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71. 发明授权

US5473627A UHV rotating fluid delivery system 失效
标题翻译：特高压旋转流体输送系统
公开(公告)号：US5473627A
公开(公告)日：1995-12-05
申请号：US93761
申请日：1993-09-02
申请人： Nick Tsujimoto , Michael Weiss
发明人： Nick Tsujimoto , Michael Weiss
IPC分类号： H01J37/02 , H01J37/305
CPC分类号： H01J37/3053 , H01J2237/2001
摘要： A rotating all metal sealed fluid delivery system for supplying fluid to an apparatus, such as an electron beam source assembly, in an UHV environment includes a housing with fluid inlet and outlet ports therethrough, opposed fluid inlet and outlet lines, an inlet and outlet bellows within the housing, and a turntable mounted in an aperture in the housing for attachment to a rotatable spindle of the apparatus. A ultra high vacuum compression gasket forms an UHV seal between the spindle and the turntable. The bellows are attached at first ends to the inlet and outlet ports, and at opposite ends to the opposed inlet and outlet lines extending to the rotatable apparatus, through the spindle and the turntable into the housing. The bellows are coiled within the housing and separated by a non-abrasive plate. Following attachment to the ports and lines, the entire length of each bellows remains within a single plane during rotation along the same axis as the axis of rotation of the apparatus. As the spindle rotates up to 360.degree., the oppositely wound bellows are moved along the axis of rotation of the spindle where one coils as the other uncoils, all in the same horizontal plane.
摘要翻译：在特高压环境中用于向诸如电子束源组件的装置供应流体的旋转全金属密封流体输送系统包括具有流体入口和出口的壳体，相对的流体入口和出口管线，入口和出口波纹管以及安装在壳体中的孔中的转盘，用于附接到该装置的可旋转主轴。超高真空压缩垫片在主轴和转台之间形成UHV密封。波纹管在第一端处连接到入口和出口，并且在相对的端部处连接到延伸到可旋转设备的相对的入口和出口管线，通过主轴和转盘进入壳体。波纹管卷绕在壳体内并由非研磨板隔开。在连接到端口和线路之后，沿着与设备的旋转轴线相同的轴线旋转期间，每个波纹管的整个长度保持在单个平面内。当主轴旋转高达360度时，相反卷绕的波纹管沿着主轴的旋转轴线移动，其中一个线圈作为另一个卷绕，全部处于相同的水平面。

72. 发明申请

US20180075091A1 GENERATING ATTRIBUTE-BASED GRANULAR DATABASE QUERY 审中-公开
公开(公告)号：US20180075091A1
公开(公告)日：2018-03-15
申请号：US15262052
申请日：2016-09-12
申请人： Michael Weiss , Kurt Heim , Lawrence S. Rosner
发明人： Michael Weiss , Kurt Heim , Lawrence S. Rosner
IPC分类号： G06F17/30
CPC分类号： G06F16/2423 , G06F3/011 , G06F3/03547 , G06F3/04817 , G06F3/04845 , G06F3/04847 , G06F3/04883 , G06F3/04886 , G06F16/248 , G06F16/951
摘要： A method for constructing an interactive database query interface. The method includes receiving a data structure including a search category for a consumable substance, an array of attributes associated with the search category, and range of values of the attributes. Each of the attributes indicates a physiological effect caused by ingesting the consumable substance. The range of values indicates intensity levels of the physiological effect. The method further includes dividing a graphical user interface in a plurality of sub-regions, and assigning a graphical representation in the graphical user interface with the search category and each of the plurality of sub-regions in the graphical user interface with one of the attributes in the array. The method further includes providing the graphical representation in the graphical user interface, where each of the plurality of attributes is displayed within the assigned sub-region of the graphical user interface.

