专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US08071761B2 Substrates for beta-lactamase and uses thereof 有权
标题翻译： β-内酰胺酶底物及其用途
公开(公告)号：US08071761B2
公开(公告)日：2011-12-06
申请号：US11606642
申请日：2006-11-29
申请人： Roger Y. Tsien , Gregor Zlokarnik
发明人： Roger Y. Tsien , Gregor Zlokarnik
IPC分类号： C07D501/14
CPC分类号： C07D501/36 , C07D501/00 , C07D505/00 , C07D519/00 , C12N9/86 , C12N15/85 , C12N2800/90 , C12N2830/002 , C12P17/184 , C12P17/188 , C12P35/00 , C12Q1/18 , C12Q1/34 , C12Q1/6897 , C12Q2334/00 , G01N2333/986 , G01N2415/00 , Y10S435/805
摘要： Substrates for β-lactamase of the general formula I in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R′ is selected from the group consisting of H, lower (i.e., alkyl of 1 to about 5 carbon atoms) and (CH2)nOH, in which n is 0 or an integer from 1 to 5; R″ is selected from the group consisting of H, physiologically acceptable metal and ammonium cations, —CHR2OCO(CH2)nCH3, —CHR2OCOC (CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, delta-butyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, acyloxyalkyl, dialkylaminocarbonyloxymethyl and aliphatic, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z′ and Z″ are linkers for the fluorescent donor and quencher moieties. Methods of assaying β-lactamase activity and monitoring expression in systems using β-lactamase as a reporter gene also are disclosed.
摘要翻译： X和Y中的一个是荧光供体部分，另一个是猝灭剂（其可以或不再发射）的通式I的β-内酰胺酶底物; R'选自H，低级（即1至约5个碳原子的烷基）和（CH 2）nOH，其中n为0或1至5的整数; -CH 2 COO（CH 2）n CH 3，-CHR 2 OCOC（CH 3）3，酰基硫代甲基，酰氧基-α-苄基，δ-丁基内酰胺，甲氧基羰氧基甲基，苯基，甲基亚磺酰基甲基， β-吗啉基乙基，二烷基氨基乙基，酰氧基烷基，二烷基氨基羰氧基甲基和脂族基，其中R2选自H和低级烷基; A选自S，O，SO，SO 2和CH 2; 和Z'和Z“是荧光供体和猝灭剂部分的接头。公开了使用β-内酰胺酶作为报道基因的系统中测定β-内酰胺酶活性和监测表达的方法。

62. 发明申请

US20070105830A1 Processes for the preparations of cefepime 失效
标题翻译：头孢吡肟制剂工艺
公开(公告)号：US20070105830A1
公开(公告)日：2007-05-10
申请号：US10552858
申请日：2004-04-15
申请人： Johannes Ludescher , Hubert Sturm , Siegfried Wolf
发明人： Johannes Ludescher , Hubert Sturm , Siegfried Wolf
IPC分类号： A61K31/545 , C07D501/14
CPC分类号： C07D501/06 , C07D501/40 , C07D513/04
摘要： This invention provides processes for preparing cefepime, including crystalline intermediates of Formula V.
摘要翻译：本发明提供了头孢吡肟制备方法，包括式Ⅴ的结晶中间体。

63. 发明申请

US20070099890A1 Novel cephalosporin derivatives, its pharmaceutically acceptable salts and manufacturing process thereof 审中-公开
标题翻译：新型头孢菌素衍生物，其药学上可接受的盐及其制备方法
公开(公告)号：US20070099890A1
公开(公告)日：2007-05-03
申请号：US10562125
申请日：2004-06-25
申请人： Sung-gyu Kim , Jeong-min Lee , Jong-ok Jeun , Sang-kwon Sohn , Kyung-il Chot , Joong-hyup Kim , Ghil-soo Nam
发明人： Sung-gyu Kim , Jeong-min Lee , Jong-ok Jeun , Sang-kwon Sohn , Kyung-il Chot , Joong-hyup Kim , Ghil-soo Nam
IPC分类号： A61K31/545 , C07D501/14
CPC分类号： C07D501/00 , Y02P20/55
摘要： Disclosed herein are novel cephalosporin compounds, pharmaceutically acceptable salts thereof, and a method for preparing the compounds. The compounds show superior antibacterial activity against a wide variety of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) strain. Accordingly, the compounds can be effectively used as antibiotics.
摘要翻译：本文公开了新型头孢菌素化合物及其药学上可接受的盐，以及制备该化合物的方法。该化合物对各种革兰氏阳性细菌，包括耐甲氧西林金黄色葡萄球菌（MRSA）菌株显示出优异的抗菌活性。因此，化合物可以有效地用作抗生素。

64. 发明申请

US20070049749A1 Method for Manufacture of Ceftriaxone Sodium 失效
标题翻译：头孢曲松钠制造方法
公开(公告)号：US20070049749A1
公开(公告)日：2007-03-01
申请号：US11532469
申请日：2006-09-15
申请人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Sharma , Brijkishore Mishra
发明人： Debashish Datta , Muralikrishna Dantu , Pollepeddi Sharma , Brijkishore Mishra
IPC分类号： C07D501/14
CPC分类号： C07D501/00
摘要： An improved process for preparation of ceftriaxone sodium of formula (II), is disclosed.
摘要翻译：公开了制备式（II）头孢曲松钠的改进方法。

