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61. 发明授权

US6103924A Process for the preparation of 2,3,5-trimethylhydroquinone diesters 失效
标题翻译：制备2,3,5-三甲基氢醌二酯的方法
公开(公告)号：US6103924A
公开(公告)日：2000-08-15
申请号：US295359
申请日：1999-04-21
申请人： Nongyuan Shi , Mario Scholz , Steffen Hasenzahl , Horst Weigel , Bernd Drapal , Ralph McIntosh , Hans J. Hasselbach , Klaus Huthmacher
发明人： Nongyuan Shi , Mario Scholz , Steffen Hasenzahl , Horst Weigel , Bernd Drapal , Ralph McIntosh , Hans J. Hasselbach , Klaus Huthmacher
IPC分类号： C07C37/01 , C07C37/07 , C07C39/08 , C07C67/00 , C07C67/29 , C07C67/293 , C07C69/16 , C07C67/48
CPC分类号： C07C37/0555 , C07C67/00
摘要： Preparation of 2,3,5-trimethylhydroquinone diesters by rearrangement of 2,6,6-trimethylcyclohex-2-ene-1,4-dione (4-oxo-isophorone, ketoisophorone) in the presence of a solid, acid catalyst and an acylating agent, for example carboxylic acid anhydrides or carboxylic acid halides. The 2,3,5-trimethylhydroquinone diester may then optionally be saponified to the free 2,3,5-trimethylhydroquinone, which is a valuable building block in the synthesis of vitamin E.
摘要翻译：通过在固体酸催化剂存在下重新配置2,6,6-三甲基环己-2-烯-1,4-二酮（4-氧代 - 异佛尔酮，酮异佛尔酮），制备2,3,5-三甲基氢醌二酯酰化剂，例如羧酸酐或羧酸酰卤。然后可以将2,3,5-三甲基氢醌二酯任选地皂化成游离的2,3,5-三甲基氢醌，其是维生素E合成中的有价值的结构单元。

62. 发明授权

US5837252A Nontoxic extract of Larrea tridentata and method of making same 失效
标题翻译：无毒提取物及其制备方法
公开(公告)号：US5837252A
公开(公告)日：1998-11-17
申请号：US726686
申请日：1996-10-07
申请人： Robert A. Sinnott , W. Dennis Clark , Kenneth Frank DeBoer
发明人： Robert A. Sinnott , W. Dennis Clark , Kenneth Frank DeBoer
IPC分类号： A23L1/30 , A61K36/00 , A61K36/185 , A61K36/28 , A61K36/29 , A61K45/06 , A61P29/00 , C07C37/07 , A01N65/00
CPC分类号： C07C37/07 , A23L33/10 , A23L33/105 , A61K36/185 , A61K36/28 , A61K36/29 , A61K45/06 , Y10S514/885 , Y10S514/886 , Y10S514/969
摘要： A nontoxic, therapeutic agent having pharmacological activity comprising concentrated extract of Larrea tridentata plant material and ascorbic acid, an ascorbic acid ester, an ascorbic acid salt, butylated hydroxyanisole, butylated hydroxytoluene, hydrogen sulfide, hypophosphorous acid, monothioglycerol, potassium bisulfite, propyl gallate, sodium bisulfite, sodium hydrosulfite, sodium thiosulfate, sulfur dioxide, sulfurous acid, a tocopherol, or vitamin E is made by a process in which the plant material is extracted using an organic solvent, preferably acetone, and is then saturated with one of the listed reducing agents acid to reduce the toxic NDGA quinone, which naturally occurs in the plant material, to NDGA itself. Additional amounts of ascorbic acid, an ascorbic acid ester, an ascorbic acid salt, butylated hydroxyanisole, butylated hydroxytoluene, hydrogen sulfide, hypophosphorous acid, monothioglycerol, potassium bisulfite, propyl gallate, sodium bisulfite, sodium hydrosulfite, sodium thiosulfate, sulfur dioxide, sulfurous acid, a tocopherol, or vitamn E may be added to the extract to inhibit the natural oxidation of the NDGA into the toxic NDGA quinone in vivo, or during processing or storage. The resulting extract is useful in the treatment of viral diseases caused by viruses from the Herpesviridae family or viruses which require the Sp1 class of proteins to initiate viral replications. The resulting compound can also be used as an anti-inflammatory when the inflaatory diseases are mediated by the effects of leukotrienes. The listed reducing agents can also be used to stabilize NDGA as a therapeutic agent or a food additive.
摘要翻译：具有药理活性的无毒性治疗剂，其包含三氯氰菊酯植物材料和抗坏血酸的浓缩提取物，抗坏血酸酯，抗坏血酸盐，丁基化羟基苯甲醚，丁基化羟基甲苯，硫化氢，次磷酸，一硫代甘油，亚硫酸氢钾，没食子酸丙酯，亚硫酸氢钠，连二亚硫酸钠，硫代硫酸钠，二氧化硫，亚硫酸，生育酚或维生素E是通过使用有机溶剂，优选丙酮萃取植物材料的方法制备的，然后用列出的一种还原剂酸降低有毒的NDGA醌，其自然发生在植物材料中，到NDGA本身。附加量的抗坏血酸，抗坏血酸酯，抗坏血酸盐，丁基化羟基苯甲醚，丁基化羟基甲苯，硫化氢，次磷酸，一硫代甘油，亚硫酸氢钾，没食子酸丙酯，亚硫酸氢钠，连二亚硫酸钠，硫代硫酸钠，二氧化硫，亚硫酸，生育酚或维生素E可以加入到提取物中以抑制NDGA在体内或在加工或储存期间自然氧化成有毒的NDGA醌。所得提取物可用于治疗由疱疹病毒科家族病毒引起的病毒性疾病或需要Sp1类蛋白质启动病毒复制的病毒。所产生的化合物也可以用作抗炎药物，当炎症疾病由白三烯的作用介导时。列出的还原剂也可用于稳定NDGA作为治疗剂或食品添加剂。

