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71. 发明授权

US07939671B2 Compounds that inhibit (block) bitter taste in composition and use thereof 有权
标题翻译：在组合物中抑制（阻断）苦味的化合物及其用途
公开(公告)号：US07939671B2
公开(公告)日：2011-05-10
申请号：US12222918
申请日：2008-08-19
申请人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07D261/08 , C07D413/14 , A61K31/44 , A61K31/42
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

72. 发明授权

US07927825B2 Methods of using T1R2/T1R3 heteromeric receptors to quantify taste of compounds for food or beverages 有权
标题翻译：使用T1R2 / T1R3异聚受体量化食物或饮料化合物味道的方法
公开(公告)号：US07927825B2
公开(公告)日：2011-04-19
申请号：US12270830
申请日：2008-11-13
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： C01N33/567 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： Methods of quantifying the taste of compounds for food and beverages are provided. These methods comprise contacting the compounds with an isolated heteromeric receptor comprising at least one T1R2 polypeptide and at least one T1R3 polypeptide.
摘要翻译：提供了定量食品和饮料化合物味道的方法。这些方法包括使化合物与包含至少一种T1R2多肽和至少一种T1R3多肽的分离的异聚受体接触。

73. 发明授权

US07883856B2 Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators 有权
标题翻译：识别特异性激活人T2R受体的苦配体和相关测定法，用于鉴定人类苦味调节剂
公开(公告)号：US07883856B2
公开(公告)日：2011-02-08
申请号：US11766974
申请日：2007-06-22
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/566 , G01N33/5008 , G01N33/5023 , G01N2500/00 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。此外，本发明还涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。也可以使用T2R配体作为治疗和调节T2R相关胃肠和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。

74. 发明申请

US20100292388A1 POLYMERIZATION PROCESS FOR PREPARING MONODISPERSAL ORGANIC/INORGANIC COMPOSITE NANO-MICROSPHERE 有权
标题翻译：单组分有机/无机复合纳米微球的制备工艺
公开(公告)号：US20100292388A1
公开(公告)日：2010-11-18
申请号：US12160802
申请日：2007-01-11
申请人： Longlan Cui , Hong Xu , Hongchen Gu
发明人： Longlan Cui , Hong Xu , Hongchen Gu
IPC分类号： C08J3/07
CPC分类号： C08F2/22
摘要： Polymerization process for preparing mono-disperse organic/inorganic nanocomposite microspheres in the field of nano technology is disclosed. The process comprises preparing of two different miniemulsion systems of A with inorganic nanoparticles and B with polymeric monomers in advance; adding water-soluble initiator into miniemulsion A, stirring till complete dissolution finally, heating the mixed system to a given temperature for isothermal reaction. The grain size of the as-prepared superparamagnetic Fe3O4/polystyrene using to present invention is homogeneous and controllable, and the magnetic particles content is controllable.
摘要翻译：公开了在纳米技术领域制备单分散有机/无机纳米复合微球的聚合方法。该方法包括预先制备具有无机纳米颗粒和B的两种不同的细乳液体系和聚合单体; 将水溶性引发剂加入到细乳液A中，搅拌至最终完全溶解，将混合体系加热至给定温度进行等温反应。使用本发明的制备的超顺磁性Fe 3 O 4 /聚苯乙烯的粒径是均匀的和可控的，并且磁性颗粒含量是可控的。

75. 发明授权

US07794959B2 Identification of bitter receptors for hydrolyzed soy protein 有权
标题翻译：鉴定水解大豆蛋白的苦味受体
公开(公告)号：US07794959B2
公开(公告)日：2010-09-14
申请号：US12053855
申请日：2008-03-24
申请人： Xiaodong Li , Hong Xu , Lan Zhang , Hanghui Liu , Keping Wu
发明人： Xiaodong Li , Hong Xu , Lan Zhang , Hanghui Liu , Keping Wu
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C12Q1/6895 , G01N33/5008 , G01N33/566 , G01N2500/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1 or hT2R67 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。本发明还涉及这些T2R受体在用于鉴定通过水解大豆蛋白材料及其衍生物和相关化合物中存在的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。此外，这些T2R配体可能被用作治疗和调节hT2R1或hT2R67相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等。

76. 发明授权

US07716469B2 Method and system for providing a circle of trust on a network 有权
标题翻译：在网络上提供信任圈的方法和系统
公开(公告)号：US07716469B2
公开(公告)日：2010-05-11
申请号：US10627019
申请日：2003-07-25
申请人： Bhavna Bhatnagar , Ping Luo , Qingwen Cheng , Shivaram Bhat , Hong Xu , Wei Sun , Aravindan Ranganathan
发明人： Bhavna Bhatnagar , Ping Luo , Qingwen Cheng , Shivaram Bhat , Hong Xu , Wei Sun , Aravindan Ranganathan
IPC分类号： H04L29/06 , H04L9/32 , G06F7/04
CPC分类号： H04L63/0815 , H04L9/3263 , H04L63/0823
摘要： Embodiments of the present invention provide a circle of trust on a network. The circle of trust is configured by exchanging credential of a first and a second affiliated entity. The credentials of the first affiliated entity is stored in a trusted partner list of the second affiliated entity. The credentials of the second affiliated entity is stored in a trusted partner list of the first affiliated entity. Thereafter, a circle of trust session may be provided when a client device initiates use of a resource on a relying party device by providing an authentication assertion reference. The identity of the issuing party of the authentication is determined as a function of the authentication assertion reference. The relying party sends an authentication query containing its credential to the issuing party. The issuing party determines if the relying party is a trusted entity based upon whether the relying party's credential is contained in the trusted partner list of the issuing party.
摘要翻译：本发明的实施例提供了一种网络上的信任圈。通过交换第一个和第二个附属实体的凭证来配置信任圈。第一个关联实体的凭证存储在第二个关联实体的可信合作伙伴列表中。第二个关联实体的凭证存储在第一个关联实体的可信赖的合作伙伴列表中。此后，当客户端设备通过提供认证断言引用来在依赖方设备上启动资源的使用时，可以提供一个信任圈。认证的发行方的身份被确定为认证断言参考的函数。依赖方向发卡方发送包含其凭据的认证查询。发行方基于信任方的凭证是否包含在发行方的受信任的合作伙伴列表中来确定依赖方是否是可信赖的实体。

