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71. 发明授权

US6059726A Method for locating the atrio-ventricular (AV) junction of the heart and injecting active substances therein 失效
标题翻译：用于定位心脏的心房（AV）交界处并在其中注射活性物质的方法
公开(公告)号：US6059726A
公开(公告)日：2000-05-09
申请号：US933915
申请日：1997-09-23
申请人： Randall J. Lee , Michael D. Lesh
发明人： Randall J. Lee , Michael D. Lesh
IPC分类号： A61B5/042 , A61B8/12 , A61M25/00 , A61M25/01
CPC分类号： A61B8/12 , A61B5/042 , A61M25/0084
摘要： A method for locating the AV junction in the heart and injecting pharmacological or biological compounds into the AV junction for purposes of enhancing or retarding electrical conduction within the AV junction. The AV junction is identified using a combination of echocardiographs and intracardiac electrograms and, once, a catheter with an injection needle and infusion port is positioned into the AV junction for purposes of direct infusion of biologically active compounds to enhance or retard atrioventricular conduction of electrical impulses.
摘要翻译：用于定位心脏中的AV结并将药理学或生物化学物质注入AV结的方法，用于增强或延缓AV结内的电传导。使用超声心动图和心内电图的组合来识别AV结，并且一旦将具有注射针和输注端口的导管定位到AV结中，以便直接输注生物活性化合物以增强或延缓房室传导电脉冲。

72. 发明授权

US07993337B2 Circumferential ablation device assembly 有权
标题翻译：周围消融装置组装
公开(公告)号：US07993337B2
公开(公告)日：2011-08-09
申请号：US12464473
申请日：2009-05-12
申请人： Michael D. Lesh
发明人： Michael D. Lesh
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/00 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002 , A61N7/02
摘要： A circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein is described. The assembly includes a circumferential oblation clement which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described.
摘要翻译：描述了适于在肺静脉中形成圆周传导阻滞的周缘消融装置组件。组合件包括周向充填部分，其适于沿着围绕肺静脉管腔的肺静脉壁消融组织的周缘区域，从而横切肺静脉的导电性，以抵抗沿着其纵向轴线并进入左心房的传导。周向消融元件包括可膨胀构件，其具有可从径向收缩位置到径向扩张位置的可调节的工作长度。赤道带包围工作长度的外表面，并且适于在由消融致动器致动时消融邻近的组织。绝缘体的图案可以包括在消融元件上，否则将跨越工作长度以形成所描述的赤道带。

73. 发明授权

US07935146B2 Percutaneous mitral annuloplasty with hemodynamic monitoring 有权
标题翻译：经皮二尖瓣成形术与血液动力学监测
公开(公告)号：US07935146B2
公开(公告)日：2011-05-03
申请号：US10806906
申请日：2004-03-23
申请人： Jonathan J. Langberg , Michael D. Lesh
发明人： Jonathan J. Langberg , Michael D. Lesh
IPC分类号： A61F2/06
CPC分类号： A61F2/2451 , A61F2/2466 , A61N2001/0585
摘要： A minimally invasive method of performing mitral annuloplasty is disclosed. An implantable device is positioned within the coronary sinus and tightened around the mitral annulus. Mitral valve regurgitation is monitored before, during, and/or after the tightening step. An on-going drug therapy may be determined, taking into account post-implantation hemodynamic function.
摘要翻译：公开了进行二尖瓣瓣环成形术的微创方法。可植入装置位于冠状窦内并且紧固在二尖瓣环周围。在紧固步骤之前，之中和/或之后监测二尖瓣反流。可以确定正在进行的药物治疗，考虑到植入后血液动力学功能。

