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61. 发明申请

US20150184203A1 NOVEL ARABINOSE-FERMENTING EUKARYOTIC CELLS 审中-公开
标题翻译：新型阿拉伯胶 - 发酵的真核细胞
公开(公告)号：US20150184203A1
公开(公告)日：2015-07-02
申请号：US14623811
申请日：2015-02-17
申请人： DSM IP ASSETS B.V.
发明人： Johannes Adrianus Maria DE BONT
IPC分类号： C12P7/06 , C12N9/90 , C12N9/12 , C12N9/80 , C12N1/14 , C12N1/16
CPC分类号： C12P7/06 , C12N1/14 , C12N1/16 , C12N9/1205 , C12N9/80 , C12N9/90 , C12P7/12 , C12Y207/01016 , C12Y305/01004 , C12Y501/03004 , C12Y503/01004 , Y02E50/17
摘要： Eukaryotic cells, preferably a yeast or a filamentous fungus, with the ability to convert L-arabinose into D-xylulose 5-phosphate are provided, said ability acquired by transformation with nucleotide sequences coding for an arabinose isomerase, a ribulokinase, and a ribulose-5-P-4-epimerase from a bacterium of genus Clavibacter, Arthrobacter or Gramella. Preferably the can produce a fermentation product such as ethanol, lactic acid, 3-hydroxy-propionic acid, acrylic acid, acetic acid, succinic acid, citric acid, amino acids, 1,3-propane-diol, ethylene, glycerol, -lactam antibiotics and cephalosporins. The invention further relates to processes for producing these fermentation products wherein a cell of the invention is used to ferment arabinose into the fermentation products.
摘要翻译：提供具有将L-阿拉伯糖转化为D-木酮糖-5-磷酸的能力的真核细胞，优选酵母或丝状真菌，所述能力通过用编码阿拉伯糖异构酶，核糖核酸激酶和核酮糖 - 来自克拉维杆菌，节杆菌或格莱美菌的5-P-4-差向异构酶。优选地，可以产生发酵产物如乙醇，乳酸，3-羟基 - 丙酸，丙烯酸，乙酸，琥珀酸，柠檬酸，氨基酸，1,3-丙二醇，乙烯，甘油， - 内酰胺抗生素和头孢菌素。本发明还涉及用于生产这些发酵产物的方法，其中本发明的细胞用于将阿拉伯糖发酵成发酵产物。

62. 发明授权

US09068194B2 Increasing plant growth by modulating omega-amidase expression in plants 有权
标题翻译：通过调节植物中的ω-酰胺酶表达来增加植物生长
公开(公告)号：US09068194B2
公开(公告)日：2015-06-30
申请号：US13037307
申请日：2011-02-28
申请人： Pat J. Unkefer , Penelope S. Anderson , Thomas J. Knight
发明人： Pat J. Unkefer , Penelope S. Anderson , Thomas J. Knight
IPC分类号： C12N15/82 , C12N9/80
CPC分类号： C12N15/8261 , C12N9/80 , C12N15/8227 , C12N15/8262 , Y02A40/146
摘要： The present disclosure relates to compositions and methods for increasing the leaf-to-root ratio of the signal metabolite 2-oxoglutaramate and related proline molecules in plants by modulating levels of ω-amidase to increase nitrogen use efficiency, resulting in enhanced growth, faster growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, increased tolerance to high salt conditions, and increased biomass yields.
摘要翻译：本公开内容涉及通过调节ω-酰胺酶水平来增加植物中信号代谢产物2-氧代谷氨酸和信号脯氨酸分子的叶根比的组合物和方法，以提高氮利用效率，从而增加生长，增长速度种子和水果/荚果产量提高，开花时间越来越高，对高盐条件的耐受性越来越高，生物质产量提高。

