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    • 72. 发明授权
    • Bioadhesive composition
    • 生物粘合剂组合物
    • US5055046A
    • 1991-10-08
    • US681590
    • 1991-04-08
    • Ratan K. ChaudhuriRama K. HaldarBalgopal Gangadharan
    • Ratan K. ChaudhuriRama K. HaldarBalgopal Gangadharan
    • A61C13/23A61K6/00A61L24/06
    • A61L24/06
    • This invention relates to superior bioadhesive compositions having time extended adhesive properties comprising a non-toxic carrier and a polymer having between about 45 and about 70 weight % of units having the structure ##STR1## between about 50 and about 30 weight % of units having the structure ##STR2## and 2 and 7 weight % of an amine salt containing a lactam functionality derived from A and/or B, wherein R is hydrogen, alkoxy, phenyl, carboxyl or --N lactam having from 3 to 6 carbon atoms; R.sub.1 is C.sub.1 to C.sub.6 alkylene and R.sub.2 is C.sub.2 to C.sub.4 alkylene; said copolymer having a number average molecular weight of about 40,000 to about 500,000 and a relatively small particle size. The invention also relates to the method of synthesizing and using the above composition.
    • 本发明涉及具有时间延长的粘合剂性质的优异的生物粘合剂组合物,其包含无毒载体和具有约45至约70重量%的具有结构“IMAGE”A的单元的聚合物。约50至约30重量%的单元 具有结构 B.和/或 C.和2和7重量%的含有衍生自A和/或B的内酰胺官能团的胺盐,其中R是氢,烷氧基,苯基,羧基或 - 具有3至6个碳原子的N内酰胺; R1是C1-C6亚烷基,R2是C2-C4亚烷基; 所述共聚物的数均分子量为约40,000至约500,000,并且具有相对小的粒度。 本发明还涉及合成和使用上述组合物的方法。
    • 75. 发明授权
    • Adhesive composition
    • 粘合剂组合物
    • US4910247A
    • 1990-03-20
    • US329036
    • 1989-03-27
    • Rama K. HaldarBalgopal GangadharanRatan K. Chaudhuri
    • Rama K. HaldarBalgopal GangadharanRatan K. Chaudhuri
    • A61K6/00A61L24/06C08K5/098C09J107/00C09J129/00C09J129/10C09J133/02C09J135/08
    • C08K5/098A61L24/06C09J129/10A61L2400/14
    • A composition containing an adhesive suitable for affixing dentures or ostomy devices to a mucous membrane, which adhesive is a mixture composed of(a) 75-25 wt. % of a blend comprising a divalent calcium salt and a monovalent sodium salt of a lower alkyl vinyl ether/maleic acid copolymer wherein the concentration of Ca is between about 10 and 15 wt. % of the blend; Na is between about 1.5 and about 4 wt. % of the blend and --COOH is between about 9 and about 25 wt. % of the blend;(b) 0-10 wt. % of a lower alkyl vinyl ether/maleic acid auxiliary metal salt wherein said metal is divalent magnesium and/or monovalent potassium and wherein said auxiliary metal represents between about 1.5 and about 15 wt. % of said auxiliary metal salt compound and(c) 25-75 wt. % of a stearic acid metal salt wherein said metal salt is magnesium stearate containing from 0% to about 75% sodium stearate.The invention also relates to the use of said composition as an adhesive used in association with mucous membranes.
    • 一种含有适于将假牙或造口术装置粘贴到粘膜上的粘合剂的组合物,该粘合剂是由(a)75-25wt。 %的包含二价钙盐和低级烷基乙烯基醚/马来酸共聚物的一价钠盐的共混物,其中Ca的浓度为约10至15wt。 %的混合物; Na为约1.5至约4wt。 共混物和-COOH的%为约9至约25重量%。 %的混合物; (b)0-10wt。 %的低级烷基乙烯基醚/马来酸辅助金属盐,其中所述金属是二价镁和/或一价钾,并且其中所述辅助金属占约1.5至约15wt。 %的所述辅助金属盐化合物和(c)25-75wt。 %的硬脂酸金属盐,其中所述金属盐是含有0%至约75%硬脂酸钠的硬脂酸镁。 本发明还涉及所述组合物作为与粘膜缔合使用的粘合剂的用途。