74. 发明申请

US20110009957A1 PERCUTANEOUS MITRAL ANNULPLASTY WITH CARDIAC RHYTHM MANAGEMENT 审中-公开
标题翻译：具有CARDIAC RHYTHM管理的PERCUTANEOUS MITRAL ANNULPLASTY
公开(公告)号：US20110009957A1
公开(公告)日：2011-01-13
申请号：US12883136
申请日：2010-09-15
申请人： Jonathan J. Langberg , Michael D. Lesh
发明人： Jonathan J. Langberg , Michael D. Lesh
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2/2466 , A61N2001/0585
摘要： A minimally invasive method of performing mitral annuloplasty is disclosed. An implantable device is positioned within the coronary sinus and tightened around the mitral annulus. Mitral valve regurgitation is monitored before, during, and/or after the tightening step. An on-going drug therapy may be determined, taking into account post-implantation hemodynamic function.
摘要翻译：公开了进行二尖瓣瓣环成形术的微创方法。可植入装置位于冠状窦内并且紧固在二尖瓣环周围。在紧固步骤之前，之中和/或之后监测二尖瓣反流。可以确定正在进行的药物治疗，考虑到植入后血液动力学功能。

75. 发明申请

US20090198330A1 COMPRESSIBLE COSMETIC PROSTHESIS WITH IMPROVED SHAPE RETENTION 审中-公开
标题翻译：具有改进形状保持性的可压缩化妆品
公开(公告)号：US20090198330A1
公开(公告)日：2009-08-06
申请号：US12024843
申请日：2008-02-01
申请人： Randy J. Kesten , Michael D. Lesh
发明人： Randy J. Kesten , Michael D. Lesh
IPC分类号： A61F2/12
CPC分类号： A61F2/12
摘要： An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.
摘要翻译：提供具有保持可流动物质的膜的可植入假体。膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。孔口具有在将假体植入病人之后可由使用者调节的尺寸。

76. 发明授权

US06989028B2 Medical system and method for remodeling an extravascular tissue structure 有权
公开(公告)号：US06989028B2
公开(公告)日：2006-01-24
申请号：US10066302
申请日：2002-01-30
申请人： Randall T. Lashinski , Matthew J. Birdsall , Michael D. Lesh
发明人： Randall T. Lashinski , Matthew J. Birdsall , Michael D. Lesh
IPC分类号： A61F2/06
CPC分类号： A61F2/2451
摘要： A medical apparatus and method suitable for remodeling a mitral valve annulus adjacent to the coronary sinus. The apparatus comprises an elongate body having a proximal region and a distal region. Each of the proximal and distal regions is dimensioned to reside completely within the vascular system. The elongate body may be moved from a first configuration for transluminal delivery to at least a portion of the coronary sinus to a second configuration for remodeling the mitral valve annulus proximate the coronary sinus. A forming element may be attached to the elongate body for manipulating the elongate body from the first transluminal configuration to the second remodeling configuration. Further, the elongate body may comprise a tube having a plurality of transverse slots therein.

77. 发明授权

US06966908B2 Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall 有权
公开(公告)号：US06966908B2
公开(公告)日：2005-11-22
申请号：US10274767
申请日：2002-10-21
申请人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
发明人： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC分类号： A61B17/00 , A61B18/00 , A61B18/08 , A61B18/14 , A61F2/958 , A61N7/02 , A61B18/18
CPC分类号： A61B18/00 , A61B18/08 , A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002 , A61N7/02
摘要： This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.

78. 发明授权

US06872205B2 Circumferential ablation device assembly 有权
标题翻译：周围消融装置组装
公开(公告)号：US06872205B2
公开(公告)日：2005-03-29
申请号：US10133523
申请日：2002-04-25
申请人： Michael D. Lesh , Michael Ronald Ross , Jonathan J. Langberg , James C. Peacock, III
发明人： Michael D. Lesh , Michael Ronald Ross , Jonathan J. Langberg , James C. Peacock, III
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/14 , A61N7/02 , A61B18/18
CPC分类号： A61B18/1492 , A61B18/00 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002 , A61N7/02
摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle.
摘要翻译：本发明是适于在肺静脉中形成圆周传导阻滞的周缘消融装置组件。该组件包括圆周消融元件，其适于沿着围绕肺静脉管腔的肺静脉壁消融组织的周缘区域，从而横切肺静脉的导电性，以抵抗沿着其纵向轴线并进入左心房的传导。周向消融元件包括可膨胀构件，其具有可从径向收缩位置到径向扩张位置的可调节的工作长度。赤道带包围工作长度的外表面，并且适于在由消融致动器致动时消融邻近的组织。赤道带相对于可扩展构件的纵向轴线具有相对于工作长度窄的长度，并且当工作长度处于径向扩张位置时也比其圆周短得多。绝缘体的图案可以包括在消融元件上，否则将跨越工作长度以形成所描述的赤道带。可膨胀构件还适于在其口部的区域中符合肺静脉，例如通过提供大量径向顺应性或通过沿具有远端减小外径的工作长度提供锥形。在组合组件中邻近周缘消融元件提供线性消融元件，该组合组件适用于在左心室的肺静脉口区域中的侵入性较小的“迷宫”型手术。

