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71. 发明授权

US5858750A Human retinol dehydrogenase type II homolog 失效
标题翻译：人类视黄醇脱氢酶II型同源物
公开(公告)号：US5858750A
公开(公告)日：1999-01-12
申请号：US977847
申请日：1997-11-25
申请人： Olga Bandman , Preeti Lal , Neil C. Corley
发明人： Olga Bandman , Preeti Lal , Neil C. Corley
IPC分类号： C12N9/04 , C12N15/09 , C07K14/435 , C12N9/14
CPC分类号： C12N9/0006
摘要： The invention provides a human retinol dehydrogenase type II homolog (HRoDH) and polynucleotides which identify and encode HRoDH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HRoDH.
摘要翻译：本发明提供了人类视黄醇脱氢酶II型同源物（HRoDH）和识别和编码HRoDH的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与HRoDH表达相关的疾病的方法。

72. 发明授权

US5846777A Two cDNAs encoding WD-40 proteins 失效
标题翻译：编码WD-40蛋白的两个cDNA
公开(公告)号：US5846777A
公开(公告)日：1998-12-08
申请号：US883534
申请日：1997-06-26
申请人： Olga Bandman , Preeti Lal , Neil C. Corley
发明人： Olga Bandman , Preeti Lal , Neil C. Corley
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/4722 , A61K38/00
摘要： The invention provides two new WD-40 proteins (WDPro) and polynucleotides which identify and encode WDPro. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of WDPro.
摘要翻译：本发明提供了两种新的WD-40蛋白（WDPro）和识别和编码WDPro的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与WDPro表达相关的疾病的方法。

73. 发明授权

US5840537A cDNA encoding a vesicle transport protein 失效
标题翻译：编码囊泡转运蛋白的cDNA
公开(公告)号：US5840537A
公开(公告)日：1998-11-24
申请号：US900927
申请日：1997-07-25
申请人： Olga Bandman , Neil C. Corley , Preeti Lal
发明人： Olga Bandman , Neil C. Corley , Preeti Lal
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a human vesicle transport protein (NVTP-1) and polynucleotides which identify and encode NVTP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NVTP-1.
摘要翻译：本发明提供了人类囊泡转运蛋白（NVTP-1）和识别和编码NVTP-1的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与NVTP-1表达相关的疾病的方法。

74. 发明授权

US06919429B2 Prostate associated Ets protein 失效
标题翻译：前列腺相关Ets蛋白
公开(公告)号：US06919429B2
公开(公告)日：2005-07-19
申请号：US09866356
申请日：2001-05-24
申请人： Olga Bandman , Karl J. Guegler , Preeti Lal , Neil C. Corley
发明人： Olga Bandman , Karl J. Guegler , Preeti Lal , Neil C. Corley
IPC分类号： C07K14/47 , C07K1/00
CPC分类号： C07K14/4748
摘要： The invention provides a human prostate associated Ets protein (PRAEP) and polynucleotides which identify and encode PRAEP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PRAEP.
摘要翻译：本发明提供了人前列腺相关的Ets蛋白（PRAEP）和识别和编码PRAEP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与PRAEP表达相关的疾病的方法。

75. 发明申请

US20050042724A1 Novel human sodium-dependent phosphate cotransporter 审中-公开
标题翻译：新型人类钠依赖性磷酸盐协同转运蛋白
公开(公告)号：US20050042724A1
公开(公告)日：2005-02-24
申请号：US10877818
申请日：2004-06-25
申请人： Preeti Lal , Olga Bandman
发明人： Preeti Lal , Olga Bandman
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/15 , C07K14/705 , A61K38/17 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/6872
摘要： The present invention provides a human sodium-dependent phosphate cotransporter (NAPTR) and polynucleotides which identify and encode NAPTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NAPTR and a method for producing NAPTR. The invention also provides for agonists, antibodies, or antagonists specifically for NAPTR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NAPTR for the treatment of diseases associated with the expression of NAPTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NAPTR. The invention also provides a method for treating disorders associated with decreased phosphate levels by administering NAPTR and a method for treating disorders associated with increased phosphate levels by administering antagonists to NAPTR.
摘要翻译：本发明提供了人类钠依赖性磷酸盐协同转运体（NAPTR）和识别和编码NAPTR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NAPTR的核酸序列和产生NAPTR的方法。本发明还提供了专门用于NAPTR的激动剂，抗体或拮抗剂。另外，本发明提供了反义分子用于编码NAPTR的多核苷酸用于治疗与NAPTR表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NAPTR的抗体的诊断测定法。本发明还提供了一种通过施用NAPTR来治疗与磷酸盐水平降低相关的疾病的方法，以及通过向NAPTR施用拮抗剂来治疗与磷酸盐水平升高相关的疾病的方法。