77. 发明申请

US20090248824A1 THEME-BASED INSTANT MESSAGING COMMUNICATIONS 审中-公开
标题翻译：基于主题的即时消息通信
公开(公告)号：US20090248824A1
公开(公告)日：2009-10-01
申请号：US12414705
申请日：2009-03-31
申请人： Steven Francis Best , Yue Ma , Su Ying Rui , Hong Xu , Zhi Yu Yue
发明人： Steven Francis Best , Yue Ma , Su Ying Rui , Hong Xu , Zhi Yu Yue
IPC分类号： G06F15/16
CPC分类号： H04L51/04
摘要： Instant messaging communications are controlled using themes. A theme is a definition of properties and features of a specific instance of an instant messaging communications environment. Themes are stored at a server computer and may be requested by users of a client computer. Themes may be made available to users based on enterprise policies established by the owner of the server computer. Once downloaded to the client computer, a theme may be personalized by the user of the client computer provided personalization is consistent with the enterprise policy. Inheritance techniques may be used to provide personalized themes that remain consistent with enterprise policy while extending functions not defined in the enterprise policy. A user may select different themes manually. Alternatively, theme selection may be automated based on system detection of events such as time of day, user location, availability of network connections and the like. Changes in a downloaded theme may be returned to and stored by the server for future use by the user of the client computer.
摘要翻译：使用主题控制即时通讯。主题是即时消息通信环境的特定实例的属性和特征的定义。主题存储在服务器计算机中，可能由客户端计算机的用户请求。可以基于由服务器计算机的所有者建立的企业策略向用户提供主题。一旦下载到客户端计算机，主题可能会由客户端计算机的用户个性化提供个性化与企业策略一致。继承技术可用于提供与企业策略保持一致的个性化主题，同时扩展未在企业策略中定义的功能。用户可以手动选择不同的主题。或者，主题选择可以基于诸如时间，用户位置，网络连接的可用性等事件的系统检测而自动化。下载的主题中的更改可能返回到服务器并由客户端计算机的用户将来使用。

78. 发明申请

US20090221798A1 HETEROMERIC TASTE RECEPTORS 有权
标题翻译：异体吸收受体
公开(公告)号：US20090221798A1
公开(公告)日：2009-09-03
申请号：US12270857
申请日：2008-11-14
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： C07K14/00
CPC分类号： G01N33/5008 , A01K2217/05 , C07K14/705 , G01N33/5041 , G01N33/566 , G01N2333/726
摘要： Heteromeric taste receptors are provided. These receptors comprise a first polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R2 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R2 polypeptide or a different GPCR; and a second polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R3 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R3 polypeptide or that of a different GPCR.
摘要翻译：提供异味味觉受体。这些受体包含第一多肽，其包含细胞外和跨膜结构域，其中跨膜结构域与特异性T1R2多肽的跨膜结构域至少95％相同，并且细胞外结构域与特异性T1R2的相应胞外结构域至少95％相同多肽或不同的GPCR; 和包含细胞外和跨膜结构域的第二多肽，其中所述跨膜结构域与特异性T1R3多肽的跨膜结构域至少95％相同，并且细胞外结构域与特异性T1R3多肽的相应细胞外结构域至少95％相同，或不同的GPCR。

79. 发明申请

US20090221001A1 Methods for identifying compounds that modulate the T1R1/T1R3 umami taste receptor 有权
标题翻译：鉴定调节T1R1 / T1R3鲜味受体的化合物的方法
公开(公告)号：US20090221001A1
公开(公告)日：2009-09-03
申请号：US12270838
申请日：2008-11-13
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/566
CPC分类号： G01N33/5008 , C12N2503/00 , C12N2510/00 , C40B30/04 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： Methods for identifying compounds that modulate the T1R1/T1R3 umami taste receptors are provided. These methods comprise screening for compounds that compete with lactisole for binding to and/or inhibiting the T1R1/T1R3 umami taste receptor.
摘要翻译：提供了鉴定调节T1R1 / T1R3鲜味受体的化合物的方法。这些方法包括筛选与乳清蛋白竞争结合和/或抑制T1R1 / T1R3鲜味受体的化合物。

80. 发明申请

US20090087866A1 HUMAN T2R RECEPTORS FOR RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权
标题翻译：人类T2R受体的RANITIDINE，STRYCHNINE和DENATONIUM及相关测定用于鉴定人体双歧杆菌调味剂
公开(公告)号：US20090087866A1
公开(公告)日：2009-04-02
申请号：US12166980
申请日：2008-07-02
申请人： Xiaodong LI , Hong Xu , Huixian Tang , Qing Li
发明人： Xiaodong LI , Hong Xu , Huixian Tang , Qing Li
IPC分类号： G01N33/567
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。

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