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61. 发明授权

US3983099A Thyroxine-and triiodothyronine-tyrosine dipeptide derivatives 失效
标题翻译：甲状腺素和三碘甲状腺原氨酸二肽衍生物
公开(公告)号：US3983099A
公开(公告)日：1976-09-28
申请号：US559862
申请日：1975-03-19
申请人： Gordon Dean Niswender
发明人： Gordon Dean Niswender
IPC分类号： C07K5/06 , G01N33/78 , C07C103/52 , C07G7/00
CPC分类号： C07K5/06191 , G01N33/78
摘要： The present invention is concerned with the production of novel derivatives of thyroid hormones which are useful in the radioimmunoassay (RIA) of such hormones. The invention is particularly concerned with derivatives of thyroxine and triiodothyronine which contain an additional phenol group which is readily iodinatable so that the phenol conjugate can be readily tagged with a radioactive iodine isotope, such as .sup.125 I or .sup.131 I, without detrimentally interfering with the ability of the tagged conjugate so competitively bind with the naturally occurring thyroid hormone in the biological liquid to be analyzed by RIA technique. The invention is also concerned with the iodine-tagged derivatives or conjugates.
摘要翻译：本发明涉及可用于这种激素的放射免疫测定（RIA）的甲状腺激素的新衍生物的生产。本发明特别涉及甲状腺素和三碘甲腺原氨酸的衍生物，其含有另外的酚基，其易于碘化，使得苯偶姻偶联物可以容易地用放射性碘同位素例如125I或131I进行标记，而不会有害地干扰标记的缀合物与通过RIA技术分析的生物液体中天然存在的甲状腺激素竞争性结合。本发明还涉及碘标记的衍生物或缀合物。

62. 发明授权

US3962039A Analytical procedure for thyroid hormones 失效
标题翻译：甲状腺激素分析方法
公开(公告)号：US3962039A
公开(公告)日：1976-06-08
申请号：US603007
申请日：1975-08-08
申请人： Harold M. Bates
发明人： Harold M. Bates
IPC分类号： C12Q1/37 , G01N33/78 , G01N31/14 , G01N33/16
CPC分类号： C12Q1/37 , G01N33/78 , Y10S435/961 , Y10S435/963 , Y10S436/804 , Y10S436/825
摘要： Thyroid hormones in blood serum are determined by admixing a blood serum sample with pepsin, incubating the sample for a period of time to allow pepsin to digest proteins having a thyroid hormone bound thereto and release the thyroid hormone from the proteins, adjusting the resulting mixture to a pH at which pepsin is inactive and assaying the mixture for the released thyroid hormone.

63. 发明授权

US3938953A Process and device for blood examination using substances labelled with radioactive nuclides 失效
标题翻译：使用放射性核素标记的物质进行血液检查的过程和装置
公开(公告)号：US3938953A
公开(公告)日：1976-02-17
申请号：US474056
申请日：1974-05-28
申请人： Stratos Paschalis , Rudolf Kern , Karl-Friedrich Muck
发明人： Stratos Paschalis , Rudolf Kern , Karl-Friedrich Muck
IPC分类号： G01N33/78 , G01N33/16
CPC分类号： G01N33/78 , Y10S436/804 , Y10S436/806 , Y10S436/81 , Y10S436/817 , Y10S436/825 , Y10S436/826
摘要： A process and device for determining a hormone in a liquid such as blood wherein measured amounts of the liquid to be tested, of a radioactively-labelled hormone, and of a hormone-binding protein or antibody, all present in a measuring vial, are contacted with an adsorbing vial formed from a mixture of a thermoplastic resin and an ion exchange resin for adsorbing unbound hormone, and the residual radioactivity of the liquid mixture is then measured after draining back into said measuring vial.

64. 发明授权

US3929981A Method for determining thyroid function 失效
标题翻译：确定甲状腺功能的方法
公开(公告)号：US3929981A
公开(公告)日：1975-12-30
申请号：US44617974
申请日：1974-02-27
申请人： SQUIBB & SONS INC
发明人： MURTY HARI S , GARA SIVA K , MURTY DASIKA R
IPC分类号： G01N33/78 , G01N33/00 , G01T1/16
CPC分类号： G01N33/78 , Y10S436/804 , Y10S436/825
摘要： In an in vitro test for the determination of thyroxine using the competitive protein-binding technique, the improvement that comprises extracting the thyroxine into a lower alkanol or dioxane, but not separating the lower alkanol or dioxane solution of thyroxine from the serum prior to measurement of the thyroxine.
摘要翻译：在使用竞争性蛋白质结合技术测定甲状腺素的体外试验中，包括将甲状腺素提取到低级链烷醇或二恶烷中而不是在测量前将甲状腺素的低级链烷醇或二恶烷溶液与血清分离的改进甲状腺素

65. 发明授权

US3850577A Rapid extraction method for serum thyroxine 失效
标题翻译：用于血清丝氨酸的快速提取方法
公开(公告)号：US3850577A
公开(公告)日：1974-11-26
申请号：US41151773
申请日：1973-10-31
申请人： ABBOTT LAB
发明人： ASHKAR F
IPC分类号： G01N33/78 , G01N33/16
CPC分类号： G01N33/78 , Y10S436/804 , Y10S436/825 , Y10S436/826
摘要： A method for determining total thyroxine by the competitive protein binding analysis procedure and in which an acid buffer is employed to liberate the bond thyroxine from the serum proteins to make the thyroxine available for competitive binding. The buffer greatly reduces extraction time in comparison to the use of alcohol, conventionally used in such procedures, and comprises a glutamate - salicylate mixture.
摘要翻译：一种通过竞争性蛋白质结合分析程序测定总甲状腺素的方法，其中使用酸缓冲液从血清蛋白质中释放甲状腺素键，以使甲状腺素可用于竞争性结合。与常规用于这种方法的醇的使用相比，缓冲液大大降低了提取时间，并且包含谷氨酸盐 - 水杨酸盐混合物。

