris Williams , James Warren , Ruomu Jiang
IPC分类号： G06N7/00 , G06F19/22 , G06F17/18 , G06N99/00
摘要： Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which are received genomic sequence reads derived from a biological sample obtained from a user. The platform also includes a bioinformatics processing pipeline including a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, and a variant refinement module for producing genotype data including a set of refined variants associated with the user. A variant imputation module produces a set of imputed variants associated with the user, and is configured to receive, as input, at least some of the genotype data and separate the genotype data into high-quality and low-quality genotypes based on a genotype quality.

80. 发明申请

US20190026156A1 GENOMIC SERVICES PLATFORM SUPPORTING MULTIPLE APPLICATION PROVIDERS 审中-公开
公开(公告)号：US20190026156A1
公开(公告)日：2019-01-24
申请号：US15872793
申请日：2018-01-16
申请人： James Lu , Jim Chou , William Lee , Chris Williams , James Warren , Ruomu Jiang
发明人： James Lu , Jim Chou , William Lee , Chris Williams , James Warren , Ruomu Jiang
IPC分类号： G06F9/50 , G06F19/28 , G06F19/18 , G06F8/30 , G06F8/34 , G06F9/48
摘要： Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which genomic sequence reads derived from a biological sample are received. The platform also includes a bioinformatics processing pipeline that comprises a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, and a variant refinement module for producing a set of refined variants associated with the biological sample. A variant imputation module produces a set of imputed variants associated with the user and a variant storage module, operating on a server-less framework, is disposed to receive a query from network infrastructure of a partner application provider and to provide selected ones of the refined or imputed variants m response to the query.

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