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61. 发明授权

US5298659A Method for the preparation of azomethines 失效
标题翻译：制备偶氮甲碱的方法
公开(公告)号：US5298659A
公开(公告)日：1994-03-29
申请号：US4349
申请日：1993-01-14
申请人： Reinhard Langer , Hans-Josef Buysch , Paul Wagner
发明人： Reinhard Langer , Hans-Josef Buysch , Paul Wagner
IPC分类号： C07B61/00 , C07C249/02 , C07C251/20
CPC分类号： C07C249/02
摘要： Azomethines can be prepared by the condensation of cycloalkanones and anilines in the presence of acid homogeneous catalysts while the water of reaction is removed azeotropically, the condensation being carried out in a continuous reaction in a column-like reactor to which a temperature profile is applied, the starting materials being fed in in the low-temperature region, and, of the reaction products, the water of reaction to be removed azeotropically being discharged also in the low-temperature region and the azomethine produced being discharged in the high-temperature region.
摘要翻译：偶氮甲碱可以通过在酸均相催化剂存在下环烷酮和苯胺的缩合制备，同时反应水共沸除去，缩合是在连续反应中进行的，其中应用了温度分布的柱状反应器，原料在低温区域进料，反应产物中的共沸脱除反应的水也在低温区域中排出，产生的偶氮甲碱在高温区域排出。

62. 发明授权

US5055414A Phenalenimine Fluorescent dyes and their use in analytical methods 失效
标题翻译：。INE。。。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：US5055414A
公开(公告)日：1991-10-08
申请号：US215478
申请日：1988-07-05
申请人： Bruce E. Babb , Fred T. Oakes
发明人： Bruce E. Babb , Fred T. Oakes
IPC分类号： G01N33/533 , C07C251/20 , C07D213/74 , C07D221/18 , C09B55/00 , C09B57/00 , C09K11/07 , G01N33/58
CPC分类号： C07D213/74 , C07C251/20 , C07D221/18 , C09B55/009 , C09B57/00 , G01N33/582 , C07C2101/14 , C07C2103/28 , Y10S436/80 , Y10S436/805
摘要： Certain phenalenimine fluorescent compounds represented by the structure ##STR1## wherein R' and R" are independently hydrogen, alkyl, cycloalkyl, aryl or a heterocycle, or R' comprises the carbon and heteroatoms which forms a fused ring with the compound nucleus, are useful in biomedical and analytical determinations. These compounds can be used for staining cells, as well as for the determination of various analytes found in human or animal biological fluids. Such determination can be carried out in solution or by using dry analytical elements. The fluorescent compounds can be reacted with quinone nuclei to form reducible compounds which are also useful in analytical methods. In addition, the compounds can be incorporated into what are known as "loadable" latex particles to form detectable labels and biological reagents.

63. 发明授权

US4956457A Disazo disulfonamides compounds 失效
标题翻译：双偶氮二磺酰胺化合物
公开(公告)号：US4956457A
公开(公告)日：1990-09-11
申请号：US391945
申请日：1989-08-10
申请人： Takeo Takayanagi
发明人： Takeo Takayanagi
IPC分类号： C07C59/90 , C07C251/20 , C07D203/12 , C07D239/26 , C07D239/46 , C07F3/00 , C07J5/00
CPC分类号： C07D239/26 , C07C251/20 , C07C59/90 , C07D203/12 , C07D239/47 , C07F3/003 , C07J5/0053
摘要： The new azo compounds are represented by the following general formula I ##STR1## Wherein R and R.sup.1 are hydrogen, --COCR.sub.3.sup.4 --COCHR.sub.2.sup.4, --SO.sub.2 CH.sub.3, --CO.sub.2 C.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 R.sup.4, --( CH.sub.2 CH.sub.2 R.sup.4).sub.2, --CH.sub.2 CH.sub.2 OH, --CONHCH.sub.2 CH.sub.2 R.sup.4 or --CH.sub.2 CH.sub.2 OCONH.sub.2 and R.sup.4 is Cl or a group of the formula ##STR2## --NHCO.sub.2 CH.sub.3 CH.sub.2 OH, --NHCO.sub.2 C.sub.2 H.sub.5, --NHOH, --NHCONHOH, or --NHCH.sub.3, whereby R.sup.1 and R.sup.2 are similar or dissimilar.
摘要翻译：新的偶氮化合物由以下通式I表示：其中R和R1是氢，-COCR34-COCHR24，-SO2CH3，-CO2C2H5，-CH2CH2R4， - （CH2CH2R4）2，-CH2CH2OH，-CONHCH2CH2R4或-CH2CH2OCONH2 并且R 4是Cl或下式的基团：-NHCO 2 CH 3 CH 2 OH，-NHCO 2 C 2 H 5，-NHOH，-NHCONHOH或-NHCH 3，其中R 1和R 2是相似的或不相似的。