66. 发明授权

US3745211A Method for determining thyroxine in blood serum and reagent therefor 失效
标题翻译：用于确定血清中的甲状腺素及其试剂的方法
公开(公告)号：US3745211A
公开(公告)日：1973-07-10
申请号：US3745211D
申请日：1971-04-08
申请人： MALLINCKRODT CHEMICAL WORKS
发明人： BROWN J , HALLETT F
IPC分类号： G01N33/78 , A61K27/04
CPC分类号： G01N33/78 , Y10S436/804 , Y10S436/808 , Y10S436/826
摘要： A BUFFERED REAGENT COMPRISING RADIOACTIVE THYROXINE AND A CHELATING AGENT. THE USE OF SUCH A SOLUTION CONTAINING THYROXINE-BINDING GLOBULIN IN THE RADIOMETRIC SERUM THYROXINE ASSAY METHOD OF JAMES L. BROWN (APPLICATION SER. NO. 8657, 785, FILLED OCT. 13, 1969) IMPROVES THE RELIABILITY OF THE RESULTS OBTAINED THEREFROM.

67. 发明授权

US3730684A Thyroxine determination method employing the competitive protein binding technique 失效
标题翻译：采用竞争性蛋白质结合技术的甲状腺素测定方法
公开(公告)号：US3730684A
公开(公告)日：1973-05-01
申请号：US3730684D
申请日：1971-11-01
申请人： BIO SCIENCE LABOR
发明人： DEMETRIOU J
IPC分类号： G01N33/78 , G01N33/16 , G01N23/10
CPC分类号： G01N33/78
摘要： A method for use in determination of thyroxine in biological fluids which comprises extracting thyroxine with tetrahydrofuran and separating thyroxine from the precipitated proteins and then from the tetrahydrofuran, and thereafter equilibrating with thyroxine binding globulin and radioactive labeled thyroxine, removing unbound thyroxine and determining the radioactive labeled thyroxine by counting techniques.
摘要翻译：一种用于测定生物体液中甲状腺素的方法，其中包括用四氢呋喃萃取甲状腺素，然后从沉淀的蛋白质中分离出甲状腺素，然后从四氢呋喃中分离出甲状腺素，然后与甲状腺素结合球蛋白和放射性标记的甲状腺素平衡，除去未结合的甲状腺素，并测定放射性标记甲状腺素计数技术。

68. 发明授权

US3507618A Apparatus and method for determining thyroid function 失效
标题翻译：用于确定甲状腺功能的装置和方法
公开(公告)号：US3507618A
公开(公告)日：1970-04-21
申请号：US3507618D
申请日：1964-11-27
申请人： SQUIBB & SONS INC
发明人： MURTY DASIKA R K , FLOREY KLAUS G
IPC分类号： G01N33/78 , G01N31/04 , G01N33/16
CPC分类号： G01N33/78 , Y10S422/903 , Y10S436/804 , Y10S436/81 , Y10S436/825 , Y10S436/826

69. 发明授权

US11085936B2 Method and a kit for simultaneous analyses of thyroid hormones and related metabolites in serum 有权
公开(公告)号：US11085936B2
公开(公告)日：2021-08-10
申请号：US16378802
申请日：2019-04-09
申请人： Peking University
发明人： Yi Wan , Hongyang Cui , Hang Liu , Shixiong Gao
IPC分类号： G01N33/78 , G01N1/40
摘要： A method and kit the simultaneous analysis of thyroid hormones (THs) and related metabolites in serum are disclosed. The method includes the extraction of THs and related metabolites, the derivatization of THs and related metabolites with 5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide (SPTPP), and the analysis of SPTPP derivatives using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Free or total THs (T3 and T4) together with their related metabolites (MIT, DIT, T0, T1, rT1, 3,3′-T2, 3,5-T2, and rT3) can be determined simultaneously, rapidly, and accurately. This invention overcomes the limitation that the traditional method can only be used for the analysis of T3 and T4 with low specificity. The invention exhibits extremely high analytical sensitivity for all of the target analytes (femtogram level). Moreover, this invention also possesses numerous other advantages, such as simple sample pretreatment, accurate determination, low cost, high efficiency, effective separation, and small sample amounts.

70. 发明申请

US20210215723A1 Biosensor for Diagnosis of Thyroid Dysfunction 有权
公开(公告)号：US20210215723A1
公开(公告)日：2021-07-15
申请号：US17256040
申请日：2019-07-12
申请人： AegirBio AB
发明人： Sudha Srivastava , Kushagr Punyani , Mohamad Takwa
IPC分类号： G01N33/78 , C12Q1/26 , C12Q1/00
摘要： The present invention relates to a biosensor and applications thereof for the quantification of free thyroid hormones to evaluate thyroid function. Methods and tools for diagnosis of thyroid-related diseases are also disclosed herein.

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