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61. 发明授权

US09420770B2 Methods of modulating thrombocytopenia and modified transgenic pigs 有权
标题翻译：调节血小板减少症和改良转基因猪的方法
公开(公告)号：US09420770B2
公开(公告)日：2016-08-23
申请号：US14491183
申请日：2014-09-19
申请人： Indiana University Research and Technology Corporation
发明人： Alfred Joseph Tector, III , Christopher Burlak
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , A01K67/027 , A61K35/407
CPC分类号： A01K67/0276 , A01K2227/108 , A01K2267/025 , A61K35/407
摘要： The application provides methods of modulating platelet uptake by liver sinusoidal endothelial cells and of modulating thrombocytopenia. Transgenic pigs modified to bind fewer platelets are provided.
摘要翻译：该应用提供了调节肝窦内皮细胞血小板摄取和调节血小板减少症的方法。提供了修饰以结合较少血小板的转基因猪。

62. 发明授权

US09415003B2 Skin care method and kit 有权
标题翻译：护肤方法和试剂盒
公开(公告)号：US09415003B2
公开(公告)日：2016-08-16
申请号：US14194944
申请日：2014-03-03
申请人： David Weck , Clemente Omar Villar
发明人： David Weck , Clemente Omar Villar
IPC分类号： A61K35/407 , A61K36/88 , A61K8/97 , A23L1/00 , A61Q19/00 , A61Q19/10
CPC分类号： A61K8/97 , A23L33/10 , A23L33/105 , A23L33/115 , A23L33/15 , A23L33/175 , A61K2800/92 , A61Q19/00 , A61Q19/007 , A61Q19/10
摘要： A skin care method and kit is disclosed that includes instructions for a dietary skin care regimen. The regimen includes a list of prohibited and allowed foods. The list of prohibited foods includes red meat, chocolate, eggs, confections, alcoholic beverages, shellfish, fried foods, and tomatoes. The list of allowed foods includes chicken, turkey, non-fried fish, vegetables, fruit other than a tomato, and olive oil as a salad dressing. The skin care kit further includes a compliance report including the list of prohibited and allowed foods with corresponding data input fields for each food in the list of prohibited and allowed foods. The user indicates an amount of each prohibited and allowed food item consumed by the user in the corresponding data input field. A compliance rating system is disclosed in which the total number of servings of prohibited and allowed foods consumed by the user determines the user's compliance level.
摘要翻译：公开了一种护肤方法和试剂盒，其包括膳食护肤方案的说明书。该方案包括禁用和允许食物的清单。禁止食物的列表包括红肉，巧克力，鸡蛋，糖果，含酒精饮料，贝类，油炸食品和西红柿。允许食品的列表包括鸡肉，火鸡，非油炸鱼，蔬菜，西红柿以外的水果，以及沙拉酱的橄榄油。皮肤护理套件还包括合规报告，其中包括禁用和允许食品列表中的禁用和允许食品列表中的每种食物的相应数据输入栏。用户指示用户在相应的数据输入字段中消耗的每个被禁止和允许的食品的量。公开了一种合规性评级系统，其中由用户消费的禁止和允许食品的总数量确定了用户的合规水平。

63. 发明申请

US20160129047A1 CONDITIONED MEDIUM FROM HUMAN ADULT LIVER STEM CELLS AND ITS USE IN THE TREATMENT OF LIVER DISORDERS 审中-公开
标题翻译：人类成年肝细胞的调节中药及其在治疗肝病中的应用
公开(公告)号：US20160129047A1
公开(公告)日：2016-05-12
申请号：US14899661
申请日：2014-07-07
申请人： UNIVERSITÉ CATHOLIQUE DE LOUVAIN
发明人： Mustapha Najimi , Etienne Sokal , Silvia Berardis
IPC分类号： A61K35/407 , C12N5/00
CPC分类号： A61K35/407 , C12N5/0037 , C12N2502/03
摘要： The invention relates to cell-free compositions obtained by culturing adult-derived human liver stem/progenitor cells (ADHLSC) in cell culture medium and isolating the resulting conditioned medium (ADHLSC-CM) that has advantageous property ties, such as anti-fibrotic effects. ADHLSC-CM, compositions based on ADHLSC-CM, and other related and derived products, can be used in cell culture processes or as a medicament, more particularly for the treatment of diseases involving organ injury, organ failure, in organ or cell transplantation or the pathological disruption, inflammation, degeneration, and/or proliferation of cells within a tissue or an organ, in particular within liver.
摘要翻译：本发明涉及通过在细胞培养基中培养成人来源的人肝干/祖细胞（ADHLSC）而获得的无细胞组合物，并分离得到的具有有利性质关系的条件培养基（ADHLSC-CM），如抗纤维化作用。 ADHLSC-CM，基于ADHLSC-CM的组合物及其它相关衍生产品可用于细胞培养过程或药物中，尤其用于治疗涉及器官损伤，器官衰竭，器官或细胞移植的疾病或组织或器官内，特别是肝脏内的细胞的病理破坏，炎症，变性和/或增殖。

