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71. 发明申请

US20130041137A1 von Willebrand Factor (vWF) - Cleaving Protease 审中-公开
标题翻译： von Willebrand因子（vWF） - 切割蛋白酶
公开(公告)号：US20130041137A1
公开(公告)日：2013-02-14
申请号：US13271761
申请日：2011-10-12
申请人： Kenji SOEJIMA , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji SOEJIMA , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C07K16/40
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val（SEQ ID NO：1）作为部分序列的多肽链，更优选包含具有成熟蛋白的部分N-末端氨基酸序列的Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val（SEQ ID NO：2），并且在还原或非还原条件下，在SDS-PAGE中具有105至160kDa的分子量。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

72. 发明申请

US20120299648A1 AMPLIFYING APPARATUS, TRANSMITTER, AND AMPLIFYING APPARATUS CONTROL METHOD 有权
标题翻译：放大装置，发射器和放大装置控制方法
公开(公告)号：US20120299648A1
公开(公告)日：2012-11-29
申请号：US13426187
申请日：2012-03-21
申请人： Hirotake Honda , Hiroaki Maeda , Yousuke Okazaki , Yoshinobu Shizawa
发明人： Hirotake Honda , Hiroaki Maeda , Yousuke Okazaki , Yoshinobu Shizawa
IPC分类号： H03G3/00
CPC分类号： H03F1/0272 , H03F1/30 , H03F3/245 , H03F2200/18 , H03F2200/462 , H03G3/3042
摘要： A power amplifying apparatus has a GaN device for RF amplification, a GaN device for monitoring, an Idq detecting circuit, and a gate bias control (GBC) circuit. The GaN device for RF amplification amplifies an input signal to output the resultant. The GaN device for monitoring is an amplification device for monitoring an input/output signal of the GaN device for RF amplification. The Idq detecting circuit detects an output signal output by the GaN device for monitoring, corresponding to an input signal, which is diverged from the input signal to be input to the GaN device for RF amplification, and is input to the GaN device for monitoring. The gate bias control circuit controls a gate voltage to be applied to the GaN device for RF amplification in accordance with the output signal detected by the Idq detecting circuit.
摘要翻译：功率放大装置具有用于RF放大的GaN器件，用于监视的GaN器件，Idq检测电路和栅极偏置控制（GBC）电路。用于RF放大的GaN器件放大输入信号以输出结果。用于监视的GaN器件是用于监视用于RF放大的GaN器件的输入/输出信号的放大器件。 Idq检测电路检测由GaN器件输出的输出信号，对应于从要输入到GaN器件的输入信号发散的输入信号进行监控，并输入到GaN器件进行监控。栅极偏置控制电路根据由Idq检测电路检测的输出信号控制施加到GaN器件的RF放大的栅极电压。

73. 发明授权

US08067221B2 Von Willebrand factor (vWF)-cleaving protease 有权
标题翻译： Von Willebrand因子（vWF） - 切蛋白酶
公开(公告)号：US08067221B2
公开(公告)日：2011-11-29
申请号：US12103899
申请日：2008-04-16
申请人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C12N9/48 , C12N1/20 , C12N15/00 , C12Q1/37 , C12Q1/00 , C12P21/04 , C07H21/04
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val（SEQ ID NO：1）作为部分序列的多肽链，更优选包含具有成熟蛋白的部分N-末端氨基酸序列的Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val（SEQ ID NO：2），并且在还原或非还原条件下，在SDS-PAGE中具有105至160kDa的分子量。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

74. 发明授权

US08003369B2 Bacteriolytic agent 有权
标题翻译：细菌分解剂
公开(公告)号：US08003369B2
公开(公告)日：2011-08-23
申请号：US12092610
申请日：2006-11-06
申请人： Shunichiro Yamaguchi , Shuji Miura , Hiroaki Maeda
发明人： Shunichiro Yamaguchi , Shuji Miura , Hiroaki Maeda
IPC分类号： C12N1/06
CPC分类号： C12N1/06 , C11D1/62
摘要： The present invention is a bacteriolytic agent containing a cationic surfactant (A) of which a counteranion is an acid having a pKa (25° C.) of 0 to 10. As the counterion, a carboxylate anion is preferable. As the cationic surfactant (A), a quaternary ammonium salt-type surfactant is preferable. Examples of the useful substance include a protein, an amino acid, a nucleic acid, an antibiotic, sugars or vitamins.The bacteriolytic agent of the present invention is excellent in a bacteriolytic power in a step of extracting a useful substance from a microorganism (useful substance producing bacterium etc.). In addition, denaturation of the useful substance during the step is small.
摘要翻译：本发明是含有阳离子性表面活性剂（A）的溶菌剂，其中抗衡阴离子是pKa（25℃）为0〜10的酸。作为抗衡离子，优选羧酸根阴离子。作为阳离子性表面活性剂（A），优选季铵盐型表面活性剂。有用物质的实例包括蛋白质，氨基酸，核酸，抗生素，糖或维生素。本发明的溶菌剂在从微生物（有用的生物细菌等）中提取有用物质的步骤中的溶菌能力优异。此外，步骤期间有用物质的变性小。

