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71. 发明申请

US20160288054A1 CONNECTING SYSTEM FOR FILTER CASSETTES 审中-公开
标题翻译：过滤器连接系统
公开(公告)号：US20160288054A1
公开(公告)日：2016-10-06
申请号：US15035764
申请日：2014-10-30
申请人： Sartorius Stedim Biotech GmbH
发明人： Thomas Krumbein , Stefan Weisshaar , Michael Bates
IPC分类号： B01D63/08 , F16B5/06 , B01D65/00
CPC分类号： B01D63/082 , B01D65/00 , B01D2313/02 , B01D2313/025 , F16B5/0642 , F16B5/065
摘要： A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).
摘要翻译：连接系统（1）具有用于过滤器盒（4）的至少一个连接器（2），该连接器可以插入到过滤器保持器中，并且在两个端板（6）之间具有过滤层（5）过滤层（5）和/或端板（6）和相邻过滤层（5）之间。连接器具有以可纵向移位的方式彼此接合的张紧部件，并且可以通过其端部彼此背离而固定到端板（6）。当连接器偏转到最大程度时，连接器对端板（6）施加预张紧力。预张力将端板（6）拉向过滤层（5），并且当将叠加在预张紧力上的接触压力施加到端板（6）上时，张紧部件可以相应地彼此推动与端板（6）。

72. 发明申请

US20160178640A1 LATERAL FLOW MEMBRANE ARRANGEMENT AND LATERAL FLOW IMMUNOASSAY DEVICE COMPRISING THE SAME 审中-公开
标题翻译：横向流膜装置和包括其的横向流动免疫器件
公开(公告)号：US20160178640A1
公开(公告)日：2016-06-23
申请号：US14910711
申请日：2014-04-29
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： Dieter MELZNER , Denise VAN ROSSUM
IPC分类号： G01N33/68 , B05D3/00 , B05D1/02 , B05D3/06 , G01N33/558 , G01N33/76
CPC分类号： G01N33/689 , B05D1/02 , B05D3/002 , B05D3/06 , G01N33/525 , G01N33/558 , G01N33/76 , G01N2333/59
摘要： The present invention relates to a lateral flow membrane arrangement (1), comprising a microporous membrane layer (2) and a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) and has at least one detection zone (5) and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (5), the liquid-impermeable support layer (3) has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonally to the lateral flow direction (a) of said liquid, the detection zone (5) has a thickness (7) of 100 to 150 μm over the entire width of the membrane, the non-detection zone has a thickness (8) of at most 300 μm over the entire width of the membrane, and the lateral flow membrane arrangement (1) has a constant thickness (9), as well as to a lateral flow immunoassay device comprising said membrane arrangement (1).
摘要翻译：本发明涉及一种横向流动膜装置（1），其包括微孔膜层（2）和液体不可渗透支撑层（3），用于通过微多孔膜层（2）横向流动液体，其中微孔膜层（2）被支撑在液体不可渗透的支撑层（3）上并且具有至少一个检测区域（5）和至少一个非检测区域，其中结合剂固定在至少一个检测区域如图5所示，液体不可渗透的支撑层（3）具有至少一个具有大厚度的区域和至少一个具有小厚度的区域，微孔膜层（2）被支撑在液体不可渗透的支撑层（3）上，使得所述至少一个检测区域设置在具有大厚度的支撑层的所述至少一个区域上方，并且所述至少一个非检测区域设置在具有小厚度的支撑层的所述至少一个区域之上，区域定向在与所述液体的横向流动方向（a）正交的方向上，检测区域（5）在膜的整个宽度上具有100至150μm的厚度（7），非检测区域具有厚度 8）在膜的整个宽度上至多为300μm，并且横向流动膜装置（1）具有恒定的厚度（9），以及包括所述膜装置（1）的横向流动免疫测定装置。