64. 发明申请

US20160060594A1 ISOLATION OF NON-EMBRYONIC STEM CELLS AND USES THEREOF 审中-公开
公开(公告)号：US20160060594A1
公开(公告)日：2016-03-03
申请号：US14853210
申请日：2015-09-14
申请人： THE JACKSON LABORATORY
发明人： Wa Xian
IPC分类号： C12N5/074 , A61K35/407 , A61K35/42 , A61K35/48 , A61K35/30 , A61K35/22 , A61K35/38 , A61K35/39
CPC分类号： C12N5/0607 , A61K35/22 , A61K35/30 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42 , A61K35/48 , C12N5/0623 , C12N5/0672 , C12N5/0676 , C12N5/0679 , C12N5/0685 , C12N5/0695 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/15 , C12N2501/155 , C12N2501/33 , C12N2501/415 , C12N2501/42 , C12N2533/52
摘要： The invention described herein relates to methods of isolating non-embryonic stem cell, e.g., adult stem cell, from a non-embryonic tissue, e.g., an adult tissue or organ. Non-embryonic stem cells (e.g., adult stem cells) thus isolated from the various tissues or organs can self-renew or propagate indefinitely in vitro, are multipotent and can differentiate into the various differentiated cell types normally found within the tissue or organ from which the stem cells are isolated. In addition, the isolated stem cells can be propagated through clonal expansion of a single isolated stem cell, to produce a clone of which at least about 40%, 70%, or 90% or more cells within the clone can be further passaged as single cell originated clones.

65. 发明申请

US20160058798A1 METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY ENDOSCOPIC-MEDIATED (OR LAPAROSCOPIC-MEDIATED) TRANSPLANTATION OF STEM CELLS INTO/ONTO BILE DUCT WALLS OF PARTICULAR REGIONS OF THE BILIARY TREE 审中-公开
标题翻译：通过内窥镜介导的（或LAPAROSCOPIC-MEDIATED）治疗胰腺癌和肝脏病变的方法将干细胞转移到双子座特定区域的双层沟渠中
公开(公告)号：US20160058798A1
公开(公告)日：2016-03-03
申请号：US14936519
申请日：2015-11-09
申请人： University of North Carolina at Chapel Hill , University of Miami , Sapienza Università di Roma
发明人： Lola M. REID , Yunfang WANG , David A. GERBER , Giacomo LANZONI , Luca INVERARDI , Juan DOMINGUEZ-BENDALA , Domenico ALVARO , Vincenzo CARDINALE , Eugenio GAUDIO , Guido CARPINO
IPC分类号： A61K35/407
CPC分类号： A61K35/407 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2430/28
摘要： A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated. The graft consists of stem cells or progenitors that are admixed with biomaterials and, optionally, with cytokines and/or native epithelial-mesenchymal cells appropriate for the maturational lineage stage of the cells to be engrafted. The cells are specifically introduced to the hepato-pancreatic common duct of the subject for treatment of pancreatic conditions or to the bile duct wall near to the liver for treatment of liver conditions and allowed to migrate to the pancreas or to the liver and expand and then rebuild part or the entirety of the diseased or dysfunctional organ.
摘要翻译：提供了修复患病或功能障碍的胰腺或肝脏的方法。该方法包括从患者的健康组织或患者的胆汁树中制备干细胞和/或祖细胞例如胆树干细胞，肝干细胞，胰腺干细胞或其后代的悬浮物，定型的祖细胞非自体供体并将细胞移植到待治疗器官附近的胆管壁。移植物由干细胞或祖细胞组成，其与生物材料以及任选的细胞因子和/或天然上皮 - 间充质细胞混合，所述细胞因子和/或天然上皮 - 间充质细胞适合于待移植的细胞的成熟谱系阶段。将细胞特异性地引入受试者的肝胰腺共同管道以治疗胰腺病症或肝脏附近的胆管壁用于治疗肝脏病症并允许迁移至胰腺或肝脏并扩张，重建部分或全部患病或功能失调的器官。

