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71. 发明授权

US07376463B2 Therapy control based on the rate of change of intracardiac impedance 有权
标题翻译：基于心内阻抗变化率的治疗控制
公开(公告)号：US07376463B2
公开(公告)日：2008-05-20
申请号：US11169339
申请日：2005-06-29
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

72. 发明授权

US06285907B1 System providing ventricular pacing and biventricular coordination 有权
公开(公告)号：US06285907B1
公开(公告)日：2001-09-04
申请号：US09316588
申请日：1999-05-21
申请人： Andrew P. Kramer , Jeffrey E. Stahmann , Rene H. Wentkowski , Kenneth L. Baker , Jesse W. Hartley , David B. Krig
发明人： Andrew P. Kramer , Jeffrey E. Stahmann , Rene H. Wentkowski , Kenneth L. Baker , Jesse W. Hartley , David B. Krig
IPC分类号： A61N1365
CPC分类号： A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3962 , A61N1/3987
摘要： A cardiac rhythm management system includes techniques for computing an indicated pacing interval, AV delay, or other timing interval. In one embodiment, a variable indicated pacing interval is computed based at least in part on an underlying intrinsic heart rate. The indicated pacing interval is used to time the delivery of biventricular coordination therapy even when ventricular heart rates are irregular, such as in the presence of atrial fibrillation. In another embodiment, a variable filter indicated AV interval is computed based at least in part on an underlying intrinsic AV interval. The indicated AV interval is used to time the delivery of atrial tracking biventricular coordination therapy when atrial heart rhythms are not arrhythmic. Other indicated timing intervals may be similarly determined. The indicated pacing interval, AV delay, or other timing interval can also be used in combination with a sensor indicated rate indicator.

73. 发明授权

US08798747B2 Method and apparatus for control of cardiac therapy using non-invasive hemodynamic sensor 有权
标题翻译：使用非侵入性血液动力学传感器控制心脏治疗的方法和装置
公开(公告)号：US08798747B2
公开(公告)日：2014-08-05
申请号：US13273108
申请日：2011-10-13
申请人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
发明人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译：心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。

74. 发明申请

US20090326599A1 CALIBRATION OF IMPEDANCE MONITORING OF RESPIRATORY VOLUMES USING THORACIC D.C. IMPEDANCE 有权
标题翻译：使用THORACIC D.C.阻抗校正呼吸道阻力监测
公开(公告)号：US20090326599A1
公开(公告)日：2009-12-31
申请号：US12557372
申请日：2009-09-10
申请人： John Hatlestad , Boyce Moon , Jesse W. Hartley , Jeffrey E. Stahmann
发明人： John Hatlestad , Boyce Moon , Jesse W. Hartley , Jeffrey E. Stahmann
IPC分类号： A61B5/091 , A61N1/365
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译：一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。控制器耦合到跨胸阻抗电路。控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。

75. 发明授权

US07630755B2 Syncope logbook and method of using same 有权
标题翻译：晕厥日志及其使用方法
公开(公告)号：US07630755B2
公开(公告)日：2009-12-08
申请号：US11121450
申请日：2005-05-04
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Avram Scheiner
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Jesse W. Hartley , Avram Scheiner
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/02405 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/1116 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61N1/362 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H40/63
摘要： Method and systems are directed to acquiring and organizing information associated with at least one syncope event. A syncope event may be a suspected syncope event, a verified syncope event or a syncope event that is suspected and verified. Automated processes are used to collect information associated with at least one syncope event and organize the information as a syncope log entry. At least one of acquiring the information and organizing the information is performed at least in part implantably.
摘要翻译：方法和系统旨在获取和组织与至少一个晕厥事件相关联的信息。晕厥事件可能是疑似晕厥事件，经过验证的晕厥事件或怀疑和验证的晕厥事件。自动进程用于收集与至少一个晕厥事件相关的信息，并将该信息组织为晕厥日志条目。至少部分地可植入地执行获取信息和组织信息中的至少一个。

76. 发明授权

US07460908B2 System providing ventricular pacing and biventricular coordination 有权
标题翻译：系统提供心室起搏和双心室协调
公开(公告)号：US07460908B2
公开(公告)日：2008-12-02
申请号：US10852602
申请日：2004-05-24
申请人： David B. Krig , Jesse W. Hartley , Wyatt Stahl , Jeffrey E. Stahmann
发明人： David B. Krig , Jesse W. Hartley , Wyatt Stahl , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3987
摘要： A cardiac rhythm management system includes techniques for computing an indicated pacing interval, AV delay, or other timing interval. In one embodiment, a variable indicated pacing interval is computed based at least in part on an underlying intrinsic heart rate. The indicated pacing interval is used to time the delivery of biventricular coordination therapy even when ventricular heart rates are irregular, such as in the presence of atrial fibrillation. In another embodiment, a variable filter indicated AV interval is computed based at least in part on an underlying intrinsic AV interval. The indicated AV interval is used to time the delivery of atrial tracking biventricular coordination therapy when atrial heart rhythms are not arrhythmic. Other indicated timing intervals may be similarly determined. The indicated pacing interval, AV delay, or other timing interval can also be used in combination with a sensor indicated rate indicator.
摘要翻译：心律管理系统包括用于计算指示的起搏间隔，AV延迟或其它定时间隔的技术。在一个实施例中，至少部分地基于潜在的内在心率来计算变量指示的起搏间隔。即使在室性心率不规则的情况下，例如在心房纤维性颤动的存在下，指示的起搏间隔也用于给双心室协调治疗的时间。在另一个实施例中，至少部分地基于潜在的固有AV间隔来计算指示AV间隔的可变滤波器。指示的AV间隔用于在心房心律不是心律不齐的时候交付心房跟踪双心室协调治疗。可以类似地确定其他指示的定时间隔。指示的起搏间隔，AV延迟或其他定时间隔也可以与传感器指示的速率指示器组合使用。

