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71. 发明授权

US5677283A .alpha.-heteroaryloxymethyl ketones as interleukin - 1 .beta. converting enzyme inhibitors 失效
标题翻译： α-杂环氧基甲基酮作为白细胞介素-1β转换酶抑制剂
公开(公告)号：US5677283A
公开(公告)日：1997-10-14
申请号：US732173
申请日：1996-10-16
申请人： Roland E. Dolle , Jasbir Singh , David A. Whipple , Catherine Prouty , Prasad V. Chaturvedula , Stanley J. Schmidt , Mohamed M. A. Awad , Denton W. Hoyer , Tina Morgan Ross
发明人： Roland E. Dolle , Jasbir Singh , David A. Whipple , Catherine Prouty , Prasad V. Chaturvedula , Stanley J. Schmidt , Mohamed M. A. Awad , Denton W. Hoyer , Tina Morgan Ross
IPC分类号： C12N9/99 , A61K31/397 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/47 , A61K31/472 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K38/00 , A61P29/00 , A61P37/00 , A61P43/00 , C07D205/04 , C07D207/38 , C07D209/12 , C07D215/14 , C07D217/16 , C07D223/08 , C07D231/20 , C07D231/22 , C07D261/12 , C07D263/06 , C07D265/06 , C07D265/30 , C07D311/46 , C07D311/50 , C07D311/56 , C07D401/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D453/02 , C07D471/04 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/09 , C07K5/097 , C07D231/04 , C07K5/00
CPC分类号： C07D401/12 , C07D207/38 , C07D231/20 , C07D231/22 , C07D261/12 , C07D311/46 , C07D311/56 , C07D409/12 , C07D413/04 , C07D417/12 , C07D453/02 , C07K5/0202 , A61K38/00
摘要： Compounds which Inhibit interleukin-1.beta. protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1## wherein n is 0-2; each AA is Independently L-valine or L-alanine; R.sub.1 is selected from the group consisting of N-�4(N,N-dimethylaminomethyl)!benzoyl, N-benzoyloxycarbonyl, N-methyl-N-�4-(pyridyl)methyl!, N-�4-(pyddyl)methyl!carbonyl, N-3-(piperidinopropionyl), N-�4-(morpholinoethoxy)benzoyl, N-2-(quinuclidinyl)carbonyl, N-(3-pyridyl)methoxy carbonyl, N-(2-pyddyl)methoxy carbonyl, N-methyl-N-benzyl carbonyl, N-methyl-N-�2-(4-pyridyl)ethyl!carbonyl, and N-(N-phenylpiperazino) carbonyl; and R.sub.8, R.sub.9 and R.sub.10 are as defined below.
摘要翻译：提供了抑制白细胞介素-1β蛋白酶活性的化合物，含有这些化合物的药物组合物和使用该化合物的方法。化合物具有式（1）其中n为0-2; 每个AA是独立的L-缬氨酸或L-丙氨酸; R1选自N- [4（N，N-二甲基氨基甲基）]苯甲酰基，N-苯甲酰氧基羰基，N-甲基-N- [4-（吡啶基）甲基]，N- [4-（吡啶基）甲基 ]羰基，N-3-（哌啶基丙酰基），N- [4-（吗啉代乙氧基）苯甲酰基，N-2-（奎宁环基）羰基，N-（3-吡啶基）甲氧基羰基，N-（2- N-甲基-N-苄基羰基，N-甲基-N- [2-（4-吡啶基）乙基]羰基和N-（N-苯基哌嗪基）羰基; 并且R 8，R 9和R 10如下所定义。