73. 发明申请

US20150376563A1 CONTAINER, TRANSPORT DEVICE, USE AND METHOD 有权
标题翻译：集装箱，运输装置，使用和方法
公开(公告)号：US20150376563A1
公开(公告)日：2015-12-31
申请号：US14764281
申请日：2014-02-04
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： Bernward Husemann , Wolfgang Kahlert , Sebastien Chaussin , Reiner Seitz
IPC分类号： C12M1/00 , F16M11/04 , F16M11/08 , B65G67/04
CPC分类号： C12M23/52 , B65G67/04 , C12M23/14 , C12M23/26 , C12M23/46 , C12M23/48 , C12M27/02 , C12M41/44 , F16M11/046 , F16M11/08
摘要： One aspect relates to a container for inserting into a holding device, comprising: a wall that is flexible at least in some areas, which wall is squashed, at least in some areas, in a transport condition in a direction opposite to a stretching direction; a handling unit connected to the wall, which is designed to come into engagement with a complementary handling unit of a transport device; a securing unit which in a transport condition hinders stretching of the wall of the bioreactor container along the stretching direction, wherein the container can, when the securing unit is released, be extended at least in some areas along the stretching direction, as well as a transport device, a use and a method.
摘要翻译：一个方面涉及一种用于插入到保持装置中的容器，包括：至少在一些区域中柔性的壁，至少在一些区域中，在与拉伸方向相反的方向上的输送状态下该壁被挤压; 连接到所述壁的处理单元，其被设计成与输送装置的互补处理单元接合; 处于运输状态的固定单元沿着拉伸方向阻碍了生物反应器容器的壁的拉伸，其中当固定单元被释放时，容器可以至少沿着拉伸方向的一些区域延伸，以及运输设备，使用和方法。

74. 发明申请

US20150300557A1 FILTER HOLDER AND METHOD FOR STERILIZING THE FILTER HOLDER 有权
标题翻译：过滤器过滤器及其过滤器的灭菌方法
公开(公告)号：US20150300557A1
公开(公告)日：2015-10-22
申请号：US14366509
申请日：2012-10-17
申请人： Sartorius Stedim Biotech GmbH
发明人： Mohammed Saeed Ajam , Jonas Mattern , Jan Schaefer
IPC分类号： F16M13/02 , A61L2/07
CPC分类号： F16M13/02 , A61L2/07 , B01D63/082 , B01D65/00 , B01D65/02 , B01D65/022 , B01D65/025 , B01D2313/02 , B01D2313/06 , B01D2321/32
摘要： A filter holder for receiving filter cassettes (19) and a method for sterilizing the filter are provided. The filter holder has first and second parallel plates (3, 4). The first plate (3) is fixed and the second plate (4) is movable along at least one rail (2) by a drive (7, 9) so that the filter cassettes (19) can be clamped between the plates (3, 4) with a predefined clamping pressure. The drive (7, 9) is designed to be removable. The at least one rail (2) has at least one tension rod (5) with a spring clamping element (6) so that the first and second plates (3, 4) can be clamped with a pre-definable pressure against the filter cassettes (19).
摘要翻译：提供一种用于接收过滤盒（19）的过滤器保持器和用于对过滤器进行灭菌的方法。过滤器保持器具有第一和第二平行板（3,4）。第一板（3）是固定的，并且第二板（4）可以通过驱动器（7,9）沿着至少一个轨道（2）移动，使得过滤器盒（19）可以夹在板（3， 4）具有预定的夹紧压力。驱动器（7,9）设计为可移动。所述至少一个轨道（2）具有至少一个具有弹簧夹紧元件（6）的张力杆（5），使得所述第一和第二板（3,4）能够以对所述过滤器盒的预定压力进行夹紧（19）。

75. 发明申请

US20150203898A1 Method For Differentiating Between Living And Dead Cells 有权
标题翻译：生活与死亡细胞分化的方法
公开(公告)号：US20150203898A1
公开(公告)日：2015-07-23
申请号：US14416463
申请日：2013-05-27
申请人： Sartorius Stedim Biotech GmbH
发明人： Alexandra Scholz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6844 , C12Q1/6851 , C12Q2600/158 , C12Q2521/507 , C12Q2527/101 , C12Q2545/113
摘要： The present invention relates to a method for quantitatively determining living and dead cells in a biological sample. The method according to the present invention is based on the determination of the amount of DNA in the sample with the aid of a DNA amplification reaction which does not impair the membrane integrity of living cells.
摘要翻译：本发明涉及一种用于定量测定生物样品中活细胞和死细胞的方法。根据本发明的方法是基于借助于不损害活细胞膜完整性的DNA扩增反应来确定样品中的DNA量。

