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71. 发明申请

US20100233276A1 COMPOSITIONS IN POWDER FORM MADE OF SOFT AGGLOMERATES OF A MICRONIZED DRUG AND OF A TWO-COMPONENTS EXCIPIENT, AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：一种微量药物和两种组分的软组合粉末形式的组合物及其制备方法
公开(公告)号：US20100233276A1
公开(公告)日：2010-09-16
申请号：US12734300
申请日：2007-10-26
申请人： Renata Raffin , Paolo Colombo , Fabio Sonvico , Gaia Colombo , Alessandra Rossi , Francesca Buttini
发明人： Renata Raffin , Paolo Colombo , Fabio Sonvico , Gaia Colombo , Alessandra Rossi , Francesca Buttini
IPC分类号： A61K9/14 , A61K9/50 , A61K9/58 , A61K9/60 , A61K9/62 , A61K9/64
CPC分类号： A61K9/1617 , A61K9/1623
摘要： The described agglomeration of drug microparticles blended with excipient microparticles is a technique for the size enlargement of micronized products that could be damaged by granulation or compaction techniques. These agglomerates can be used as oral prompt or delayed-release dosage forms administered as they are or dispersed in a liquid. The composition and quantity of the excipient microparticles resulted to be the crucial factors for the agglomerate quality. Therefore, adjusting the content of surface-active agent between 8-20%, of the excipient microparticles it is possible to agglomerate microparticles of drugs that could not be agglomerated per se. Increasing the surfactant concentration in the spray-dried excipient microparticles or increasing the fraction of these excipient microparticles in the blend, the agglomeration was improved. The spray drying technique concentrates the surface-active agent on the microparticle surface. By tumbling, the surface-active agent present on microparticles excipient surface was spread to fill the inter-particle interstices of drug particles giving rise to more resistant agglomerates. This phenomenon occurred also by vibration; the production in this case was quicker.
摘要翻译：与赋形剂微粒混合的药物微粒的所述团聚是用于通过造粒或压实技术损坏的微粉化产品的尺寸增大的技术。这些附聚物可以作为口服或缓释剂型使用，或者分散在液体中。赋形剂微粒的组成和数量是聚集质量的关键因素。因此，调整表面活性剂的含量在8〜20％之间，赋形剂微粒可能聚集本身不能团聚的药物微粒。增加喷雾干燥的赋形剂微粒中的表面活性剂浓度或增加共混物中这些赋形剂微粒的分数，聚集得到改善。喷雾干燥技术将表面活性剂浓缩在微粒表面上。通过翻滚，存在于微粒赋形剂表面上的表面活性剂被扩散以填充药物颗粒的颗粒间隙，从而产生更多的抗凝结物质。这种现象也是由振动引起的。在这种情况下的生产更快。

72. 发明申请

US20100011871A1 PRESSURE SENSOR DEVICE 有权
标题翻译：压力传感器装置
公开(公告)号：US20100011871A1
公开(公告)日：2010-01-21
申请号：US12520641
申请日：2007-12-18
申请人： Marco Bigliati , Paolo Colombo , Giorglo Martinengo , Daniel Verner Mueller , Mauro Zorzetto
发明人： Marco Bigliati , Paolo Colombo , Giorglo Martinengo , Daniel Verner Mueller , Mauro Zorzetto
IPC分类号： G01L9/00
CPC分类号： G01L9/0052 , G01L19/0672 , G01L19/143 , G01L19/147
摘要： A pressure-sensor device (1) comprises:—a pressure-sensitive component (9) having a body, defined in which is a blind cavity, and having a membrane portion (9a), operatively associated to which is a detection element (R); and—a connection structure (2), which has a duct in communication with the cavity of the pressure-sensitive component (9) and is to receive a fluid, a pressure of which is to be detected. The connection structure (2) comprises a supporting body (2a) of the pressure-sensitive component (9), which defines a respective passage (2b), and a compressible element (12, 18) that is designed to be in contact with the fluid and is configured for compensating possible variations of volume thereof. The compressible element (12, 18) is positioned at least in part within the cavity (11) of the pressure-sensitive component (9) and/or in a stretch of the passage (2b) of the supporting body (2a) that is close to the cavity (11) of the pressure-sensitive component (9).
摘要翻译：一种压力传感器装置（1）包括： - 具有主体的压敏部件（9），其限定为盲腔，并且具有膜部分（9a），其可操作地与检测元件（R ）; 和连接结构（2），其具有与压敏部件（9）的空腔连通的管道，并且接收要被检测的压力的流体。连接结构（2）包括限定相应通道（2b）的压敏部件（9）的支撑体（2a）和设计成与所述压力敏感部件（9）接触的可压缩元件（12,18）并且被配置为补偿其体积的可能变化。可压缩元件（12,18）至少部分地位于压敏部件（9）的空腔（11）内和/或定位在支撑体（2a）的通道（2b）靠近压敏部件（9）的空腔（11）。