73. 发明授权

US08993516B2 Meal-time insulin analogues of enhanced stability 有权
标题翻译：膳食时间胰岛素类似物具有增强的稳定性
公开(公告)号：US08993516B2
公开(公告)日：2015-03-31
申请号：US12937612
申请日：2009-04-14
申请人： Michael Weiss
发明人： Michael Weiss
IPC分类号： A61K38/28 , C07K14/62 , A61K38/00
CPC分类号： C07K14/62 , A61K38/00
摘要： A method treating a patient includes administering a physiologically effective amount of a fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof to the patient. The fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof, contains an insulin A-chain sequence modified at position A8 and an insulin B-chain sequence or an analogue thereof. The fibrillation-resistant insulin analogue may exhibit thermodynamic stability similar to or exceeding that of wild-type human insulin and displays a susceptibility to fibrillation similar to or exceeding that of wild-type human insulin. An insulin analogue may display greater in vitro insulin receptor binding than normal insulin while displaying binding to IGFR less than twice that of normal insulin and less than that of fast-acting insulin analogs. The fibrillation-resistant insulin may be used to treat a patient by subcutaneous injection or by using an implantable or external insulin pump, due to its fibrillation resistance.
摘要翻译：治疗患者的方法包括向患者施用生理有效量的抗纤维化的胰岛素类似物或其生理上可接受的盐。抗纤维化胰岛素类似物或其生理上可接受的盐含有在A8位修饰的胰岛素A链序列和胰岛素B链序列或其类似物。抗纤维化胰岛素类似物可以表现出类似于或超过野生型人胰岛素的热力学稳定性，并显示与类似于或超过野生型人胰岛素的纤维性颤动的易感性。胰岛素类似物可能显示比正常胰岛素更大的体外胰岛素受体结合，同时显示与IGFR的结合小于正常胰岛素的两倍，并且低于快速作用的胰岛素类似物的结合。抗纤维化胰岛素可用于通过皮下注射或通过使用可植入或外用胰岛素泵治疗患者，由于其抗纤维化作用。

74. 发明授权

US08921313B2 Halogen-stabilized insulin 有权
标题翻译：卤素稳定型胰岛素
公开(公告)号：US08921313B2
公开(公告)日：2014-12-30
申请号：US13018011
申请日：2011-01-31
申请人： Michael Weiss
发明人： Michael Weiss
IPC分类号： A61K38/28 , A61P3/10 , C07K14/62 , A61K38/00
CPC分类号： C07K14/62 , A61K38/00 , A61K38/28
摘要： An insulin analogue comprises a B-chain polypeptide incorporating a halogenated phenylalanine at position B24, B25 or B26. The halogenated phenylalanine may be ortho-monofluoro-phenylalanine, ortho-monobromo-phenylalanine, ortho-monochloro-phenylalanine, or para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The halogenated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Halogen substitution-based stabilization of insulin may enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration.
摘要翻译：胰岛素类似物包含在位置B24，B25或B26掺入卤代苯丙氨酸的B链多肽。卤代苯丙氨酸可以是邻位一氟 - 苯丙氨酸，邻 - 一溴 - 苯丙氨酸，邻 - 一氯 - 苯丙氨酸或对 - 单氯 - 苯丙氨酸。类似物可以是哺乳动物胰岛素，例如人胰岛素。核酸编码这样的胰岛素类似物。卤化胰岛素类似物保留显着的活性。治疗患者的方法包括向患者施用生理有效量的胰岛素类似物或其生理上可接受的盐。基于卤素替代的胰岛素稳定可以增强在缺乏制冷的发展中国家地区的糖尿病治疗。

75. 发明申请

US20140299439A1 ACTUATOR DEVICE FOR ACTUATING A COUPLING MECHANISM 审中-公开
标题翻译：用于执行联动机构的执行器装置
公开(公告)号：US20140299439A1
公开(公告)日：2014-10-09
申请号：US14363119
申请日：2012-08-09
申请人： Michael Weiss , Klaus Hahn
发明人： Michael Weiss , Klaus Hahn
IPC分类号： F16D25/06
CPC分类号： F16D25/06 , F01P7/16 , F01P2007/143 , F04D13/021 , F16D15/00 , F16D25/061
摘要： An actuator device for actuating a coupling mechanism or a transmission in a drive wheel in a belt drive or chain drive, includes a shaft, releasably connectable to the drive wheel and at least partially hollow, a push rod connected to the coupling mechanism or transmission and displaceable coaxially to the longitudinal axis of the shaft, a housing having an internal bore for at least partially receiving the shaft, and at least one first bearing disposed in the internal bore of the housing for rotatably supporting the shaft. The actuator device constitutes a fluidic actuator having at least one first pressure chamber capable of being pressurized with a fluid.
摘要翻译：用于致动联动机构或传动装置的传动装置，其中传动装置或传动装置在传动带驱动装置或链条传动装置中包括可释放地连接到驱动轮并且至少部分中空的轴，连接到联接机构或传动装置的推杆和可与轴的纵向轴线同轴地移动，壳体具有用于至少部分地容纳轴的内孔，以及设置在壳体的内孔中的至少一个第一轴承，用于可旋转地支撑轴。致动器装置构成具有能够被流体加压的至少一个第一压力室的流体致动器。