63. 发明授权

US5817891A Preparation of alkylphenols 失效
标题翻译：烷基酚的制备
公开(公告)号：US5817891A
公开(公告)日：1998-10-06
申请号：US715830
申请日：1996-09-19
申请人： Franz Josef Brocker , Peter Trubenbach , Manfred Baumann , Jurgen Schubert
发明人： Franz Josef Brocker , Peter Trubenbach , Manfred Baumann , Jurgen Schubert
IPC分类号： C07C37/07
CPC分类号： C07C37/07
摘要： A process for the preparation of alkylphenols of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 stand for hydrogen or C.sub.1 -C.sub.8 alkyl, by reaction of an alkylcyclohex-2-en-1-one of the formula II ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 have the aforementioned meanings, at temperatures of from 200.degree. to 400.degree. C. and pressures ranging from 0.01 to 50 bar in the presence of palladium-on-.alpha.-Al.sub.2 O.sub.3 catalysts, wherein the catalyst used has a specific surface area (BET) of from 1 to 10 m.sup.2 /g, a pore diameter of from 5 nm to 300 .mu.m and a pore volume of from 0.1 to 0.5 cm.sup.3 /g, from 80 to 100% of the pores having a diameter of from 40 to 400 nm, and also novel palladium-on-.alpha.-Al.sub.2 O.sub.3 catalysts as obtained from a fine-grained alumina powder by steps of molding, pyrolysis and calcination.
摘要翻译：通过烷基环己-2-烯-1-酮的反应制备式I的烷基酚的方法，其中R 1，R 2，R 3，R 4和R 5代表氢或C 1 -C 8烷基，其中R 1，R 2，R 3，R 4和R 5具有上述含义的式II（II）中的一种，在200-400℃的温度和0.01至50巴的压力下，的钯 - α-Al 2 O 3催化剂，其中使用的催化剂具有1至10m 2 / g的比表面积（BET）为1至10m 2 / g，孔径为5nm至300μm，孔体积为0.1至 0.5cm 3 / g，直径为40〜400nm的孔的80〜100％，以及由细晶粒状氧化铝粉末得到的新型钯 - α-Al 2 O 3催化剂，其通过成型，热解和煅烧。

64. 发明授权

US5750743A Method for preparing a solution of an alkali salt of anthrahydroquinone 失效
标题翻译：制备蒽醌的碱金属盐溶液的方法
公开(公告)号：US5750743A
公开(公告)日：1998-05-12
申请号：US766469
申请日：1996-12-12
申请人： Hiroyuki Suganuma
发明人： Hiroyuki Suganuma
IPC分类号： C07C37/07 , A01N31/16 , C07C37/64 , C07C39/235 , C07C37/86
CPC分类号： C07C37/64 , C07C2103/24
摘要： A method for preparing a solution of an alkali salt of anthrahydroquinone, which comprises reacting a solution of an alkali salt of 1,4-dihydro-9,10-dihydroxyanthracene with anthraquinone in the presence of an alkali.
摘要翻译：一种制备蒽醌的碱金属盐溶液的方法，该方法包括在碱的存在下使1,4-二氢-9,10-二羟基蒽的碱金属盐与蒽醌反应。

