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71. 发明授权

US5612325A Vitamin D analogues having a halogen-or azido- substituted side chain 失效
标题翻译：维生素D类似物具有卤素或叠氮基取代的侧链
公开(公告)号：US5612325A
公开(公告)日：1997-03-18
申请号：US367206
申请日：1995-01-03
申请人： Kai Hansen , Henrik Pedersen
发明人： Kai Hansen , Henrik Pedersen
IPC分类号： A61K31/59 , A61K31/593 , A61P3/08 , A61P9/12 , A61P11/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C401/00
CPC分类号： C07C401/00
摘要： A compound of formula I ##STR1## wherein R stands for a straight or branched, saturated or unsaturated alkyl group containing from 4 to 12 carbon atoms optionally substituted with a hydroxy group, and possibly containing a ring structure, and in which at least one of the carbon atoms not bearing hydroxyl group is substituted with one or more halogen atoms or an azido group; and prodrugs of I in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo, in pure form or in mixtures. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells. The compounds are prepared by oxidizing 1(S),3(R)-bis-(tert-butyldimethylsilyloxy)-20(S)formyl-9,10-seco-pregna-5(E),7(E),10(19)-triene, reducing the resulting product; alkylating the reduction product and then subjecting the alkylated product to triplet-sensitized photoisomerization.
摘要翻译： PCT No.PCT / DK95 / 00305 Sec。 371日期1995年1月3日 102（e）日期1995年1月3日PCT 1993年9月23日PCT公布。第WO94 / 07851号公报日期1994年04月14日一种式I化合物其中R代表任选被羟基取代的含有4至12个碳原子的直链或支链饱和或不饱和烷基，并且可能含有环结构，其中至少一个不含羟基的碳原子被一个或多个卤素原子或叠氮基取代; 和其中一个或多个羟基被掩蔽为可以在体内，纯形式或混合物中再转化为羟基的基团的I前药。这些化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。通过氧化1（S），3（R） - 双 - （叔丁基二甲基甲硅烷氧基）-20（S）甲酰基-9,10-仲孕-5（E），7（E），10（ 19） - 三烯，还原所得产物; 烷基化还原产物，然后使烷基化产物进行三重敏感的光异构化。

72. 发明授权

US5322851A Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US5322851A
公开(公告)日：1994-06-21
申请号：US22168
申请日：1993-02-25
申请人： Jens K. Perregaard , Kim Andersen , Klaus P. Boegesoe , Henrik Pedersen
发明人： Jens K. Perregaard , Kim Andersen , Klaus P. Boegesoe , Henrik Pedersen
IPC分类号： C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/445 , C07D403/04 , C07D403/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Specific 2- and 2,5-substituted indoles or 2,3-dihydroindole compounds of the following formula ##STR1## wherein, R is formula 1a ##STR2## and X, X', Ar, R.sup.1, n, U, Z, V and W are defined in the specification are provided, having long lasting serotonin activity with specific binding to 5-HT.sub.2 receptors of the central nervous system. These compounds are suitable for therapeutic treatment of CNS disorders, such as anxiety, depression, sleep disturbances, migraine, negative symptoms of schizophrenia, and Parkinson's disease.
摘要翻译：具体的2-和2,5-取代的吲哚或2,3-二氢吲哚化合物，其结构式如下：其中R为式1a 1a和X，X'，Ar，R 1，n，U，Z，提供说明书中定义的V和W具有与中枢神经系统的5-HT2受体特异性结合的持久的5-羟色胺活性。这些化合物适用于治疗CNS疾病，如焦虑症，抑郁症，睡眠障碍，偏头痛，精神分裂症阴性症状和帕金森病。

