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61. 发明授权

US11292771B2 Amidine catalyst for curable compositions 有权
公开(公告)号：US11292771B2
公开(公告)日：2022-04-05
申请号：US16843379
申请日：2020-04-08
申请人： SIKA TECHNOLOGY AG
发明人： Rita Cannas , Urs Burckhardt
IPC分类号： C07D239/06 , C08G77/38 , C09D183/06 , C09J183/06
摘要： The present invention relates to an amidine of the formula (I) and its use as a catalyst for crosslinking a curable composition. The amidine of the formula (I) contains at least one aliphatic amidine group. It is substantially odorless and nonvolatile at room temperature and accelerates the crosslinking of curable compositions very efficiently, without impairing the storage stability of the compositions. It is particularly suitable for compositions based on polymers containing silane groups, with which it is compatible, as a result of which such compositions do not have a tendency to separation or migration or evaporation of the catalyst.

62. 发明申请

US20210052585A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME 有权
公开(公告)号：US20210052585A1
公开(公告)日：2021-02-25
申请号：US16982842
申请日：2019-03-29
申请人： Arbutus Biopharma Corporation
发明人： Yingzhi Bi , Bruce D. Dorsey , Yi Fan , Christopher Brooks Moore , Duyan Nguyen
IPC分类号： A61K31/506 , A61K45/06 , C07D233/26 , C07D239/06 , C07C255/61 , C07D401/12 , C07D401/14 , C07D211/60 , C07C217/58 , A61K31/4164 , A61K31/505 , A61K31/277 , A61K31/4545 , A61K31/444 , A61K31/445 , A61K31/137
摘要： The present invention includes substituted 3,3′bis(phenoxymethyl)-1,1′-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.

63. 发明申请

US20190330157A1 THERAPEUTIC COMPOUNDS 审中-公开
公开(公告)号：US20190330157A1
公开(公告)日：2019-10-31
申请号：US16429507
申请日：2019-06-03
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： Swati S. More , Robert Vince
IPC分类号： C07D233/44 , A61P25/16 , C07C279/08 , A61P35/00 , A61P5/48 , C07C279/06 , C07D239/47 , C07D239/22 , C07C335/12 , C07D213/61 , C07C335/40 , C07C335/04 , C07D239/18 , C07D239/06 , C07D233/64 , C07D233/52 , C07D233/50 , C07D231/38 , C07C281/18 , C07C281/16 , C07C281/14 , C07C279/22 , C07C279/18
摘要： The invention provides methods for producing analgesia in an animal comprising administering to the animal a compound of the formula Ia′, Ib′, Ic′, and Id′: and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as described herein.

64. 发明授权

US09738614B2 Malignant and non-malignant disease treatment with Ras antagonists 有权
公开(公告)号：US09738614B2
公开(公告)日：2017-08-22
申请号：US15080995
申请日：2016-03-25
申请人： PISCES THERAPEUTICS, LLC
发明人： James H. Wikel , Michael J. Brownstein
IPC分类号： C07D239/06 , A61K31/41 , C07D257/04 , C07D233/20 , C07D285/06
CPC分类号： C07D257/04 , A61K31/41 , C07D233/20 , C07D239/06 , C07D285/06
摘要： The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition. The present disclosure also describes a method for inhibiting such Ras-induced or mediated cellular processes. The method entails administering a Ras antagonist in an amount effective to inhibit such cellular processes.