76. 发明申请

US20150140637A1 PROCESS FOR THE SEPARATION OF A MIXTURE OF A PROTEIN AND ITS REACTION PRODUCT WITH A POLYALKYLENE GLYCOL 审中-公开
标题翻译：分离蛋白质及其反应产物与聚乙烯甘油的混合物的方法
公开(公告)号：US20150140637A1
公开(公告)日：2015-05-21
申请号：US14117782
申请日：2012-03-21
申请人： Sartorius Stedim Biotech GmbH
发明人： Wolfgang Demmer , Louis Villain , Hans-Heinrich Hoerl
IPC分类号： C12N9/36
CPC分类号： C12N9/2462 , A61K47/60 , C07K1/16
摘要： The present invention relates to a process for the separation of a mixture of a protein and its reaction product with a polyalkylene glycol, comprising the steps: a) providing a mixture comprising the protein and the reaction product in a fluid, b) bringing the mixture of step a) into contact with a microporous cellulose acetate membrane with adsorption of the reaction product onto the cellulose acetate membrane, the protein not becoming adsorbed onto the cellulose acetate membrane, c) removal of the protein from the cellulose acetate membrane, and d) desorbing the reaction product from the cellulose acetate membrane, the reaction product being selected from the group comprising the protein which is mono- or polyfunctionalized by the polyalkylene glycol, or mixtures thereof.
摘要翻译：本发明涉及将蛋白质及其反应产物与聚亚烷基二醇的混合物分离的方法，包括以下步骤：a）在流体中提供包含蛋白质和反应产物的混合物，b）使混合物步骤a）与微孔乙酸纤维素膜接触，将反应产物吸附到乙酸纤维素膜上，蛋白质不被吸附到乙酸纤维素膜上，c）从乙酸纤维素膜上除去蛋白质，和d）从醋酸纤维素膜解吸反应产物，反应产物选自由聚亚烷基二醇单或多官能化的蛋白质组或其混合物。

77. 发明申请

US20150041386A1 FILTER ELEMENT WITH IMPROVED TESTABILITY AFTER DRY STEAMING 审中-公开
标题翻译：干燥蒸汽后具有改进的耐候性的过滤元件
公开(公告)号：US20150041386A1
公开(公告)日：2015-02-12
申请号：US14388846
申请日：2013-03-16
申请人： Sartorius Stedim Biotech GmbH
发明人： Bjoern Hansmann , Volkmar Thom , Thomas Loewe
IPC分类号： B01D29/11 , B29C65/02 , B01D29/13
CPC分类号： B01D29/111 , B01D29/13 , B01D65/003 , B01D65/022 , B01D67/0088 , B01D67/009 , B01D67/0093 , B01D69/02 , B01D2323/02 , B01D2323/30 , B01D2325/22 , B01D2325/36 , B29C65/02 , B29K2081/06 , B29K2105/0067 , B29K2105/04 , B29L2031/14 , Y10T156/10
摘要： The present invention relates to a melt-joined filter element with improved testability after dry steaming or alternatively after sterilization by irradiation, to a method for producing the filter element according to the invention, and to the use of the filter element for filtering solutions.
摘要翻译：本发明涉及一种在干蒸汽之后或者通过照射灭菌后具有改进的可验证性的熔融接合过滤元件，本发明涉及一种根据本发明的过滤元件的制造方法，以及过滤元件用于过滤溶液的用途。