73. 发明授权

US4923880A 4,5,6,7-Tetrahydroisothiazolo (4,5-c) pyridine derivatives 失效
标题翻译： 4,5,6,7-四氢异噻唑（4,5-c）吡啶衍生物
公开(公告)号：US4923880A
公开(公告)日：1990-05-08
申请号：US322632
申请日：1989-03-13
申请人： Povl Krogsgaard-Larsen , Erik Falch , Henrik Pedersen
发明人： Povl Krogsgaard-Larsen , Erik Falch , Henrik Pedersen
IPC分类号： A61K20060101 , A61K31/425 , A61K31/435 , A61K31/44 , A61P25/28 , C07D20060101 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to novel compounds of the following formula: ##STR1## individual isomers and pharmaceutically acceptable acid addition salts thereof, whereinR.sup.1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy;R.sup.2 is alkyl, alkenyl, alkynyl, branched or unbranched, with 1-6 carbon atoms inclusive, which group may be optionally substituted with fluoro, hydroxy or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy;R.sup.3 and R.sup.4 are the same or different, and each represents hydrogen, alkyl(1-6 C-atoms), cycloalkyl (3-6 C-atoms), phenyl optionally substituted with halogen trifluoromethyl, lower alkyl, hydroxy or lower alkoxy, or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy.The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of formula I.

74. 发明授权

US4866077A 1,2,3-Triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists 失效
标题翻译：可用作乙酰胆碱激动剂的1,2,3-三唑和四唑取代的哌啶或四氢吡啶化合物
公开(公告)号：US4866077A
公开(公告)日：1989-09-12
申请号：US209994
申请日：1988-06-22
申请人： Klaus P. Bogeso , Klaus G. Jensen , Ejner K. Moltzen , Henrik Pedersen
发明人： Klaus P. Bogeso , Klaus G. Jensen , Ejner K. Moltzen , Henrik Pedersen
IPC分类号： A61K31/4427 , A61K31/445 , A61P21/00 , A61P25/02 , A61P25/28 , C07D401/04 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to novel compounds of the following formula, where the dotted line designates an optional bond: ##STR1## wherein "het" designates a five membered heterocyclic ring which may include 1 or 2 double bonds and 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, provided that "het" may not designate a 1,2,4- or 1,3,4-oxadiazole;R.sup.1 is selected from hydrogen, lower alkyl, optionally substituted with phenyl which may be substituted with halogen, lower alkyl, or lower alkoxy, or a group R.sup.6 --CO--NH--CH.sub.2 -- or R.sup.6 --O--CO--, wherein R.sup.6 is lower alkyl, branched or unbranched, or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy, lower alkoxy, or lower acyloxy;R.sup.2 and R.sup.3 are the same or different, each representing hydrogen, lower alkyl, cycloalkyl (3-6 C-atoms), lower alkenyl, lower alkadienyl, lower alkynyl, optionally substituted with hydroxy, halogen or phenyl, in which the phenyl group may be substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy; R.sup.2 and R.sup.3 may further, respectively, be selected from trifluoromethyl or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy, lower alkoxy or lower acyloxy, or R.sup.2 and R.sup.3 may, respectively, be a group OR.sup.7 or SR.sup.7 wherein R.sup.7 is defined as R.sup.2 or R.sup.3, andif "het" includes 2 or more carbon atoms, R.sup.4 and R.sup.5 are the same or different, and each is defined as R.sup.2 or R.sup.3, and if "het" includes only one carbon atom, there is only one substituent, R.sup.4, on the heterocyclic ring, and R.sup.4 is defined as R.sup.2 or R.sup.3,as well as individual stereo isomers and pharmaceutically acceptable acid addition salts thereof.The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of formula I.

75. 发明申请

US20180340174A1 METHOD FOR IDENTIFICATION OF MOLECULES WITH DESIRED CHARACTERISTICS 审中-公开
公开(公告)号：US20180340174A1
公开(公告)日：2018-11-29
申请号：US15525681
申请日：2015-11-11
申请人： Mikkel Dybro Lundorf , Henrik Pedersen , NANOCORE APS
发明人： Mikkel Dybro Lundorf , Henrik Pedersen , Tore Dehli
IPC分类号： C12N15/10
摘要： A method for identifying molecules with desired characteristics such as high affinity for a surface or material is described. A particularly useful method covered by the present invention allows identification of molecules which bind a material with high affinity in the presence of fluid or soluble polymers, such that said molecules can be used to produce a composite in which they efficiently anchor a material in a matrix comprising solid forms of a polymer. Compositions/kits useful for identification of molecules with desired characteristics are also described.