76. 发明授权

US08850805B2 Exhaust manifold 有权
标题翻译：排气歧管
公开(公告)号：US08850805B2
公开(公告)日：2014-10-07
申请号：US13533644
申请日：2012-06-26
申请人： Ralf Riekers , Michael Weiss
发明人： Ralf Riekers , Michael Weiss
IPC分类号： F01N1/00 , F01N13/18 , F01N13/10
CPC分类号： F01N13/102 , F01N13/10 , F01N13/107 , F01N13/1827 , F01N13/1838 , F01N2450/24
摘要： The present invention relates to an exhaust manifold for an internal combustion engine, in particular in a motor vehicle, comprising a housing from which a plurality of inlet pipes emanate, which, in the built-in state, lead to cylinders of the internal combustion engine, and comprising a flange, which is welded to the inlet pipes and which, in the built-in state, is screwed to the cylinder head of the internal combustion engine by means of a screw connection. The fatigue strength of the exhaust manifold can be improved by subdividing the flange into at least two partial flanges in a longitudinal direction of the exhaust manifold.
摘要翻译：本发明涉及一种用于内燃机，特别是机动车辆的排气歧管，其特征在于，包括一个外壳，多个入口管从该外壳排出，该外壳在内置状态下通向内燃机的气缸并且包括法兰，其被焊接到入口管，并且在内置状态下，通过螺纹连接将其拧入内燃机的气缸盖。可以通过将凸缘细分成排气歧管的纵向方向上的至少两个局部凸缘来提高排气歧管的疲劳强度。

77. 发明申请

US20140243139A1 ASSEMBLY HAVING A BELT-PULLEY DRIVE 审中-公开
标题翻译：装配皮带驱动装置
公开(公告)号：US20140243139A1
公开(公告)日：2014-08-28
申请号：US14348274
申请日：2012-03-12
申请人： Michael Weiss , Klaus Hahn
发明人： Michael Weiss , Klaus Hahn
IPC分类号： F16H37/02
CPC分类号： F16H37/02 , F02B67/06 , F16D11/12 , F16D11/14 , F16D2011/006 , F16H3/54 , F16H55/36
摘要： Assembly having a belt-pulley drive, having a pulley wheel which can be driven by a belt and is configured for transmitting a torque to a drive shaft of the assembly. The assembly has a switchable gear mechanism which makes a transmission ratio possible between the rotational speed of the pulley wheel and the rotational speed of the drive shaft.
摘要翻译：具有皮带轮驱动装置的组件具有带轮，该皮带轮可以由皮带驱动并被构造成将扭矩传递到组件的驱动轴。组件具有可切换的齿轮机构，其使得在滑轮的旋转速度和驱动轴的转速之间可以实现传动比。