73. 发明授权

US07399528B2 Powder particles with smooth surface for use in inhalation therapy 有权
标题翻译：具有光滑表面的粉末颗粒用于吸入治疗
公开(公告)号：US07399528B2
公开(公告)日：2008-07-15
申请号：US10806240
申请日：2004-03-23
申请人： Giovanni Caponetti , Pier Luigi Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
发明人： Giovanni Caponetti , Pier Luigi Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
IPC分类号： B32B5/16 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1623 , Y10T428/2991 , Y10T428/2998
摘要： Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.
摘要翻译：用于制备用于通过吸入给药的粉末混合物并且具有大于90微米的中值粒径和表示为小于或等于1.1的分形维数的表面粗糙度的载体颗粒可以通过使具有中等直径大于90微米，重复使用溶剂润湿阶段并进行干燥。

74. 发明授权

US07323133B2 Method for producing micromanufactured items in ceramic materials 有权
标题翻译：在陶瓷材料中制造微型制品的方法
公开(公告)号：US07323133B2
公开(公告)日：2008-01-29
申请号：US10485067
申请日：2002-05-13
申请人： Giorgio Maccagnan , Paolo Colombo
发明人： Giorgio Maccagnan , Paolo Colombo
IPC分类号： B29C47/00 , C04B33/00
CPC分类号： C04B35/6264 , C04B35/634 , C04B35/636 , C04B35/82 , C04B38/065 , C04B2111/00129 , C04B2235/483 , C04B2235/5212 , C04B2235/5248 , C04B2235/6021 , C04B2235/94 , C04B2235/95 , C04B20/0008 , C04B35/00
摘要： A method for producing ceramic micromanufactured items comprises the following stages: a starting material constituting at least a micromanufactured item (1) is prepared and used to from the micromanufactured item (1); said starting material includes at least a pre-ceramic polymer, and the method further comprises a stage in which the inner structure of the starting material is modified, said structure being turned from a polymeric structure to a ceramic structure after the forming stage of said micromanufactured item (1).
摘要翻译：制造陶瓷微制品的方法包括以下步骤：制备至少构成微制品（1）的起始材料并从微制造品（1）中使用; 所述起始材料至少包括预陶瓷聚合物，并且所述方法还包括其中所述起始材料的内部结构被改性的阶段，所述结构在所述微制造的成型阶段之后从聚合物结构转变为陶瓷结构项目（1）。

