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71. 发明授权

US08396539B2 Implantable medical device having optical fiber for sensing electrical activity 有权
标题翻译：具有用于感测电活动的光纤的可植入医疗装置
公开(公告)号：US08396539B2
公开(公告)日：2013-03-12
申请号：US11676128
申请日：2007-02-16
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61B5/04
CPC分类号： A61B5/0071 , A61B5/0084 , A61B5/0452
摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.
摘要翻译：一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

72. 发明授权

US08348884B2 Delivery of a sympatholytic cardiovascular agent to the central nervous system 有权
标题翻译：交配性心血管药物向中枢神经系统递送
公开(公告)号：US08348884B2
公开(公告)日：2013-01-08
申请号：US12128046
申请日：2008-05-28
申请人： Keith R. Hildebrand , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
发明人： Keith R. Hildebrand , Michael R. Ujhelyi , Xiaohong Zhou , Daniel C. Sigg , Linda M. Page
IPC分类号： A61M31/00
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西汀，脱甲基丸，美托咪定和右美托咪定）。

73. 发明申请

US20120185007A1 VAGAL STIMULATION 有权
标题翻译： VAGAL刺激
公开(公告)号：US20120185007A1
公开(公告)日：2012-07-19
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

74. 发明授权

US08126539B2 Method and apparatus for monitoring T-wave alternans 有权
标题翻译：用于监测T波交替的方法和装置
公开(公告)号：US08126539B2
公开(公告)日：2012-02-28
申请号：US11871405
申请日：2007-10-12
申请人： Xiaohong Zhou , Jeffrey M. Gillberg
发明人： Xiaohong Zhou , Jeffrey M. Gillberg
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/021 , A61N1/3702
摘要： An implantable medical device and associated method assess T-wave alternans by sensing a cardiac electrogram (EGM) signal and selecting a pair of consecutive T-wave signals from the EGM signal. A first amplitude and a second amplitude from each of the consecutive T-wave signals are determined. The differences between the first amplitudes and the second amplitudes of the consecutive T-wave signal pairs are used to compute a T-wave alternans metric.
摘要翻译：可植入医疗装置和相关方法通过感测心电图（EGM）信号和从EGM信号中选择一对连续的T波信号来评估T波交替。确定来自每个连续T波信号的第一幅度和第二幅度。使用连续T波信号对的第一幅度和第二幅度之间的差异来计算T波交替量度。

75. 发明申请

US20110245700A1 DETECTION OF T-WAVE ALTERNANS PHASE REVERSAL FOR ARRHYTHMIA PREDICTION AND SUDDEN CARDIAC DEATH RISK STRATIFICATION 有权
标题翻译： T-WAVE ALTERNANS相关检测ARRHYTHMIA预测和SUDDEN CARDIAC死亡风险分析
公开(公告)号：US20110245700A1
公开(公告)日：2011-10-06
申请号：US12749753
申请日：2010-03-30
申请人： Raja N. Ghanem , Xiaohong Zhou
发明人： Raja N. Ghanem , Xiaohong Zhou
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/7264 , A61B5/7275 , A61N1/36507 , G06F19/00
摘要： An implantable medical device and associated method for classifying a patient's risk for arrhythmias by sensing a cardiac electrogram (EGM) signal and selecting a first pair of T-wave signals and a second pair of T-wave signals. A first difference between the two T-wave signals of the first pair is compared to a second difference between the two T-wave signals of the second pair. A T-wave alternans phase reversal is detected in response to comparing the first difference and the second difference, and the patient's arrhythmia risk is classified in response to detecting the phase reversal.
摘要翻译：一种用于通过感测心电图（EGM）信号和选择第一对T波信号和第二对T波信号来分类患者心律失常风险的可植入医疗装置和相关方法。将第一对的两个T波信号之间的第一个差异与第二对的两个T波信号之间的第二个差值进行比较。响应于比较第一个差异和第二个差异，检测到T波交替相位逆转，并且响应于检测相位反转来分类患者的心律失常风险。

