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71. 发明授权

US08557844B2 Substrate reduction therapy 有权
标题翻译：底物还原疗法
公开(公告)号：US08557844B2
公开(公告)日：2013-10-15
申请号：US12666279
申请日：2008-06-26
申请人： Frances Mary Platt , Emyr Lloyd-Evans , Forbes Dennison Porter
发明人： Frances Mary Platt , Emyr Lloyd-Evans , Forbes Dennison Porter
IPC分类号： A61K31/445 , A61K31/706
CPC分类号： C07J43/003 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/42 , A61K31/431 , A61K31/445 , A61K31/513 , A61K31/52 , A61K31/5375 , A61K31/575 , A61K31/58 , A61K31/661 , A61K31/6615 , A61K31/675 , A61K31/685 , A61K31/7008 , A61K31/7012 , A61K31/7072 , A61K31/708 , C07D211/94 , C07D473/16 , C07H19/06 , C07H19/20 , C07J7/009
摘要： The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
摘要翻译：本发明提供了一种化合物，其是鞘脂生物合成抑制剂，其用于治疗具有次级尼曼 - 皮克型C型疾病如细胞表型的疾病。

72. 发明授权

US08426445B2 Iminosugars and methods of treating bunyaviral and togaviral diseases 有权
标题翻译：亚米诺糖和治疗双性腺病毒和披膜病毒疾病的方法
公开(公告)号：US08426445B2
公开(公告)日：2013-04-23
申请号：US12813882
申请日：2010-06-11
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , Y02A50/382 , Y02A50/397 , Y02A50/409
摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：提供了治疗和/或预防使用亚氨基二糖（例如DNJ衍生物）引起的属于布尼亚病毒科或披膜病毒科的病毒引起的疾病或病症的新方法。

73. 发明申请

US20110184019A1 Long chain N-Alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链N-烷基化合物及其氧杂衍生物
公开(公告)号：US20110184019A1
公开(公告)日：2011-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , C12N5/071 , A61P31/12
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

74. 发明申请

US20110065754A1 IMINOSUGARS AND METHODS OF TREATING FILOVIRAL DISEASES 审中-公开
标题翻译： IMINOSUGARS AND METHODS OF TREAL FILOVIRAL DISEASES
公开(公告)号：US20110065754A1
公开(公告)日：2011-03-17
申请号：US12873708
申请日：2010-09-01
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/14 , C12N5/02
CPC分类号： A61K31/445
摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Filoviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：本发明提供了使用亚氨基二糖（例如DNJ衍生物）治疗由属于病毒属的病毒引起的病毒或病症的方法。

75. 发明申请

US20100317696A1 IMINOSUGARS AND METHODS OF TREATING BUNYAVIRAL AND TOGAVIRAL DISEASES 有权
标题翻译：麻醉药和治疗疟疾和瘟疫的方法
公开(公告)号：US20100317696A1
公开(公告)日：2010-12-16
申请号：US12813882
申请日：2010-06-11
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/14
CPC分类号： A61K31/445 , Y02A50/382 , Y02A50/397 , Y02A50/409
摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Bunyaviridae or Togaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：提供了治疗和/或预防使用亚氨基二糖（例如DNJ衍生物）引起的属于布尼亚病毒科或披膜病毒科的病毒引起的疾病或病症的新方法。