65. 发明授权

US5670465A Preparation of p-fuchsones and synthesis of p-dihydroxylated aromatic compounds therefrom 失效
标题翻译： β-胡椒碱的制备及其由对二羟基化芳族化合物的合成
公开(公告)号：US5670465A
公开(公告)日：1997-09-23
申请号：US464311
申请日：1995-06-05
申请人： Michel Costantini , Daniel Manaut , Daniel Michelet
发明人： Michel Costantini , Daniel Manaut , Daniel Michelet
IPC分类号： B01J27/02 , B01J27/08 , B01J31/02 , C07B61/00 , C07C37/07 , C07C37/20 , C07C37/60 , C07C37/88 , C07C39/08 , C07C39/11 , C07C39/12 , C07C45/29 , C07C45/45 , C07C45/51 , C07C49/603 , C07C49/657 , C07C49/683 , C07C49/747 , C07C49/753
CPC分类号： C07C37/07 , C07C37/60 , C07C45/512 , C07C45/513 , C07C49/683 , C07C49/747 , C07C49/753
摘要： p-Dihydroxylated aromatic compounds are prepared via the oxidation of p-fuchsones, the latter advantageously being synthesized by reacting a phenolic compound having at least one hydrogen atom in the para-position to the hydroxyl function with a non-enolizable ketonic compound, in the presence of a catalytically effective amount of an acid catalyst and, optionally, a cocatalytically effective amount of an ionizable sulfur-containing compound.
摘要翻译：对 - 二羟基化的芳族化合物是通过p-胡蜂酮的氧化制备的，后者有利地通过使对位中具有至少一个氢原子的酚化合物与羟基官能团与非烯醇化酮化合物反应来合成，存在催化有效量的酸催化剂和任选的助催化有效量的可电离的含硫化合物。

66. 发明授权

US5414155A Preparation of o-dihydroxylated aromatic compounds via oxidation of o-fuchsones 失效
标题翻译：通过o-五味子的氧化制备邻二羟基化芳族化合物
公开(公告)号：US5414155A
公开(公告)日：1995-05-09
申请号：US179130
申请日：1994-01-10
申请人： Michel Costantini , Daniel Manaut , Daniel Michelet
发明人： Michel Costantini , Daniel Manaut , Daniel Michelet
IPC分类号： C07C37/07 , C07C37/50 , C07C37/60 , C07C39/08
CPC分类号： C07C37/60
摘要： o-Dihydroxylated aromatic compounds, for example pyrocatechol, are selectively prepared by reacting an o-fuchsone with an oxidizing agent, for example hydrogen peroxide, optionally in the presence of a catalytically effective amount of an acid catalyst.
摘要翻译： O-二羟基化芳族化合物，例如邻苯二酚，可以通过使o-氟沙星与氧化剂（例如过氧化氢）反应，任选地在催化有效量的酸催化剂存在下进行选择性制备。

67. 发明授权

US5248840A Process for the preparation of hydrooxydiphenyls 失效
标题翻译：制备氢化二苯乙烯的方法
公开(公告)号：US5248840A
公开(公告)日：1993-09-28
申请号：US950619
申请日：1992-09-24
申请人： Otto Immel , Gerhard Darsow , Udo Birkenstock
发明人： Otto Immel , Gerhard Darsow , Udo Birkenstock
IPC分类号： B01J23/656 , B01J27/13 , C07B61/00 , C07C37/07 , C07C39/15
CPC分类号： C07C37/07
摘要： To prepare hydroxydiphenyls, a compound or a mixture of several compounds consisting of completely or partly hydrogenated hydroxydiphenyl is dehydrogenated catalytically in the gas phase, a catalyst being employed which comprises, as the active constituents, a combination of rhodium and one or more other platinum metal(s) from the group comprising platinum, palladium, ruthenium and iridium, and which comprises, as promoters, one or more alkali metal hydroxides and/or alkali metal sulphates, the support of which comprises chromium and manganese.
摘要翻译：为了制备羟基二苯，将由完全或部分氢化的羟基二苯组成的化合物或几种化合物的混合物在气相中催化脱氢，使用的催化剂包括作为活性组分的铑和一种或多种其它铂金属的组合其包含铂，钯，钌和铱的基团，并且其包含作为助催化剂的一种或多种碱金属氢氧化物和/或碱金属硫酸盐，其载体包含铬和锰。

