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71. 发明申请

US20160013037A1 APPARATUS AND METHODS FOR PLASMA-ASSISTED REACTION CHEMICAL IONIZATION (PARCI) MASS SPECTROMETRY 有权
标题翻译：用于等离子体辅助反应化学离子化（PARCI）质谱的装置和方法
公开(公告)号：US20160013037A1
公开(公告)日：2016-01-14
申请号：US14764047
申请日：2014-01-28
申请人： GEORGETOWN UNIVERSITY
发明人： Kaveh Jorabchi , Haopeng Wang
IPC分类号： H01J49/00 , H01J49/04 , G01N30/72
CPC分类号： H01J49/0031 , G01N30/7206 , G01N30/7233 , H01J49/04 , H01J49/105 , H01J49/145
摘要： Plasma-assisted reaction chemical ionization (PARCI) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The PARCI apparatuses, kits, and methods described in this application relate to systems that comprise a chemical reaction interface (CRI) containing reactant gas plasma and an ionization chamber that is downstream from the CRI. The ionization chamber facilitates formation of ions from element-specific products of the CRI by an electron source or an ionization gas. In particular, PARCI provides a method for conducting highly sensitive mass spectrometric elemental analysis of analyte compounds with high ionization potential elements; for example, fluorine, chlorine, and bromine.
摘要翻译：等离子体辅助反应化学电离（PARCI）通过产生带正电荷和带负电荷的离子提供高度敏感的元素分析。本申请中描述的PARCI装置，试剂盒和方法涉及包含含有反应物气体等离子体的化学反应界面（CRI）和在CRI下游的电离室的系统。电离室有助于通过电子源或电离气体从CRI的元素特异性产物形成离子。特别地，PARCI提供了用于对具有高电离电位元素的分析物化合物进行高灵敏度质谱元素分析的方法; 例如氟，氯和溴。

72. 发明申请

US20150281273A1 SYSTEM AND METHOD FOR DETERMINING MALICIOUS NETWORK ATTACKS 有权
标题翻译：用于确定恶意网络攻击的系统和方法
公开(公告)号：US20150281273A1
公开(公告)日：2015-10-01
申请号：US14242235
申请日：2014-04-01
申请人： GEORGETOWN UNIVERSITY
发明人： Thomas Clay SHIELDS
IPC分类号： H04L29/06
CPC分类号： G06F12/1408 , G06F12/1466 , G06F21/50 , G06F21/552 , G06F2212/1052 , G06F2212/402 , G06F2221/034 , H04L9/0894 , H04L9/14 , H04L9/30 , H04L9/32 , H04L63/1408 , H04L63/1441
摘要： A system and method for deterring malicious network attacks. The system and method is configured to execute instructions on at least one of the processors to generate a plurality of random blocks of data; generate a first XOR result by using the XOR function with the plurality of random blocks of data as the XOR function inputs; generate a tail value by using the XOR function with the first XOR result and a random encryption key as the XOR function inputs; encrypt a designated file using the random encryption key; write the plurality of random blocks and tail value to at least one storage medium; and write the encrypted designated file to at least one storage medium.
摘要翻译：一种防止恶意网络攻击的系统和方法。该系统和方法被配置为在至少一个处理器上执行指令以产生多个随机数据块; 通过使用具有多个随机数据块的XOR函数作为XOR功能输入来产生第一异或结果; 通过使用具有第一异或结果的XOR函数和随机加密密钥作为XOR函数输入生成尾值; 使用随机加密密钥加密指定的文件; 将多个随机块和尾值写入至少一个存储介质; 并将加密的指定文件写入至少一个存储介质。

73. 发明申请

US20150272976A1 FLAVIVIRUS PROTEASE INHIBITORS 审中-公开
标题翻译： FLAVIVIRUS PROTEASE抑制剂
公开(公告)号：US20150272976A1
公开(公告)日：2015-10-01
申请号：US14437434
申请日：2013-10-23
申请人： GEORGETOWN UNIVERSITY
发明人： Radhakrishnan Padmanabhan , Tadahisa Teramoto , Mark Manzano
IPC分类号： A61K31/7032 , A61K31/519 , A61K45/06 , A61K31/352 , A61K31/4178 , A61K31/12 , A61K31/44 , A61K31/426
CPC分类号： A61K31/7032 , A61K31/12 , A61K31/352 , A61K31/415 , A61K31/4178 , A61K31/426 , A61K31/44 , A61K31/519 , A61K31/7034 , A61K45/06 , Y02A50/385 , Y02A50/389 , Y02A50/393
摘要： Methods of treating or preventing a Flavivirus infection in a subject are provided. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus protease inhibitor. These methods are useful in treating and/or preventing Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus. Methods of inhibiting a Flavivirus protease in a cell are also provided.
摘要翻译：提供了治疗或预防受试者中黄病毒感染的方法。所述方法包括向受试者施用治疗有效量的黄病毒病毒抑制剂，例如黄病毒蛋白酶抑制剂。这些方法可用于治疗和/或预防黄病毒感染，例如西尼罗河病毒，登革热病毒和日本脑炎病毒。还提供了抑制细胞中黄病毒蛋白酶的方法。

