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71. 发明申请

US20070292355A1 Anti-infection augmentation foamable compositions and kit and uses thereof 审中-公开
标题翻译：抗感染增加可发泡组合物和试剂盒及其用途
公开(公告)号：US20070292355A1
公开(公告)日：2007-12-20
申请号：US11732547
申请日：2007-04-04
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K31/015 , A61K31/415 , A61K31/4164 , A61K31/425 , A61K31/433 , A61K31/44 , A61K31/497 , A61P11/00 , A61P35/00 , A61P31/18 , A61P31/12 , A61P31/10 , A61P27/16 , A61P17/00 , A61K31/505 , A61K31/52 , A61K31/522 , A61K31/551 , A61K31/70 , A61K36/00 , A61K38/00
CPC分类号： A61K9/12 , A01N25/16 , A61K31/015 , A61K31/415 , A61K31/4164 , A61K31/425 , A61K31/433 , A61K31/44 , A61K31/497 , A61K31/505 , A61K31/52 , A61K31/522 , A61K31/551 , A61K31/70 , A61K36/00 , A61K2300/00
摘要： Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti-infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
摘要翻译：抗感染性可发泡组合物和试剂盒包括可发泡载体; 治疗安全有效的抗感染剂浓度; 选自由角质分解剂和皮肤渗透增强剂组成的组的增强剂; 和推进剂。将组合物容纳在容器中并且在释放时可膨胀以形成易碎泡沫。选择发泡载体以在增塑剂和抗感染剂的存在下产生良好或优异的质量的泡沫。描述了治疗，缓解或预防皮肤，体腔或粘膜表面疾病的方法，其中所述疾病涉及作为其病因之一的真菌，细菌或病毒感染。

72. 发明申请

US20070253911A1 Foamable compositions, kits and methods for hyperhidrosis 有权
标题翻译：可发泡组合物，多汗症的成套工具和方法
公开(公告)号：US20070253911A1
公开(公告)日：2007-11-01
申请号：US11717897
申请日：2007-03-13
申请人： Dov Tamarkin , Meir Eini , Ella Zlatkis
发明人： Dov Tamarkin , Meir Eini , Ella Zlatkis
IPC分类号： A61K9/10
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/062 , A61K8/31 , A61K9/0014 , A61K9/107 , A61Q15/00 , A61Q19/00
摘要： The composition of the present invention is geared towards treating hyperhidrosis or any condition involving and/or promoting excessive sweating, typically involving the whole body, include hyperthyroidism or similar endocrine disorders; endocrine treatment for prostatic cancer or other types of malignant disorder; severe psychiatric disorders; obesity and menopause. The foamable composition of the present invention is suitable for treating palmar hyperhidrosis; axillary hyperhidrosis; plantar hyperhidrosis; hyperhidrosis of the trunk and/or the thighs; and facial hyperhidrosis; and any combination of them consisting of a therapeutic foamable composition including: an active agent, suitable for the treatment or prevention of hyperhidrosis.
摘要翻译：本发明的组合物用于治疗多汗症或涉及和/或促进过度出汗（通常涉及全身）的任何病症，包括甲状腺机能亢进或类似的内分泌紊乱; 内分泌治疗前列腺癌或其他类型的恶性疾病; 精神障碍严重; 肥胖和绝经。本发明的可发泡组合物适用于治疗手掌多汗症; 腋窝多汗; 足底多汗症; 树干和/或大腿多汗; 和面部多汗症; 以及它们由治疗性可发泡组合物组成的任何组合物，其包含：适于治疗或预防多汗症的活性剂。

73. 发明申请

US20060088561A1 Pharmaceutical composition for topical application 有权
公开(公告)号：US20060088561A1
公开(公告)日：2006-04-27
申请号：US11294318
申请日：2005-12-05
申请人： Meir Eini , Dov Tamarkin
发明人： Meir Eini , Dov Tamarkin
IPC分类号： A61K36/899 , A61K36/738 , A61K31/496 , A61K31/225 , A61K31/43 , A61K31/545
CPC分类号： A21D2/14 , A21D2/16 , A23C9/1315 , A23C11/04 , A23C13/12 , A23C15/16 , A23C19/055 , A23C19/093 , A23D7/0053 , A23D7/0056 , A23D7/011 , A23D7/013 , A23D9/007 , A23G1/305 , A23G1/36 , A23G1/38 , A23G3/346 , A23G2200/08 , A23J3/227 , A23L7/109 , A23L7/122 , A23L7/183 , A23L13/43 , A23L19/18 , A23L23/10 , A23L33/115 , A23P20/11 , A61K8/342 , A61K8/922 , A61K9/0014 , A61K9/0048 , A61K31/225 , A61K31/351 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/573 , A61K31/65 , A61K36/738 , A61K36/899 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61Q19/00 , Y10S514/863 , Y10S514/864 , A61K2300/00
摘要： A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.