63. 发明授权

US08992935B2 Means of controlling infection persistence of Helicobacter pylori 有权
标题翻译：控制幽门螺杆菌感染持续性的手段
公开(公告)号：US08992935B2
公开(公告)日：2015-03-31
申请号：US13806084
申请日：2011-06-24
申请人： Mohammed Benghezal , Tobias Schoep , Alma Fulurija , Douglas E. Berg , Barry J. Marshall
发明人： Mohammed Benghezal , Tobias Schoep , Alma Fulurija , Douglas E. Berg , Barry J. Marshall
IPC分类号： C07K14/195 , A61K39/02 , C12N1/36 , C12N9/80 , A61K39/00
CPC分类号： A61K39/105 , A61K2039/522 , C12N1/36 , C12N9/80 , C12Y305/01005 , Y02A50/412 , Y02A50/466 , Y02A50/467
摘要： The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.
摘要翻译：本发明涉及一种控制幽门螺杆菌（幽门螺杆菌）感染持久性的方法。特别地，本发明涉及一种分离的经遗传修饰的幽门螺杆菌，其包含功能性脲酶，其中SEQ ID NO：1的氨基酸529和氨基酸555之间的连续氨基酸序列被改变以产生所述修饰的幽门螺杆菌无法建立或维持持续感染。

64. 发明申请

US20140351998A1 ENGINEERING PLANTS FOR EFFICIENT UPTAKE AND UTILIZATION OF UREA TO IMPROVE CROP PRODUCTION 审中-公开
标题翻译：工程植物有效利用和利用乌拉圭来提高作物生产
公开(公告)号：US20140351998A1
公开(公告)日：2014-11-27
申请号：US14083491
申请日：2013-11-19
申请人： PIONEER HI BRED INTERNATIONAL INC
发明人： RAJEEV GUPTA , Zhenglin Hou , Dale F. Loussaert , Bo Shen , Lawrence Kent Wood
IPC分类号： C12N15/82 , C12N9/80 , C05C9/00 , C07K14/415 , C07K14/395 , A01G1/00 , C07K14/40 , C07K14/39 , C07K14/405 , C07K14/335 , C07K14/195 , C07K14/35 , C07K14/38 , C07K14/32
CPC分类号： C12N15/8243 , C05C9/00 , C07K14/195 , C07K14/32 , C07K14/335 , C07K14/35 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/395 , C07K14/40 , C07K14/405 , C07K14/415 , C12N9/80 , C12N15/8261 , Y02A40/146
摘要： The present invention provides polynucleotides and related polypeptides related to urea uptake. The invention provides genomic sequences for urea transporter, urease and glutamine synthetase genes. Urea transporters, urease and glutamine synthetase are responsible for controlling nitrogen utilization efficiency in plants. Urea transporter, urease or glutamine synthetase sequences are provided for improving grain yield and plant growth. The invention further provides recombinant expression cassettes, host cells and transgenic plants.
摘要翻译：本发明提供了与尿素摄取相关的多核苷酸和相关多肽。本发明提供尿素转运蛋白，脲酶和谷氨酰胺合成酶基因的基因组序列。尿素转运蛋白，脲酶和谷氨酰胺合成酶负责控制植物的氮利用效率。提供尿素转运蛋白，脲酶或谷氨酰胺合成酶序列用于改善谷物产量和植物生长。本发明还提供了重组表达盒，宿主细胞和转基因植物。

65. 发明申请

US20140248256A1 DIMERIC BACTERIOPHAGE LYSINS 有权
标题翻译：二甲基胆碱酯酶
公开(公告)号：US20140248256A1
公开(公告)日：2014-09-04
申请号：US14349736
申请日：2012-10-04
申请人： THE ROCKEFELLER UNIVERSITY
发明人： Vincent A. Fischetti , Gregory Resch
IPC分类号： C12N9/80 , A01N63/00
CPC分类号： C12N9/2462 , A01N63/00 , A01N63/02 , A61K38/00 , A61K38/47 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N9/2405 , C12N9/80 , C12N2795/10022 , C12N2795/10033 , C12N2795/10071 , C12Y302/01017
摘要： The present invention provides isolated dimeric Streptococcus-specific phage lysins having two Streptococcus-specific phage lysin monomers covalently linked to each other, and having killing activity against one or more Streptococcus bacteria. Also provided for are pharmaceutical compositions of dimeric lysins and their use in therapeutic treatment or alleviation of infections or bacterial colonizations. The dimeric lysins may also be used to decontaminate porous and non-porous surfaces or devices.
摘要翻译：本发明提供了分离的二聚链球菌特异性噬菌体溶素，其具有彼此共价连接的两种链球菌特异性噬菌体溶素单体，并且具有针对一种或多种链球菌的杀伤活性。还提供了二聚赖氨酸的药物组合物及其在治疗性治疗或缓解感染或细菌定植中的用途。二聚赖氨酸也可用于净化多孔和无孔表面或器件。

