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71. 发明授权

US08623292B2 Dehydration sensors with ion-responsive and charged polymeric surfactants 有权
标题翻译：具有离子响应和带电聚合物表面活性剂的脱水传感器
公开(公告)号：US08623292B2
公开(公告)日：2014-01-07
申请号：US12858204
申请日：2010-08-17
申请人： Xuedong Song , Ning Wei , Ronnie L. Phillips
发明人： Xuedong Song , Ning Wei , Ronnie L. Phillips
IPC分类号： G01N33/48
CPC分类号： G01N33/558 , A61F13/42 , A61F13/84 , A61F2013/00429 , A61F2013/0094 , A61F2013/00948 , A61F2013/15081 , A61F2013/15154 , A61F2013/8473
摘要： A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa ≦10−3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (≧1 wt. % solute) in water and aqueous solutions of low ionic concentration of ≦0.1 wt. % salts, but insoluble ( 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.
摘要翻译：描述了用于确定尿液的相对离子强度的侧流测定装置。该装置包括其中布置有聚电解质的缓冲区和具有非扩散固定在其中的pH指示剂的指示区，指示区与缓冲区分离并且定位成与缓冲区相邻并且与缓冲区流体连通。检测区域是缓冲区的一部分，并且具有包含弱聚合酸和具有pKa 10-3的弱聚合物碱的缓冲组分和对样品溶液中的相对离子浓度有反应的一类带电聚合物表面活性剂和带电荷的pH指示剂，其电荷与带电聚合物表面活性剂的电荷相反。带电荷的聚合物表面活性剂可溶于大约或等于约1重量％（> = 1重量％溶质）的水和低离子浓度@ 0.1重量％的水溶液。％盐，但不溶于（<1重量％溶质）在高离子浓度> 0.1重量％的水溶液中。％盐。本发明还描述了结合这种测定装置的吸收制品以及使用这种测试形式监测尿样的脱水或测试离子强度的方法。

72. 发明申请

US20130289508A1 Dryness Indicator For An Absorbent Article 有权
标题翻译：吸湿用品干燥指标
公开(公告)号：US20130289508A1
公开(公告)日：2013-10-31
申请号：US13459834
申请日：2012-04-30
申请人： Ning Wei , Shiming Zhuang , Xuedong Song , Kimberly Nicole Struk
发明人： Ning Wei , Shiming Zhuang , Xuedong Song , Kimberly Nicole Struk
IPC分类号： A61F13/42
CPC分类号： A61F13/42 , A61F2013/422 , A61F2013/423 , G04F13/06
摘要： A dryness indicator includes a wicking strip continuous between a reservoir end and an opposed open end; a liquid-impermeable top layer disposed on one side of the wicking strip; and a liquid-impermeable bottom layer disposed on the opposite side of the wicking strip, wherein the top layer is affixed to the bottom layer to at least partially enclose the wicking strip, and wherein the indicator is configured such that the open end of the wicking strip can be placed in liquid communication with an object or surface. The dryness indicator also includes a reservoir including an oil-based colorant with the potential to be in liquid communication with the reservoir end of the wicking strip, wherein the wicking strip is configured such that colorant wicking from the reservoir end and an unreacted water-based fluid wicking from the open end meet to define a timing line.
摘要翻译：干燥指示器包括在储存器端和相对开口端之间连续的芯吸条; 设置在芯吸条的一侧的不透液顶层; 以及设置在所述芯吸条的相对侧上的液体不可渗透的底层，其中所述顶层固定到所述底层以至少部分地包围所述芯吸条，并且其中所述指示器构造成使得所述芯吸的开口端条带可以与物体或表面液体连通。干燥指示器还包括储存器，其包括油基着色剂，其具有与芯吸条带的储存器端部液体连通的潜力，其中芯吸条被配置为使得从储存器端部着色剂芯吸和未反应的水基来自开口端的流体芯吸满足以限定时间线。

73. 发明授权

US07985209B2 Wound or surgical dressing 有权
标题翻译：伤口或手术敷料
公开(公告)号：US07985209B2
公开(公告)日：2011-07-26
申请号：US11303011
申请日：2005-12-15
申请人： Julie M. Villanueva , Curtis Neil Sayre , Lei Huang , Kevin Peter McGrath , Ning Wei
发明人： Julie M. Villanueva , Curtis Neil Sayre , Lei Huang , Kevin Peter McGrath , Ning Wei
IPC分类号： A61F13/02
CPC分类号： A61L15/46 , A61L2300/102 , A61L2300/404 , A61L2300/80
摘要： A wound or surgical dressing is disclosed. The wound or surgical dressing is configured to cover or surround a wound, a surgical incision, or any type of skin irritation. In accordance with the present disclosure, the wound or surgical dressing is treated with a bacteriostatic composition that is capable of binding and trapping negatively charged matter, such as bacteria, pathogens, and the like. The bacteriostatic composition comprises a cationic polymer, a cationic oligomer, or particles coated with a cationic material. The bacteriostatic composition is bonded to the wound or surgical dressing in a manner such that the bacteriostatic composition is not substantially transferred to a patient being treated.
摘要翻译：披露伤口或手术敷料。伤口或手术敷料构造成覆盖或围绕伤口，手术切口或任何类型的皮肤刺激。根据本公开，伤口或外科敷料用能够结合并捕获带负电荷的物质如细菌，病原体等的抑菌组合物进行处理。抑菌组合物包含阳离子聚合物，阳离子低聚物或涂覆有阳离子材料的颗粒。抑菌组合物以使得抑菌组合物基本上不被转移到被治疗的患者的方式结合到伤口或外科敷料上。

