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71. 发明申请

US20130137665A1 DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY 有权
标题翻译：具有肌钙蛋白受体拮抗剂和BETA2 ADRENERGIC受体激动剂的DIAMIDE化合物
公开(公告)号：US20130137665A1
公开(公告)日：2013-05-30
申请号：US13369109
申请日：2012-02-08
申请人： Adam Hughes , Daniel Byun , Yan Chen , Melissa Fleury , John R. Jacobsen , Eric L. Stangeland , Richard D. Wilson , Rose Yen
发明人： Adam Hughes , Daniel Byun , Yan Chen , Melissa Fleury , John R. Jacobsen , Eric L. Stangeland , Richard D. Wilson , Rose Yen
IPC分类号： A61K31/4709 , C07D401/12 , A61K31/56
CPC分类号： C07D401/12 , A61K31/444 , A61K31/4709 , A61K31/56 , A61K45/06
摘要： This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities. The invention also relates to pharmaceutical compositions comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compounds as bronchodilating agents to treat pulmonary disorders.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐。这些化合物具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性。本发明还涉及包含这些化合物的药物组合物，用于制备这些化合物的方法和中间体，以及使用这些化合物作为支气管扩张剂来治疗肺部疾病的方法。

72. 发明授权

US08438853B2 Combustor end cap assembly 有权
标题翻译：燃烧器端盖组件
公开(公告)号：US08438853B2
公开(公告)日：2013-05-14
申请号：US12247615
申请日：2008-10-08
申请人： Andrew Green , Peter Stuttaford , Yan Chen , Hany Rizkalla
发明人： Andrew Green , Peter Stuttaford , Yan Chen , Hany Rizkalla
IPC分类号： F02C1/00 , F02G3/00
CPC分类号： F01D9/023 , F23R3/002 , F23R3/283 , F23R3/286 , F23R2900/03041 , F23R2900/03044
摘要： A combustor end cap assembly having an improved cooling configuration is disclosed. Embodiments of the present invention are directed towards an apparatus and method for cooling an effusion plate of the combustor end cap assembly. The combustor end cap assembly also incorporates an impingement plate having a plurality of cooling holes with the impingement plate positioned a predetermined distance from the effusion plate. The cooling fluid passes through the impingement plate and is directed towards and onto the effusion plate for cooling of the effusion plate.
摘要翻译：公开了一种具有改进的冷却结构的燃烧器端盖组件。本发明的实施例涉及一种用于冷却燃烧器端盖组件的渗出板的装置和方法。燃烧器端盖组件还包括具有多个冷却孔的冲击板，冲击板定位在距离排出板预定距离处。冷却流体通过冲击板并且朝向和朝向积液板上并用于冷却渗出板。

73. 发明申请

US20120330019A1 Hepatitis C Virus Inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20120330019A1
公开(公告)日：2012-12-27
申请号：US13597381
申请日：2012-08-29
申请人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
发明人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
IPC分类号： C07K5/062 , C07C311/51 , C07D217/24
CPC分类号： A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的丙型肝炎病毒抑制剂：其中R1，R2，R3，R'，B，Y和X在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

74. 发明申请

US20120302888A1 ARRAY ULTRASOUND ENDOSCOPIC PROBE, A MANUFACTURE METHOD THEREOF AND A FIXING AND ROTATING DEVICE 审中-公开
标题翻译：阵列超声内窥镜探针，其制造方法及固定和旋转装置
公开(公告)号：US20120302888A1
公开(公告)日：2012-11-29
申请号：US13479017
申请日：2012-05-23
申请人： Jiyan Dai , Kwok Fung Cheung , Dan Zhou , Yat Ching Chiu , Kwok Ho Lam , Yan Chen , Helen L. W. Chan
发明人： Jiyan Dai , Kwok Fung Cheung , Dan Zhou , Yat Ching Chiu , Kwok Ho Lam , Yan Chen , Helen L. W. Chan
IPC分类号： A61B8/12 , H01L41/22
CPC分类号： A61B1/0011 , A61B8/12 , A61B8/44 , A61B8/4444 , Y10T29/42
摘要： This invention relates to a radial array ultrasound endoscopic probe and its manufacture method and a fixing and rotating device. The probe comprises: a metal cylinder located at the center; a plurality of piezoelectric elements which are cut from piezoelectric ceramic or single crystal rings and arranged around the metal cylinder, said piezoelectric elements and said metal cylinder being provided with a backing material layer for absorbing sound therebetween, said piezoelectric elements being covered with a matching material layer on the outer side thereof, and said piezoelectric elements are filled with decoupling material therebetween; a plurality of coaxial cables correspondingly connected with the plurality of piezoelectric elements; and a circular lattice in a gear shape which sleeves over said metal cylinder and functions to arrange and separate the coaxial cables. In the invention, the plurality of piezoelectric elements are directly cut out from the piezoelectric ceramic or single crystal ring, thus non-concentricity of arrays, misalignment of arrays at interface, the probe being liable to damage, disengagement and break-off, etc., that may arise from forcedly curling multiple lays of materials of a specific thickness, are avoided.
摘要翻译：本发明涉及径向阵列超声内窥镜探针及其制造方法和固定旋转装置。探头包括：位于中心的金属圆筒; 多个压电元件，其从压电陶瓷或单晶环切割并布置在金属圆筒周围，所述压电元件和所述金属圆筒设置有用于吸收声音的背衬材料层，所述压电元件被匹配材料覆盖并且所述压电元件在其之间填充有去耦材料; 多个同轴电缆，与多个压电元件相对应地连接; 以及齿轮形状的圆形格子，其套在所述金属圆筒上并且用于布置和分离同轴电缆。在本发明中，多个压电元件从压电陶瓷或单晶环直接切出，因此阵列的非同心度，界面处的阵列不对准，探头易于损坏，脱离和断开等。可能会由于强制卷曲特定厚度的材料而产生。

