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61. 发明申请

US20160318841A1 PRODUCTION PROCESS AND PURIFICATION PROCESS OF 4-HYDROXY-BENZOIC ACID LONG CHAIN ESTER 有权
标题翻译： 4-羟基苯甲酸长链的生产工艺和纯化工艺
公开(公告)号：US20160318841A1
公开(公告)日：2016-11-03
申请号：US15130180
申请日：2016-04-15
申请人： UENO FINE CHEMICALS INDUSTRY, LTD.
发明人： Yusuke KITA , Toshihide KOMATSU , Takaya HISANO , Kuniyo YANAGAWASE , Mio TSUCHIYA
IPC分类号： C07C67/28 , C07C67/52 , C07C67/58
CPC分类号： C07C67/28 , C07C67/03 , C07C67/52 , C07C67/58 , C07C69/84
摘要： The present invention relates to a production process of a 4-hydroxy-benzoic acid long chain ester, that includes a step of reacting a 4-hydroxy-benzoic acid short chain ester with an aliphatic alcohol in the presence of a metal catalyst. The present invention also relates to a purification process of a 4-hydroxy-benzoic acid long chain ester, that includes a step of adding an acid aqueous solution to a crude composition including the 4-hydroxy-benzoic acid long chain ester, separating the crude composition to an organic phase and a water phase and extracting the organic phase.
摘要翻译：本发明涉及4-羟基 - 苯甲酸长链酯的制备方法，其包括在金属催化剂存在下使4-羟基 - 苯甲酸短链酯与脂族醇反应的步骤。本发明还涉及4-羟基 - 苯甲酸长链酯的纯化方法，其包括将酸性水溶液加入到包含4-羟基 - 苯甲酸长链酯的粗制组合物中的步骤，组成到有机相和水相并萃取有机相。

62. 发明申请

US20160272570A1 PROCESS FOR PRODUCING LIGHT (METH)ACRYLIC ESTERS 有权
标题翻译：生产轻质（甲基）丙烯酸酯的方法
公开(公告)号：US20160272570A1
公开(公告)日：2016-09-22
申请号：US15032864
申请日：2014-10-21
申请人： ARKEMA FRANCE
发明人： Serge TRETJAK , Stephane DENIS , Lionel DELAIS , Anne MORELIERE
IPC分类号： C07C67/08 , C07C67/58 , C07C67/54
CPC分类号： C07C67/08 , C07C45/52 , C07C51/44 , C07C51/487 , C07C67/54 , C07C67/58 , Y02P20/582 , C07C47/22 , C07C57/04 , C07C69/54
摘要： The subject matter of the present invention is an improvement in the continuous production of methyl (meth)acrylate or of ethyl (meth)acrylate by direct esterification of (meth)acrylic acid with methanol or ethanol, under reaction conditions for which the acid is in excess relative to the alcohol, in particular with an acid/alcohol molar ratio of between 1.0 and 4, and under a pressure ranging from atmospheric pressure to 5 bar. The process of the invention makes it possible to minimize the formation of ethyl ethoxypropionate during the esterification reaction, and results in an improvement in the material balance, simplification of the purification train for the desired ester, and optimization of the energy balance.
摘要翻译：本发明的主题是通过（甲基）丙烯酸与甲醇或乙醇直接酯化（甲基）丙烯酸甲酯或（甲基）丙烯酸乙酯）在酸处于反应条件的条件下连续生产的改进特别是酸/醇摩尔比在1.0和4之间，以及在大气压至5巴的压力下。本发明的方法使得在酯化反应期间使乙氧基丙酸乙酯的形成最小化成为可能，并且导致材料平衡的改善，所需酯的纯化系的简化和能量平衡的优化。

