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71. 发明申请

US20080146842A1 Purification of bis (thiohydrazide amides) 失效
标题翻译：双（硫代酰肼）酰胺的纯化
公开(公告)号：US20080146842A1
公开(公告)日：2008-06-19
申请号：US11901265
申请日：2007-09-14
申请人： Shoujun Chen , Zhi-Qiang Xia , Elena I. Kostik , Keizo Koya , Lijun Sun
发明人： Shoujun Chen , Zhi-Qiang Xia , Elena I. Kostik , Keizo Koya , Lijun Sun
IPC分类号： C07C243/12
CPC分类号： C07C327/56
摘要： Disclosed herein are methods of purifying a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R1, R2, R3, R4, R7, R8, Z, and Y are defined herein.
摘要翻译：本文公开了纯化以下结构式的双（硫代酰肼酰胺）化合物的方法：其中R 1，R 2，R 3， R 4，R 7，R 8，Z和Y在本文中定义。

72. 发明申请

US20070275960A1 Phenyl and pyridyl compounds for inflammation and immune-related uses 审中-公开
标题翻译：用于炎症和免疫相关用途的苯基和吡啶基化合物
公开(公告)号：US20070275960A1
公开(公告)日：2007-11-29
申请号：US11698982
申请日：2007-01-25
申请人： Jun Jiang , Junyi Zhang , Nha Vo , Shoujun Chen
发明人： Jun Jiang , Junyi Zhang , Nha Vo , Shoujun Chen
IPC分类号： A61K31/535 , A61K31/34 , A61K31/38 , A61K31/41 , A61K31/54 , C07D239/00 , C07D277/20 , C07D333/00 , C07D413/00 , C12N5/08 , C07D417/00 , C07D409/00 , C07D307/02 , C07D271/10 , A61P37/00 , A61K31/42 , A61K31/425 , A61K31/505
CPC分类号： C07D333/38 , C07D277/28 , C07D277/56 , C07D307/68 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R1, X1, X2, Y, Z, L, and n are defined herein. The compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物或前药，其中R 1，X 1，X， > 2 ，Y，Z，L和n在本文中定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

73. 发明申请

US20070249051A1 Vinyl-phenyl derivatives for inflammation and immune-related uses 有权
标题翻译：用于炎症和免疫相关用途的乙烯基苯基衍生物
公开(公告)号：US20070249051A1
公开(公告)日：2007-10-25
申请号：US11699002
申请日：2007-01-25
申请人： Gary Bohnert , Shoujun Chen , Yu Xie
发明人： Gary Bohnert , Shoujun Chen , Yu Xie
IPC分类号： A61K31/165 , A61K31/44 , A61K31/4965 , A61K31/55 , A61K31/69 , A61P29/00 , A61P37/08 , C12N5/00
CPC分类号： C07C233/65 , A61K31/165 , A61K31/366 , A61K31/44 , A61K31/4965 , A61K31/55 , A61K31/69 , C07C233/66 , C07C233/75 , C07C233/76 , C07C233/81 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D211/70 , C07D211/78 , C07D213/74 , C07D213/81 , C07D213/82 , C07D223/04 , C07D223/06 , C07D239/28 , C07D263/32 , C07D277/56 , C07D401/12 , C07D401/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , Y02A50/422
摘要： The invention relates to compounds of structural formula (Ia): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, X3, X4, X6, X10, R1, Y, Z, L, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（Ia）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X 1，X 2，X， X 3，X 4，X 6，X 10，R 1，Y，Z ，L和n在本文中定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

74. 发明申请

US20060217389A1 Compounds for the treatment of proliferative disorders 有权
标题翻译：用于治疗增殖性疾病的化合物
公开(公告)号：US20060217389A1
公开(公告)日：2006-09-28
申请号：US11355922
申请日：2006-02-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/426 , A61K31/42
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译：本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b， SUB> 2 在本文中定义。这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。

75. 发明申请

US20060122183A1 Taxol enhancer compounds 有权
标题翻译：紫杉醇增强剂化合物
公开(公告)号：US20060122183A1
公开(公告)日：2006-06-08
申请号：US11244324
申请日：2005-10-05
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
IPC分类号： A61K31/53 , A61K31/505 , A61K31/44 , A61K31/337 , A61K31/277 , A61K31/16
CPC分类号： A61K47/48176 , A61K31/16 , A61K31/165 , A61K31/277 , A61K31/337 , A61K31/381 , A61K31/44 , A61K31/505 , A61K31/53 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D305/14 , C07D307/68 , C07D333/38 , C07D333/68 , C07D407/12
摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5—R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.
摘要翻译：公开了由结构式（I）表示的化合物：Y是共价键，亚苯基或取代或未取代的直链烃基。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选地，Y是共价键或-C（R 7 R 8） - 。 R 1和R 2分别独立地是芳基或取代的芳基，R 3和R 4是独立的-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 5 -R 6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 7和R 8各自独立地为-H，脂族或取代的脂族基团或R 7为-H， 8是取代或未取代的芳基，或者R 7和R 8一起是C2-C6取代或未取代的亚烷基。 Z是-O或-S。还公开了包含本发明化合物和药学上可接受的载体或稀释剂的药物组合物。还公开了通过向受试者施用结构式（I）的化合物与紫杉醇或紫杉醇的类似物组合治疗患有癌症的受试者的方法。