66. 发明申请

US20130005002A1 AMIDASE AND USE THEREOF FOR PRODUCING 3-AMINOCARBOXYLIC ACID ESTERS 审中-公开
标题翻译：用于生产3-氨基羧酸酯的氨基酸及其用途
公开(公告)号：US20130005002A1
公开(公告)日：2013-01-03
申请号：US13497985
申请日：2010-09-24
申请人： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
发明人： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
IPC分类号： C12P13/00 , C12N9/80
CPC分类号： C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
摘要： Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
摘要翻译：制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到根据权利要求1的通过加入多肽的对映选择性脱酰作用。

67. 发明申请

US20120184018A1 Genetically Programmed Expression of Selectively Sulfated Proteins in Eubacteria 有权
标题翻译：选择性硫酸化蛋白在细菌中的遗传程序表达
公开(公告)号：US20120184018A1
公开(公告)日：2012-07-19
申请号：US13326143
申请日：2011-12-14
申请人： Chang C. Liu , Peter G. Schultz
发明人： Chang C. Liu , Peter G. Schultz
IPC分类号： C12N9/80 , C12N15/63 , C12N1/21 , C12N15/55
CPC分类号： C12N9/93 , C07K14/815 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid sulfotyrosine and translation systems.
摘要翻译：本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸磺基酪氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。本发明提供了例如但不限于新型正交氨酰-tRNA合成酶，编码新合成酶分子的多核苷酸，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸磺酰酪氨酸的蛋白质的翻译方法和翻译系统。

68. 发明申请

US20120149071A1 D-AMINOACYLASE 审中-公开
标题翻译： D-氨基酸
公开(公告)号：US20120149071A1
公开(公告)日：2012-06-14
申请号：US13345399
申请日：2012-01-06
申请人： Kimiyasu Isobe , Seiki Yamaguchi
发明人： Kimiyasu Isobe , Seiki Yamaguchi
IPC分类号： C12N9/80 , C12N1/20 , C12P13/04 , C12N1/21 , C12N15/55 , C12N15/74
CPC分类号： C12N9/80
摘要： A D-aminoacylase having a high substrate specificity is provided. This D-aminoacylase can produce D-amino acids from N-acetyl-D,L-amino acids conveniently and efficiently at a low cost.A D-aminoacylase produced by a microorganism of genus Defluvibacter; which acts on a N-acetyl-D-amino acid; which has a molecular weight (as determined by electrophoresis) of about 55,000 daltons, and an isoelectric point (as determined by two-dimensional electrophoresis for denatured system) of 5.3; which acts on N-acetyl-D-valine, N-acetyl-D-leucine, and the like, but not on N-acetyl-L-valine, N-acetyl-L-leucine, and the like; which has an optimal temperature of 37° C. (pH 8) and an optimal pH value of 8 to 8.5 at 37° C.; and whose activity is inhibited by Mn2+, Co2+, Ni2+, and Zn2+ each at 1 mmol/L, and by dithiothreitol, 2-mercaptoethanol, o-phenanthroline, and L-cysteine each at 5 mmol/L.
摘要翻译：提供了具有高底物特异性的D-氨基酸酰化酶。该D-氨基酸酶可以以低成本方便且有效地从N-乙酰基-D，L-氨基酸产生D-氨基酸。由去纤维杆菌属的微生物产生的D-氨基酸酰化酶; 其作用于N-乙酰基-D-氨基酸; 其具有约55,000道尔顿的分子量（通过电泳测定）和5.3的等电点（通过用于变性体系的二维电泳测定）; 其作用于N-乙酰基-D-缬氨酸，N-乙酰基-D-亮氨酸等，但不适用于N-乙酰基-L-缬氨酸，N-乙酰基-L-亮氨酸等; 其最适温度为37℃（pH8），最适pH值为8〜8.5，在37℃下。 Mn2 +，Co2 +，Ni2 +和Zn2 +各自以1 mmol / L的速度抑制其活性，二硫苏糖醇，2-巯基乙醇，邻菲咯啉和L-半胱氨酸各自以5 mmol / L的速度进行抑制。

