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72. 发明授权

US06486213B1 Block and graft copolymers and methods relating thereto 失效
标题翻译：嵌段和接枝共聚物及其相关方法
公开(公告)号：US06486213B1
公开(公告)日：2002-11-26
申请号：US08483475
申请日：1995-06-07
申请人： Guohua Chen , Allan S. Hoffman
发明人： Guohua Chen , Allan S. Hoffman
IPC分类号： A61K4730
CPC分类号： A61K9/0014 , A61K8/91 , A61K9/2027 , A61K9/2031 , A61K47/32 , A61K47/34 , A61K2800/54 , A61Q19/00 , C08F265/10 , C08F291/00 , C08G81/00 , C08L71/02 , C08F220/06 , C08L2666/24 , C08L2666/04
摘要： There is disclosed block and graft copolymers, and hydrogels thereof, which, in one embodiment, contain both a temperature-sensitive polymer component and a pH-sensitive polymer component, and the use of such copolymers for topical drug delivery to a treatment area. The block and graft copolymers may be physically mixed with one or more drugs (or with other polymers) to form a copolymer-drug mixture. These mixtures may be applied as solid particles suspended in a pharmaceutically acceptable carrier, or as a liquid which gels upon contact with the treatment area. Upon contact with the treatment area, the pH-sensitive polymer component hydrates and swells, thereby causing release of the drug from the mixture. In addition, such hydration and swelling causes the pH-sensitive polymer component to adhere to the tissue of the treatment area, thus prolonging contact time. The temperature-sensitive polymer component resists hydration and swelling of the mixture, thereby imparting a sustained and controlled release of the drug to the treatment area. In another embodiment of this invention, block and graft copolymers, and hydrogels thereof, are disclosed having broad industrial applicability.
摘要翻译：公开了嵌段和接枝共聚物及其水凝胶，其在一个实施方案中同时包含温度敏感的聚合物组分和pH敏感的聚合物组分，以及使用这些共聚物来局部给药到处理区域。嵌段和接枝共聚物可以与一种或多种药物（或与其它聚合物）物理混合以形成共聚物 - 药物混合物。这些混合物可以作为悬浮在药学上可接受的载体中的固体颗粒施用，或作为与处理区域接触时凝胶化的液体施用。与处理区域接触时，pH敏感的聚合物组分水合并溶胀，从而导致药物从混合物中释放出来。此外，这种水合和溶胀导致pH敏感聚合物组分粘附到处理区域的组织，从而延长接触时间。温度敏感的聚合物组分抵抗混合物的水合和溶胀，由此赋予药物持续且受控的释放到治疗区域。在本发明的另一个实施方案中，公开了具有广泛的工业实用性的嵌段和接枝共聚物及其水凝胶。

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