66. 发明授权

US09186381B2 Medicament for liver regeneration and for treatment of liver failure 有权
标题翻译：用于肝脏再生和用于治疗肝衰竭的药物
公开(公告)号：US09186381B2
公开(公告)日：2015-11-17
申请号：US14009738
申请日：2012-04-10
申请人： Lars Zender , Torsten Wuestefeld
发明人： Lars Zender , Torsten Wuestefeld
IPC分类号： C12N15/11 , C12N5/00 , C12N5/02 , A61K35/407 , C12N15/113 , A61K31/353 , A61K31/00 , A61K31/416 , A61K31/713 , C07C237/42 , C07D213/75 , C07D231/56
CPC分类号： A61K35/407 , A61K31/00 , A61K31/352 , A61K31/353 , A61K31/416 , A61K31/4709 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/713 , A61M1/36 , C07C237/42 , C07D213/75 , C07D231/54 , C07D231/56 , C07D311/30 , C07D311/36 , C07D401/12 , C07D407/12 , C07D473/38 , C07D487/04 , C12N5/067 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12Y207/11024
摘要： The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
摘要翻译：本发明涉及抑制MKK4活性的化合物作为治疗患有肝功能损害的患者的药物的用途，涉及使用化合物作为治疗肝衰竭的药物，包括急性 /暴发性或慢性肝衰竭和/或用于增加患者中肝组织的再生。

67. 发明申请

US20150290327A1 SULFATED ALGINATE HYDROGELS FOR CELL CULTURE AND THERAPY 有权
标题翻译：用于细胞培养和治疗的硫酸化氢化物
公开(公告)号：US20150290327A1
公开(公告)日：2015-10-15
申请号：US14441177
申请日：2013-11-04
申请人： ETH ZURICH
发明人： Marcy Zenobi-Wong , Gemma Palazzolo , Rami Mhanna , Jana Becher , Stefanie Moller , Matthias Schnabelrauch , Ece Oeztuerk , Oystein Arlov
IPC分类号： A61K47/36 , A61K35/32 , C12N5/00 , A61K35/33 , A61K35/407 , A61K35/545 , A61K35/30 , A61K35/28
CPC分类号： A61K47/36 , A01N1/0231 , A61K35/28 , A61K35/30 , A61K35/32 , A61K35/33 , A61K35/407 , A61K35/545 , A61L27/20 , A61L27/3804 , A61L27/383 , A61L27/52 , A61L2430/06 , A61L2430/32 , C12N5/0012 , C12N2533/74 , C08L5/04
摘要： The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.
摘要翻译：本发明涉及提供嵌入式哺乳动物细胞的方法，包括以下步骤：在水溶液中提供藻酸盐硫酸盐; 在凝胶化步骤中使藻酸盐硫酸盐反应形成水凝胶，提供前体细胞，并在嵌入步骤中将前体细胞包埋在硫酸化藻酸盐水凝胶中，从而产生硫酸化藻酸盐水凝胶包埋的细胞。本发明还涉及硫酸化藻酸盐水凝胶和包含嵌入硫酸化藻酸盐水凝胶中的哺乳动物细胞的细胞移植物。

