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71. 发明申请

US20080295646A1 Method of Making Metal Nanoprisms Having a Predetermined Thickness 有权
标题翻译：制作具有预定厚度的金属纳米棱镜的方法
公开(公告)号：US20080295646A1
公开(公告)日：2008-12-04
申请号：US11629830
申请日：2005-06-29
申请人： Chad A. Mirkin , Gabriella Metraux
发明人： Chad A. Mirkin , Gabriella Metraux
IPC分类号： B22F9/24
CPC分类号： B22F9/24 , B22F1/0018 , B22F2001/0037 , B22F2998/10 , B22F2999/00 , B82Y30/00 , B22F2202/11 , B22F1/0081
摘要： A method of preparing metal nanoprisms having a unimodal size distribution and a predetermined thickness. The present method also allows control over nanoprism edge length.
摘要翻译：制备具有单峰尺寸分布和预定厚度的金属纳米棱镜的方法。本方法还允许控制纳米棱镜边缘长度。

72. 发明申请

US20080293588A1 NANODISK CODES 审中-公开
标题翻译：纳米尼克码
公开(公告)号：US20080293588A1
公开(公告)日：2008-11-27
申请号：US12119081
申请日：2008-05-12
申请人： Chad A. Mirkin , Jill E. Millstone , Lidong Qin , Matthew J. Banholzer
发明人： Chad A. Mirkin , Jill E. Millstone , Lidong Qin , Matthew J. Banholzer
IPC分类号： C40B30/04
CPC分类号： G01N33/54373 , C12Q1/6816 , C12Q2563/179
摘要： The invention relates to nanodisk codes and methods of using the nanodisk codes in encoding and detection schemes. In one aspect, the invention relates to nanodisk codes having a binary encoding scheme and functionalized such that the encoding of the nanodisk codes is detectable.
摘要翻译：本发明涉及纳米盘代码和在编码和检测方案中使用纳米盘代码的方法。一方面，本发明涉及具有二进制编码方案并且被功能化的纳米盘代码，使得可以检测纳米盘代码的编码。

73. 发明授权

US07361310B1 Direct write nanolithographic deposition of nucleic acids from nanoscopic tips 失效
标题翻译：从纳米尖端直接写入纳米光刻的核酸
公开(公告)号：US07361310B1
公开(公告)日：2008-04-22
申请号：US10307515
申请日：2002-12-02
申请人： Chad A. Mirkin , Linette Demers , David S. Ginger
发明人： Chad A. Mirkin , Linette Demers , David S. Ginger
IPC分类号： B01L3/02
CPC分类号： G03F7/0002 , G01Q80/00 , Y10T436/2575
摘要： The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure.
摘要翻译：描述了使用直写式纳米光刻技术在不同基底上产生锚定的纳米级核酸图案，包括导电和绝缘基底。含有反应性基团如硫醇基团的核酸（包括寡核苷酸）的修饰使得在合适的条件下使用合适的扫描探针显微镜尖端进行图案化。反应性基团提供化学吸附或共价结合到基底表面。所得到的表现出良好稳定性的核酸特征可与互补核酸杂交，并使用例如用核酸官能化的纳米颗粒进行相应的探测。可以通过选择尖端处理，相对湿度和核酸结构来控制图案化。

74. 发明授权

US07250499B2 Nanoparticles having oligonucleotides attached thereto and uses therefor 有权
标题翻译：纳米颗粒具有附着于其上的寡核苷酸并用于其中
公开(公告)号：US07250499B2
公开(公告)日：2007-07-31
申请号：US10716829
申请日：2003-11-18
申请人： Chad A. Mirkin , Robert L. Letsinger , Zhi Li
发明人： Chad A. Mirkin , Robert L. Letsinger , Zhi Li
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y15/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/00 , C40B40/06 , Y10S977/924 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2525/161 , C12Q2565/625 , C12Q2537/125
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.
摘要翻译：本发明提供了检测核酸的方法。所述方法包括使核酸与一种或多种具有与其连接的寡核苷酸的颗粒接触。在该方法的一个实施方案中，寡核苷酸与纳米颗粒连接并具有与核酸序列的部分互补的序列。作为纳米颗粒上的寡核苷酸与核酸的杂交的结果，导致可检测的变化（优选变色）。本发明还提供包含颗粒的组合物和试剂盒。本发明还提供了合成独特的纳米颗粒 - 寡核苷酸缀合物的方法，通过该方法产生的缀合物和使用缀合物的方法。此外，本发明提供纳米材料和包含纳米颗粒的纳米结构和使用纳米颗粒的纳米加工方法。最后，本发明提供了从其他核酸中分离选择的核酸的方法。

