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71. 发明授权

US09263638B2 Preparation of stable, bright luminescent nanoparticles having compositionally engineered properties 有权
标题翻译：具有组成工程化特性的稳定的，明亮的发光纳米颗粒的制备
公开(公告)号：US09263638B2
公开(公告)日：2016-02-16
申请号：US14073078
申请日：2013-11-06
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Marc D. Schrier , Donald Zehnder , Joseph Treadway , Joseph Bartel
IPC分类号： H01L33/28 , B82Y30/00 , C09C1/10 , C09K11/02 , C09K11/56 , C09K11/88
CPC分类号： H01L33/28 , B82Y30/00 , C01P2004/04 , C01P2004/64 , C09C1/10 , C09K11/02 , C09K11/565 , C09K11/883 , Y10S977/824 , Y10S977/834 , Y10T428/2991
摘要： A method is provided for preparing luminescent semiconductor nanoparticles composed of a first component X, a second component A, and a third component B, wherein X, A, and B are different, by combining B with X and A in an amount such that the molar ratio B:(A+B) is in the range of approximately 0.001 to 0.20 and the molar ratio X:(A+B) is in the range of approximately 0.5:1.0 to 2:1. The characteristics of the thus-prepared nanoparticles can be substantially similar to those of nanoparticles containing only X and B while maintaining many useful properties characteristic of nanoparticles containing only X and A. The nanoparticles so prepared can additionally exhibit emergent properties such as a peak emission energy less than that characteristic of a particle composed of XA or XB alone; this method is particularly applicable to the preparation of stable, bright nanoparticles that emit in the red to infrared regions of the electromagnetic spectrum. Luminescent semiconductor nanoparticles having exemplary properties are also provided.
摘要翻译：提供一种制备由第一组分X，第二组分A和第三组分B组成的发光半导体纳米颗粒的方法，其中X，A和B不同，通过将B与X和A组合使得其量使得摩尔比B：（A + B）在约0.001至0.20的范围内，摩尔比X：（A + B）在约0.5:1.0至2:1的范围内。如此制备的纳米颗粒的特征可以与仅含有X和B的纳米颗粒的特征基本相似，同时保持了仅含有X和A的纳米颗粒的许多有用特性。如此制备的纳米颗粒可另外显示出出现特性，例如峰值发射能小于单独由XA或XB组成的颗粒的特征; 该方法特别适用于在电磁光谱的红色至红外区域中发射的稳定的明亮纳米粒子的制备。还提供了具有示例性质的发光半导体纳米颗粒。

72. 发明授权

US09212385B2 Fluorinated resorufin compounds and their application 有权
标题翻译：氟化合物及其应用
公开(公告)号：US09212385B2
公开(公告)日：2015-12-15
申请号：US13612681
申请日：2012-09-12
申请人： Robert H. Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
发明人： Robert H. Batchelor , Yue Ge , Iain Johnson , Wai-Yee Leung , Jixiang Liu , Brian Patch , Peter Smalley , Thomas Steinberg , Kyle Gee
IPC分类号： A61B10/00 , A61B8/00 , A61B5/00 , C12Q1/28 , C07D265/38 , C07D413/12 , C07D495/04 , C09B19/00
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译：本发明提供可用于各种测定形式的新型氟化聚砜化合物。还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。

73. 发明授权

US09181472B2 Magnesium-based coatings for nanocrystals 有权
标题翻译：纳米晶体的镁基涂层
公开(公告)号：US09181472B2
公开(公告)日：2015-11-10
申请号：US12602493
申请日：2008-05-30
申请人： Joseph Bartel
发明人： Joseph Bartel
IPC分类号： C09K11/56 , C09K11/02 , C09K11/88
CPC分类号： C09K11/025 , C09K11/883 , C09K11/885
摘要： Semiconductor nanocrystal compositions comprising magnesium containing shells and methods of preparing them are described. The compositions provide strong emission in the blue and green wavelengths as well as chemical and photostability that have not been achieved with conventional shell materials.
摘要翻译：描述了包含镁的壳的半导体纳米晶体组合物及其制备方法。该组合物提供蓝色和绿色波长的强烈发射以及尚未用常规外壳材料实现的化学和光稳定性。

74. 外观设计

USD738527S1 Electroblotting apparatus 有权
标题翻译：电击装置
公开(公告)号：USD738527S1
公开(公告)日：2015-09-08
申请号：US29456029
申请日：2013-05-28
申请人： LIFE TECHNOLOGIES CORPORATION
设计人： Ronen Benarieh , Raviv Lifshitz

75. 外观设计

USD737702S1 Cell counter 有权
标题翻译：细胞计数器
公开(公告)号：USD737702S1
公开(公告)日：2015-09-01
申请号：US29496665
申请日：2014-07-16
申请人： LIFE TECHNOLOGIES CORPORATION
设计人： Saul Selberg , Sandro Klein , Kyle Curts , Joseph Lee , Lance Hussey , Shushuo Wu

