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71. 发明授权

US06709660B1 Meningococcal antigens 失效
标题翻译：脑膜炎球菌抗原
公开(公告)号：US06709660B1
公开(公告)日：2004-03-23
申请号：US09302626
申请日：1999-04-30
申请人： Vincenzo Scarlato , Vega Masignani , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Vincenzo Scarlato , Vega Masignani , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
IPC分类号： A61K39095
CPC分类号： C07K14/22 , A61K39/00
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译：本发明提供来自脑膜炎奈瑟菌（A＆B）菌株的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。

72. 发明授权

US10596246B2 Adjuvanted combinations of meningococcal factor H binding proteins 有权
公开(公告)号：US10596246B2
公开(公告)日：2020-03-24
申请号：US14368957
申请日：2011-12-29
申请人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K47/64 , A61K39/09 , A61K39/00 , A61K39/39
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.

73. 发明授权

US09511130B2 Escherichia coli vaccine combination 有权
标题翻译：大肠杆菌疫苗组合
公开(公告)号：US09511130B2
公开(公告)日：2016-12-06
申请号：US14344892
申请日：2012-09-14
申请人： Laura Serino , Mariagrazia Pizza
发明人： Laura Serino , Mariagrazia Pizza
IPC分类号： A61K39/108 , C07K14/245 , A61K39/00
CPC分类号： A61K39/0258 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55516 , A61K2039/55544 , A61K2039/70 , C07K14/245 , Y02A50/474
摘要： The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid sequence set forth in SEQ ID NO:2 or a protein having at least 80% similarity thereto, and (ii) putative Lipoprotein (orf3526) having the amino acid sequence set forth in SEQ ID NO:8 or a protein having at least 80% similarity thereto.
摘要翻译：本发明提供了包含以下组合的免疫原性组合物：（i）具有SEQ ID NO：2所示氨基酸序列的细菌Ig样结构域蛋白片段（orf405B）或与其具有至少80％相似性的蛋白质，和）推定的具有SEQ ID NO：8所示氨基酸序列的脂蛋白（orf3526）或与其具有至少80％相似性的蛋白质。

74. 发明授权

US08980286B2 Multiple variants of meningococcal protein NBM1870 有权
标题翻译：脑膜炎球菌蛋白NBM1870的多种变体
公开(公告)号：US08980286B2
公开(公告)日：2015-03-17
申请号：US13364264
申请日：2012-02-01
申请人： Maurizio Comanducci , Mariagrazia Pizza
发明人： Maurizio Comanducci , Mariagrazia Pizza
IPC分类号： A61K39/095 , C07K14/22
CPC分类号： A61K39/095 , A61K39/102 , A61K39/39 , A61K2039/55505 , A61K2039/575 , C07K14/22 , C07K14/285 , C07K2319/00
摘要： Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting anti-meningococcal antibody responses, and that it is expressed across all meningococcal serogroups. Forty-two different NMB 1870 sequences have been identified, and these group into three variants. Serum raised against a given variant is bactericidal within the same variant group, but is not active against strains which express one of the other two variants i.e. there is intra-variant cross-protection, but not inter-variant cross-protection. For maximum cross-strain efficacy, therefore, the invention uses mixture comprising different variants of NMB 1870.
摘要翻译：脑膜炎球菌蛋白NMB1870已经在现有技术中描述。本发明人已经发现NMB1870是用于引发抗脑膜炎球菌抗体应答的有效抗原，并且其在所有脑膜炎球菌血清群中表达。已经确定了42种不同的NMB 1870序列，并且这些序列分为三个变体。针对给定变体产生的血清在同一变体组内是杀菌的，但对于表达其它两种变体之一的菌株不具有活性，即存在变异体内的交叉保护，而不是变异体间交叉保护。因此，为了获得最大的交叉应变效能，本发明使用包含NMB1870不同变体的混合物。

75. 发明授权

US08663656B2 Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages 有权
标题翻译：用于广泛保护以防止高毒力脑膜炎球菌谱系的多肽疫苗
公开(公告)号：US08663656B2
公开(公告)日：2014-03-04
申请号：US10530753
申请日：2003-10-02
申请人： Mariagrazia Pizza
发明人： Mariagrazia Pizza
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/102 , C07K14/22 , C07K2319/00
摘要： A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, after administration to a subject, is able to induce an antibody response in that subject, wherein the antibody response is bactericidal against two or three of hypervirulent lineages A4, ET 5 and lineage 3 of N. meningitidis serogroup B. Rather than consisting of a single antigen, the composition comprises a mixture of 10 or fewer purified antigens, and should not include complex or undefined mixtures of antigens such as outer membrane vesicles. Five protein antigens are used in particular: (1) a ‘NadA’ protein; (2) a ‘741’ protein; (3) a ‘936’ protein; (4) a ‘953’ protein; and (5) a ‘287’ protein.
摘要翻译：少数定义的抗原可以提供对脑膜炎球菌感染的广泛保护，并且本发明提供一种组合物，其在施用于受试者之后能够在该受试者中诱导抗体应答，其中所述抗体应答对两个或三个高毒力谱系A4，ET5和脑膜炎奈瑟氏球菌血清群B的谱系3.不是由单一抗原组成，组合物包含10个或更少的纯化抗原的混合物，并且不应包括复合物或未定义的抗原混合物，例如外膜囊泡特别使用5种蛋白质抗原：（1）“NadA”蛋白; （2）'741'蛋白质; （3）'936'蛋白质; （4）'953'蛋白质; 和（5）'287'蛋白质。