63. 发明授权

US09403751B2 Liquid-liquid extraction process for the production of acrylic esters 有权
标题翻译：用于生产丙烯酸酯的液 - 液萃取方法
公开(公告)号：US09403751B2
公开(公告)日：2016-08-02
申请号：US14493559
申请日：2014-09-23
申请人： Arkema France
发明人： Serge Tretjak , Stephane Denis
IPC分类号： C07C67/58 , C07C67/08 , B01J4/00 , B01D11/04
CPC分类号： C07C67/58 , B01D11/04 , B01D11/043 , B01J4/001 , C07C67/08 , C07C69/54
摘要： The invention relates to a liquid-liquid extraction process, comprising: the provision of a main input liquid stream, comprising at least one compound of interest and an excess compound; the provision of a liquid scrubbing stream; the extraction of the excess compound from the main input liquid stream by contact with the liquid scrubbing stream, making it possible to collect a main output liquid stream, depleted in excess compound with respect to the main input liquid stream; in which: the main input liquid stream and the liquid scrubbing stream exhibit a difference in density of less than or equal to 50 kg/m3 and also an interfacial tension of less than or equal to 3 dyn/cm; and the extraction stage is carried out in a packed contactor with a ratio by weight as input liquid scrubbing stream/main liquid stream ranging from 0.3 to 0.5. The invention also relates to a process for the production of acrylic ester in which the production stream is treated by means of the above liquid-liquid extraction process.
摘要翻译：本发明涉及一种液体 - 液体提取方法，包括：提供主要输入液体流，其包含至少一种目标化合物和过量化合物; 提供液体洗涤流; 通过与液体洗涤流接触从主输入液体流中提取过量化合物，使得可以收集相对于主要输入液体流消耗过量化合物的主要输出液体流; 其中：主输入液体流和液体洗涤流表现出小于或等于50kg / m 3的密度差，以及小于或等于3达因/厘米的界面张力; 并且萃取阶段在填充接触器中进行，重量比为输入液体洗涤流/主液流，范围为0.3至0.5。本发明还涉及生产丙烯酸酯的方法，其中通过上述液 - 液萃取方法处理生产流。

64. 发明申请

US20140012037A1 Ethyl Acetate Production 有权
标题翻译：乙酸乙酯生产
公开(公告)号：US20140012037A1
公开(公告)日：2014-01-09
申请号：US14023125
申请日：2013-09-10
申请人： Greenyug, LLC
发明人： Sagar B. Gadewar , Peter K. Stoimenov
IPC分类号： C07C67/58
CPC分类号： C07C67/58 , B01D3/001 , B01D3/009 , C07C67/40 , Y02P20/127 , Y02P20/582 , C07C69/14
摘要： A method of purifying an ethyl acetate stream comprises contacting an inlet stream with a solvent, transferring at least a portion of the impurity compound from the inlet stream into the solvent to form an extract and a purified product, separating the extract from the purified product, separating the portion of the impurity compound from the extract, forming an impurities stream and a regenerated solvent, and recycling at least a portion of the regenerated solvent to contact the inlet stream. The inlet stream comprises ethyl acetate and an impurity compound, and the extract comprises the solvent and the portion of the impurity compound transferred from the inlet stream.
摘要翻译：纯化乙酸乙酯料流的方法包括使入口流与溶剂接触，将至少一部分杂质化合物从入口流转移到溶剂中以形成提取物和纯化产物，将提取物与纯化产物分离，从提取物中分离杂质化合物的一部分，形成杂质流和再生溶剂，再循环至少一部分再生溶剂与入口流接触。入口流包括乙酸乙酯和杂质化合物，并且提取物包含溶剂和从入口流转移的部分杂质化合物。