74. 发明申请

US20150044293A1 RADIOPROTECTOR COMPOUNDS 审中-公开
标题翻译：放射性化合物
公开(公告)号：US20150044293A1
公开(公告)日：2015-02-12
申请号：US14385575
申请日：2013-03-14
申请人： GEORGETOWN UNIVERSITY
发明人： Eliot M. Rosen , Milton Brown , Saijun Fan , Thomas Walls , Kathryn E. Ditmer
IPC分类号： C07D209/58 , A61K31/343 , C07D209/42 , A61N5/10 , C07D407/06 , C07D307/42 , A61K31/404 , C07D209/18 , A61K31/341 , C07D207/48
CPC分类号： C07D209/58 , A61K31/341 , A61K31/343 , A61K31/404 , A61N5/10 , A61N2005/1094 , C07D207/16 , C07D207/48 , C07D209/18 , C07D209/42 , C07D209/88 , C07D307/42 , C07D307/46 , C07D407/06
摘要： Radioprotector compounds including 3,3′-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.
摘要翻译：提供了包括3,3'-二吲哚基甲烷（DIM）类似物的放射防护剂化合物。还提供了它们用于减少或防止辐射损伤，杀死肿瘤细胞和保护非肿瘤细胞以及治疗癌症的方法。

75. 发明授权

US08940787B2 Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections 有权
标题翻译：使用青蒿素治疗由致癌病毒诱导的肿瘤和治疗病毒感染
公开(公告)号：US08940787B2
公开(公告)日：2015-01-27
申请号：US13777244
申请日：2013-02-26
申请人： Georgetown University
发明人： Richard Schlegel , Dan-Paul Hartmann , Astrid Baege
IPC分类号： C07D493/18 , A61K31/357 , A61K31/365 , A61K31/366 , A61K45/06 , A61K31/335
CPC分类号： A61K31/366 , A61K31/335 , A61K31/357 , A61K31/365 , A61K45/06 , C07D493/18 , A61K2300/00
摘要： In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds.
摘要翻译：在某些方面，本发明涉及通过施用青蒿素相关化合物治疗增殖性宫颈疾病（例如子宫颈癌和子宫颈发育不良）和治疗病毒感染的方法。在某些方面，本发明涉及通过施用青蒿素相关化合物治疗由致癌病毒诱导的肿瘤，杀死或抑制鳞状细胞癌的方法，以及抑制病毒复制的方法。

76. 发明申请

US20150010575A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER USING AN ANTI-C-MET ANTIBODY 有权
标题翻译：使用抗C-MET抗体治疗癌症的联合治疗
公开(公告)号：US20150010575A1
公开(公告)日：2015-01-08
申请号：US14323642
申请日：2014-07-03
申请人： SAMSUNG ELECTRONICS CO., LTD. , GEORGETOWN UNIVERSITY
发明人： Bo Gyou KIM , Shangzi Wang , Ji Min Lee , Kyung Ah Kim , Louis M. Weiner
IPC分类号： A61K39/395 , A61K38/48 , C12Q1/68 , A61K38/45 , A61K38/18 , G01N33/50 , A61K38/46 , A61K45/06
CPC分类号： C12Q1/6886 , A61K38/08 , A61K38/10 , A61K38/1774 , A61K38/1808 , A61K39/39558 , A61K45/06 , C07K16/2836 , C12Q2600/106 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , G01N2800/52 , A61K2300/00
摘要： A target substance used for combination treatment with an anti-c-Met antibody, a pharmaceutical composition for combination administration for preventing and/or treating cancer including an anti-c-Met antibody and an inhibitor against the target substance as active ingredients, a method for preventing and/or treating cancer including co-administering an anti-c-Met antibody and an inhibitor against the target substance, and a method for screening a drug for preventing and/or treating cancer using the target substance.
摘要翻译：用于与抗c-Met抗体组合治疗的靶物质，用于预防和/或治疗癌症的组合用药物组合物，包括抗c-Met抗体和针对所述靶物质的抑制剂作为活性成分的方法用于预防和/或治疗癌症，包括共同施用抗c-Met抗体和针对靶物质的抑制剂，以及使用目标物质筛选用于预防和/或治疗癌症的药物的方法。