65. 发明授权

US08906927B2 Penta-substituted tetrahydropyrimidines with aggregation-induced emission characteristics and preparation method and use thereof 有权
标题翻译：具有聚集诱发发射特性的五取代四氢嘧啶类及其制备方法和用途
公开(公告)号：US08906927B2
公开(公告)日：2014-12-09
申请号：US14113694
申请日：2011-12-24
申请人： Qiuhua Zhu , Shuwen Liu
发明人： Qiuhua Zhu , Shuwen Liu
IPC分类号： C09K11/06 , C07D239/06 , C07D401/04 , H01L51/05 , H01L51/50 , H01L51/00
CPC分类号： C09K11/06 , C07D239/06 , C07D401/04 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , H01L51/005 , H01L51/50 , H01L51/5012
摘要： The present invention provides a series of penta-substituted tetrahydropyrimidines with aggregation-induced emission (AIE) characteristics and preparation method and use thereof. The AIE penta-substituted tetrahydropyrimidines have structures shown as formula (I). R1 is selected from a group consisting of linear or branched alkyls and substituted alkyls. R2 and R4 is respectively selected from a group consisting of linear or branched alkyls, substituted alkyls, cycloalkyls, substituted cycloalkyls, aryls, substituted aryls, polycyclic aryls, substituted polycyclic aryls, heterocyclyls, substituted heterocyclyls, aromatic heterocyclyls and substituted aromatic heterocyclyls. R3 is selected from a group consisting of aryls, substituted aryls, polycyclic aryls, substituted polycyclic aryls, aromatic heterocyclyls and substituted aromatic heterocyclyls. The penta-substituted tetrahydropyrimidines can be prepared by multi-component reactions (MCR). There are 1˜3 aryls in the structure of the penta-substituted tetrahydropyrimidines. The penta-substituted tetrahydropyrimidines possess strong AIE properties and can be used for preparing organic electro-luminescence or photo-luminescence devices, or chemical and biological fluorescent sensors or probes.
摘要翻译：本发明提供一系列具有聚集诱发发射（AIE）特性的五取代四氢嘧啶和其制备方法和用途。 AIE五取代四氢嘧啶具有式（I）所示的结构。 R 1选自直链或支链烷基和取代的烷基。 R2和R4分别选自直链或支链烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，多环芳基，取代的多环芳基，杂环基，取代的杂环基，芳族杂环基和取代的芳族杂环基。 R 3选自芳基，取代的芳基，多环芳基，取代的多环芳基，芳族杂环基和取代的芳族杂环基。五取代的四氢嘧啶可以通过多组分反应（MCR）制备。五取代四氢嘧啶的结构中有1〜3个芳基。五取代的四氢嘧啶具有强的AIE性质，可用于制备有机电致发光或光致发光器件，或化学和生物荧光传感器或探针。

66. 发明授权

US08895736B1 Synthesis of substituted 2-nitromalonaldehyde intermediates toward the preparation of polyaza-adamantanes 有权
标题翻译：取代的2-硝基醛醛中间体合成制备多金属 - 金刚烷
公开(公告)号：US08895736B1
公开(公告)日：2014-11-25
申请号：US12932930
申请日：2011-02-25
申请人： Alfred G. Stern , Craig J. Diamond
发明人： Alfred G. Stern , Craig J. Diamond
IPC分类号： C07D239/06 , C07D487/08
CPC分类号： C07D239/06 , C07C251/08 , C07D487/08
摘要： The present invention relates to methods for synthesizing energetic compounds and intermediates thereof. Specifically, the present invention relates to methods for synthesizing adamantanes and intermediates that are useful in such synthesis. Synthesized intermediates are useful in the synthesis of bicyclic and tricyclic substituted adamantanes. Examples of various intermediates are: acyclic 2-nitromalonaldehyde intermediates, 2,6,9-tri-substituted-4,8-dinitro-2,6,9-triazabicyclo[3.3.1]nona-3,7-dienes and 2,6-dinitro-4,8,9,10-tetra-aza-4,8,9,10-tetra-substituted adamantanes. Intermediates synthesized according to the methods of the present invention are useful toward the synthesis of tetraaza-adamantanes, which can serve as precursors to potentially superior new high-energy-density compounds (HEDCs).
摘要翻译：本发明涉及合成能量化合物的方法及其中间体。具体地，本发明涉及用于合成金刚烷和中间体的方法。合成的中间体可用于双环和三环取代的金刚烷的合成。各种中间体的实例是：无环2-硝基丙醛中间体，2,6,9-三取代-4,8-二硝基-2,6,9-三氮杂二环[3.3.1]壬-3,7-二烯和2， 6-二硝基-4,8,9,10-四氮杂-4,8,9,10-四取代金刚烷。根据本发明的方法合成的中间体可用于四氮杂 - 金刚烷的合成，四氮杂金刚烷可以作为潜在优异的新型高能密度化合物（HEDC）的前体。

67. 发明授权

US08541423B2 Methods and compositions for treating pain 有权
标题翻译：治疗疼痛的方法和组合物
公开(公告)号：US08541423B2
公开(公告)日：2013-09-24
申请号：US13444213
申请日：2012-04-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： A61P29/00 , A61K31/522 , A61K31/513 , C07D239/06
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译：本申请涉及治疗疼痛，失禁等条件的化合物和方法。