76. 发明申请

US20100198284A1 DETECTING AND TREATING ELECTROMECHANICAL DISSOCIATION OF THE HEART 有权
标题翻译：检测和治疗心脏的机械分离
公开(公告)号：US20100198284A1
公开(公告)日：2010-08-05
申请号：US12697019
申请日：2010-01-29
申请人： Xiaohong Zhou , Paul G. Krause , William T. Donofrio
发明人： Xiaohong Zhou , Paul G. Krause , William T. Donofrio
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/0551 , A61N1/36114 , A61N1/36557 , A61N1/36564 , A61N1/3962
摘要： In some examples, an electromechanical disassociation state (EMD) of a heart of a patient can be treated by delivering electrical stimulation to a tissue site to at least one of modulate afferent nerve activity or inhibit efferent nerve activity upon determining that the heart is in an electromechanical dissociation state, where the tissue site comprises at least one of a nonmyocardial tissue site or a nonvascular cardiac tissue site. The delivery of electrical stimulation may effectively treat the EMD state of the heart, e.g., by enabling effective mechanical contraction of the heart. In another example, an electromechanical disassociation state of a heart of a patient can be treated by determining autonomic nervous system activity associated with a detected EMD state of the heart of a patient, and delivering electrical stimulation therapy to the patient based on the determined autonomic nervous system activity of the patient associated with the EMD state.
摘要翻译：在一些示例中，可以通过将电刺激递送至组织部位至少调整传入神经活动或抑制传出神经活动的至少一种来治疗患者心脏的机电解离状态（EMD），确定心脏处于机电解离状态，其中组织部位包含非心肌组织部位或非血管心脏组织部位中的至少一个。电刺激的递送可以有效地治疗心脏的EMD状态，例如通过使心脏有效的机械收缩。在另一个示例中，可以通过确定与患者的心脏的检测到的EMD状态相关联的自主神经系统活动来治疗患者的心脏的机电解离状态，并且基于确定的自主神经向患者输送电刺激疗法与EMD状态相关的患者的系统活动。

77. 发明申请

US20080200769A1 IMPLANTABLE MEDICAL DEVICE HAVING OPTICAL FIBER FOR SENSING ELECTRICAL ACTIVITY 有权
标题翻译：具有用于传感电活动的光纤的可植入医疗装置
公开(公告)号：US20080200769A1
公开(公告)日：2008-08-21
申请号：US11676128
申请日：2007-02-16
申请人： VINOD SHARMA , Xiaohong Zhou
发明人： VINOD SHARMA , Xiaohong Zhou
IPC分类号： A61N5/06
CPC分类号： A61B5/0071 , A61B5/0084 , A61B5/0452
摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.
摘要翻译：一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

78. 发明申请

US20080177068A1 QUINAZOLE DERIVATIVES 审中-公开
标题翻译：喹唑啉衍生物
公开(公告)号：US20080177068A1
公开(公告)日：2008-07-24
申请号：US11939244
申请日：2007-11-13
申请人： Wenlin Huang , Xiaohong Zhou
发明人： Wenlin Huang , Xiaohong Zhou
IPC分类号： C07D239/94
CPC分类号： C07D239/94
摘要： The present invention relates to quinazoline derivatives represented by general formula (I): wherein X, Y, Z, R1, R2, R3, and R4 are as defined herein. The invention also relates to a method of preparing these compounds, and use of these compounds for inhibiting tumor growth.
摘要翻译：本发明涉及由通式（I）表示的喹唑啉衍生物：其中X，Y，Z，R 1，R 2，R 3， >和R 4'如本文所定义。本发明还涉及制备这些化合物的方法，以及这些化合物用于抑制肿瘤生长的用途。

79. 发明授权

US07142928B2 Field stimulation about a discontinuity of the myocardium to capture the heart at reduced pacing thresholds 失效
公开(公告)号：US07142928B2
公开(公告)日：2006-11-28
申请号：US10308302
申请日：2002-12-03
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0587 , A61N1/0573
摘要： Improved pacing thresholds for capturing the heart are achieved by forming a discontinuity in the cardiac tissue of the heart chamber, disposing a pacing electrode at a distance exceeding a space constant of the cardiac tissue from the discontinuity in the cardiac tissue, and applying a stimulus of a first polarity at an energy insufficient to cause the directly stimulated tissue adjacent to the pacing electrode to propagate a depolarization wave through the cardiac tissue mass of the heart chamber but sufficient to induce a transmembrane potential change at the tissue adjacent to the discontinuity that results in a propagated wave front. Thus, pacing energy is advantageously reduced.

80. 发明授权

US07027856B2 Method for determining a metric of non-sustained arrhythmia occurrence for use in arrhythmia prediction and automatic adjustment of arrhythmia detection parameters 失效
标题翻译：确定用于心律失常预测和心律失常检测参数自动调整的非持续性心律失常发生度量的方法
公开(公告)号：US07027856B2
公开(公告)日：2006-04-11
申请号：US10261316
申请日：2002-09-30
申请人： Xiaohong Zhou , Bruce D. Gunderson , Walter H. Olson , Robert W. Stadler
发明人： Xiaohong Zhou , Bruce D. Gunderson , Walter H. Olson , Robert W. Stadler
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61N1/3956
摘要： An implantable medical device and associated method are provided for detecting non-sustained arrhythmias and determining a metric of non-sustained arrhythmias. The metric may be used for predicting the occurrence of a sustained arrhythmia or for automatically adjusting the parameters used for detecting a sustained arrhythmia.
摘要翻译：提供可植入医疗装置和相关方法用于检测非持续性心律失常并确定非持续性心律失常的度量。该度量可以用于预测持续性心律失常的发生或用于自动调整用于检测持续性心律失常的参数。

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