76. 发明授权

US06524838B1 Human peptidyl-prolyl isomerases 失效
标题翻译：人肽基脯氨酰异构酶
公开(公告)号：US06524838B1
公开(公告)日：2003-02-25
申请号：US09639378
申请日：2000-08-15
申请人： Olga Bandman , Preeti Lal , Neil C. Corley , Chandra Patterson , Mariah R. Baughn
发明人： Olga Bandman , Preeti Lal , Neil C. Corley , Chandra Patterson , Mariah R. Baughn
IPC分类号： C12N990
CPC分类号： C12N9/90
摘要： The invention provides human peptidyl-prolyl isomerases (HPPIP) and polynucleotides which identify and encode HPPIP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPPIP.
摘要翻译：本发明提供了鉴定和编码HPPIP的人肽基 - 脯氨酰异构酶（HPPIP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HPPIP表达相关的病症的方法。

77. 发明授权

US06465619B1 Transducin beta-1 subunit 失效
标题翻译：转导蛋白β-1亚基
公开(公告)号：US06465619B1
公开(公告)日：2002-10-15
申请号：US09489506
申请日：2000-01-21
申请人： Olga Bandman , Preeti Lal , Neil C. Corley , Purvi Shah
发明人： Olga Bandman , Preeti Lal , Neil C. Corley , Purvi Shah
IPC分类号： C07K1400
CPC分类号： C07K14/4722
摘要： The invention provides a human transducin beta-1 subunit (TBS) and polynucleotides which identify and encode TBS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating or preventing diseases associated with expression of TBS.
摘要翻译：本发明提供了人转导素β-1亚基（TBS）和识别和编码TBS的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗或预防与TBS表达相关的疾病的方法。

78. 发明授权

US06416755B1 Human beta-alanine-pyruvate aminotransferase 失效
标题翻译：人β-丙氨酸 - 丙酮酸氨基转移酶
公开(公告)号：US06416755B1
公开(公告)日：2002-07-09
申请号：US09593722
申请日：2000-06-13
申请人： Olga Bandman , Preeti Lal , Neil C. Corley
发明人： Olga Bandman , Preeti Lal , Neil C. Corley
IPC分类号： A61K3851
CPC分类号： C12N9/1096 , C12Q1/6883
摘要： The invention provides a human beta-alanine-pyruvate aminotransferase (HAPA) and polynucleotides which identify and encode HAPA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HAPA.
摘要翻译：本发明提供了人β-丙氨酸 - 丙酮酸氨基转移酶（HAPA）和识别和编码HAPA的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与HAPA表达相关的病症的方法。

79. 发明授权

US06379913B1 Human serine carboxypeptidase 失效
标题翻译：人丝氨酸羧肽酶
公开(公告)号：US06379913B1
公开(公告)日：2002-04-30
申请号：US09299689
申请日：1999-04-26
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N948
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.
摘要翻译：本发明提供了人丝氨酸羧肽酶（CPEPT）和识别和编码CPEPT的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与CPEPT表达相关的疾病的方法。

80. 发明授权

US06326207B1 Human sodium-dependent phosphate cotransporter 有权
标题翻译：人类钠依赖性磷酸盐协同转运蛋白
公开(公告)号：US06326207B1
公开(公告)日：2001-12-04
申请号：US09391958
申请日：1999-09-08
申请人： Preeti Lal , Olga Bandman
发明人： Preeti Lal , Olga Bandman
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/6872
摘要： The present invention provides a human sodium-dependent phosphate cotransporter (NAPTR) and polynucleotides which identify and encode NAPTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NAPTR and a method for producing NAPTR. The invention also provides for agonists, antibodies, or antagonists specifically for NAPTR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NAPTR for the treatment of diseases associated with the expression of NAPTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NAPTR. The invention also provides a method for treating disorders associated with decreased phosphate levels by administering NAPTR and a method for treating disorders associated with increased phosphate levels by administering antagonists to NAPTR.
摘要翻译：本发明提供了人类钠依赖性磷酸盐协同转运体（NAPTR）和识别和编码NAPTR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NAPTR的核酸序列和产生NAPTR的方法。本发明还提供了专门用于NAPTR的激动剂，抗体或拮抗剂。另外，本发明提供了反义分子用于编码NAPTR的多核苷酸用于治疗与NAPTR表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NAPTR的抗体的诊断测定法。本发明还提供了一种通过施用NAPTR来治疗与磷酸盐水平降低相关的疾病的方法，以及通过向NAPTR施用拮抗剂来治疗与磷酸盐水平升高相关的疾病的方法。

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