77. 发明授权

US08200326B2 Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance 有权
标题翻译：使用胸部直流阻抗校正阻抗监测呼吸体积
公开(公告)号：US08200326B2
公开(公告)日：2012-06-12
申请号：US12557372
申请日：2009-09-10
申请人： John D. Hatlestad , Loell Boyce Moon , Jesse W. Hartley , Jeffrey E. Stahmann
发明人： John D. Hatlestad , Loell Boyce Moon , Jesse W. Hartley , Jeffrey E. Stahmann
IPC分类号： A61B5/05 , A61B5/08
CPC分类号： A61N1/36521 , A61B5/0809 , A61B2560/0223 , A61N1/3756
摘要： A system includes an implantable medical device that includes a trans-thoracic impedance measurement circuit providing a trans-thoracic impedance signal of a subject. A controller is coupled to the trans-thoracic impedance circuit. The controller extracts a respiration signal from the trans-thoracic impedance signal, measures a breathing volume of the subject using the amplitude of the respiration signal and a breathing volume calibration factor, computes an adjusted breathing volume calibration factor using a reference baseline value of the trans-thoracic impedance and a measured baseline value of the trans-thoracic impedance, and computes a calibrated breathing volume using the adjusted breathing volume calibration factor.
摘要翻译：一种系统包括可植入医疗装置，其包括提供受试者的胸部阻抗信号的跨胸阻抗测量电路。控制器耦合到跨胸阻抗电路。控制器从胸部阻抗信号中提取呼吸信号，使用呼吸信号的幅度和呼吸音量校准因子来测量受试者的呼吸体积，使用反式信号的参考基准值计算调整后的呼吸量校准因子胸廓阻抗和经胸阻抗的测量基线值，并使用调整后的呼吸量校准因子计算校准呼吸量。

78. 发明授权

US08135465B2 System providing ventricular pacing and biventricular coordination 有权
标题翻译：系统提供心室起搏和双心室协调
公开(公告)号：US08135465B2
公开(公告)日：2012-03-13
申请号：US12325887
申请日：2008-12-01
申请人： David B. Krig , Jesse W. Hartley , Wyatt Stahl , Jeffrey E. Stahmann
发明人： David B. Krig , Jesse W. Hartley , Wyatt Stahl , Jeffrey E. Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/395
摘要： A cardiac rhythm management system includes techniques for computing an indicated pacing interval, AV delay, or other timing interval. In one embodiment, a variable indicated pacing interval is computed based at least in part on an underlying intrinsic heart rate. The indicated pacing interval is used to time the delivery of biventricular coordination therapy even when ventricular heart rates are irregular, such as in the presence of atrial fibrillation. In another embodiment, a variable filter indicated AV interval is computed based at least in part on an underlying intrinsic AV interval. The indicated AV interval is used to time the delivery of atrial tracking biventricular coordination therapy when atrial heart rhythms are not arrhythmic. Other indicated timing intervals may be similarly determined. The indicated pacing interval, AV delay, or other timing interval can also be used in combination with a sensor indicated rate indicator.
摘要翻译：心律管理系统包括用于计算指示的起搏间隔，AV延迟或其它定时间隔的技术。在一个实施例中，至少部分地基于潜在的内在心率来计算变量指示的起搏间隔。即使在室性心率不规则的情况下，例如在心房纤维性颤动的存在下，指示的起搏间隔也用于给双心室协调治疗的时间。在另一个实施例中，至少部分地基于潜在的固有AV间隔来计算指示AV间隔的可变滤波器。指示的AV间隔用于在心房心律不是心律不齐的时候交付心房跟踪双心室协调治疗。可以类似地确定其他指示的定时间隔。指示的起搏间隔，AV延迟或其他定时间隔也可以与传感器指示的速率指示器组合使用。

79. 发明授权

US07953485B2 Therapy control based on the rate of change of intracardiac impedance 有权
标题翻译：基于心内阻抗变化率的治疗控制
公开(公告)号：US07953485B2
公开(公告)日：2011-05-31
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

80. 发明申请

US20080249583A1 THERAPY CONTROL BASED ON THE RATE OF CHANGE OF INTRACARDIAC IMPEDANCE 有权
标题翻译：基于内皮抑素变化率的治疗控制
公开(公告)号：US20080249583A1
公开(公告)日：2008-10-09
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/368
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

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