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    • 72. 发明申请
    • Non-Surgical Method and System for Reducing Snoring
    • 用于减少打鼾的非手术方法和系统
    • US20120222685A1
    • 2012-09-06
    • US13367052
    • 2012-02-06
    • Joseph E. Kovarik
    • Joseph E. Kovarik
    • A61F5/56
    • A61F5/566
    • A method, system and device for addressing the reduction of snoring includes a removable or dissolvable strip of material that adhere to mucosal tissue of a person's soft palate to provide stiffening support therefore, thus reducing the occurrence of vibration of such tissue during sleep. Preferred embodiments include of a specially textured surface, either one both or at least the outer side of an adhesive strip (the side facing away from the mucosal tissue to which it is attached) that has anti-microbial characteristics, bioluminescent expressions, etc. and a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human's mouth.
    • 用于解决打鼾减少的方法,系统和装置包括粘附到人的软腭的粘膜组织的可移除或可溶解的材料条,从而提供加强支撑,从而减少睡眠期间这种组织的振动的发生。 优选的实施方案包括具有抗微生物特性,生物发光表达等的粘合剂条的两侧或至少外侧(背离其附着的粘膜组织的一侧)的特殊纹理表面,以及 表面形貌抵抗通常存在于人的口中的不想要的细菌的生物粘附。
    • 76. 发明授权
    • Method and system for reducing the likelihood of developing depression in an individual
    • US11273187B2
    • 2022-03-15
    • US17011175
    • 2020-09-03
    • Joseph E. Kovarik
    • Joseph E. Kovarik
    • A61K35/74A61K31/715A61K38/17A61K31/58A61K35/00
    • A method for reducing the likelihood of developing depression in an individual involves providing in the gut of an individual a population of beneficial bacteria selected from the group consisting of bacterial species able to make small chain fatty acids, and preferably butyrate, and administering fiber to the individual to maintain a therapeutically effective amount of the beneficial bacteria in the gut of the individual. The individual's gut microbiome is modified to reduce the number of undesired bacteria and to increase the number of beneficial bacteria. Bacteria are preferably modified to remove one or more virulence facts or alternatively to produce increased amounts of SCFA's, such as butyrate. Beneficial bacteria may be encapsulated in a frangible enclosure to ensure they arrive in an individual's body while still viable, e.g. such as being first released in the lower gut rather than being exposed to the harsh conditions of an individual's stomach. In other embodiments, a therapeutically effective amount of a bacterial formulation comprising Faecalibacterium prausnitzii is administered. Other embodiments include the administration of a bacterial formulation comprising at least one of Coprococcus, Roseburia, Bifidobacterium, Faecalibacterium prausnitzii and L. casei to treat depression.