74. 发明申请

US20050232869A1 Nonsteroidal immunomodulating kit and composition and uses thereof 有权
标题翻译：非甾体免疫调节试剂盒及其组合物和用途
公开(公告)号：US20050232869A1
公开(公告)日：2005-10-20
申请号：US11078902
申请日：2005-03-11
申请人： Dov Tamarkin , Meir Eini , Doron Friedman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
IPC分类号： A61K8/04 , A61K8/67 , A61K31/07 , A61K31/203 , A61L9/04 , A61M11/00 , A61Q19/00 , A61K7/42
CPC分类号： A61K9/122 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K9/10 , A61K31/07 , A61K31/203 , A61Q19/00
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a nonsteroidal immunomodulating agent as a foam. The pressurized product includes a foamable composition including: a) a container accommodating a pressurized product; and b) an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a nonsteroidal immunomodulating agent; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.1% to about 5% by weight of a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof; v. about 0.01 % to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; vi. water; and vii. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种组合物和治疗试剂盒，其包括气溶胶包装组件，其包括容纳加压产品的容器和能够释放可发泡组合物的出口，其包括作为泡沫的非甾体免疫调节剂。加压产品包括可发泡组合物，其包括：a）容纳加压产品的容器; 和b）能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物，其包含：i。非甾体免疫调节剂; ii。选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.1重量％至约5重量％的治疗活性泡沫佐剂，其选自脂肪醇，脂肪酸，羟基脂肪酸; 及其混合物; 约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; vi。水; 和vii。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。

75. 发明申请

US20050205086A1 Retinoid immunomodulating kit and composition and uses thereof 审中-公开
标题翻译：类视黄醇免疫调节试剂盒及其组合物和用途
公开(公告)号：US20050205086A1
公开(公告)日：2005-09-22
申请号：US11078948
申请日：2005-03-11
申请人： Dov Tamarkin , Meir Eini , Doron Friedman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
IPC分类号： A61K8/04 , A61K8/67 , A61K31/07 , A61K31/203 , A61L9/04 , A61M11/00 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K9/122 , A61K31/07 , A61K31/203
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a retinoid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a retinoid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.
摘要翻译：一种组合物和治疗试剂盒，其包括气溶胶包装组件，其包括容纳加压产品的容器和能够释放可发泡组合物的出口，其包含类视黄醇作为泡沫。加压产品包括可发泡组合物，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物，其包含：i。类视黄醇 ii。选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。组合物还可以包括治疗活性的泡沫佐剂，其选自脂肪醇，脂肪酸，羟基脂肪酸; 及其混合物。

76. 发明申请

US20050075407A1 Foam incorporating eutetic mixture 审中-公开
标题翻译：泡沫混合可溶性混合物
公开(公告)号：US20050075407A1
公开(公告)日：2005-04-07
申请号：US10922555
申请日：2004-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K8/04 , A61K8/365 , A61K8/42 , A61K9/12 , A61K31/167 , A61K31/196 , A61K31/496 , A61Q19/00 , C08J9/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/342 , A61K8/37 , A61K8/39 , A61K8/731 , A61K9/0014 , A61K47/10 , A61K2800/91 , A61Q19/00 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a surface-active agent a gelling agent and a combination of active agents, which creates, upon admixing, a eutectic mixture. The foam carrier further comprises active agents and excipients with therapeutic properties.
摘要翻译：本发明涉及一种无醇化妆品或药物泡沫载体，其包含水，表面活性剂，胶凝剂和活性剂的组合，其在混合时产生共晶混合物。泡沫载体还包含具有治疗性质的活性剂和赋形剂。

77. 发明授权

US06348229B1 Food comprising thixotropic composition of unsaturated fat and process for manufacture thereof 失效
标题翻译：食品包含不饱和脂肪的触变组合物及其制造方法
公开(公告)号：US06348229B1
公开(公告)日：2002-02-19
申请号：US09526509
申请日：2000-03-16
申请人： Meir Eini , Dov Tamarkin
发明人： Meir Eini , Dov Tamarkin
IPC分类号： A23D9007
CPC分类号： A23G1/36 , A21D2/14 , A21D2/16 , A23C9/1315 , A23C11/04 , A23C13/12 , A23C15/16 , A23C19/055 , A23C19/093 , A23D7/0053 , A23D7/0056 , A23D9/007 , A23G1/305 , A23G3/346 , A23G2200/08 , A23J3/227 , A23L7/109 , A23L7/122 , A23L7/183 , A23L13/43 , A23L19/18 , A23L23/10 , A23L33/115 , A23P20/11 , A61K8/342 , A61K8/922 , A61K9/0048 , A61K31/351 , A61K31/573 , A61K31/65 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61Q19/00
摘要： The present invention relates to food products having a thixotropic composition containing an unsaturated oil in high proportion and to the process of preparing a food product comprising an thixotropic unsaturated oil composition or having such a thixotropic composition applied thereto to produce a coated food product.
摘要翻译：本发明涉及具有高比例含不饱和油的触变组合物的食品以及制备包含触变性不饱和油组合物或具有这种触变组合物的食品的制备方法以制备包衣食品。