74. 发明授权

US07943395B2 Extension of the dynamic detection range of assay devices 有权
标题翻译：扩展检测装置的动态检测范围
公开(公告)号：US07943395B2
公开(公告)日：2011-05-17
申请号：US10718997
申请日：2003-11-21
申请人： Ning Wei , Rameshbabu Boga
发明人： Ning Wei , Rameshbabu Boga
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/54366 , Y10S436/807
摘要： A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes multiple detection zones, one of which is premised on “competitive” binding of the analyte and the other is premised on “sandwich” binding of the analyte. The present inventors believe that the combination of these zones may enable the detection of an analyte over extended concentration ranges.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的存在或数量的流通测定装置。该设备利用多个检测区域，其中之一是以分析物的“竞争性”结合为前提，另一个则以分析物的“三明治”结合为前提。本发明人认为，这些区域的组合可以使得能够在扩展的浓度范围内检测分析物。

75. 发明申请

US20100248299A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20100248299A1
公开(公告)日：2010-09-30
申请号：US12749814
申请日：2010-03-30
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译：合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。染料溶液也可以干燥，从而产生水溶液的干燥残余物。据信这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

76. 发明授权

US07687245B2 Microbial detection and quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US07687245B2
公开(公告)日：2010-03-30
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/22
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译：合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。染料溶液也可以干燥，从而产生水溶液的干燥残余物。据信这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

77. 发明申请

US20070249012A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20070249012A1
公开(公告)日：2007-10-25
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. A lateral flow device incorporating solvatochromic dyes and a method of detecting bacteria are also included.
摘要翻译：溶剂化色素染料在本文中用于通过将它们并入各种底物如薄膜，机织和非织造织物，纸巾，共成型和气流成网材料和粘合梳理纤维网中来表示细菌的存在。这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。还包括含有溶剂化色素染料的侧流装置和检测细菌的方法。

78. 发明申请

US20060068500A1 Detecting yeast infections using a lateral flow assay 审中-公开
标题翻译：使用侧流测定法检测酵母菌感染
公开(公告)号：US20060068500A1
公开(公告)日：2006-03-30
申请号：US10951367
申请日：2004-09-28
申请人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
发明人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N2333/40
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in liquid communication with a conjugate pad and a wicking pad. The conjugate pad has a gold colloid-containing detection probe. The porous membrane has a detection zone where an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. The control zone is located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. A sample containing an analyte is deposited on the conjugate pad, interacts with the detection probes, and moves toward the control zone for detection.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与结合垫和芯吸垫液体连通的多孔膜。共轭垫具有含金胶体的检测探针。多孔膜具有检测区，其中固定的第一捕获试剂被配置为结合至少一部分分析物和分析物 - 共轭复合物以产生检测信号。控制区位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。将含有分析物的样品沉积在共轭垫上，与检测探针相互作用，并朝向控制区移动进行检测。

79. 发明申请

US20050102218A1 Data processing system, methods and computer program for determining the transaction costs for a linked set of stock transactions 审中-公开
标题翻译：数据处理系统，方法和计算机程序，用于确定一系列交易的交易成本
公开(公告)号：US20050102218A1
公开(公告)日：2005-05-12
申请号：US10704892
申请日：2003-11-10
申请人： Timothy Sargent , John Wightkin , Ning Wei
发明人： Timothy Sargent , John Wightkin , Ning Wei
IPC分类号： G06Q40/00 , G06F17/60
CPC分类号： G06Q40/06 , G06Q40/04
摘要： A data processing system, methods and computer program that determine transaction costs associated with a stock trade. A first portion of the analysis is a trade identification and association portion that identifies previous related trades from a database and orders the trades by ticker identity, time, price and share volume. A second portion determines individual transaction costs, including individual liquidity charge, individual liquidity premium and individual spread charge. A third portion determines cumulative liquidity charge, cumulative liquidity premium and cumulative spread charge. The program that enables the various analyses is also disclosed.
摘要翻译：确定与股票交易相关的交易成本的数据处理系统，方法和计算机程序。分析的第一部分是贸易识别和关联部分，其识别来自数据库的先前的相关交易，并且通过交易者身份，时间，价格和份额来订购交易。第二部分确定个人交易成本，包括个人流动性费用，个人流动性溢价和个人差价费用。第三部分确定累积流动性费用，累积流动性溢价和累积分摊费用。还公开了能够进行各种分析的程序。

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