65. 发明申请

US20130217768A1 SIMPLE PROCESS TO PRODUCE AND SEPARATE WATER SOLUBLE AND OIL SOLUBLE ANTIOXIDATIVE FLAVORING COMPOSITIONS FROM LABIATAE HERBS USING GREEN SOLVENTS 有权
标题翻译：使用绿色溶剂生产和分离水溶性和油溶性抗氧化成分的简单方法来自LABIATAE HERBS
公开(公告)号：US20130217768A1
公开(公告)日：2013-08-22
申请号：US13881259
申请日：2011-10-25
申请人： Roger Nahas , Elizabeth Barren , Gregory S. Reynhout
发明人： Roger Nahas , Elizabeth Barren , Gregory S. Reynhout
IPC分类号： C07B63/00 , C07C51/48 , C07C67/58
CPC分类号： C07B63/00 , A23L33/105 , A23V2002/00 , A61K36/53 , A61K2236/39 , B01D11/0288 , C07C51/48 , C07C67/58 , A23V2200/02 , A23V2250/21
摘要： Processes for preparing water soluble and oil soluble antioxidant compositions extracted together from Labiatae herbs in a single extraction using an alcohol and water solvent, followed by a simple, yet effective purification step that allows the separation of the water soluble antioxidative fractions containing mainly rosmarinic acid from antioxidative fractions containing mainly carnosic acid and carnosol, without cumbersome acid/base partitioning steps.
摘要翻译：制备水溶性和油溶性抗氧化剂组合物的方法，使用酒精和水溶剂在单次提取中提取Labiatae草药，然后进行简单而有效的纯化步骤，其允许将主要含有迷迭香酸的水溶性抗氧化级分从主要含有鼠尾草酸和鼠尾草酚的抗氧化成分，没有繁琐的酸/碱分配步骤。

66. 发明授权

US08182553B2 Process for purification of fatty acid alkyl esters and use of agents to facilitate such purification 有权
标题翻译：脂肪酸烷基酯的纯化方法和促进这种纯化的试剂的使用
公开(公告)号：US08182553B2
公开(公告)日：2012-05-22
申请号：US12160756
申请日：2007-01-11
申请人： David Frykerås , Jan Warnqvist
发明人： David Frykerås , Jan Warnqvist
IPC分类号： C10L1/18 , C07C67/58
CPC分类号： C11C3/10 , C07C67/56 , Y02E50/13 , C07C69/24 , C07C69/52
摘要： A method of purifying an organic solution comprising contacting a flocculating and sequestering agent with the organic solution, which organic solution comprises fatty acid alkyl esters. Also provided is a process for purification of the organic solution. The process comprises adding a flocculating and sequestering agent to the organic solution to facilitate the purification, and removing a portion from the organic solution, which portion comprises the flocculating and sequestering agent and impurities.
摘要翻译：一种纯化有机溶液的方法，包括使絮凝和螯合剂与有机溶液接触，该有机溶液包含脂肪酸烷基酯。还提供了有机溶液的纯化方法。该方法包括向有机溶液中加入絮凝和螯合剂以促进纯化，并从有机溶液中除去部分，该部分包含絮凝和螯合剂和杂质。

67. 发明申请

US20110130450A1 PRAVASTATIN EXTRACTION 审中-公开
标题翻译： PRAVASTATIN萃取
公开(公告)号：US20110130450A1
公开(公告)日：2011-06-02
申请号：US12936351
申请日：2009-03-31
申请人： Aad Johannes Bouman , Robertus Mattheus De Pater , Piotr Wnukowski
发明人： Aad Johannes Bouman , Robertus Mattheus De Pater , Piotr Wnukowski
IPC分类号： A61K31/351 , C07C67/58 , A61P3/06 , A61P9/00
CPC分类号： C07C69/33 , C07C67/58 , C07C2602/26
摘要： The present invention provides a method for the purification of pravastatin comprising extracting a solution comprising pravastatin in a water-immiscible solvent with water at a pH value ranging from 5.0 to 7.0.
摘要翻译：本发明提供了一种纯化普伐他汀的方法，其包括在与水不混溶性溶剂中的pH为5.0-7.0的水中提取包含普伐他汀的溶液。