65. 发明申请

US20070004916A1 Process for the production of cefotaxime sodium 审中-公开
标题翻译：头孢噻肟钠生产工艺
公开(公告)号：US20070004916A1
公开(公告)日：2007-01-04
申请号：US11487959
申请日：2006-07-17
申请人： Siddiqui Jaweed Mukarram , Rashid Khan , Ram Yadav , Mohammed Khan
发明人： Siddiqui Jaweed Mukarram , Rashid Khan , Ram Yadav , Mohammed Khan
IPC分类号： C07D501/14
CPC分类号： C07D501/34
摘要： A process for the production of 7-[2-(2-amino-4-thiazolyl)-2-syn-methoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) in aqueous isopropyl alcohol is provided. The synthesis provides the product in greater than 99 % HPLC purity.
摘要翻译：在异丙醇水溶液中生产7- [2-（2-氨基-4-噻唑基）-2-顺 - 甲氧基亚氨基 - 乙酰氨基] -3-乙酰氧基甲基-3-头孢烯-4-羧酸（头孢噻肟）的方法是提供。该合成法以高于99％的HPLC纯度提供产品。

66. 发明申请

US20060292665A1 Glutaryl amidases and their uses 审中-公开
标题翻译：谷氨酰胺酶及其用途
公开(公告)号：US20060292665A1
公开(公告)日：2006-12-28
申请号：US11448141
申请日：2006-06-05
申请人： Charles Sio , Ludwina Otten , Robbert Cool , Wilhelmus Quax
发明人： Charles Sio , Ludwina Otten , Robbert Cool , Wilhelmus Quax
IPC分类号： C12P35/02 , C12P21/06 , C07H21/04 , C07D501/00 , C12N9/80 , C07D501/14 , C12N15/74 , C12N1/21
CPC分类号： C12N9/84 , C12P35/02
摘要： The invention relates to a new class of isolated, single or multiple mutated glutaryl amidases from Pseudomonas SY-77, or a functional part, derivative or analogue thereof. The invention also relates to a method for preparing 7-aminocephalosporanic acid from cephalosporin C, using a glutaryl amidase according to the invention. The invention also provides a method for preparing aminodesacetoxycephalosporanic acid.
摘要翻译：本发明涉及来自假单胞菌SY-77或其功能部分，衍生物或类似物的新类型的分离的，单个或多个突变的戊二酰胺化酶。本发明还涉及使用本发明的戊二酰胺酶从头孢菌素C制备7-氨基头孢烷酸的方法。本发明还提供了制备氨基脱乙酸基头孢烷酸的方法。

67. 发明申请

US20060281915A1 Acid cefotetan totally solvent-free and method for obtaining same 审中-公开
标题翻译：酸性头孢替坦完全无溶剂和获得相同的方法
公开(公告)号：US20060281915A1
公开(公告)日：2006-12-14
申请号：US11410022
申请日：2006-04-25
申请人： Maurizio Zenoni , Alessandro Donadelli
发明人： Maurizio Zenoni , Alessandro Donadelli
IPC分类号： C07D501/14
CPC分类号： C07D501/00
摘要： The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by initial isolation of the crude product with a limited tautomer content, followed by purification through a chromatographic column. The invention also concerns the acid cefotetan totally solvent-free thereby obtained.
摘要翻译：本发明涉及通过初始分离具有有限的互变异构体含量的粗产物，然后通过色谱柱纯化，获得基本上不含互变异构体的头孢替坦的方法。本发明还涉及由此获得的完全无溶剂的酸性头孢替坦。