76. 发明授权

US08470341B2 Escherichia coli immunogens with improved solubility 有权
标题翻译：具有改善溶解性的大肠杆菌免疫原
公开(公告)号：US08470341B2
公开(公告)日：2013-06-25
申请号：US12735848
申请日：2009-02-23
申请人： Laura Serino , Mariagrazia Pizza , Danilo Gomes Moriel , Maria Rita Fontana
发明人： Laura Serino , Mariagrazia Pizza , Danilo Gomes Moriel , Maria Rita Fontana
IPC分类号： A61K39/108 , C07K14/00 , C12N1/20
CPC分类号： A61K39/0258 , C07K14/245
摘要： Variants of the pathogenic E. coli ‘AcfD precursor’ have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.
摘要翻译：与天然AcfD蛋白质相比，与天然AcfD蛋白质在主体中产生基本上相似的免疫应答的天然AcfD蛋白质相比，鉴定出致病性大肠杆菌“AcfD前体”的变体具有增加的溶解度。

77. 发明申请

US20100166788A1 IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI 审中-公开
标题翻译：来自UROPATHOGENIC ESCHERICHIA COLI的免疫原
公开(公告)号：US20100166788A1
公开(公告)日：2010-07-01
申请号：US12377572
申请日：2007-08-15
申请人： Francesco Berlanda Scorza , Danilo Gomes Moriel , Jörg Hacker , Mariagrazia Pizza , Laura Serino , Maria Rita Fontana
发明人： Francesco Berlanda Scorza , Danilo Gomes Moriel , Jörg Hacker , Mariagrazia Pizza , Laura Serino , Maria Rita Fontana
IPC分类号： A61K39/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/16 , A61K38/08 , A61K38/10 , A61P37/04
CPC分类号： A61K39/0258 , Y02A50/474
摘要： Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
摘要翻译：本文公开了可以包含在对致病性大肠杆菌菌株特异性的免疫原性组合物中的各种多肽。这些多肽具有让其免疫系统可接近的细胞位置。编码多肽的基因最初被鉴定为存在于致病菌株536中，但不存在于非致病菌株中。

78. 发明申请

US20100143418A1 Immunising Against Meningococcal Serogroup Y Using Proteins 审中-公开
标题翻译：使用蛋白免疫脑膜炎球菌血清群Y
公开(公告)号：US20100143418A1
公开(公告)日：2010-06-10
申请号：US11587189
申请日：2005-04-22
申请人： Mario Contorni , Marzia Giuliani , Mariagrazia Pizza
发明人： Mario Contorni , Marzia Giuliani , Mariagrazia Pizza
IPC分类号： A61K39/095 , A61P31/04
CPC分类号： A61K39/095
摘要： The invention uses polypeptide antigens and/or OMVs to immunize against serogroups A, C, W135 and Y (and against serogroup Y in particular). Serogroup B polypeptides can achieve this protection, thus permitting a single polypeptide-based vaccine to be used for protecting against all of serogroups A, B, C, W135 and Y.
摘要翻译：本发明使用多肽抗原和/或OMV免疫血清群A，C，W135和Y（特别是针对血清群Y）。血清群B多肽可以实现这种保护，从而允许单一的基于多肽的疫苗用于保护所有血清群A，B，C，W135和Y.

79. 发明申请

US20060051840A1 Hybrid expression of neisserial proteins 有权
标题翻译： neisserial蛋白的杂交表达
公开(公告)号：US20060051840A1
公开(公告)日：2006-03-09
申请号：US11067260
申请日：2005-02-25
申请人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
发明人： Maria Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Guiliani , Mariagrazia Pizza
IPC分类号： C07K14/22 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH.
摘要翻译：两个或更多个Neisserial蛋白（例如A和B）被表达为单独的杂合蛋白，其可以简单地用式NH 2 -A-B-COOH表示。

80. 发明授权

US09011869B2 Hybrid and tandem expression of Neisserial proteins 有权
标题翻译：奈瑟氏球蛋白的杂交和串联表达
公开(公告)号：US09011869B2
公开(公告)日：2015-04-21
申请号：US13159370
申请日：2011-06-13
申请人： Mariagrazia Pizza
发明人： Mariagrazia Pizza
IPC分类号： A61K39/00 , A61K39/095 , C07K14/22 , A61K39/39
CPC分类号： A61K39/095 , A61K39/00 , A61K39/39 , A61K2039/53 , A61K2039/55505 , C07K14/22 , Y02A50/464 , Y02A50/466
摘要： Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH2-A-[-X-L-]n-B—COOH where X is an amino acid sequence, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is an optional C-terminal amino acid sequence, and n is an integer greater than I. Proteins where each of the n-X— moieties shares sequence identity to each other —X— moiety, the protein is a ‘tandem protein’.
摘要翻译：连接两个或多个Neisserial蛋白，使得它们被翻译为单个多肽链。杂交蛋白由式NH2-A - [ - XL-] nB-COOH表示，其中X是氨基酸序列，L是任选的接头氨基酸序列，A是任选的N-末端氨基酸序列，B是任选的C-末端氨基酸序列，n是大于I的整数。每个nX-部分各自具有彼此-X-部分的序列同一性的蛋白质，该蛋白质是“串联蛋白质”。

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