69. 发明申请

US20120021469A1 AMIDASES AND METHODS OF THEIR USE 审中-公开
标题翻译：其使用方法及方法
公开(公告)号：US20120021469A1
公开(公告)日：2012-01-26
申请号：US13256581
申请日：2010-03-26
申请人： Owen Gooding , Robert J. Jones , Gjalt Huisman , Jie Yang , Louis Clark
发明人： Owen Gooding , Robert J. Jones , Gjalt Huisman , Jie Yang , Louis Clark
IPC分类号： C12N9/80 , C12N15/70 , C07C237/10 , C12P13/02 , C12P17/10 , C07C229/26 , C12N15/55 , C12N1/21
CPC分类号： C12N9/80 , C12P13/02 , C12P13/04 , C12P41/007
摘要： The disclosure relates to engineered amidase polypeptides and processes of using the polypeptides for chiral resolution of amino acid amide compounds. The disclosure further relates to the polynucleotides that encode the engineered amidase polypeptides and related vectors, host cells, and methods for making the engineered amidase polypeptides.
摘要翻译：本公开涉及工程化的酰胺酶多肽和使用该多肽用于手性拆分氨基酸酰胺化合物的方法。本公开还涉及编码工程化的酰胺酶多肽和相关载体的多核苷酸，宿主细胞和用于制备工程化的酰胺酶多肽的方法。

70. 发明申请

US20110244530A1 L-SUCCINYLAMINOACYLASE AND PROCESS FOR PRODUCING L-AMINO ACID USING IT 有权
标题翻译： L-磺酰氨基酸和使用其生产L-氨基酸的方法
公开(公告)号：US20110244530A1
公开(公告)日：2011-10-06
申请号：US12989728
申请日：2009-05-07
申请人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Takeshi Miyata , Aya Oosato , Shinya Kumagai , Toshihide Yamada
发明人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Takeshi Miyata , Aya Oosato , Shinya Kumagai , Toshihide Yamada
IPC分类号： C12P13/06 , C12P13/04 , C07H21/04 , C12N9/80
CPC分类号： C12N9/80 , A23L33/175 , C12P13/04 , C12P13/06 , C12P41/007
摘要： The present invention provides an L-aminoacylase which is able to produce L-tert-leucine being useful as an intermediate for pharmaceuticals.A protein which is characterized in being represented by any of the following (a) to (d): (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; and (d) a protein which consists of an amino acid sequence where one or several amino acid (s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity.
摘要翻译：本发明提供能够产生L-叔亮氨酸的L-氨基酸酰基酶，其可用作药物的中间体。特征在于以下（a）〜（d）中任一项所示的蛋白质：（a）由由SEQ ID No：1所示的核酸序列组成的基因编码的蛋白质; （b）由SEQ ID No：2所示的氨基酸序列组成的蛋白质; （c）由严格条件下与SEQ ID No：1所示核酸序列互补且具有L-琥珀酰氨基酰化酶活性的核酸序列杂交的多核苷酸编码的蛋白质; 和（d）由氨基酸序列组成的蛋白质，其中一个或几个氨基酸被取代，缺失，插入和/或添加在由SEQ ID No：2所示的氨基酸序列组成的蛋白质中并具有L-琥珀酰氨基酰化酶活性。

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