75. 发明申请

US20110064488A1 IMAGE FORMING APPARATUS 有权
标题翻译：图像形成装置
公开(公告)号：US20110064488A1
公开(公告)日：2011-03-17
申请号：US12879585
申请日：2010-09-10
申请人： Tomoko TAKAHASHI , Naoyuki Ozaki , Ryuji Yoshida , Nobuyuki Koinuma , Hiroaki Maeda , Shunichi Hashimoto , Mugijirou Uno , Yoshinori Nakagawa , Mikio Ishibashi , Hideki Zemba
发明人： Tomoko TAKAHASHI , Naoyuki Ozaki , Ryuji Yoshida , Nobuyuki Koinuma , Hiroaki Maeda , Shunichi Hashimoto , Mugijirou Uno , Yoshinori Nakagawa , Mikio Ishibashi , Hideki Zemba
IPC分类号： G03G15/01
CPC分类号： G03G15/0131 , G03G15/1605 , G03G15/161
摘要： An image forming apparatus including a conveyance unit to convey a transfer medium, a first image forming unit to form a monochrome image transferred at a first transfer position onto the transfer medium, and a second image forming unit disposed downstream from the first image forming unit in a direction of conveyance of the transfer medium, including an intermediate transfer body to form a multi-colored toner image on the intermediate transfer body. The multi-colored toner image is transferred onto the transfer medium at a second transfer position. The conveyance unit is separated from the intermediate transfer body at the second transfer position in a monochrome mode to form the monochrome image using only the first image forming unit, and contacts the intermediate transfer body at the second transfer position in a full-color mode to form a full-color image using both the first and second image forming units.
摘要翻译：一种图像形成装置，包括：传送单元，用于传送转印介质;第一图像形成单元，形成在第一转印位置转印到转印介质上的单色图像;以及第二图像形成单元，设置在第一图像形成单元的下游转印介质的输送方向，包括中间转印体，以在中间转印体上形成多色调色剂图像。多色调色剂图像在第二转印位置转印到转印介质上。输送单元在单色模式下在第二转印位置处与中间转印体分离，以仅使用第一图像形成单元形成单色图像，并且以全色模式在第二转印位置处接触中间转印体，使用第一和第二图像形成单元形成全色图像。

76. 发明授权

US07786797B2 Amplifying apparatus 有权
标题翻译：放大装置
公开(公告)号：US07786797B2
公开(公告)日：2010-08-31
申请号：US12580802
申请日：2009-10-16
申请人： Yousuke Okazaki , Hiroaki Maeda , Takashi Ono , Hirotake Honda , Yoshinobu Shizawa
发明人： Yousuke Okazaki , Hiroaki Maeda , Takashi Ono , Hirotake Honda , Yoshinobu Shizawa
IPC分类号： H03F3/68
CPC分类号： H03F3/2176 , H03F1/0288 , H03F1/56 , H03F2200/378 , H03F2200/387 , H03F2200/465
摘要： The amplifying apparatus includes an amplifier having a circuit constant determined so as to satisfy a condition for E-class operation; power detecting unit which detects an output electricity from the amplifier; and controlling unit which controls the circuit constant in accordance with the output power detected by the power detecting unit.
摘要翻译：放大装置包括具有确定为满足E级操作条件的电路常数的放大器; 功率检测单元，其检测来自放大器的输出电力; 以及根据由功率检测单元检测到的输出功率来控制电路恒定的控制单元。