78. 发明申请

US20130081583A1 REGULATABLE COOLANT PUMP HAVING INTEGRATED PRESSURE CHAMBER 审中-公开
标题翻译：具有集成压力室的稳定的冷却泵
公开(公告)号：US20130081583A1
公开(公告)日：2013-04-04
申请号：US13424703
申请日：2012-03-20
申请人： Michael Weiss , Klaus Hahn
发明人： Michael Weiss , Klaus Hahn
IPC分类号： F01P5/10
CPC分类号： F04D15/0038
摘要： A regulatable coolant pump of an internal combustion engine having a pump housing in which a pump shaft with an associated impeller is rotatably mounted. The impeller conveys a coolant via an intake connection into a pressure channel of the coolant pump, a volume flow of the coolant pump being adjustable by a guide plate that externally surrounds the impeller at least in some regions and is displaceable by a pressure medium. The guide plate is connected in rotationally fixed fashion to the impeller and is continuously axially displaceable between two end positions and guided with a cylindrical bushing, with play at both sides, in an annular groove of the impeller or of an insert enclosed by the impeller. The guide plate, the pump shaft, the insert part, and/or the impeller together delimit a pressure chamber that is charged by the pressure medium in order to displace the guide plate.
摘要翻译：具有泵壳体的内燃机的可调节冷却剂泵，其中具有相关联的叶轮的泵轴可旋转地安装在其中。叶轮通过进气连接将冷却剂输送到冷却剂泵的压力通道中，冷却剂泵的体积流量可由至少在一些区域外部围绕叶轮的导向板调节，并且可由压力介质移动。引导板以旋转固定的方式连接到叶轮，并且在两个端部位置之间连续地轴向移动，并且在圆柱形衬套的作用下被引导，在两侧游隙，在叶轮的环形槽或由叶轮封闭的插入件中。引导板，泵轴，插入部分和/或叶轮一起限定由压力介质充电以便移动导板的压力室。

79. 发明授权

US08253071B2 Flat heating element 有权
标题翻译：扁平加热元件
公开(公告)号：US08253071B2
公开(公告)日：2012-08-28
申请号：US12096266
申请日：2006-12-11
申请人： Michael Weiss
发明人： Michael Weiss
IPC分类号： B60L1/02 , H05B3/34
CPC分类号： H05B3/34 , H05B1/0238 , H05B2203/003 , H05B2203/005 , H05B2203/011 , H05B2203/014 , H05B2203/017 , H05B2203/029 , H05B2214/04
摘要： This invention relates to a flat heating element (20), in particular for heating surfaces in contact with the user in the passenger compartment of a vehicle, comprising at least one electrical conductor (25).According to the invention, the electrical conductivity of at least one of these electrical conductors (25) is at least temporarily reduced if the temperature thereof at least locally exceeds a permissible maximum temperature.
摘要翻译：本发明涉及平面加热元件（20），特别是用于加热与车辆乘客室内的使用者接触的表面，其包括至少一个电导体（25）。根据本发明，如果这些电导体（25）中的至少一个的电导率至少局部地超过允许的最高温度，则其至少暂时降低。

80. 发明授权

US08240280B2 Device for camshaft adjustment in an internal combustion engine 有权
标题翻译：内燃机凸轮轴调整装置
公开(公告)号：US08240280B2
公开(公告)日：2012-08-14
申请号：US12529961
申请日：2008-02-13
申请人： Michael Busse , Michael Weiss
发明人： Michael Busse , Michael Weiss
IPC分类号： F01L1/34
CPC分类号： F01L1/3442 , F01L2001/34456 , F01L2001/34463 , F01L2001/34466 , F01L2001/34469
摘要： A device for camshaft adjustment in an internal combustion engine which has an inner rotor rotationally fixed to a camshaft. The inner rotor is rotationally adjustable relative to an outer rotor that is driveably connected to a crankshaft. At least one hydraulic chamber limited by side walls is introduced into the outer rotor and is divided into two partial chambers by an element extending radially outward from the inner rotor. To lock relative movement between the inner and outer rotor, two locking pins penetrating the inner rotor axially engage in two recesses of one of the side walls designed as a locking cover. To adjust the play of the locking pins in the recesses, at least one of the recesses has a stop surface for the locking pin, the position of which changes as viewed circumferentially with the radial distance from the axis of the inner rotor.
摘要翻译：一种用于内燃机中的凸轮轴调节的装置，其具有旋转地固定到凸轮轴的内转子。内转子相对于可驱动地连接到曲轴的外转子可旋转地调节。由侧壁限制的至少一个液压室被引入外转子中，并且通过从内转子径向向外延伸的元件分成两个部分室。为了锁定内转子和外转子之间的相对运动，穿过内转子的两个锁定销轴向接合在设计为锁定盖的侧壁之一的两个凹部中。为了调节凹槽中的锁定销的游隙，至少一个凹槽具有用于锁定销的止动表面，其位置随着与内转子的轴线的径向距离周向地变化。

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