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71. 发明授权

US06432915B1 Human mitochondrial chaperone protein 失效
标题翻译：人线粒体伴侣蛋白
公开(公告)号：US06432915B1
公开(公告)日：2002-08-13
申请号：US09416488
申请日：1999-10-12
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.
摘要翻译：本发明提供一种人线粒体伴侣蛋白（Hmt-GrpE）和识别和编码Hmt-GrpE的多核苷酸。本发明还提供表达载体和宿主细胞以及生产Hmt-GrpE的方法。本发明还提供特异性结合Hmt-GrpE的抗体或拮抗剂及其在预防和治疗癌症中的用途。本发明还提供诊断测定。本发明还提供了使用Hmt-GrpE鉴定抗真菌和抗原虫治疗剂。

72. 发明授权

US06428949B1 Human phosphatase inhibitor protein 失效
标题翻译：人类磷酸酶抑制蛋白
公开(公告)号：US06428949B1
公开(公告)日：2002-08-06
申请号：US09262610
申请日：1999-03-04
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C07K1447
CPC分类号： C07K14/4703
摘要： The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.
摘要翻译：本发明提供了一种鉴定和编码HPIP的新型人磷酸酶抑制蛋白（HPIP）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HPIP的核酸序列和用于产生HPIP的方法。本发明还提供了特异性结合HPIP的激动剂，抗体或拮抗剂及其在预防和治疗与HPIP表达相关的疾病中的用途。另外，本发明提供反义分子用于编码HPIP的多核苷酸用于治疗与HPIP表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合HPIP的抗体的诊断测定法。

73. 发明授权

US06395468B1 Human phosphatidylinositol synthase 失效
标题翻译：人类磷脂酰肌醇合成酶
公开(公告)号：US06395468B1
公开(公告)日：2002-05-28
申请号：US09216066
申请日：1998-12-18
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： C12Q100
CPC分类号： C12N9/1288 , A61K38/00 , C07K2319/00 , Y02A50/411
摘要： The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.
摘要翻译：本发明提供了人磷脂酰肌醇合成酶（PISH）和识别和编码PISH的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码PISH的核酸序列和产生PISH的方法的宿主细胞。本发明还提供了特异性结合PISH的激动剂，抗体或拮抗剂及其在预防和治疗与PISH表达相关的疾病中的用途。本发明还提供了使用PISH筛选抗原虫和抗真菌治疗剂。此外，本发明提供了反义分子用于编码PISH的多核苷酸用于治疗与PISH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合PISH的抗体的诊断测定法。

74. 发明授权

US6110722A F.sub.0 ATP synthase subunit 失效
标题翻译： F0 ATP合酶亚基
公开(公告)号：US6110722A
公开(公告)日：2000-08-29
申请号：US66049
申请日：1998-04-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N9/14 , C12N15/60 , C12N9/88 , A61K38/51
CPC分类号： C12N9/14
摘要： The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYS and for treating disorders associated with expression of ASYS.
摘要翻译：本发明提供了人ATP合酶亚基（ASYS）和编码ASYS的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了用于产生ASYS和用于治疗与ASYS表达相关的疾病的方法。

75. 发明授权

US6103874A Human KDEL receptor 失效
标题翻译：人类KDEL受体
公开(公告)号：US6103874A
公开(公告)日：2000-08-15
申请号：US133735
申请日：1998-08-13
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P5/14 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K14/00 , A61K38/16 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.
摘要翻译：本发明提供了一种新的人KDEL受体（NHKR）和识别并编码NHKR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHKR的核酸序列和生产NHKR的方法。本发明还提供了特异性结合NHKR的激动剂，抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。

