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71. 发明申请

US20110301857A1 Slope-Based Compensation Including Secondary Output Signals 有权
标题翻译：包括次级输出信号的斜率补偿
公开(公告)号：US20110301857A1
公开(公告)日：2011-12-08
申请号：US13117872
申请日：2011-05-27
申请人： Dijia Huang , Huan-Ping Wu
发明人： Dijia Huang , Huan-Ping Wu
IPC分类号： G06F19/00
CPC分类号： G01N27/3274 , G01N33/48714
摘要： A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.
摘要翻译：生物传感器系统从分析和/或次要输出信号确定分析物浓度。生物传感器系统通过从输出信号提取的一个或多个指数函数来调整从输出信号确定分析物浓度的相关性。索引函数确定与一个或多个错误参数的至少一个斜率偏差或归一化斜率偏差。可以使用分析物浓度和输出信号之间的斜率调整的相关性来确定包括归因于偏压的成分的输出信号具有改进的精度和/或精度的分析物浓度。

72. 发明申请

US20110108440A1 Underfill Recognition System for a Biosensor 有权
标题翻译：生物传感器底层识别系统
公开(公告)号：US20110108440A1
公开(公告)日：2011-05-12
申请号：US12910449
申请日：2010-10-22
申请人： Huan-Ping Wu , Joseph E. Perry , Christine Trippel , Eric Maurer
发明人： Huan-Ping Wu , Joseph E. Perry , Christine Trippel , Eric Maurer
IPC分类号： G01N27/26
CPC分类号： G01N27/4163 , G01N27/327 , G01N27/3274
摘要： A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample.
摘要翻译：具有底部填充识别系统的生物传感器评估是否根据样品的体积分析一种或多种分析物的样品。底部填充识别系统将轮询和测试激励信号应用于样品。轮询信号产生一个或多个轮询输出信号，其可以用于检测样本何时存在并确定样本是否具有足够的分析体积。测试激励信号产生一个或多个测试输出信号，其可用于确定样品中的一种或多种分析物浓度。

73. 发明申请

US20090148875A1 Control markers for auto-detection of control solution and method of use 有权
标题翻译：用于自动检测对照溶液的控制标记和使用方法
公开(公告)号：US20090148875A1
公开(公告)日：2009-06-11
申请号：US12316133
申请日：2008-12-10
申请人： Jing Lin , Fu Hsiung Tsai , Huan-Ping Wu , Nicole D. Ellis , Henry C. Arndt
发明人： Jing Lin , Fu Hsiung Tsai , Huan-Ping Wu , Nicole D. Ellis , Henry C. Arndt
IPC分类号： C12Q1/54
CPC分类号： G01N27/26 , C12Q1/001 , G01N27/327 , G01N27/3274 , G01N33/66 , G01N33/96 , G01N2496/00 , Y10T436/10 , Y10T436/104998 , Y10T436/13 , Y10T436/144444
摘要： A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
摘要翻译：执行在电化学测试传感器中区分对照溶液与样品的方法。该方法包括向对照溶液中加入对照标记物。对照溶液包括对照标记物和分析物。测试传感器包括工作和对电极以及试剂。对测试传感器施加电位以氧化对照标记物和分析物。测量所得的电流。将电位施加到测试传感器的低于其中电位足以氧化分析物而不是对照标记的其他电位。测量所得的电流。基于测量的电流确定是否存在对照溶液或样品。为了增加所测量的电流，与对照溶液相比，在不存在盐的情况下，盐可以以足以将电流增加至少5％的量加入到对照溶液中。

74. 发明申请

US20090014339A1 Oxidizable Species as an Internal Reference in Control Solutions for Biosensors 有权
标题翻译：可氧化物种作为生物传感器控制解决方案的内部参考
公开(公告)号：US20090014339A1
公开(公告)日：2009-01-15
申请号：US11887879
申请日：2006-04-07
申请人： Greg P. Beer , Huan-Ping Wu
发明人： Greg P. Beer , Huan-Ping Wu
IPC分类号： C12Q1/00
CPC分类号： G01N27/3274 , C12Q1/004 , G01N33/48707 , G01N33/49 , G01N33/66 , G01N33/96 , Y10T436/104998
摘要： Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.
摘要翻译：用于测量生物样品中特别是葡萄糖的分析物存在的电化学仪表的性能的测试包括引入含有预定量的分析物和预定量的内部参考化合物的对照溶液。选择内部参考化合物使得其以比用于氧化分析物的电位大的电位被氧化，从而使得可以将对照溶液与生物样品区分开。

75. 发明申请

US20070246357A1 Concentration Determination in a Diffusion Barrier Layer 有权
标题翻译：扩散阻挡层中的浓度测定
公开(公告)号：US20070246357A1
公开(公告)日：2007-10-25
申请号：US11734251
申请日：2007-04-11
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： G01N27/26
CPC分类号： G01N27/3271 , B32B38/18 , B32B2307/202 , C12Q1/004 , C12Q1/005 , C12Q1/006 , C12Q1/6813 , C12Q1/6825 , G01N27/3272 , G01N27/3276 , G01N27/3277 , G01N27/40 , G01N33/5438
摘要： The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced.
摘要翻译：本发明涉及改进的电化学生物传感器条和用于确定样品中分析物浓度的方法。通过选择性地测量驻留在扩散阻挡层中的可测量物质，基本排除驻留在扩散阻挡层外部的可测量物质，可以减少由诸如红细胞的样品组分引入的测量误差和制造方差。

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