72. 发明授权

US5256657A Succinamide derivative matrix-metalloprotease inhibitors 失效
标题翻译：琥珀酰胺衍生物基质金属蛋白酶抑制剂
公开(公告)号：US5256657A
公开(公告)日：1993-10-26
申请号：US747887
申请日：1991-08-19
申请人： Jasbir Singh , Barry A. Morgan , James A. Gainor , Thomas D. Gordon , Robert C. Wahl
发明人： Jasbir Singh , Barry A. Morgan , James A. Gainor , Thomas D. Gordon , Robert C. Wahl
IPC分类号： C07C317/28 , C07C323/41 , C07D209/20 , A61K31/215 , A61K31/16 , A61K31/38 , A61K31/405 , A61K31/415 , A61K31/44 , C07C235/02 , C07C321/04 , C07D279/16 , C07D401/12 , C07D409/12 , C07D413/12
CPC分类号： C07C323/41 , C07C317/28 , C07D209/20
摘要： Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH.sub.2 R.sup.1 has the R-configuration, the carbon atom bearing CH.sub.2 R.sup.2 has the S-configuration, R.sup.1 is isopropyl, R.sup.2 is 3-indolyl, m is 2, n is 0, p is 2 and R.sup.3 and R.sup.4 taken alone are each methyl or R.sup.3 and R.sup.4 taken together with N are morpholino and pharmaceutically acceptable acid addition salts or solvates or acid addition salts-solvates thereof, which are matrix-metalloprotease inhibitors useful in treatment of disease in which matrix-metalloprotease promoted connective tissue remodelling is a causative factor, for example, rheumatoid arthritis and cancer, and a method of preparation and method of use thereof and methods of preparation of intermediates therefor are disclosed.
摘要翻译：结构式为其中X为HONH或HO的化合物，特别是其中带有CH2R1的碳原子具有R-构型，带有CH2R2的碳原子具有S-构型，R1是异丙基，R2是3-吲哚基，m为2，n为0，p为2，R 3和R 4各自为甲基，R 3和R 4与N一起为吗啉代和其药学上可接受的酸加成盐或溶剂化物或其酸加成盐 - 溶剂化物，其为基质可用于治疗基质金属蛋白酶促进结缔组织重塑的疾病的金属蛋白酶抑制剂是类风湿性关节炎和癌症的致病因素，其制备方法及其使用方法及其制备方法。

73. 发明授权

US4279697A Method of and apparatus for shutting down a gas-cooled nuclear reactor 失效
标题翻译：关闭气冷式核反应堆的方法和装置
公开(公告)号：US4279697A
公开(公告)日：1981-07-21
申请号：US964937
申请日：1978-11-30
申请人： Theodor Overhoff , Rudolf Schulten , Jasbir Singh , Gerd Sylvester , Josef Witte
发明人： Theodor Overhoff , Rudolf Schulten , Jasbir Singh , Gerd Sylvester , Josef Witte
IPC分类号： G21C9/033 , G21C7/22 , G21C9/02 , G21C7/06
CPC分类号： G21C9/02 , G21C7/22 , Y02E30/33 , Y02E30/39
摘要： A gas-cooled nuclear reactor whose nuclear-fuel elements are constituted by graphite-encapsulated nuclear fuel particles and have graphite coatings is shut down in accordance with the present invention by introducing into the primary coolant gas circulation, a gadolinium-containing substance which is dispersed in the primary cooling gas before the latter enters the space between the fuel elements within the reactor core so that the gadolinium-containing substance is at least partly deposited on the free graphitic surfaces of the fuel elements.
摘要翻译：一种气体冷却的核反应堆，其核燃料元件由石墨包封的核燃料颗粒构成并具有石墨涂层，根据本发明通过将主要的冷却剂气体循环引入分散的含钆物质来关闭在第一冷却气体中，其在后者进入反应堆堆芯内的燃料元件之间的空间中，使得含钆物质至少部分地沉积在燃料元件的游离石墨表面上。

74. 发明申请

US20130162190A1 INTEGRATED CONTROLLER FOR CLOSURE OPERATOR UNIT 审中-公开
标题翻译：封闭操作器单元集成控制器
公开(公告)号：US20130162190A1
公开(公告)日：2013-06-27
申请号：US13813233
申请日：2011-08-01
申请人： Travis William Smith , Nikolai Klepikov , Jasbir Singh , Ray Hawkins , Geoff Baker
发明人： Travis William Smith , Nikolai Klepikov , Jasbir Singh , Ray Hawkins , Geoff Baker
IPC分类号： H02P31/00 , F16P3/00
CPC分类号： E06B9/70 , E05Y2201/434 , E05Y2900/106 , F16P3/00 , H02K5/10 , H02K5/18 , H02K5/22 , H02K7/1004 , H02K7/1085 , H02K9/04 , H02K11/33 , H02P1/30 , H02P5/68 , H02P29/024 , H02P29/0241 , H02P31/00
摘要： An integrated controller for an operator unit for powering an overhead garage roller door or roller shutter is described. The operator unit comprises a motor, an output drive assembly, a timing assembly unit, and a clutch assembly for providing selective engagement between motor powered operation and manual operation (provided by a chain rotating a chain wheel). The motor is arranged to drive a shaft which, in turn, provides drive to the roller door or shutter assembly (not shown), which includes an axle around which the roller door or shutter is wound. The integrated controller comprises an inverter for receiving a single phase power supply and supplying three phase power to drive the motor; and a drive controller in operable association with the inverter for providing active management of the operation of the motor.
摘要翻译：描述了用于为架空车库门或卷帘提供动力的操作单元的集成控制器。操作单元包括电动机，输出驱动组件，定时组件单元和离合器组件，用于提供电动机供电操作和手动操作之间的选择性接合（由旋转链轮的链条提供）。马达被布置成驱动轴，该轴又向辊门或快门组件（未示出）提供驱动，所述滚轮门或快门组件（未示出）包括滚轮门或快门卷绕的轴。集成控制器包括用于接收单相电源并提供三相电力以驱动电动机的逆变器; 以及与所述逆变器可操作地相关联的驱动控制器，用于主动地管理所述电动机的操作。