76. 发明授权

US6087108A RNA editing enzyme 失效
标题翻译： RNA编辑酶
公开(公告)号：US6087108A
公开(公告)日：2000-07-11
申请号：US128395
申请日：1998-08-03
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/00 , C12N15/55 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/00 , A61K38/00
摘要： The present invention provides a human RNA editing enzyme (REE-2) and polynucleotides which identify and encode REE-2. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for producing REE-2 and for treating diseases associated with expression of REE-2.
摘要翻译：本发明提供了人类RNA编辑酶（REE-2）和识别和编码REE-2的多核苷酸。本发明还提供表达载体和宿主细胞，激动剂，抗体或拮抗剂。本发明提供了生产REE-2和治疗与REE-2表达有关的疾病的方法。

77. 发明授权

US06060297A Rho protein 失效
标题翻译： Rho蛋白
公开(公告)号：US06060297A
公开(公告)日：2000-05-09
申请号：US842976
申请日：1997-04-17
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12N9/16 , C07H21/04 , C12N15/63
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.
摘要翻译：本发明提供了人类Rho蛋白（HRHO）和识别和编码HRHO的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明提供了用于产生HRHO和用于治疗或预防与HRHO表达相关的病症的方法。

78. 发明授权

US6034063A Human phosphatidylinositol transfer protein gamma 失效
标题翻译：人类磷脂酰肌醇转移蛋白γ
公开(公告)号：US6034063A
公开(公告)日：2000-03-07
申请号：US231258
申请日：1999-01-15
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a new human phosphatidylinositol transfer protein gamma (PITP.gamma.) and polynucleotides which identify and encode PITP.gamma.. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PITP.gamma..
摘要翻译：本发明提供了新的人磷脂酰肌醇转移蛋白γ（PITPγ）和识别和编码PITPγ的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与PITPγ的表达相关的疾病的方法。

79. 发明授权

US6020478A Human tumor-associated antigen 失效
标题翻译：人肿瘤相关抗原
公开(公告)号：US6020478A
公开(公告)日：2000-02-01
申请号：US808148
申请日：1997-02-28
申请人： Jennifer L. Hillman , Surya K. Goli , Hong Zhang
发明人： Jennifer L. Hillman , Surya K. Goli , Hong Zhang
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , G01N33/574 , C07H21/04
CPC分类号： G01N33/57492 , C07K14/4748 , A61K38/00 , A61K48/00 , G01N2333/705
摘要： The present invention provides a human tumor-associated antigen (PRAT) and polynucleotides which identify and encode PRAT. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with the expression of PRAT.
摘要翻译：本发明提供了人肿瘤相关抗原（PRAT）和识别和编码PRAT的多核苷酸。此外，本发明提供表达载体和宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与PRAT表达相关的疾病的方法。

80. 发明授权

US5994112A Human protein tyrosine kinase 失效
标题翻译：人蛋白酪氨酸激酶
公开(公告)号：US5994112A
公开(公告)日：1999-11-30
申请号：US728520
申请日：1996-10-09
申请人： Surya K. Goli
发明人： Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K39/395 , A61K45/00 , A61P9/10 , A61P17/00 , A61P29/00 , A61P35/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12P21/08 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00
摘要： The present invention provides a novel protein tyrosine kinase (HPTYK) and polynucleotides which identify and encode HPTYK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPTYK and a method for producing HPTYK. The invention also provides pharmaceutical compositions containing HPTYK or antagonists to HPTYK, and for the use of these compositions in the treatment of diseases associated with the expression of HPTYK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPTYK for the treatment of diseases associated with the expression of HPTYK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HPTYK or antibodies which specifically bind to HPTYK.
摘要翻译：本发明提供了一种鉴定和编码HPTYK的新型蛋白酪氨酸激酶（HPTYK）和多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HPTYK的核酸序列的宿主细胞和用于产生HPTYK的方法。本发明还提供了含有HPTYK或HPTYK拮抗剂的药物组合物，以及这些组合物用于治疗与HPTYK表达有关的疾病的药物组合物。另外，本发明提供了反义分子用于编码HPTYK的多核苷酸用于治疗与HPTYK表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体与编码HPTYK的多核苷酸或特异性结合HPTYK的抗体的基因组序列或转录物杂交的诊断测定法。

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