77. 发明授权

US07687478B2 Disialoundecasaccharide chain asparagine/fatty acid amide and medical drug containing the same 有权
标题翻译：二十二糖链天冬酰胺/脂肪酸酰胺和含有药物的药物相同
公开(公告)号：US07687478B2
公开(公告)日：2010-03-30
申请号：US10562059
申请日：2004-06-29
申请人： Yasuhiro Kajihara , Hiroaki Maeda , Kazuhiro Fukae
发明人： Yasuhiro Kajihara , Hiroaki Maeda , Kazuhiro Fukae
IPC分类号： C08B37/00 , C07H5/04 , C07H5/06 , A61K31/715
CPC分类号： A61K31/738 , C08B37/00
摘要： An asparagine-linked disialoundecaoligosaccharide-fatty acid amide, a drug containing the same, and a drug containing an asparagine-linked disialoundecaoligosaccharide.
摘要翻译：天冬酰胺连接的二唾液酸寡糖 - 脂肪酸酰胺，含有其的药物和含有天冬酰胺连接的二唾液酸寡糖的药物。

78. 发明申请

US20090143569A1 BACTERIOLYTIC AGENT 有权
标题翻译：微生物剂
公开(公告)号：US20090143569A1
公开(公告)日：2009-06-04
申请号：US12092610
申请日：2006-11-06
申请人： Shunichiro Yamaguchi , Shuji Miura , Hiroaki Maeda
发明人： Shunichiro Yamaguchi , Shuji Miura , Hiroaki Maeda
IPC分类号： C12P21/00 , C07C211/01 , C12P13/04 , C12P19/34 , C12P19/00 , C07K2/00 , C07K16/00 , C07C229/00 , C07H21/00
CPC分类号： C12N1/06 , C11D1/62
摘要： The present invention is a bacteriolytic agent containing a cationic surfactant (A) of which a counteranion is an acid having a pKa (25° C.) of 0 to 10. As the counterion, a carboxylate anion is preferable. As the cationic surfactant (A), a quaternary ammonium salt-type surfactant is preferable. Examples of the useful substance include a protein, an amino acid, a nucleic acid, an antibiotic, sugars or vitamins.The bacteriolytic agent of the present invention is excellent in a bacteriolytic power in a step of extracting a useful substance from a microorganism (useful substance producing bacterium etc.). In addition, denaturation of the useful substance during the step is small.
摘要翻译：本发明是含有阳离子性表面活性剂（A）的溶菌剂，其中抗衡阴离子是pKa（25℃）为0〜10的酸。作为抗衡离子，优选羧酸根阴离子。作为阳离子性表面活性剂（A），优选季铵盐型表面活性剂。有用物质的实例包括蛋白质，氨基酸，核酸，抗生素，糖或维生素。本发明的溶菌剂在从微生物（有用的生物细菌等）中提取有用物质的步骤中的溶菌能力优异。此外，步骤期间有用物质的变性小。

79. 发明申请

US20080254527A1 VON WILLEBRAND FACTOR (vWF) - CLEAVING PROTEASE 有权
标题翻译： VON WILLEBRAND因子（vWF） - 清洁保护
公开(公告)号：US20080254527A1
公开(公告)日：2008-10-16
申请号：US12103899
申请日：2008-04-16
申请人： Kenji SOEJIMA , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji SOEJIMA , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C12N9/48 , C07K16/00
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val（SEQ ID NO：1）作为部分序列的多肽链，更优选包含具有成熟蛋白的部分N-末端氨基酸序列的Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val（SEQ ID NO：2），并且在还原或非还原条件下，在SDS-PAGE中具有105至160kDa的分子量。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

80. 发明授权

US07361748B2 von Willebrand factor (vWF)—cleaving protease 有权
标题翻译： von Willebrand因子（vWF） - 切蛋白酶
公开(公告)号：US07361748B2
公开(公告)日：2008-04-22
申请号：US11296294
申请日：2005-12-08
申请人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： C07H21/04 , C07K14/00
CPC分类号： C12N9/6489 , A61K31/711 , A61K38/00 , C12N9/50 , C12N9/6421
摘要： This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val (SEQ ID NO: 2), and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.
摘要翻译：本发明旨在分离和鉴定vWF特异性切割蛋白酶。 vWF特异性切割蛋白酶切割vWF的残基Tyr 842和Met 843之间的键，并且包含具有Leu-Leu-Val-Ala-Val（SEQ ID NO：1）作为部分序列的多肽链，更优选包含具有成熟蛋白的部分N-末端氨基酸序列的Ala-Ala-Gly-Gly-Ile-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val（SEQ ID NO：2），并且在还原或非还原条件下，在SDS-PAGE中具有105至160kDa的分子量。这种vWF特异性切割蛋白酶的分离和鉴定已经导致了患有由蛋白酶缺乏引起的疾病的患者（例如血栓性血小板减少性紫癜）的替代疗法的可能性。

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