75. 发明申请

US20130047236A1 AUTHENTICATION SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：认证系统及其方法
公开(公告)号：US20130047236A1
公开(公告)日：2013-02-21
申请号：US13639934
申请日：2010-09-29
申请人： Jasbir Singh
发明人： Jasbir Singh
IPC分类号： G06F21/00
CPC分类号： H04L63/08 , G06F21/36
摘要： The invention relates to a system and method for authentication of subscribers of a system (1), wherein an authentication key (1200) of a subscriber (10) is transmitted from an input unit (30) to an authentication unit (40) of the system (1), and wherein the subscriber (10) is authenticated by the authentication unit (40) based on the transmitted authentication key (1200) by means of saved authentication data (120), wherein each of the authentication keys is composed of a subset of a predefined authentication character (1201) set, wherein the system (1) dynamically generates a multidimensional visual representation (190) by geometrically arranging authentication characters of the authentication character (1201) set comprising successive characters of the authentication key (1200), and displays said multidimensional visual representation (190) by means of an output unit (20), wherein first geometrical orientations (195) of pairs of successive characters of the authentication key (1200) within the visual representation (190) is determined by the subscriber (10) and that said first geometrical orientations (195) are entered by the subscriber (10) for each of the pair of successive characters of the authentication key (1200) by means of the input unit (30) of the system (1), wherein each of said entered geometrical orientation (196) is transmitted to the system (1) and second geometrical orientations are generated based on the visual representation, and wherein the first and second geometrical orientations are compared by means of the authentication unit (40), wherein on successful comparison the subscriber (10) is authenticated by means of the authentication unit (40).
摘要翻译：本发明涉及一种用于认证系统（1）的用户的系统和方法，其中订户（10）的认证密钥（1200）从输入单元（30）发送到所述用户（10）的认证单元（40）系统（1），并且其中所述用户（10）由所述认证单元（40）基于所发送的认证密钥（1200）通过保存的认证数据（120）进行认证，其中每个所述认证密钥由其中所述系统（1）通过几何地布置包括认证密钥（1200）的连续字符的认证字符（1201）集合的认证字符来动态地生成多维视觉表示（190），所述认证字符（1201）并且通过输出单元（20）显示所述多维视觉表示（190），其中认证密钥（1200）的连续字符对中的第一几何取向（195）在视觉表示（190）内由用户（10）确定，并且所述第一几何取向（195）由所述用户（10）针对所述认证密钥（1200）的所述一对连续字符中的每一个借助于系统（1）的输入单元（30），其中所述输入的几何取向（196）中的每一个被传送到系统（1），并且基于视觉表示产生第二几何取向，并且其中第一和第二几何通过认证单元（40）比较取向，其中在成功比较时，订户（10）通过认证单元（40）进行认证。

76. 发明申请

US20130038134A9 NON-MOVING PART OR STATIC ELECTRIC GENERATOR 审中-公开
标题翻译：非移动部件或静态电力发电机
公开(公告)号：US20130038134A9
公开(公告)日：2013-02-14
申请号：US13395633
申请日：2010-01-14
申请人： Jasbir Singh
发明人： Jasbir Singh
IPC分类号： H01F38/00 , H02N11/00
CPC分类号： H02K53/00
摘要： A static or non-moving part electric power generator achieved by a changing (fluctuating) magnetic field (flux) by passing a pulsating direct current (DC) through a coil of wire wound on either a magnet or any material capable of producing a magnetic field, which in turn induces an alternating current (AC) in an adjacent secondary coil winding, and wherein a portion of the AC produced is used in recharging a DC source.
摘要翻译：通过使脉动直流（DC）通过缠绕在磁体上的线圈或能够产生磁场的任何材料的线圈通过变化（波动的）磁场（磁通）而实现的静态或非移动部分发电机，其又在相邻次级线圈绕组中引起交流电（AC），并且其中所产生的AC的一部分用于对DC源再充电。