75. 发明申请

US20070154404A1 Insulin highly respirable microparticles 有权
标题翻译：胰岛素高度可呼吸的微粒
公开(公告)号：US20070154404A1
公开(公告)日：2007-07-05
申请号：US10593861
申请日：2004-03-26
申请人： Paolo Colombo , Stefano Cagnani , Paolo Ventura
发明人： Paolo Colombo , Stefano Cagnani , Paolo Ventura
IPC分类号： A61K38/28 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1688 , A61K38/28
摘要： The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).
摘要翻译：本发明描述了用于生产高吸入性气溶胶的肽治疗剂的新颖干粉及其制备方法。胰岛素是优选实施方案中的肽治疗剂。制备用于肺部给药的胰岛素粉末的特征在于允许粉末流动并易于雾化的微粒的特殊结构和形状。在该专利中描述的典型的胰岛素干粉末显示具有低抽头密度的波纹状，非团聚微粒。平均几何直径（粒径）在1.0和10.0微米之间，质量中值空气动力学直径（MMAD）在1.0和4.0微米之间。这些胰岛素肺粉末在体外表现出非常高的可呼吸分数（> 75％）。

76. 发明申请

US20060155116A1 Hypoallergenic variants of the parietaria judaica major allergens, uses thereof and compostitions comprising them 审中-公开
标题翻译：疟原虫主要过敏原的低过敏变体，其用途和包含它们的组合物
公开(公告)号：US20060155116A1
公开(公告)日：2006-07-13
申请号：US10557586
申请日：2004-05-19
申请人： Maria Costa , Domenico Geraci , Paolo Colombo , Rosa Passantino , Angela Bonura
发明人： Maria Costa , Domenico Geraci , Paolo Colombo , Rosa Passantino , Angela Bonura
IPC分类号： A61K39/35 , A61K36/00 , C07K14/415 , C07H21/04
CPC分类号： C07K14/415 , A61K39/36 , Y02A50/396
摘要： A multimer protein molecule comprising at least a first amino acid sequence having substantially the sequence of one of the Parietaria judaica major allergens and a second amino acid sequence having substantially the sequence of one of the Parietaria judaica major allergens Par j 1 or Par j 2, and a third sequence of one of the Parietaria judaica major allergens Par j 1 or Par j 2. The molecule is also mutated in the amino acid region corresponding to loop 1, so that is hypoallergenic. The molecule can be utilized for medical use as a hypoallergenic agent.
摘要翻译：包含至少第一氨基酸序列的多聚体蛋白质分子，所述第一氨基酸序列具有基本上为所述Parietaria judaica主要变应原之一的序列和基本上具有Parietaria judaica主要变应原Parj 1或Par j 2之一的序列的第二氨基酸序列，以及Parietaria judaica主要变应原Parj 1或Par j 2之一的第三序列。该分子也在对应于环1的氨基酸区域中突变，因此是低变应原性的。该分子可用作医疗用作低变应原剂。

77. 发明申请

US20050212491A1 Protection system of a vehicle battery 有权
标题翻译：汽车电池保护系统
公开(公告)号：US20050212491A1
公开(公告)日：2005-09-29
申请号：US10521353
申请日：2003-07-30
申请人： Paolo Colombo , Marco Bigliati
发明人： Paolo Colombo , Marco Bigliati
IPC分类号： H02J7/00
CPC分类号： H02J7/0032
摘要： A system for protecting the battery of a vehicle comprises a device (1) for electrically disconnecting of connecting the battery (BA) with respect to an electric load (CS); the device (1) comprises switch means (20, 21) and a microprocessor control circuit (15). The control circuit (15) comprises means for calculating a mean value of voltage of the battery (BA) and comparing it with a threshold value, in order to control the switch means (20, 21). The threshold value is variable as a function of the ambient temperature and the time of inactivity of the motor, and the switch means comprises a bistable electromagnetic arrangement, capable of passing from a first to a second stable condition following a pulse generated by the control circuit (15).
摘要翻译：一种用于保护车辆电池的系统包括用于相对于电负载（CS）电连接电池（BA）的装置（1）; 装置（1）包括开关装置（20,21）和微处理器控制电路（15）。控制电路（15）包括用于计算电池（BA）的电压的平均值并将其与阈值进行比较的装置，以便控制开关装置（20,21）。阈值是随着环境温度和电动机不活动的时间的变化而变化的，并且开关装置包括双稳态电磁装置，其能够在由控制电路产生的脉冲之后从第一稳定状态传递到第二稳定状态（15）。