78. 发明授权

US5227163A Lice-repellant compositions 失效
标题翻译：虱子驱避剂组合物
公开(公告)号：US5227163A
公开(公告)日：1993-07-13
申请号：US902415
申请日：1992-06-19
申请人： Meir Eini , Dov Tamarkin
发明人： Meir Eini , Dov Tamarkin
IPC分类号： A01N27/00 , A01N31/02 , A01N31/04 , A01N31/06 , A01N35/06 , A01N37/02 , A01N49/00 , A01N65/00 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/37 , A61K36/00 , A61Q17/02
CPC分类号： A61K8/33 , A01N27/00 , A01N31/02 , A01N31/04 , A01N31/06 , A01N35/06 , A01N37/02 , A01N49/00 , A01N65/00 , A01N65/06 , A01N65/08 , A01N65/22 , A01N65/36 , A61K8/34 , A61K8/35 , A61K8/37 , A61Q17/02 , Y10S424/10 , Y10S514/919
摘要： It has been discovered that terpenoids, especially terpenoid-alcohols (terpene-ols) and terpenoid-esters, and some aldehydes and ketones of terpenes, in a concentration of between 0.01% and 50% by weight, most preferably between 0.01% and 10%, are very good lice repellents. The active agent can be combined with a pharmaceutically and/or cosmetically acceptable carrier for topical administration, such as an aqueous or alcohol solution, a gel, cream, or a powder, and administered with or without additives such as other insect repellents, agents increasing solubility or delaying release of active agents, antimicrobials, antioxidants and fragrances. Examples demonstrate efficacy in in vitro and in in vivo testing.
摘要翻译：已经发现萜类化合物，特别是萜烯醇（萜烯醇）和萜烯酯，以及萜烯的一些醛和酮，其浓度为0.01重量％至50重量％，最优选为0.01重量％至10重量％，是非常好的虱子驱避剂。活性剂可以与用于局部给药的药学和/或化妆品可接受的载体组合，例如水或醇溶液，凝胶，奶油或粉末，并且与或不与添加剂一起施用，例如其他驱虫剂，增加剂活性剂，抗微生物剂，抗氧化剂和香料的溶解度或延迟释放。实施例证明在体外和体内测试中的功效。

79. 发明申请

US20060275221A1 Saccharide foamable compositions 有权
标题翻译：糖类可发泡组合物
公开(公告)号：US20060275221A1
公开(公告)日：2006-12-07
申请号：US11430437
申请日：2006-05-09
申请人： Dov Tamarkin , Doron Friedman , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Alex Besonov
IPC分类号： A61K8/00 , A61K9/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种可发泡组合物，其含有用于治疗各种疾病的糖类，包括水，糖类，约0.2％至约5％重量的表面活性剂，至少约0.01％至约5％一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物，以及以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

80. 发明授权

US08709385B2 Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses 有权
标题翻译：具有活性剂和/或治疗细胞和用途的泊洛沙姆可发泡药物组合物
公开(公告)号：US08709385B2
公开(公告)日：2014-04-29
申请号：US12836444
申请日：2010-07-14
申请人： Dov Tamarkin , Alex Besonov , Tal Berman , David Schuz , Elana Gazal
发明人： Dov Tamarkin , Alex Besonov , Tal Berman , David Schuz , Elana Gazal
IPC分类号： A61K8/00 , A61K8/02 , A61K9/00 , A61K9/12 , A61K31/00 , A61K31/60 , A61P17/00 , A61P31/00 , A61P29/00
CPC分类号： A61K9/122 , A61K8/046 , A61K8/90 , A61K9/06 , A61K9/107 , A61K31/19 , A61K31/196 , A61K31/506 , A61K31/522 , A61K31/60 , A61K31/7056 , A61K47/10 , A61K47/36 , A61Q19/00
摘要： Pharmaceutical or cosmetic compositions and methods for their use are provided comprising water and a surfactant polymer system comprising a Poloxamer at a concentration of about 0.1% to about 15% by weight; wherein when the Poloxamer is between about 0.1% to about 5% Poloxamer. The composition can further comprise a supporting agent comprising a non-ionic surface active agent or a supporting agent comprising a non surfactant polymer or polysaccharide and an active agent, where the Poloxamer is capable of fixing the composition on delivery to a body surface. There are further provided therapeutic cell compositions and their uses.
摘要翻译：提供了用于其使用的药物或化妆品组合物和方法，其包含水和表面活性剂聚合物体系，其包含浓度为约0.1重量％至约15重量％的泊洛沙姆; 其中当泊洛沙姆为约0.1％至约5％泊洛沙姆时。组合物还可以包含含有非离子表面活性剂或包含非表面活性剂聚合物或多糖和活性剂的支持剂的支持剂，其中泊洛沙姆能够将组合物在输送到身体表面时固定。还提供治疗细胞组合物及其用途。

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