68. 发明申请

US20060259993A1 Amidases, nucleic acids encoding them and methods for making and using them 审中-公开
标题翻译：酰胺酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US20060259993A1
公开(公告)日：2006-11-16
申请号：US10502832
申请日：2003-01-28
申请人： Nelson Barton , David Weiner , William Greenberg , Samantha Luu , Kristine Chang , Elizabeth Waters
发明人： Nelson Barton , David Weiner , William Greenberg , Samantha Luu , Kristine Chang , Elizabeth Waters
IPC分类号： A01K67/027 , A01H5/00 , C12N1/21 , C12Q1/68 , C07H21/04 , C07D501/00 , C12N9/80 , C07D501/14 , C12N15/74 , C12N15/82 , C12P35/02
CPC分类号： C07D501/00 , A01K2217/05 , A61K38/00 , C12N9/78 , C12P35/00 , C12P35/02 , C12P41/007 , C12Q1/34
摘要： This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having activity in the hydrolysis of amides, including enzymes having peptidase, protease and/or hydantoinase activity. In alternative aspects, the enzymes of the invention can be used to used to increase flavor in food (e.g., enzyme ripened cheese), promote bacterial and fungal killing, modify and de-protect fine chemical intermediates, synthesize peptide bonds, carry out chiral resolutions, hydrolyze Cephalosporin C. The enzymes of the invention can be used to generate 7-aminocephalosporanic acid (7-ACA) and semi-synthetic cephalosporin antibiotics, including caphalothin, cephaloridine and cefuroxime. The enzymes of the invention can be used as antimicrobial agents, e.g., as cell wall hydrolytic agents. The invention also provides a fluorescent amidase substrate comprising 7-(ε-D-2-aminoadipoyladipoylamido)-4-methylcoumarin.
摘要翻译：本发明提供酰胺酶，编码酰胺酶的多核苷酸，制备和使用这些多核苷酸和多肽的方法。一方面，本发明提供了具有仲酰胺酶活性的酶，例如在酰胺水解中具有活性，包括具有肽酶，蛋白酶和/或乙内酰脲酶活性的酶。在替代方面，本发明的酶可用于增加食物中的风味（例如酶熟干酪），促进细菌和真菌杀死，改善和去保护精细化学中间体，合成肽键，进行手性拆分，水解头孢菌素C.本发明的酶可用于产生7-氨基头孢烷酸（7-ACA）和半合成头孢菌素抗生素，包括沙司他啶，头孢菌啶和头孢呋辛。本发明的酶可以用作抗微生物剂，例如细胞壁水解剂。本发明还提供了包含7-（ε-D-2-氨基己二酰己二酰氨基）-4-甲基香豆素的荧光酰胺酶底物。

69. 发明申请

US20060149055A1 Process for the manufacture of cefpodoxime proxetil 审中-公开
标题翻译：头孢泊肟酯的制备方法
公开(公告)号：US20060149055A1
公开(公告)日：2006-07-06
申请号：US10541473
申请日：2003-01-06
申请人： Milind Gharpure , Sanjay Deshmukh , Rajendra Mahale
发明人： Milind Gharpure , Sanjay Deshmukh , Rajendra Mahale
IPC分类号： C07D501/14
CPC分类号： C07D501/60 , C07D501/04 , C07D501/12
摘要： A process for obtaining cefpodoxime proxetil of formula (I), of high purity conforming to pharmacopoeial specifications is disclosed. The process comprises addition of a solution of methanesulfonic acid in water to a solution of impure cefpodoxime proxetil of formula (I) in an organic solvent to form the corresponding cefpodoxime proxetil methanesulfonate of formula (II1), followed by addition of a co-solvent and separation of the aqueous phase containing cefpodoxime proxetil methanesulfonate of formula (II1) having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6 and subsequent neutralization of the methaneulfonate salt (II1) with a base to give cefpodoxime proxetil (I) free of impurities and having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6, or, addition of impure cefpodoxime proxetil of formula (I) to a solution of methanesulfonic acid in water to form the corresponding solution of cefpodoxime proxetil methanesulfonate of formula (II1) in water, followed by sequential addition of a first organic solvent and a co-solvent and separation of the aqueous phase containing cefpodoxime proxetil methanesulfonate of formula (II1) having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6 and subsequent neutralization of the methaneulfonate salt (II1) with a base to give cefpodoxime proxetil (I) free of impurities and having a diastereomeric ratio of (R/R+S) between 0.5 to 0.6.
摘要翻译：公开了一种获得符合药典规格的高纯度的式（I）头孢泊肟酯的方法。该方法包括将甲磺酸水溶液加入到有机溶剂中的式（I）不纯的头孢泊肟酯的溶液中以形成相应的式（II）的头孢泊肟甲磺酸盐，随后通过加入共溶剂和含有非对映异构体比率为（R / R + S）为0.5至0.6的式（II-1）的头孢泊肟甲基磺酸酯的水相的分离，随后中和具有碱的甲磺酸盐（II-1），得到不含杂质并且（R / R + S）的非对映异构体比率在0.5至0.6之间的头孢泊肟酯（I），或加入不纯式（I）的头孢泊肟酯与甲磺酸在水中的溶液形成相应的式（II ^{1）的头孢泊肟甲磺酸盐溶液在水中的溶液，然后依次加入第一有机溶剂和共溶剂和水相c的分离使用具有（R / R + S）的非对映异构体比率为0.5至0.6的随后的甲磺酸盐中和的式（II-1）的头孢泊肟甲磺酸酯（II ^{1）），得到不含杂质的头孢泊肟酯（I）和（R / R + S）的非对映异构体比例在0.5至0.6之间。}}

70. 发明申请

US20060142563A1 Crystalline anhydrous cefdinir and crystalline cefdinir hydrates 审中-公开
公开(公告)号：US20060142563A1
公开(公告)日：2006-06-29
申请号：US11222299
申请日：2005-09-08
申请人： Devalina Law , Rodger Henry , Xiaochun Lou
发明人： Devalina Law , Rodger Henry , Xiaochun Lou
IPC分类号： C07D501/14
CPC分类号： C07D501/22 , C07D501/00
摘要： A novel crystalline cefdinir anhydrate and novel crystalline cefdinir hydrates, ways to make them and use them, compositions comprising them and made with them, and methods of treatment using them are disclosed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式