78. 发明申请

US20150001147A1 FILTER MODULE AND MODULAR FILTER SYSTEM 有权
标题翻译：过滤模块和模块化过滤系统
公开(公告)号：US20150001147A1
公开(公告)日：2015-01-01
申请号：US14376490
申请日：2013-02-08
申请人： Sartorius Stedim Biotech GmbH
发明人： Martin Leuthold , Stefan Weisshaar , Christoph Schich , Thomas Krumbein
IPC分类号： B01D29/05 , B01D29/56
CPC分类号： B01D29/05 , B01D29/56 , B01D63/082 , B01D65/003 , B01D2313/04 , B01D2313/06 , B01D2313/19 , B01D2319/025
摘要： One aspect of the invention relates to a filter module comprising: —a filter element having at least one filter medium which separates a filtrate side and a retentate side of the filter element from one another, and having a filter medium holder to which the filter medium is attached and which has at least one holder intake channel and at least one holder discharge channel, —a first filter cartridge part having at least one first cartridge intake channel and at least one first cartridge discharge channel, —a second filter cartridge channel having at least one second cartridge intake channel and at least one second cartridge discharge channel, wherein the filter medium holder is arranged in an arrangement position between the first filter cartridge part and the second filter cartridge part in a fluid-tight manner, wherein the at least one holder intake channel has a fluid connection with the at least one first cartridge intake channel and the at least one second cartridge intake channel, in order to form a module intake channel, wherein the at least one holder discharge channel has a fluid connection with the at least one first cartridge discharge channel and the at least one second cartridge discharge channel, in order to form a module discharge channel, wherein the module intake channel has a fluid connection with the retentate side of the filter medium and wherein the module discharge channel has a fluid connection with the filtrate side of the filter medium, and a modular filter system.
摘要翻译：本发明的一个方面涉及一种过滤器模块，其包括：一个过滤元件，其具有至少一个过滤介质，该过滤介质将过滤元件的滤液侧和滞留侧彼此分离，并具有过滤介质保持器，过滤介质被附接并且具有至少一个保持器进入通道和至少一个保持器排出通道， - 第一过滤器滤芯部件，其具有至少一个第一盒式进样通道和至少一个第一盒式排出通道， - 第二过滤器滤芯通道，至少一个第二墨盒进气通道和至少一个第二墨盒排出通道，其中所述过滤介质保持器以流体密封的方式布置在所述第一过滤器滤芯部件和所述第二过滤器滤芯部件之间的布置位置，其中所述至少一个夹持器进气通道与至少一个第一墨盒进气通道和至少一个第二墨盒进样口c具有流体连接通道，以便形成模块进入通道，其中所述至少一个保持器排出通道与所述至少一个第一盒排出通道和所述至少一个第二盒排出通道具有流体连接，以形成模块排出通道，其中所述模块进入通道与所述过滤介质的滞留侧具有流体连接，并且其中所述模块排出通道与所述过滤介质的滤液侧具有流体连接，以及模块化过滤器系统。

79. 发明申请

US20130278635A1 ASSEMBLING METHOD, MONITORING METHOD, COMMUNICATION METHOD, AUGMENTED REALITY SYSTEM AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：组装方法，监控方法，通信方法，增强现实系统和计算机程序产品
公开(公告)号：US20130278635A1
公开(公告)日：2013-10-24
申请号：US13920333
申请日：2013-06-18
申请人： Sartorius Stedim Biotech GmbH
发明人： Frank Maggiore
IPC分类号： G06T19/00
CPC分类号： G08B21/00 , G05B2219/32014 , G05B2219/39449 , G06F3/011 , G06F3/0304 , G06T19/006
摘要： An augmented reality system, an assembling method for assembling a first set-up component to a second set-up component under the assistance of an augmented reality system, a method for monitoring a set-up component and a method for transmitting data from or to a set-up component are provided. The augmented realty system may capture a variable marker associated with the respective set-up component. The augmented reality system can recognize the location and/or status of the variable marker and thus decide whether the connection between the first and second set-up component is established correctly or not. Further, data can be transmitted by the variable marker monitored by the augmented reality system.
摘要翻译：增强现实系统，用于在增强现实系统的辅助下将第一组装组件组装到第二组装组件的组装方法，用于监视组装组件的方法和用于从提供了一个设置组件。增强的房地产系统可以捕获与相应的建立组件相关联的变量标记。增强现实系统可以识别可变标记的位置和/或状态，从而确定第一和第二设置组件之间的连接是否正确建立。此外，可以通过由增强现实系统监视的变量标记来传送数据。

80. 发明授权

US12128331B2 Method for degassing a cross-flow diafiltration unit, cross-flow diafiltration method and cross-flow diafiltration unit 有权
公开(公告)号：US12128331B2
公开(公告)日：2024-10-29
申请号：US17705907
申请日：2022-03-28
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： Martin Leuthold , Alexander Helling , Ceren Gencoglu
IPC分类号： B01D61/10 , B01D19/00 , B01D63/08 , B01D65/02
CPC分类号： B01D19/0031 , B01D61/10 , B01D63/08 , B01D65/022 , B01D2311/2657 , B01D2315/10 , B01D2315/16 , B01D2321/04
摘要： A method for degassing a cross-flow diafiltration unit, a cross-flow diafiltration method and a cross-flow diafiltration unit. The degassing method includes (i) providing a cross-flow diafiltration unit having a diafiltration channel, a retentate channel and a permeate channel, a first filter material that delimits the diafiltration channel from the retentate channel, and a second filter material that delimits the retentate channel from the permeate channel; and thereafter (ii) feeding a liquid into the retentate channel so that the liquid flows in a flow direction through the retentate channel and penetrates through the first filter material into the diafiltration channel, whereby the retentate channel and the diafiltration channel are filled with and degassed by the liquid.

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