68. 发明申请

US20150231182A1 CELL SYSTEMS AND METHODS FOR DELIVERING DISEASE-SPECIFIC THERAPIES 审中-公开
标题翻译：细胞系统和递送疾病治疗方法
公开(公告)号：US20150231182A1
公开(公告)日：2015-08-20
申请号：US14426618
申请日：2013-09-06
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： Nolan L. Boyd , Stuart K. Williams , James B. Hoying , Venkat M. Ramakrishnan
IPC分类号： A61K35/407 , A61K38/57 , A61K47/46 , A61K38/37
CPC分类号： A61K35/407 , A61K35/34 , A61K35/35 , A61K35/39 , A61K38/37 , A61K38/57 , A61K47/46 , A61K48/00 , A61K48/0075 , A61L27/24 , A61L27/3625 , A61L27/3645 , A61L27/3804 , A61L27/3834
摘要： Cell systems for delivering disease-specific therapies are provided that include a therapeutic cell combined with a plurality of stromal vascular fraction cells or a stromal vascular fraction cell-derived vasculature. The cell systems can include the therapeutic cells and the stromal vascular fraction cells in a biocompatible matrix or can further combine the therapeutic cells and stromal vascular fraction cells with microvessel fragments. Further provided are methods of treating a disease characterized by missing or defiicent gene products wherein a subject is administered an effective amount of a cell system that includes a therapeutic cell for supplying the missing or deficient gene products and a plurality of stromal vascular fraction cells.
摘要翻译：提供用于递送疾病特异性疗法的细胞系统，其包括与多个基质血管部分细胞或基质血管部分细胞衍生的脉管系统结合的治疗细胞。细胞系统可以包括生物相容性基质中的治疗细胞和基质血管部分细胞，或者可以将治疗细胞和基质血管部分细胞与微血管碎片进一步组合。还提供了治疗特征为缺失或缺乏基因产物的疾病的方法，其中给予受试者有效量的细胞系统，其包括用于供应缺失或缺乏的基因产物的治疗细胞和多个基质血管部分细胞。

69. 发明授权

US09107910B2 Isolated liver stem cells 有权
标题翻译：分离肝干细胞
公开(公告)号：US09107910B2
公开(公告)日：2015-08-18
申请号：US14294886
申请日：2014-06-03
申请人： Universite Catholique de Louvain
发明人： Etienne Sokal , Mustapha Najimi
IPC分类号： C12N5/074 , C12N5/071 , A61K48/00 , C12N15/00 , A61K35/407 , G01N33/50
CPC分类号： A61K35/28 , A61K35/407 , C12N5/0672 , G01N33/5067
摘要： Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver. The isolated progenitor stem cells have uses in medicine, hepatology, inborn errors of liver metabolism transplantation, infectious diseases and liver failure. Methods of isolating these cells and their culture is described. The isolated cells are characterized before and after differentiation. Their use for transplantation and as animal models of human disease, toxicology and pharmacology is disclosed.
摘要翻译：公开了分离的肝脏祖细胞干细胞和分离的肝脏祖细胞干细胞的细胞群。祖细胞源于成年肝脏，特别是成人肝脏。分离的祖细胞干细胞在医学，肝病学，肝脏代谢移植，先天性肝脏代谢异常，传染病和肝功能衰竭方面都有应用。描述了分离这些细胞及其培养物的方法。分离细胞的特征在分化前后。公开了其用于移植和用作人类疾病，毒理学和药理学的动物模型。

70. 发明授权

US09089549B2 Compositions and methods for preventing cardiac arrhythmia 有权
公开(公告)号：US09089549B2
公开(公告)日：2015-07-28
申请号：US14622167
申请日：2015-02-13
申请人： CorMatrix Cardiovascular, Inc.
发明人： Robert G Matheny
IPC分类号： A61K35/34 , A61K35/36 , A61K35/12 , A61K35/38 , A61K35/37 , A61K35/407 , A61K45/06 , A61K9/00
CPC分类号： A61K35/407 , A61K9/0012 , A61K31/138 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/216 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/4166 , A61K31/439 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4458 , A61K31/47 , A61K31/505 , A61K31/5377 , A61K31/5415 , A61K35/12 , A61K35/22 , A61K35/34 , A61K35/36 , A61K35/38 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/202 , A61K38/2026 , A61K38/2066 , A61K38/2086 , A61K38/2093 , A61K38/217 , A61K38/48 , A61K45/06 , A61L27/3633 , A61L27/3834 , A61L27/54
摘要： Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.

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