75. 发明授权

US08299094B2 Hepatitis C virus inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US08299094B2
公开(公告)日：2012-10-30
申请号：US12966175
申请日：2010-12-13
申请人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
发明人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的丙型肝炎病毒抑制剂：其中R1，R2，R3，R'，B，Y和X在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

76. 发明申请

US20120264625A1 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF CERVICAL CANCER 审中-公开
标题翻译：组合物，套件和方法，用于鉴定，评估，预防和治疗癌症
公开(公告)号：US20120264625A1
公开(公告)日：2012-10-18
申请号：US13273808
申请日：2011-10-14
申请人： John E. Monahan , Xumei Zhao , Yan Chen , Karen Glatt , Shubhangi Kamatkar
发明人： John E. Monahan , Xumei Zhao , Yan Chen , Karen Glatt , Shubhangi Kamatkar
IPC分类号： G01N33/574 , G01N21/76 , G01N21/64 , C12Q1/68 , C40B30/04
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57411 , G01N33/57488 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.
摘要翻译：本发明涉及与宫颈癌相关的核酸分子和蛋白质，包括恶变前病症如发育不良。还提供了用于检测，表征，预防和治疗人类宫颈癌的组合物，试剂盒和方法。

77. 发明申请

US20120142653A1 C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS 有权
标题翻译： C-28作为HIV成熟抑制剂的改性C-3白蛋白酸衍生物
公开(公告)号：US20120142653A1
公开(公告)日：2012-06-07
申请号：US13151722
申请日：2011-06-02
申请人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Yan Chen , Ny Sin
发明人： Alicia Regueiro-Ren , Zheng Liu , Jacob Swidorski , Nicholas A. Meanwell , Sing-Yuen Sit , Jie Chen , Yan Chen , Ny Sin
IPC分类号： A61K31/58 , A61P37/00 , A61P31/18 , C07J53/00 , A61K31/56
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译：阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。特别地，具有独特抗病毒活性的改良的C-3和C-28桦木酸衍生物作为HIV成熟抑制剂提供。这些化合物可用于治疗艾滋病毒和艾滋病。

78. 发明申请

US20120064548A1 NOVEL GENES, COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF CERVICAL CANCER 审中-公开
标题翻译：新陈代谢，组合物，试剂盒和方法，用于鉴定，评估，预防和治疗癌症
公开(公告)号：US20120064548A1
公开(公告)日：2012-03-15
申请号：US13271941
申请日：2011-10-12
申请人： Robert Schlegel , Yan Chen , Xumei Zhao , John E. Monahan , Shubhangi Kamatkar , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersh
发明人： Robert Schlegel , Yan Chen , Xumei Zhao , John E. Monahan , Shubhangi Kamatkar , Manjula Gannavarapu , Karen Glatt , Sebastian Hoersh
IPC分类号： G01N33/53 , C12N15/63 , C12N1/21 , C12N1/19 , C07K16/00 , G01N33/50 , C12N5/10 , C07H21/04 , C07K14/00
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/158 , Y10T436/143333
摘要： The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.
摘要翻译：本发明涉及新发现的与子宫颈癌相关的核酸分子和蛋白质，包括恶化前的疾病如发育不良。提供了用于检测，表征，预防和治疗人类宫颈癌的组合物，试剂盒和方法。

79. 发明申请

US20120028923A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权
标题翻译：用于抑制JAK路径的组合物和方法
公开(公告)号：US20120028923A1
公开(公告)日：2012-02-02
申请号：US13192344
申请日：2011-07-27
申请人： Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人： Hui Li , Thilo J. Heckrodt , Yan Chen , Darren John McMurtrie , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号： A61K31/506 , C12N9/99 , A61P37/06 , A61K31/675 , C07D413/14 , A61K31/685 , C07D413/12 , C07F9/6558
CPC分类号： C07D413/12 , C07B59/002 , C07B2200/05 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.
摘要翻译：公开了式I的化合物，含有它们的组合物，以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶，特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。还公开了制备该化合物的方法。

80. 发明申请

US20120016131A1 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权
公开(公告)号：US20120016131A1
公开(公告)日：2012-01-19
申请号：US13241041
申请日：2011-09-22
申请人： Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
发明人： Hui Li , Thilo J. Heckrodt , Yan Chen , Vanessa Taylor , Rajinder Singh , Pingyu Ding , Rose Yen
IPC分类号： C07D413/12
CPC分类号： C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.

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