79. 发明授权

US06869431B2 Medical device with sensor cooperating with expandable member 有权
标题翻译：带传感器的医疗设备与可扩展部件配合使用
公开(公告)号：US06869431B2
公开(公告)日：2005-03-22
申请号：US09949479
申请日：2001-09-07
申请人： Mark A. Maguire , Martin F. O'Sullivan , Edward L. Carcamo , Michael D. Lesh , Alan K. Schaer , Kevin J. Taylor , Guillermo P. Picazo
发明人： Mark A. Maguire , Martin F. O'Sullivan , Edward L. Carcamo , Michael D. Lesh , Alan K. Schaer , Kevin J. Taylor , Guillermo P. Picazo
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/14 , A61B19/00 , A61N7/02 , A61B18/18
CPC分类号： A61B18/00 , A61B18/1492 , A61B2017/00092 , A61B2017/00243 , A61B2017/00526 , A61B2017/22051 , A61B2017/22067 , A61B2018/00065 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00357 , A61B2018/00369 , A61B2018/00375 , A61B2018/00702 , A61B2018/00791 , A61B2018/1253 , A61B2090/3784 , A61N7/02
摘要： Disclosed is a method for attaching a sensor to an inflatable balloon. The method involves bonding the sensor to the balloon with an adhesive while the balloon is in an expanded state and then collapsing the balloon after the adhesive has at least partially cured. The method reduces the possibility of a failure of the bond between the sensor and the balloon. The method is particularly useful in the construction of a tissue ablation catheter for forming a lesion along a substantially circumferential region of tissue wherein a sensor is used for monitoring the temperature of the tissue being ablated.
摘要翻译：公开了一种将传感器附接到可充气球囊的方法。该方法包括使用粘合剂将传感器粘合到球囊上，同时气囊处于膨胀状态，然后在粘合剂具有至少部分固化之后使囊膨胀。该方法降低了传感器和气囊之间的接合故障的可能性。该方法特别可用于组织消融导管的构造，用于沿着组织的基本圆周区域形成病变，其中传感器用于监测被消融的组织的温度。

80. 发明授权

US06709456B2 Percutaneous mitral annuloplasty with hemodynamic monitoring 有权
标题翻译：经皮二尖瓣成形术与血液动力学监测
公开(公告)号：US06709456B2
公开(公告)日：2004-03-23
申请号：US09968272
申请日：2001-10-01
申请人： Jonathan J. Langberg , Michael D. Lesh
发明人： Jonathan J. Langberg , Michael D. Lesh
IPC分类号： A61F206
CPC分类号： A61F2/2451 , A61F2/2466 , A61N2001/0585
摘要： A minimally invasive method of performing mitral annuloplasty is disclosed. An implantable device is positioned within the coronary sinus and tightened around the mitral annulus. Mitral valve regurgitation is monitored before, during, and/or after the tightening step. An on-going drug therapy may be determined, taking into account post-implantation hemodynamic function.
摘要翻译：公开了进行二尖瓣瓣环成形术的微创方法。可植入装置位于冠状窦内并且紧固在二尖瓣环周围。在紧固步骤之前，之中和/或之后监测二尖瓣反流。可以确定正在进行的药物治疗，考虑到植入后血液动力学功能。

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