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    • 71. 发明授权
    • Method and aparatus for determining an analyte in a biological sample
    • 用于测定生物样品中分析物的方法和装置
    • US5770454A
    • 1998-06-23
    • US737135
    • 1996-11-07
    • Matthias EssenpreisDirk BoeckerHeinz-Michael HeinHans-Peter Haar
    • Matthias EssenpreisDirk BoeckerHeinz-Michael HeinHans-Peter Haar
    • A61B5/00G01N21/49G01N21/00
    • A61B5/1455A61B5/14532G01N21/49A61B2562/0233A61B2562/0242A61B2562/043
    • A method and apparatus for analytical determination of a concentration of an analyte in a biological sample include a series of hardware elements and method steps which perform at least two detection measurements, with each detection measurement including the step of irradiating light at an irradiation site as primary light into the biological sample through a boundary surface. The light is propagated along a light path, and light is detected as it emerges from the biological sample as secondary light through a detection site. The irradiation site and detection site are separated by a measuring distance. At least two detection measurements are performed with at least two different measurement light paths between the irradiation site and the detection site. Each of the detection measurements is a frequency-domain spectroscopic measurement which is performed at at least two different wavelengths of light, and includes a comparison of a phase shift of the secondary light with the primary light as a first measurement variable, and an intensity of the secondary light as a second measurement variable. The method also includes the steps of determining the analyte concentration based upon the first and second measurement variables.
    • PCT No.PCT / DE95 / 00593 Sec。 371日期:1996年11月7日 102(e)日期1996年11月7日PCT提交1995年5月3日PCT公布。 公开号WO95 / 32416 PCT 日期:1995年11月30日用于分析生物样品中分析物浓度的方法和装置包括执行至少两次检测测量的一系列硬件元件和方法步骤,每个检测测量包括将光照射到 照射部位作为通过边界表面进入生物样品的初级光。 光沿光路传播,当从生物样品出现时,通过检测部位作为二次光检测出光。 照射部位和检测部位通过测量距离分开。 在照射部位和检测部位之间至少有两个不同的测量光路进行至少两次检测测量。 每个检测测量是在至少两个不同波长的光下执行的频域光谱测量,并且包括将次级光与初级光的相移作为第一测量变量的比较,以及 次光作为第二测量变量。 该方法还包括基于第一和第二测量变量确定分析物浓度的步骤。
    • 72. 发明授权
    • Test carrier analysis system
    • 测试载体分析系统
    • US5413764A
    • 1995-05-09
    • US503585
    • 1990-04-03
    • Hans-Peter Haar
    • Hans-Peter Haar
    • G01N21/78G01N21/86G01N33/52G01N21/75
    • G01N21/8483G01N33/521
    • A test carrier analysis system for analyzing a body fluid, the system including a test carrier (1) with a detection layer (20) on which a detectable change specific to the analysis takes place, obeying an evaluation curve, to the concentration of the component, and wherein the evaluation curve is dependent on the manufacturing batch of the test carrier. The system further includes an evaluator having a measuring and digitization circuit (25) which generates from the physically detectable change an intermediate result independent of the evaluation curve in the form of a finite number of digital output states, and having a display (7) for indicating the output states in the form of an alpha and/or numeric code. A readable information carrier element is provided having a correlation thereon between the alphanumeric codes of the display (7) corresponding to the output states and the concentration values determined in accordance with the evaluation curve.
    • 一种用于分析体液的测试载体分析系统,所述系统包括具有检测层(20)的测试载体(1),在所述测试载体(1)上发生对所述分析特异性的可检测变化,服从评估曲线, ,并且其中评估曲线取决于测试载体的制造批次。 该系统还包括具有测量和数字化电路(25)的评估器,其从物理上可检测的变化产生独立于有限数量的数字输出状态形式的评估曲线的中间结果,并且具有显示器(7),用于 以alpha和/或数字代码的形式指示输出状态。 提供了一种可读信息载体元件,其在与输出状态相对应的显示器(7)的字母数字代码与根据评估曲线确定的浓度值之间具有相关性。