76. 发明申请

US20100291602A1 CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF LOW ABUNDANT HUMAN PLASMA PROTEIN BIOMARKERS 有权
标题翻译：使用低等离子人血浆蛋白生物标志物的新面板进行的皮肤纤维化临床诊断
公开(公告)号：US20100291602A1
公开(公告)日：2010-11-18
申请号：US12779349
申请日：2010-05-13
申请人： Bevin GANGADHARAN , Nicole Zitzmann , Raymond A. Dwek
发明人： Bevin GANGADHARAN , Nicole Zitzmann , Raymond A. Dwek
IPC分类号： G01N33/53 , G01N33/566 , G01N33/00
CPC分类号： G01N33/5767 , G01N33/57438 , G01N33/6893 , G01N2333/47 , G01N2333/4728 , G01N2333/775 , G01N2333/924 , G01N2500/00 , G01N2800/085 , G01N2800/52 , G01N2800/54 , G01N2800/56 , G01N2800/7057
摘要： The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analysed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-III, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46-5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2-glycoprotein. These biomarkers can be used in conjunction with polypeptides in WO/2008/031051. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers.
摘要翻译：本发明人提出了用于诊断肝纤维化和肝硬化的人血浆蛋白生物标志物的新颖小组。目前尚无可靠的非侵入性肝纤维化评估方法。使用基于2D-PAGE的蛋白质组学研究来鉴定潜在的纤维化生物标志物。对丙型肝炎病毒（HCV）感染引起的肝硬化患者血浆进行了分析。鉴定了与肝脏瘢痕形成相关并且潜在地也与病毒感染相关的几种蛋白质。这些蛋白质包括14-3-3蛋白ζ/δ，脂连蛋白，afamin，α-1-抗胰蛋白酶，α-2-HS-糖蛋白，载脂蛋白C-III，载脂蛋白E，C4b结合蛋白β链，完整/切割补体 C3dg，皮质类固醇结合球蛋白，纤维蛋白原γ链，β接触珠蛋白，pH 5.46-5.49，触珠蛋白相关蛋白，血红蛋白，免疫球蛋白J链，富含亮氨酸的α-2-糖蛋白，脂质转移抑制蛋白，视黄醇结合蛋白4，血清对氧磷酶/芳基酯酶1，性激素结合球蛋白和锌-α-2-糖蛋白。这些生物标志物可以与WO / 2008/031051中的多肽结合使用。这些新型生物标志物的浓度可以使用免疫测定来确定，其中浓度将反映纤维化程度。提出了每种新型生物标志物的纤维化评分量表。所有新生物标志物的得分的添加剂结果将给出更可靠的纤维化程度的指示，而不是检查个体生物标志物。

77. 发明申请

US20100222383A1 Iminosugars and methods of treating viral diseases 有权
标题翻译：伊莫诺斯和治疗病毒性疾病的方法
公开(公告)号：US20100222383A1
公开(公告)日：2010-09-02
申请号：US12656992
申请日：2010-02-22
申请人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
摘要翻译：提供了使用亚氨基二糖治疗或预防由登革热病毒引起或与登革热病毒有关的病毒感染的方法。

78. 发明申请

US20070224648A1 Methods and compositions for the diagnosis of treatment of type 2 diabetes 审中-公开
标题翻译：诊断治疗2型糖尿病的方法和组成
公开(公告)号：US20070224648A1
公开(公告)日：2007-09-27
申请号：US11523479
申请日：2006-09-19
申请人： Roger Cox , Frances Ashcroft , Helen Freeman , Kenju Shimomura
发明人： Roger Cox , Frances Ashcroft , Helen Freeman , Kenju Shimomura
IPC分类号： G01N33/567 , A61K31/155 , C12N5/06 , C12N1/18
CPC分类号： G01N33/74 , A61K31/155 , G01N2333/62 , G01N2500/00 , G01N2800/042
摘要： Methods and compositions for the modulation of insulin secretion.
摘要翻译：用于调节胰岛素分泌的方法和组合物。

79. 发明申请

US20210063404A1 LOW AFFINITY RED FLUORESCENT INDICATORS FOR IMAGING CA2+ IN EXCITABLE AND NONEXCITABLE CELLS 有权
公开(公告)号：US20210063404A1
公开(公告)日：2021-03-04
申请号：US16977396
申请日：2019-03-01
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
发明人： Yu-Fen Chang , Jiahui Wu , Matthew J. Daniels , Robert E. CAMPBELL
IPC分类号： G01N33/58 , G01N21/64
摘要： The present disclosure relates to genetically encoded low affinity, fluorescent Ca2+ indicators, which may be targeted to endoplasmic reticulum, the sarcoplasmic reticulum and/or the mitochondria. It also relates to polynucleotides, vectors and host cells which encode or include such low affinity Ca2+ indicators, and methods of detecting Ca2+ levels in a cell using such indicators.

80. 发明授权

US10799580B2 Expression vector delivery system and use thereof for inducing an immune response 有权
公开(公告)号：US10799580B2
公开(公告)日：2020-10-13
申请号：US15758505
申请日：2016-09-09
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Robert Seder , Geoffrey Lynn , Leonard Seymour
IPC分类号： A61K39/39 , A61K47/64 , A61K48/00 , A61K47/59 , A61K47/65 , A61K39/00
摘要： Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.

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