76. 外观设计

USD736111S1 Fluorometer device 有权
标题翻译：荧光计装置
公开(公告)号：USD736111S1
公开(公告)日：2015-08-11
申请号：US29500911
申请日：2014-08-29
申请人： LIFE TECHNOLOGIES CORPORATION
设计人： Sandro Klein , Xin Mathers , Joseph Lee , Josh Mead

77. 外观设计

USD731673S1 Multi-block PCR thermal cycler device 有权
标题翻译：多块PCR热循环仪
公开(公告)号：USD731673S1
公开(公告)日：2015-06-09
申请号：US29502919
申请日：2014-09-22
申请人： LIFE TECHNOLOGIES CORPORATION
设计人： Sandro Klein , Joseph Lee , Byron Lee , Shushuo Wu , Lance Hussey

78. 发明授权

US08999965B2 Anthraquinone based near IR emitting compounds and uses thereof 有权
标题翻译：基于蒽醌的近红外发射化合物及其用途
公开(公告)号：US08999965B2
公开(公告)日：2015-04-07
申请号：US13126234
申请日：2009-10-20
申请人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
发明人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
IPC分类号： A61K31/33 , C12Q1/68 , C09B1/516 , G01N21/64
CPC分类号： G01N33/52 , C07C225/36 , C07C237/10 , C07C2603/24 , C07D205/04 , C07D213/36 , C07D233/61 , C07D249/04 , C07D295/13 , C07D295/192 , C07H21/04 , C09B1/5165 , C12Q1/6816 , C12Q1/6841 , G01N21/6428 , G01N2021/6441
摘要： Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.
摘要翻译：近红外发射荧光化合物; 制备方法和含有所述化合物的试剂盒; 以及它们在荧光检测生物材料中的应用。

79. 发明授权

US08994743B2 Virtual cellular staining 有权
标题翻译：虚拟细胞染色
公开(公告)号：US08994743B2
公开(公告)日：2015-03-31
申请号：US13314001
申请日：2011-12-07
申请人： Jonathan Young , Kathleen Free , Elizabeth Browne
发明人： Jonathan Young , Kathleen Free , Elizabeth Browne
IPC分类号： G06T11/00
CPC分类号： G06T11/001 , G01N1/30 , G06K9/00127 , G06K9/0014 , G06K9/00201 , G06T7/0012 , G06T15/04 , G06T19/20 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024 , G06T2219/2012
摘要： Systems and methods are used to display cell structures of a biological cell. A plurality of cell structures of a biological cell is stored and for each cell structure of the plurality of cell structures one or more stain colors are stored. A selected cell structure is received from an input device. One or more stain colors of the selected cell structure are retrieved. The one or more stain colors of the selected cell structure are displayed. A selected stain color is received from the input device. The selected cell structure is displayed in the selected stain color in an exemplary cell image. Further, a three-dimensional image of a biological cell is stored. The three-dimensional image is displayed on a display that includes a touch screen. A movement selection is received from the touch screen. The three-dimensional image is displayed on the display according to the movement selection.
摘要翻译：系统和方法用于显示生物细胞的细胞结构。存储生物细胞的多个细胞结构，并且对于多个细胞结构的每个细胞结构，存储一种或多种染色。从输入设备接收所选择的单元结构。检索所选择的细胞结构的一种或多种染色。显示所选单元结构的一个或多个染色。从输入装置接收选定的染色。所选择的单元格结构以示例单元图像中所选择的着色颜色显示。此外，存储生物细胞的三维图像。三维图像显示在包括触摸屏的显示器上。从触摸屏接收移动选择。根据移动选择，三维图像显示在显示器上。

80. 发明授权

US08981100B2 Use of novel coumarins as glutathione and thiol labels 有权
标题翻译：使用新型香豆素作为谷胱甘肽和硫醇标记
公开(公告)号：US08981100B2
公开(公告)日：2015-03-17
申请号：US12666256
申请日：2008-07-24
申请人： Hee Chol Kang , Kyle Gee , Iain Johnson , Michael Janes
发明人： Hee Chol Kang , Kyle Gee , Iain Johnson , Michael Janes
IPC分类号： C07D491/16 , C07D491/00 , G01N33/52
CPC分类号： G01N33/52 , C07D491/06 , C07D491/16 , C07F9/5442 , C07K5/0215 , G01N33/582 , G01N2333/4701 , Y10T436/17 , Y10T436/182
摘要： Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.
摘要翻译：描述了与结合硫醇化合物的亲电子反应性基团取代的荧光喹诺酮香豆素化合物。该化合物可用于检测活细胞中氧化应激和相关过程。

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