76. 发明授权

US06800660B2 Taxol enhancer compounds 失效
标题翻译：紫杉醇增强剂化合物
公开(公告)号：US06800660B2
公开(公告)日：2004-10-05
申请号：US10193075
申请日：2002-07-10
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
IPC分类号： A61K3116
CPC分类号： A61K47/48176 , A61K31/16 , A61K31/165 , A61K31/277 , A61K31/337 , A61K31/381 , A61K31/44 , A61K31/505 , A61K31/53 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D305/14 , C07D307/68 , C07D333/38 , C07D333/68 , C07D407/12
摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.
摘要翻译：公开了由结构式（I）表示的化合物：Y是共价键，亚苯基或取代或未取代的直链烃基。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选地，Y是共价键或-C（R7R8） - ，R1和R2独立地是芳基或取代的芳基，R3和R4独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基.R 5 -R 6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基.R 7和R 8各自独立地为-H，脂族或取代的脂族基团，或者R 7是 -H和R8是取代或未取代的芳基，或者R 7和R 8一起是C 2 -C 6取代或未取代的亚烷基。Z = O或= S。还公开了药物组合物，其包含本发明和药学上可接受的载体或稀释剂。还公开了通过向受试者施用结构式（I）的化合物与紫杉醇或紫杉醇的类似物组合治疗患有癌症的受试者的方法。

77. 发明授权

US06743919B2 2-aroylimidazole compounds for treating cancer 失效
标题翻译：用于治疗癌症的2-芳酰基咪唑化合物
公开(公告)号：US06743919B2
公开(公告)日：2004-06-01
申请号：US10233371
申请日：2002-08-29
申请人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
发明人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
IPC分类号： C07D47102
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z1 is ═O, ═S, ═NOR11, or ═NR11. R is represented by a Structural Formula selected from (II)-(VII): The variables in Structural Formulas (II)-(VII) are described below.
摘要翻译：公开了由结构式（I）表示的化合物：R1是任选地与取代或未取代的芳基稠合的取代或未取代的2-咪唑基.Z1 = O，= S，= NOR11或= NR11.R 由选自（II） - （VII）的结构式表示：结构式（II） - （VII）中的变量如下所述。

78. 发明授权

US08809396B2 Substituted fused-ring compounds for inflammation and immune-related uses 有权
标题翻译：用于炎症和免疫相关用途的取代稠环化合物
公开(公告)号：US08809396B2
公开(公告)日：2014-08-19
申请号：US12541623
申请日：2009-08-14
申请人： Gary Bohnert , Shoujun Chen
发明人： Gary Bohnert , Shoujun Chen
IPC分类号： A61K31/165
CPC分类号： C07C233/81 , C07C233/65 , C07C233/75 , C07C233/80 , C07C2602/10 , C07C2602/12
摘要： The invention relates to compounds of structural formula (I) or (II): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein L, L1, Y, R1, R2, R9, R10, ring A, ring B, ring C, and ring D are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（I）或（II）的化合物或其药学上可接受的盐，溶剂化物，包合物或前药，其中L，L1，Y，R1，R2，R9，R10，环A，环B ，环C和环D在本文中定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

79. 发明授权

US08802721B2 Thiophene compounds for inflammation and immune-related uses 有权
标题翻译：用于炎症和免疫相关用途的噻吩化合物
公开(公告)号：US08802721B2
公开(公告)日：2014-08-12
申请号：US11340292
申请日：2006-01-25
申请人： Lijun Sun , Shoujun Chen , Jun Jiang , Zhi-Qiang Xia , Yu Xie , Chih-Yi Yu
发明人： Lijun Sun , Shoujun Chen , Jun Jiang , Zhi-Qiang Xia , Yu Xie , Chih-Yi Yu
IPC分类号： A01N43/12 , A61K31/38 , C07D417/14 , C07D409/14 , C07D409/12 , A61K31/4436 , C07D333/38 , A61K31/4427 , C07D413/14 , A61K31/444 , A61K31/381 , C07D409/04 , C07D333/20 , C07D413/10
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4427 , A61K31/4436 , A61K31/444 , C07D333/20 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , Y02A50/422
摘要： The invention relates to compounds of structural formulas (I) and (XVI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, Z, L, L2, R1, R2, R3, R21, n, q, and t are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（I）和（XVI）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X1，X2，Z，L，L2，R1，R2，R3，R21，n ，q和t在本文中定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

80. 发明申请

US20140171446A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 有权
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US20140171446A1
公开(公告)日：2014-06-19
申请号：US14115506
申请日：2012-05-03
申请人： Shoujun Chen , Gary Bohnert , Jun Jiang , Zhiqiang Xia
发明人： Shoujun Chen , Gary Bohnert , Jun Jiang , Zhiqiang Xia
IPC分类号： C07D417/14 , C07D405/14 , C07D401/12 , C07D401/14 , C07D213/82
CPC分类号： C07D417/14 , A61K31/165 , A61K31/44 , A61K31/497 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些化合物或其药学上可接受的盐，溶剂合物，包合物或前药。

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