75. 发明授权

US07098320B1 Nanoparticles having oligonucleotides attached thereto and uses therefor 有权
公开(公告)号：US07098320B1
公开(公告)日：2006-08-29
申请号：US09975384
申请日：2001-10-11
申请人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas Andrew Taton
发明人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas Andrew Taton
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y15/00 , C07B2200/11 , C07H21/00 , C12Q1/6813 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/06 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2525/161 , C12Q2565/625 , C12Q2537/125
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

76. 发明授权

US06902895B2 Nanoparticles having oligonucleotides attached thereto and uses therefor 有权
公开(公告)号：US06902895B2
公开(公告)日：2005-06-07
申请号：US09976900
申请日：2001-10-12
申请人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
发明人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
IPC分类号： B82B1/00 , C07B61/00 , C07H21/00 , C12Q1/68 , C40B40/06 , C07H21/02 , C07H21/04 , G01N33/53
CPC分类号： C07H21/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07B2200/11 , C12Q1/6813 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/06 , Y10S977/924 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2565/625 , C12Q2537/125 , C12Q2525/161
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

77. 发明授权

US06812334B1 Nanoparticles having oligonucleotides attached thereto and uses therefor 有权
公开(公告)号：US06812334B1
公开(公告)日：2004-11-02
申请号：US09976618
申请日：2001-10-12
申请人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
发明人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
IPC分类号： C07H2100
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y15/00 , C07B2200/11 , C07H21/00 , C12Q1/6813 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/06 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2525/161 , C12Q2565/625 , C12Q2537/125
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

78. 发明授权

US06759199B2 Nanoparticles having oligonucleotides attached thereto and uses therefor 有权
公开(公告)号：US06759199B2
公开(公告)日：2004-07-06
申请号：US09957318
申请日：2001-09-20
申请人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
发明人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
IPC分类号： C12Q168
CPC分类号： C07H21/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07B2200/11 , C12Q1/6813 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/06 , Y10S977/924 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2565/625 , C12Q2537/125 , C12Q2525/161
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

79. 发明授权

US06709825B2 Nanoparticles having oligonucleotides attached thereto and uses therefor 有权
公开(公告)号：US06709825B2
公开(公告)日：2004-03-23
申请号：US09974500
申请日：2001-10-10
申请人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
发明人： Chad A. Mirkin , Robert L. Letsinger , Robert C. Mucic , James J. Storhoff , Robert Elghanian , Thomas A. Taton
IPC分类号： C12Q168
CPC分类号： C07H21/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07B2200/11 , C12Q1/6813 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/06 , Y10S977/924 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2565/625 , C12Q2537/125 , C12Q2525/161
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

80. 发明授权

US06635311B1 Methods utilizing scanning probe microscope tips and products therefor or products thereby 有权
标题翻译：使用扫描探针显微镜尖端及其产品或其产品的方法
公开(公告)号：US06635311B1
公开(公告)日：2003-10-21
申请号：US09477997
申请日：2000-01-05
申请人： Chad A. Mirkin , Richard Piner , Seunghun Hong
发明人： Chad A. Mirkin , Richard Piner , Seunghun Hong
IPC分类号： B05D500
CPC分类号： B82B3/00 , B05D1/007 , B05D1/185 , B05D1/26 , G01Q80/00 , G03F7/0002 , G03F7/165 , Y10S977/84 , Y10S977/857 , Y10S977/863 , Y10S977/877 , Y10T428/24917 , Y10T436/24
摘要： A method of direct-write nanolithography comprising: providing a solid substrate comprising a surface; providing a nanoscopic tip coated with patterning compound; and contacting the coated tip with the substrate, so that the patterning compound is delivered to the substrate so as to produce a desired pattern in submicrometer dimensions. Nanolithographic resolution can be affected by substrate grain size, diffusion rate of the patterning compound, tip-substrate contact time, the rate of transport of the patterning compound from the tip to the substrate, and tip sharpness. The method is a useful tool for fabrication of nanoscale structures.
摘要翻译：一种直写式纳米光刻方法，包括：提供包含表面的固体基质; 提供涂有图案化合物的纳米级尖端; 并使涂覆的末端与基底接触，使得图案化化合物被递送到基底，从而在亚微米尺寸上产生所需的图案。纳米光刻分辨率可能受衬底晶粒尺寸，图形化合物的扩散速率，尖端 - 衬底接触时间，图案化合物从尖端到衬底的传输速率和尖端锐度的影响。该方法是制造纳米级结构的有用工具。

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