76. 发明授权

US10030065B2 MHC multimers, methods for their generation, labeling and use 有权
公开(公告)号：US10030065B2
公开(公告)日：2018-07-24
申请号：US12644554
申请日：2009-12-22
申请人： Liselotte Brix , Henrik Pedersen , Tina Jakobsen , Jørgen Schøller , Jesper Lohse , Katja Brunstedt , Kivin Jacobsen
发明人： Liselotte Brix , Henrik Pedersen , Tina Jakobsen , Jørgen Schøller , Jesper Lohse , Katja Brunstedt , Kivin Jacobsen
IPC分类号： C07K14/74 , A61K47/61 , A61K47/64 , A61K47/66 , B82Y5/00 , A61K38/00
摘要： The present invention relates to a soluble negative control MHC multimer comprising a nonsense peptide that binds the MHC protein efficiently, but that does not support binding of the resultant MHC-peptide complex to the desired T Cell Receptor. The nonsense peptide is designed to i) have a length enabling binding to the MHC allele in question, ii) have appropriate amino acids at relevant anchor positions which anchor the nonsense peptide to the peptide-binding groove of the MHC, iii) have amino acids outside the anchor positions that do not support binding to a T Cell Receptor, and iv) have an amino acid sequence that is different from the linear sequence of any naturally occurring peptide.

77. 发明授权

US08932992B2 Templated molecules and methods for using such molecules 有权
标题翻译：模板分子和使用这种分子的方法
公开(公告)号：US08932992B2
公开(公告)日：2015-01-13
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
IPC分类号： C40B40/06 , C12Q1/68 , C12Q1/70 , G01N33/53 , C07H21/00 , C07K4/00
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译：本发明涉及一种合成模板分子的方法。在本发明的一个方面，模板分子连接到模板，其模板化其合成。该内容允许生成可以被筛选的文库。治疗活动。

78. 发明授权

US08808984B2 Method for synthesising templated molecules 有权
标题翻译：合成模板分子的方法
公开(公告)号：US08808984B2
公开(公告)日：2014-08-19
申请号：US12179323
申请日：2008-07-24
申请人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
发明人： Henrik Pedersen , Anette Holtmann , Thomas Franch , Alex Haahr Gouliaev , Jakob Felding
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C40B40/00 , C40B50/00
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译：本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。该方法可以用于产生可以选择用于生物活性的模板分子的文库。

79. 发明申请

US20140163926A1 AUTOMATED ROOT CAUSE ANALYSIS 有权
标题翻译：自动原因分析
公开(公告)号：US20140163926A1
公开(公告)日：2014-06-12
申请号：US14233744
申请日：2011-12-09
申请人： Henrik Pedersen
发明人： Henrik Pedersen
IPC分类号： G05B23/02
CPC分类号： G05B23/02 , F01D17/02 , F01D21/00 , F01D21/003 , F02C9/00 , G05B23/0278 , G06Q10/0631 , G07C3/00
摘要： A method for performing computerized automated root cause analysis for a complex product, such as a turbine, and computer-readable medium encoded with programming instructions for performing such a root cause analysis are provided. The method may include: monitoring the product; detecting a product misbehavior; forming a misbehavior pattern with timeslots of normal operation and timeslots of misbehavior operation; comparing timeslots of the misbehavior pattern to corresponding timeslots of channels of information in at least one database relating to the product; measuring how close the misbehavior pattern numerically fits to the information; and automatically identifying a best numerical fit.
摘要翻译：提供了一种用于对复杂产品（例如涡轮机）执行计算机化的自动根本原因分析的方法以及用编程指令编码的用于执行这种根本原因分析的计算机可读介质。该方法可以包括：监控产品; 检测产品的不当行为; 形成了正常运作时间和不当行为时间的不正当行为模式; 将不正当行为模式的时间间隔与至少一个与产品相关的数据库中的信息通道的相应时隙进行比较; 衡量不正当行为模式在数字上与信息的接近程度; 并自动识别最佳数值拟合。

80. 发明授权

US08101392B2 Glucoamylase variants 失效
公开(公告)号：US08101392B2
公开(公告)日：2012-01-24
申请号：US12905348
申请日：2010-10-15
申请人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
IPC分类号： C12N9/34 , C12N9/30 , C12N9/26 , C12N9/24 , C12N9/00 , C12P19/20 , C12P19/14 , C07H21/04 , C07K1/00
CPC分类号： C12N9/2428 , C12P19/14 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.

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