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    • 72. 发明授权
    • Resilient hinge with coil spring on pintle
    • 弹簧铰链与螺旋弹簧在枢轴上
    • US4377019A
    • 1983-03-22
    • US277283
    • 1981-06-25
    • Jun Takahashi
    • Jun Takahashi
    • G03B27/62E05F1/12G03G15/04
    • E05F1/1207E05Y2900/20Y10T16/53888Y10T16/5513
    • A hinge device used with a rotation member having a rotational moment which varies in accordance with a rotation angle. The hinge device comprises a core bar inserted into a fixed member, a flat wire torsion spring fixed at its ends to the core bar and to the rotation members, respectively, a lever memer fixed to a portion of the core bar, and a first flat spring biasing the rotation of the core bar in a certain direction and having its ends abutting the fixed member and the rotation member. A second flat member is provided to operate against the spring torque of the flat wire torsion spring having its ends abutting the fixed member and the rotation member.
    • 一种与旋转构件一起使用的铰链装置,其具有根据旋转角度而变化的旋转力矩。 铰链装置包括插入固定构件的芯棒,在其端部分别固定到芯棒和旋转构件的扁平线扭簧,固定到芯棒的一部分的杠杆存储器,以及第一平面 弹簧将芯棒的旋转偏压到一定方向,并且其端部抵靠固定构件和旋转构件。 第二扁平构件设置成抵抗扁平线扭转弹簧的弹簧扭矩,其扁平线扭转弹簧的端部抵靠固定构件和旋转构件。
    • 77. 发明授权
    • Indoline derivatives
    • 二氢吲哚衍生物
    • US08686024B2
    • 2014-04-01
    • US13148011
    • 2010-02-03
    • Hachiro SugimotoJun TakahashiTakashi TakahashiIchiro Hijikuro
    • Hachiro SugimotoJun TakahashiTakashi TakahashiIchiro Hijikuro
    • A61K31/404C07D209/10
    • C07D405/14C07D209/08C07D401/06C07D401/12C07D403/06C07D403/12C07D405/06C07D405/12C07D409/12
    • The present invention provides a novel indoline derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or a salt thereof represented by the following formula (1) that has an excellent butyrylcholinesterase inhibitory activity. In the formula, R1 represents an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an arylalkyl group, a heteroarylalkyl group, a cycloalkylalkyl group, a heterocycloalkylalkyl group, a dihydrofurylalkyl group, an alkenyl group, a tetrahydronaphthyl group, or an indanyl group; R2 represents a hydrogen atom, an alkyl group, an arylalkyl group, a cycloalkylalkyl group, a heteroarylalkyl group, a heterocycloalkylalkyl group, an aryl group, or an acyl group; R3 each independently represents a hydrogen atom, an alkyl group, or a dialkylaminocarbonyl group; R4 each independently represents a hydrogen atom or an alkyl group; and R5 represents a hydrogen atom or an alkyl group. Each functional group may have a substituent.
    • 本发明提供具有优异的丁酰胆碱酯酶抑制活性的新型二氢吲哚衍生物或其药理学上可接受的盐或其由下式(1)表示的衍生物或其盐的溶剂合物。 在该式中,R 1表示烷基,环烷基,杂环烷基,芳基,杂芳基,芳烷基,杂芳基烷基,环烷基烷基,杂环烷基烷基,二氢呋喃基烷基,烯基, 四氢萘基或茚满基; R2表示氢原子,烷基,芳基烷基,环烷基烷基,杂芳基烷基,杂环烷基烷基,芳基或酰基; R3各自独立地表示氢原子,烷基或二烷基氨基羰基; R4各自独立地表示氢原子或烷基; R 5表示氢原子或烷基。 每个官能团可以具有取代基。