68. 发明授权

US4933507A Method of dehydrogenating cyclohexenone 失效
标题翻译：脱氢环己烯酮的方法
公开(公告)号：US4933507A
公开(公告)日：1990-06-12
申请号：US277597
申请日：1988-11-29
申请人： Satoshi Inoki , Yasushi Nakashima , Fujihisa Matsunaga
发明人： Satoshi Inoki , Yasushi Nakashima , Fujihisa Matsunaga
IPC分类号： B01J27/232 , B01J23/58 , C07B61/00 , C07C27/00 , C07C29/145 , C07C37/07 , C07C39/04 , C07C67/00
CPC分类号： C07C37/07 , Y02P20/52
摘要： Phenol is produced by dehydrogenating cyclohexenone through a vapor-phase reaction in the presence hydrogen using a solid-phase catalyst having platinum and alkali metal carried on a support.

69. 发明授权

US4915875A Oxidation products of paramethyl-substituted hindered phenols 失效
标题翻译：对甲基取代的受阻酚的氧化产物
公开(公告)号：US4915875A
公开(公告)日：1990-04-10
申请号：US926693
申请日：1986-11-04
申请人： Timothy R. Diephouse , Robert M. Strom
发明人： Timothy R. Diephouse , Robert M. Strom
IPC分类号： C07C37/07 , C07C43/178 , C07C45/36 , C07C45/51 , C07C46/08 , C07C67/055
CPC分类号： C07C46/08 , C07C37/07 , C07C41/06 , C07C45/36 , C07C45/513 , C07C67/055
摘要： Paramethyl-substituted hindered phenols are selectively oxidized by contacting with an oxidizing agent at elevated temperatures in the presence of a heterogeneous oxidative coupling catalyst. In the absence of an optional nucleophile the products comprise carbon-carbon oxidative coupling products. In the presence of a nucleophile, addition products result that may be further oxidized by continued exposure to the oxidizing agent to yield substituted p-hydroxybenzaldehydes.
摘要翻译：通过在异相氧化偶联催化剂存在下在升高的温度下与氧化剂接触，选择性地氧化对甲基取代的受阻酚。在不存在任选的亲核试剂的情况下，产物包含碳 - 碳氧化偶联产物。在亲核试剂的存在下，加成产物可导致通过持续暴露于氧化剂而进一步氧化，得到取代的对羟基苯甲醛。

70. 发明授权

US4760160A Preparation of 3-cyano-4-fluorophenol 失效
标题翻译： 3-氰基-4-氟苯酚的制备
公开(公告)号：US4760160A
公开(公告)日：1988-07-26
申请号：US818639
申请日：1986-01-14
申请人： Jan H. H. Meurs , David W. Sopher
发明人： Jan H. H. Meurs , David W. Sopher
IPC分类号： C07C43/23 , B01J23/00 , B01J25/00 , C07B61/00 , C07C27/00 , C07C37/07 , C07C37/62 , C07C39/27 , C07C41/00 , C07C67/00 , C07C213/00 , C07C215/76 , C07C253/00 , C07C255/49 , C07C255/53 , C07C255/59 , C07C121/52
CPC分类号： C07C255/00 , C07C37/07
摘要： The invention provides a process for the preparation of 4-fluorophenols of formula ##STR1## wherein n is 0 to 3, each R independently represents a halogen atom or an alkyl, alkoxy, cyano or optionally substituted amino group and Z represents a hydrogen or halogen atom or a cyano group characterized by reacting a fluorohalocyclohexadienone of formula ##STR2## wherein X represents a halogen atom, with a compound of formula A-Z, wherein Z is as defined above and A represents a hydrogen or alkali metal atom, provided that when both A and Z are hydrogen, the reaction is carried out in the additional presence of a Group VIII metal hydrogenation catalyst, and 4-fluorophenols of formula I per se wherein Z is a CN group.
摘要翻译：本发明提供制备式（I）的4-氟苯酚的方法，其中n为0至3，每个R独立地表示卤素原子或烷基，烷氧基，氰基或任选取代的氨基，Z表示氢或卤素原子或氰基，其特征在于使式（VI）的氟代卤代环己烯酮（其中X表示卤素原子）与式AZ化合物反应，其中Z如上所定义，A代表氢或碱金属原子条件是当A和Z均为氢时，反应在额外存在第VIII族金属氢化催化剂的情况下进行，以及其中Z为CN基团的式I的4-氟苯酚。

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