77. 发明申请

US20110099668A1 Expressing GLK in plants 审中-公开
标题翻译：在植物中表达GLK
公开(公告)号：US20110099668A1
公开(公告)日：2011-04-28
申请号：US12151046
申请日：2008-05-01
申请人： Jasbir Singh , Ghislaine C. Allard , Leonid V. Savitch , Rajagopal Subramaniam
发明人： Jasbir Singh , Ghislaine C. Allard , Leonid V. Savitch , Rajagopal Subramaniam
IPC分类号： A01H5/00 , C12N15/82 , C12N15/63 , A01H1/00 , C12N5/04 , C07H21/04
CPC分类号： C12N15/8282
摘要： The present invention provides, in part, GLK1 nucleic acid molecules and polypeptides that can be used to confer resistance to a pathogen in a plant. The present invention also provides methods of detecting disease resistance genes and plants.
摘要翻译：本发明部分提供可用于赋予植物中病原体抗性的GLK1核酸分子和多肽。本发明还提供了检测抗病基因和植物的方法。

78. 发明申请

US20080125477A1 7-(ACRYLOYL) INDOLE COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译： 7-（丙烯酸）单体组合物及其制备方法和使用方法
公开(公告)号：US20080125477A1
公开(公告)日：2008-05-29
申请号：US11748897
申请日：2007-05-15
申请人： Jasbir Singh , Matt Shaoming Duan , Thorsteinn Thorsteinsson , Mitchell B. Friedman , Mark Gurney
发明人： Jasbir Singh , Matt Shaoming Duan , Thorsteinn Thorsteinsson , Mitchell B. Friedman , Mark Gurney
IPC分类号： A61K31/404 , A61P31/00 , A61P19/00 , A61P3/00 , A61P15/00 , A61P25/00 , A61P11/00
CPC分类号： A61K9/4866 , A61K9/14 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2095 , A61K9/4858 , A61K31/404
摘要： The present invention is directed to pharmaceutical compositions of 7-(acryloyl)indoles, such as 4,5 -Dichloro-thiophene-2-sulfonic acid [(E)-3-[1-(2,4-dichlorophenylmethyl)-5-fluoro-3-methyl-1H-indol-7-yl]-acryloyl]amide (DTSI), having a structure shown below. The invention is also directed to methods of treatment utilizing formulations of the DTSI and processes of preparation of the formulations.
摘要翻译：本发明涉及7-（丙烯酰基）吲哚的药物组合物，例如4,5-二氯 - 噻吩-2-磺酸[（E）-3- [1-（2,4-二氯苯基甲基）-5- 氟-3-甲基-1H-吲哚-7-基] - 丙烯酰基]酰胺（DTSI），具有下面所示的结构。本发明还涉及使用DTSI制剂的治疗方法和制剂的制备方法。

79. 发明授权

US07341533B2 CVT housing having wear-resistant bore 失效
标题翻译： CVT外壳具有耐磨孔
公开(公告)号：US07341533B2
公开(公告)日：2008-03-11
申请号：US10693186
申请日：2003-10-24
申请人： Yucong Wang , Sime Stavreski , Jasbir Singh
发明人： Yucong Wang , Sime Stavreski , Jasbir Singh
IPC分类号： F16H57/00 , C23C4/08 , C23C4/12
CPC分类号： F16H57/021 , C23C4/073 , C23C4/131 , F16H55/56 , Y10T74/2186 , Y10T428/12757
摘要： A continuously variable transmission (CVT) includes an aluminum housing member having a bore formed therein. A rotatable pulley member is supported on a bearing within the bore. The bore includes a layer of thermal spray coating for improved wear resistance so that the bore supports the bearing without a steel sleeve therebetween.
摘要翻译：无级变速器（CVT）包括其中形成有孔的铝壳体构件。可旋转的滑轮构件支撑在孔内的轴承上。该孔包括一层热喷涂，以提高耐磨性，使得该孔支撑轴承而其间没有钢套筒。

80. 发明申请

US20060128780A1 Cyclic substituted fused pyrrolocarbazoles and isoindolones 有权
公开(公告)号：US20060128780A1
公开(公告)日：2006-06-15
申请号：US11346524
申请日：2006-02-02
申请人： Robert Hudkins , Dandu Reddy , Jasbir Singh , Rabindranath Tripathy , Ted Underiner
发明人： Robert Hudkins , Dandu Reddy , Jasbir Singh , Rabindranath Tripathy , Ted Underiner
IPC分类号： A61K31/407 , C07D487/02
CPC分类号： C07D487/04 , C07D209/94
摘要： The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.

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