77. 发明申请

US20140349285A1 POLYMERASE DRIVEN NESA 有权
标题翻译：聚合酶驱动NESA
公开(公告)号：US20140349285A1
公开(公告)日：2014-11-27
申请号：US14212124
申请日：2014-03-14
申请人： GEORGETOWN UNIVERSITY
发明人： Mark Danielsen , Berenice Alfonso , Bolor Tumurpurev
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2521/301 , C12Q2525/131 , C12Q2525/307
摘要： The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising (a) exposing the target polynucleotide to an initiating oligonucleotide; (b) extending the initiating oligonucleotide with an extended sequence complementary to the target sequence; (c) ligating the initiating oligonucleotide sequence with the extended sequence to form a circular oligonucleotide having a nicking endonuclease (NE) recognition/cutting sequence; (d) exposing the circular oligonucleotide to a DNA polymerase and a DNA synthesis primer to synthesize DNA having a NE recognition sequence; (e) exposing the synthesized DNA to a probe having the NE recognition/cutting sequence to form a double stranded DNA having a full NE site; (f) exposing the double stranded DNA to a nicking endonuclease (NE) to cleave the probe; and (g) detecting the cleaved probe. The presence of the cleaved probe indicates the presence of the target polynucleotide.
摘要翻译：本发明涉及一种用于检测具有靶序列的靶多核苷酸的新方法，其包括（a）将靶多核苷酸暴露于起始寡核苷酸; （b）以与靶序列互补的延伸序列扩展起始寡核苷酸; （c）将起始寡核苷酸序列与扩展序列连接以形成具有切口核酸内切酶（NE）识别/切割序列的环状寡核苷酸; （d）将环状寡核苷酸暴露于DNA聚合酶和DNA合成引物以合成具有NE识别序列的DNA; （e）将合成的DNA暴露于具有NE识别/切割序列的探针以形成具有完整的NE位点的双链DNA; （f）将双链DNA暴露于切口内切核酸酶（NE）以切割探针; 和（g）检测切割的探针。切割的探针的存在表明靶多核苷酸的存在。

78. 发明申请

US20140341965A1 Compositions and Methods Comprising Biodegradable Scaffolds and Retinal Pigment Epithelial Cells 审中-公开
标题翻译：包含生物可降解支架和视网膜色素上皮细胞的组合物和方法
公开(公告)号：US20140341965A1
公开(公告)日：2014-11-20
申请号：US14211533
申请日：2014-03-14
申请人： Georgetown University
发明人： Nady Golestaneh
IPC分类号： A61L31/16 , A61K35/30 , C12N5/079 , A61L31/04
CPC分类号： C12N5/0621 , A61K35/30 , A61L27/227 , A61L27/24 , A61L27/3813 , A61L27/58 , A61L2400/12 , A61L2430/16 , C12N2533/30 , C12N2533/90
摘要： The invention relates to compositions comprising a monolayer of functional retinal pigment epithelial (RPE) cells attached to a transplantable, biodegradable scaffold. The invention also relates to methods of using these compositions.
摘要翻译：本发明涉及包含附着在可移植的可生物降解的支架上的功能性视网膜色素上皮（RPE）细胞单层的组合物。本发明还涉及使用这些组合物的方法。

79. 发明申请

US20140323563A1 USE OF STRIGOLACTONES AND STRIGOLACTONE ANALOGS FOR TREATING PROLIFERATIVE CONDITIONS 审中-公开
标题翻译： STRIGOLACTONES和STRIGOLACTONE ANALOGS用于处理增效条件的应用
公开(公告)号：US20140323563A1
公开(公告)日：2014-10-30
申请号：US14345371
申请日：2012-09-20
申请人： Georgetown University , The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat
发明人： Yoram Kapulnik , Hinanit Koltai , Ronit Yarden , Cristina Prandi
IPC分类号： C07D307/93
CPC分类号： C07D307/93 , A61K31/365 , A61K31/403 , A61K31/404 , A61K33/24 , C07D405/12 , C07D407/12 , C07D409/14 , C07D495/04 , A61K2300/00
摘要： Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
摘要翻译：式X的化合物，其中P1是包含一个6元环和2个5元环的稠环体系; v表示S或R配置; 或其各种异构体或其药学上可接受的盐，或其混合物，用于制备用于预防或抑制细胞增殖或诱导细胞死亡的活性剂。

80. 发明申请

US20140294845A1 ANTI-PLEIOTROPHIN ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗真菌抗体及其使用方法
公开(公告)号：US20140294845A1
公开(公告)日：2014-10-02
申请号：US14171102
申请日：2014-02-03
申请人： Georgetown University
发明人： J. Yun Tso , Anton Wellstein , Debra Chao
IPC分类号： C07K16/22 , A61K47/48
CPC分类号： C07K16/22 , A61K47/6845 , A61K2039/505 , C07K2317/73
摘要： The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The present invention provides for methods of inhibiting cancer cell growth or angiogenesis in a subject comprising administering to said subject an effective amount of the antibodies described herein. The present invention also provides for methods of making the neutralizing antibodies described herein.
摘要翻译：本发明涉及中和多余营养素的至少一种生物学活性的抗体。抗体可以在体外或体内抑制癌细胞生长和血管生成。本发明提供了抑制受试者中癌细胞生长或血管生成的方法，包括向所述受试者施用有效量的本文所述的抗体。本发明还提供了制备本文所述的中和抗体的方法。

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