68. 发明授权

US08283385B2 Reversibly switchable surfactants and methods of use thereof 有权
标题翻译：可逆切换的表面活性剂及其使用方法
公开(公告)号：US08283385B2
公开(公告)日：2012-10-09
申请号：US11599623
申请日：2006-11-15
申请人： Philip G. Jessop
发明人： Philip G. Jessop
IPC分类号： B01F17/16 , B01F17/04 , B01F17/22 , B01F3/08 , C07B63/02 , B01D17/04 , B01D17/05 , C07C257/10 , C07C279/02 , C07D233/06 , C07D239/06 , C07F7/10 , C08F2/22 , C08F2/32
CPC分类号： C08K5/29 , B01D17/047 , B01D21/01 , B01F17/0042 , B03D1/01 , C07B63/02 , C07C257/14 , C08F2/24 , Y02W10/37
摘要： Reversible switchable surfactants are provided. A surfactant is the salt of an amidine or guanidine: having at least one R group that is a hydrophobic moiety selected from the group consisting of higher aliphatic moiety, higher siloxyl moiety, higher aliphatic/siloxyl moiety, aliphatic/aryl moiety, siloxyl/aryl moiety, and aliphatic/siloxyl/aryl moiety. The other R groups are smaller moieties such as H, C1 to C4 aliphatic or the like. The surfactant is turned on by a gas that liberates hydrogen ions, such as, for example, carbon dioxide, which liberates hydrogen ions in the presence of water. The surfactant is turned off by exposure to a flushing gas and/or heating. When “on” the surfactants are useful to stabilize emulsions, and when “off” they are useful to separate immiscible liquids or a liquid and a solid. The surfactants find uses in polymerization and in the oil industry.
摘要翻译：提供可逆切换表面活性剂。表面活性剂是脒或胍的盐：具有至少一个R基团，其是疏水部分，其选自高级脂族部分，高级甲硅烷氧基部分，高级脂族/硅氧烷基部分，脂族/芳基部分，硅氧烷/芳基部分和脂肪族/酪醇酰/芳基部分。其它R基团是较小的部分，例如H，C 1至C 4脂族基等。表面活性剂通过释放氢离子的气体导通，例如二氧化碳，二氧化碳在水存在下释放出氢离子。通过暴露于冲洗气体和/或加热来关闭表面活性剂。当表面活性剂可用于稳定乳液时，并且当它们脱离时它们可用于分离不混溶的液体或液体和固体。表面活性剂用于聚合和石油工业。

69. 发明授权

US08110683B2 Piperidinyl compounds that selectively bind integrins 有权
标题翻译：选择性结合整联蛋白的哌啶基化合物
公开(公告)号：US08110683B2
公开(公告)日：2012-02-07
申请号：US12975900
申请日：2010-12-22
申请人： Bart De Corte , William A. Kinney , Bruce E. Maryanoff , Shyamali Ghosh , Li Liu
发明人： Bart De Corte , William A. Kinney , Bruce E. Maryanoff , Shyamali Ghosh , Li Liu
IPC分类号： C07D239/06
CPC分类号： C07D471/04 , A61K31/4523 , A61K45/06 , A61K51/0455 , A61K51/0459 , C07D401/12 , C07D401/14 , C07D405/14 , Y02P20/582 , A61K2300/00
摘要： The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated disorder.
摘要翻译：本发明涉及选择性结合整联蛋白受体的哌啶基化合物和用于治疗整联蛋白介导的病症的方法。

70. 发明申请

US20110269784A1 USE OF TETRAHYDROPYRIMIDINES 审中-公开
标题翻译：四氢嘧啶的使用
公开(公告)号：US20110269784A1
公开(公告)日：2011-11-03
申请号：US12863832
申请日：2009-01-30
申请人： Rene Tolba , Gerhild van Echten-Deckert , Georg Lentzen , Andreas Bilstein
发明人： Rene Tolba , Gerhild van Echten-Deckert , Georg Lentzen , Andreas Bilstein
IPC分类号： A61K31/505 , A61P25/00 , C07D239/06 , A61P29/00
CPC分类号： A61K31/495
摘要： Tetrahydropyrimidines of the formula where R is a hydrogen atom or a hydrocarbon radical comprising up to eight carbon atoms, R′ is hydrogen, OH or OR″ and R″ is R or COR, with R having the above described significance for use in the prevention or treatment of post-operative inflammatory stresses and pain.
摘要翻译：其中R是氢原子或包含至多8个碳原子的烃基，R'是氢，OH或OR“和R”是R或COR的下式的四氢嘧啶，其中R具有上述意义用于预防或治疗术后炎症应激和疼痛。

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