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71. 发明申请

US20110151530A1 ENZYMATIC PRODUCTION OF 2-HYDROXY-ISOBUTYRATE (2-HIBA) 审中-公开
标题翻译： 2-羟基异丁酸酯（2-HIBA）的酶促生产
公开(公告)号：US20110151530A1
公开(公告)日：2011-06-23
申请号：US13060636
申请日：2009-08-25
申请人： Philippe Soucaille , Cédric Boisart
发明人： Philippe Soucaille , Cédric Boisart
IPC分类号： C12P7/42 , C12N1/00 , C12N1/21
CPC分类号： C12P7/42
摘要： The present invention concerns a new method for the biological preparation of 2-hydroxy-isobutyrate (2-HIBA), including a fermentation method with microorganisms modified to favour production of 2-HIBA from renewable resources. The invention also concerns the modified microorganisms used in such fermentation method.
摘要翻译：本发明涉及一种用于生物制备2-羟基 - 异丁酸酯（2-HIBA）的新方法，其包括使用微生物修饰的发酵方法以有利于从可再生资源生产2-HIBA。本发明还涉及用于这种发酵方法的改性微生物。

72. 发明申请

US20100261240A1 METHOD OF PURIFYING ALCOHOL FROM A FERMENTATION BROTH 有权
标题翻译：从发酵豆中提炼酒精的方法
公开(公告)号：US20100261240A1
公开(公告)日：2010-10-14
申请号：US12743988
申请日：2007-11-30
申请人： Frederic Ollivier
发明人： Frederic Ollivier
IPC分类号： C12P7/20
CPC分类号： C07C29/84 , C07C31/205
摘要： Method for purifying an alcohol, notably 1,3-propanediol, from a fermentation broth.
摘要翻译：从发酵液中纯化醇，特别是1,3-丙二醇的方法。

73. 发明申请

US20100086982A1 PROCESS FOR THE BIOLOGICAL PRODUCTION OF n-BUTANOL WITH HIGH YIELD 审中-公开
标题翻译：具有高毒性的正丁醇生物生产工艺
公开(公告)号：US20100086982A1
公开(公告)日：2010-04-08
申请号：US12447726
申请日：2007-10-29
申请人： Philippe Soucaille
发明人： Philippe Soucaille
IPC分类号： C12P7/16 , C12N1/00 , C12N1/21
CPC分类号： C12P7/16 , C12N15/74 , Y02E50/10
摘要： The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host C. acetobutilicum transformed i) to eliminate the butyrate pathway ii) to eliminate the acetone pathway iii) to eliminate the lactate pathway and iv) to eliminate the acetate pathway. In another aspect of the present invention, the hydrogen flux is decreased and the reducing power redirected to n-butanol production by attenuating the expression of the hydrogenase gene. Optionally the n-butanol produced can be eliminated during the fermentation by gas striping and further purified by distillation.
摘要翻译：本发明提供从可发酵碳源以高产率生产正丁醇的方法。在本发明的一个方面，葡萄糖转化为正丁醇的方法是通过使用重组生物体来实现的，所述重组生物体包含转化的丙酮丁酸宿主，i）消除丁酸途径ii）消除丙酮途径iii ）以消除乳酸通路，和iv）消除醋酸途径。在本发明的另一方面，通过减弱氢化酶基因的表达，氢通量降低，还原力转向正丁醇生产。任选地，在发酵期间可以通过气体分离消除产生的正丁醇，并通过蒸馏进一步纯化。

74. 发明授权

US11655486B2 Microorganism and method for improved 1,3-propanediol production by fermentation on a culture medium with high glycerine content 有权
公开(公告)号：US11655486B2
公开(公告)日：2023-05-23
申请号：US16636237
申请日：2018-08-03
申请人： METABOLIC EXPLORER
发明人： Céline Raynaud , Olivier Tourrasse , Nadège Dumoulin
IPC分类号： C12P7/18 , C12N1/20 , C12R1/22 , C12R1/145
CPC分类号： C12P7/18 , C12N1/205 , C12R2001/145 , C12R2001/22
摘要： The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a recombinant microorganism converting glycerol into 1,3-propanediol and overexpressing the hcpR and/or frdX gene on a medium comprising glycerine. A recombinant microorganism for the production of 1,3 propanediol from glycerol, wherein said microorganism converts glycerol into 1,3-propanediol and 10 overexpresses the hcpR and/or the frdX gene.