78. 发明申请

US20050118113A1 Powder particles with smooth surface for use in inhalation therapy 有权
标题翻译：具有光滑表面的粉末颗粒用于吸入治疗
公开(公告)号：US20050118113A1
公开(公告)日：2005-06-02
申请号：US10806240
申请日：2004-03-23
申请人： Giovanni Caponetti , Pier Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
发明人： Giovanni Caponetti , Pier Catellani , Ruggero Bettini , Paolo Colombo , Paolo Ventura
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K47/26 , A61K47/40 , A61K31/4745 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1623 , Y10T428/2991 , Y10T428/2998
摘要： Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.
摘要翻译：用于制备用于通过吸入给药的粉末混合物并且具有大于90微米的中值粒径和表示为小于或等于1.1的分形维数的表面粗糙度的载体颗粒可以通过使具有中等直径大于90微米，重复使用溶剂润湿阶段并干燥。

79. 发明申请

US20050019411A1 Powder for nasal administration of drugs 审中-公开
标题翻译：用于鼻内给药的粉剂
公开(公告)号：US20050019411A1
公开(公告)日：2005-01-27
申请号：US10492816
申请日：2002-10-17
申请人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Pier Luigi Catellani , Mariella Artusi , Cecilia Sacchetti
发明人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Pier Luigi Catellani , Mariella Artusi , Cecilia Sacchetti
IPC分类号： A61K9/00 , A61K9/16 , A61K9/14 , D04H1/00
CPC分类号： A61K9/0043 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention concerns drug formulae for nasal administration and insufflators filled with said formula. The present invention also concerns methods for making said formulae available as well as primary particles for obtaining chimerical agglomerates that can be used in said formulae.
摘要翻译：本发明涉及用于鼻腔给药的药物配方和填充有所述配方的吹入器。本发明还涉及使所述配方可用的方法以及用于获得可用于所述配方中的嵌合共聚物的初级颗粒。

80. 发明授权

US06266222B1 ESD protection network for circuit structures formed in a semiconductor 有权
标题翻译：用于在半导体中形成的电路结构的ESD保护网络
公开(公告)号：US06266222B1
公开(公告)日：2001-07-24
申请号：US09223621
申请日：1998-12-30
申请人： Paolo Colombo , Jacopo Mulatti , Roberto Annunziata , Giovanni Campardo , Marco Maccarrone
发明人： Paolo Colombo , Jacopo Mulatti , Roberto Annunziata , Giovanni Campardo , Marco Maccarrone
IPC分类号： H02H904
CPC分类号： H01L27/0259 , H01L27/0251
摘要： An ESD protection network protects a CMOS circuit structure integrated in a semiconductor substrate. The circuit structure includes discrete circuit blocks formed in respective substrate portions which are electrically isolated from one another and independently powered from at least one primary voltage supply having a respective primary ground, and from at least one secondary voltage supply having a respective secondary ground. This network includes a first ESD protection element for an input stage of the circuit structure; a second ESD protection element for an output stage of the circuit structure, the first and second protection elements having an input/output pad of the integrated circuit structure in common; a first ESD protection element between the primary supply and the primary ground; and a second ESD protection element between the secondary supply and the secondary ground.
摘要翻译： ESD保护网络保护集成在半导体衬底中的CMOS电路结构。电路结构包括形成在相应的衬底部分中的分立电路块，它们彼此电绝缘并且由至少一个具有各自的初级接地的初级电压源以及至少一个具有相应次级接地的次级电压源独立供电。该网络包括用于电路结构的输入级的第一ESD保护元件; 用于所述电路结构的输出级的第二ESD保护元件，所述第一和第二保护元件具有所述集成电路结构的输入/输出焊盘; 主要供电和主地面之间的第一个ESD保护元件; 以及在次级电源和次级接地之间的第二ESD保护元件。

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