68. 发明申请

US20100324328A1 Process For Isolating Mono-Carboxy Substituted Probucol Derivatives 审中-公开
标题翻译：用于分离单羧基取代的Probucol衍生物的方法
公开(公告)号：US20100324328A1
公开(公告)日：2010-12-23
申请号：US12666101
申请日：2008-06-25
申请人： Jeremy Stephen Parker , Evan William Snape
发明人： Jeremy Stephen Parker , Evan William Snape
IPC分类号： C07C67/58
CPC分类号： C07C319/20 , C07C319/28 , C07C323/20
摘要： A process for isolating a compound of formula (I) or a salt thereof, where X and R1 are as defined in the specification, from a mixture containing it, and the corresponding diacid and dihydroxy derivative, said process comprising (i) adding to an organic solution containing said compounds, water and a one or more salts, all of which are bases selected from a carbonate or hydrogen carbonate base, (ii) separating the aqueous phase containing the compound of formula (II) from the organic phase containing the compounds of formula (I) and (III); then (iii) recovering the compound of formula (I) from remaining organic phase. The process provides for efficient isolation of the target compound, even on a large scale.
摘要翻译：一种分离式（I）化合物或其盐的方法，其中X和R 1如说明书中所定义，含有它的混合物和相应的二酸和二羟基衍生物，所述方法包括（i）加入到含有所述化合物的有机溶液，水和一种或多种盐，其全部为选自碳酸盐或碳酸氢盐碱的碱，（ii）将含有式（II）化合物的水相与含有化合物的有机相分离的式（I）和（III）; 然后（iii）从剩余的有机相中回收式（I）化合物。该方法即使在大规模的情况下也能有效地分离目标化合物。

69. 发明授权

US06965043B1 Process for making high purity fatty acid lower alkyl esters 失效
标题翻译：制备高纯度脂肪酸低级烷基酯的方法
公开(公告)号：US06965043B1
公开(公告)日：2005-11-15
申请号：US09554211
申请日：1998-11-02
申请人： Corey James Kenneally , Gary Allen Busch , Erich William Gansmuller
发明人： Corey James Kenneally , Gary Allen Busch , Erich William Gansmuller
IPC分类号： C07C51/00 , C07C67/03 , C07C67/54 , C07C67/58
CPC分类号： C07C67/03 , C07C67/54 , C07C67/58 , C07C69/24
摘要： Processes for the synthesis of high purity fatty acid lower alkyl esters comprise the steps of: (a) converting a fatty acid source to a product mixture comprising lower alkyl esters and by-products; (b) water-washing the product mixture at elevated temperature and elevated pressure to remove by-products; and (c) fractionally distilling the water-washed product mixture to obtain high purity fatty acid lower alkyl esters. At least a portion of the fatty acids have from about 20 to about 24 carbon atoms. The high purity lower alkyl esters have an acid value no greater than about 1.0.
摘要翻译：用于合成高纯度脂肪酸低级烷基酯的方法包括以下步骤：（a）将脂肪酸源转化成包含低级烷基酯和副产物的产物混合物; （b）在高温和高压下水洗产品混合物以除去副产物; 和（c）分级蒸馏水洗产物混合物以获得高纯度脂肪酸低级烷基酯。至少一部分脂肪酸具有约20至约24个碳原子。高纯度低级烷基酯的酸值不大于约1.0。

70. 发明申请

US20050234123A1 Process 审中-公开
标题翻译：处理
公开(公告)号：US20050234123A1
公开(公告)日：2005-10-20
申请号：US10497012
申请日：2002-11-26
申请人： Aldo Belli , Vincenzo Cannata , Telly Fonduca , Martin Hedberg , Andreas Westermark , Marco Villa
发明人： Aldo Belli , Vincenzo Cannata , Telly Fonduca , Martin Hedberg , Andreas Westermark , Marco Villa
IPC分类号： A61K31/21 , A61K31/216 , A61P29/00 , C07B61/00 , C07C67/08 , C07C67/58 , C07C201/02 , C07C203/04 , C07C301/00 , C07C303/28 , C07C309/66 , C07C309/67 , C07C309/73 , C07C23/02
CPC分类号： C07C309/73 , A61K31/21 , C07C67/08 , C07C67/58 , C07C201/02 , C07C303/28 , C07C309/66 , C07C309/67 , C07C69/734 , C07C203/04
摘要： At the present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester. The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.
摘要翻译：本发明涉及制备（S） - 萘普生4-硝基氧丁基酯的新方法及其中获得和使用的新中间体。本发明还涉及新中间体用于制备药学活性化合物如（S） - 萘普生4-硝基氧基丁基酯的用途。本发明还涉及根据本发明的方法制备的（S） - 萘普生4-硝基氧基丁基酯在制备用于治疗疼痛的药物中的用途。

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