75. 发明授权

US11293039B2 Method for producing organic acid salts from fermentation broth 有权
公开(公告)号：US11293039B2
公开(公告)日：2022-04-05
申请号：US16652812
申请日：2018-10-01
申请人： METABOLIC EXPLORER
发明人： Antoine Sevenier , Cédric Colomb , Benjamin Martin
IPC分类号： C12P7/54 , C12P7/42 , C12P7/52 , C12P7/56
摘要： The invention relates to a method for producing salts of butyric acid, lactic acid, propionic acid, valeric acid, acetic acid, glycolic acid, sorbic acid, fumaric acid, formic acid, malic acid, tartaric acid, citric acid, derivatives of said organic acids and mixtures thereof, comprising at least the successive steps of: •i) culturing a microorganism in an appropriate culture medium comprising a carbon source and a nitrogen source, during a sufficient time to obtain a fermentation broth comprising the organic acid(s); •ii) pre-treating said fermentation broth comprising at least clarification of the fermentation broth and separation of organic acids by evaporation of the clarified fermentation broth and then condensation of the volatile fraction containing organic acids (CVAF); •v) adding inorganic bases to said CVAF •vii) eliminating the remaining water of the CVAF, and recovering the organic acid salts.

76. 发明授权

US10858675B2 Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux 有权
公开(公告)号：US10858675B2
公开(公告)日：2020-12-08
申请号：US15564943
申请日：2016-04-07
申请人： METABOLIC EXPLORER
发明人： Wanda Dischert , Laurence Dumon-Seignovert , Perrine Vasseur , Gwénaëlle Bestel-Corre , Philippe Soucaille
IPC分类号： C12P7/42 , C12N15/52 , C07K14/245 , C07K14/39 , C07K14/395 , C12N9/04 , C12N9/02 , C12N9/18
摘要： The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized production of 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.

77. 发明授权

US10689671B2 Microorganism and method for the production of 1.2-propanediol based on NADPH dependent acetol reductase and improved NADPH supply 有权
公开(公告)号：US10689671B2
公开(公告)日：2020-06-23
申请号：US15310156
申请日：2015-05-12
申请人： METABOLIC EXPLORER
发明人： Pascale Aliprandi , Emilie Navarro , Céline Raynaud , Gwénaëlle Bestel Corre , Philippe Soucaille
IPC分类号： C12P7/18 , C12N9/04 , C12N15/52 , C12N15/74
摘要： The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.

78. 发明申请

US20200181652A1 CONVERSION OF METHYLGLYOXAL INTO HYDROXYACETONE USING NOVEL ENZYMES AND APPLICATIONS THEREOF 审中-公开
公开(公告)号：US20200181652A1
公开(公告)日：2020-06-11
申请号：US16465560
申请日：2017-12-29
申请人： METABOLIC EXPLORER
发明人： Laetitia FAURE , Gwenaëlle CORRE , Céline RAYNAUD , Laurence DUMON-SEIGNOVERT
IPC分类号： C12P7/18 , C12N9/04 , C12P7/28 , C12N9/88 , C12N9/02
摘要： The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.

79. 发明申请

US20190367898A1 METHODS AND MICROORGANISMS FOR THE PRODUCTION OF GLYCOLIC ACID AND/OR GLYOXYLIC ACID 审中-公开
公开(公告)号：US20190367898A1
公开(公告)日：2019-12-05
申请号：US16476208
申请日：2018-01-26
申请人： METABOLIC EXPLORER
发明人： Wanda DISCHERT , Gwenaëlle CORRE , Philippe SOUCAILLE
IPC分类号： C12N9/88 , C12P7/42 , C12P7/40 , C12N9/04
摘要： The present invention relates to methods and recombinant microorganisms useful for the production of glycolic acid and/or glyoxylic acid. The methods of the invention involve either only one step of fermentation of the modified microorganisms of the invention or one step of fermentation of the modified microorganisms of the invention and one step of either biological or chemical conversion of the glycolic acid or of the glyoxylic acid, the microorganism of the invention over expressing a phosphoketolase gene.

80. 发明授权

US10385322B2 Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate 有权
公开(公告)号：US10385322B2
公开(公告)日：2019-08-20
申请号：US15516282
申请日：2015-10-02
申请人： METABOLIC EXPLORER
发明人： Zhen Chen , Feng Geng , An-Ping Zeng , Wanda Dischert , Philippe Soucaille
IPC分类号： C12N1/20 , C12N9/06 , C12P7/18 , C12P7/42
摘要： The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.

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