64. 发明授权

US4863910A Complexes of AZO compounds and/or their salts and an antitumor agent and a method for reducing the growth of tumors 失效
标题翻译： AZO化合物和/或其盐的复合物和抗肿瘤剂以及减少肿瘤生长的方法
公开(公告)号：US4863910A
公开(公告)日：1989-09-05
申请号：US876834
申请日：1986-05-20
申请人： Takeo Takayanagi
发明人： Takeo Takayanagi
IPC分类号： C07C59/90 , C07C251/20 , C07D203/12 , C07D239/26 , C07D239/46 , C07F3/00 , C07J5/00
CPC分类号： C07D239/26 , C07C251/20 , C07C59/90 , C07D203/12 , C07D239/47 , C07F3/003 , C07J5/0053
摘要： A complex of an azo compound of the formula ##STR1## wherein R and R' are selected from the group consisting of hydrogen, --COCR.sub.4.sup.3, --COCHR.sub.2.sup.4, --CO.sub.2 C.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 R.sup.4, --(CH.sub.2 CH.sub.2 R.sup.4)2, --CH.sub.2 CH.sub.2 OH, --CONHCH.sub.2 CH.sub.2 R.sup.4 and --CH.sub.2 CH.sub.2 OCOHN.sub.2, R.sup.4 is selected from the group consisting of chlorine, ##STR2## --NHCO.sub.2 CH.sub.2 CH.sub.2 OH, --HNCO.sub.2 C.sub.2 H.sub.5, --NHOH, --NHCONHOH and --NHCH.sub.3 ; R.sup.1 and R.sup.2 are individually selected from the group consisting of ##STR3## --NHCH.sub.2 CH.sub.2 Cl, --NHCONHOH, --NHCO.sub.2 C.sub.2 H.sub.5, 6-mercapropurin, 5-fluoruracil and prenissolin, R.sup.3 is selected from the group consisting of hydrogen, --COCHR.sub.2.sup.4, --SO.sub.2 CH.sub.3, --COC.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 R.sub.4 and --CONH.sub.2, R.sup.4 is the same as defined herein above, or their pharmaceutically acceptable metal salts, and an antitumor agent selected from the group consisting of nitrogen mustard, cyclophosphamid, thyothepa, 6-mercaptopurine, 5-fluoruracil, vinblastine, L-asparaginase and prednisolone and treatment of tumors and living tissue.
摘要翻译：其中R和R'选自氢，-COCR 43，-COCHR 24，-CO 2 C 2 H 5，-CH 2 CH 2 R 4， - （CH 2 CH 2 R 4）2，-CH 2 CH 2 OH，-CONHCH 2 CH 2 R 4和 -CH 2 CH 2 OCOHN 2，R 4选自氯，H 2 CO 2 CH 2 CH 2 OH，-HNCO 2 C 2 H 5，-NHOH，-NHCONHOH和-NHCH 3; R1和R2分别选自由以下组成的组：图1所示的组合物，其中R 1选自氢，-COCHR 24，-SO 2 CH 3，-OR 2，CH 2， COC2H5，-CH2CH2R4和-CONH2，R4与上文定义的相同，或其药学上可接受的金属盐，以及选自氮芥，环磷酰胺，甲状腺硫酸，6-巯基嘌呤，5-氟尿嘧啶，长春花碱，L-天冬酰胺酶和泼尼松龙以及治疗肿瘤和活组织。

65. 发明授权

US4702863A Indoaniline and indophenol compounds, a process for their preparation, dyeing compositions containing them and a hair-dyeing process 失效
标题翻译：吲哚苯胺和靛酚化合物，其制备方法，含有它们的染色组合物和染发方法
公开(公告)号：US4702863A
公开(公告)日：1987-10-27
申请号：US884904
申请日：1986-07-14
申请人： Andree Bugaut , Alex M. Junino
发明人： Andree Bugaut , Alex M. Junino
IPC分类号： A61K8/00 , A61K8/34 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/49 , A61Q5/10 , C07C67/00 , C07C241/00 , C07C251/20 , C09B53/02 , C07C50/04 , C07C50/06
CPC分类号： C09B53/02 , A61K8/413 , A61Q5/10
摘要： New indolaniline and indophenol compounds of formula (I): ##STR1## wherein Z represents a monohydroxylated or polyhydroxylated hydrocarbon radical, of 1 to 6 carbon atoms, or an aminoalkyl radical of formula ##STR2## wherein n is an integer from 1 to 6 and R.sub.1 and R.sub.2, which are identical or different, represent a hydrogen atom or an alkyl, hydroxyalkyl or acyl radical of 1 to 4 carbon atoms; R represents a hydrogen atom or an alkyl, hydroxyalkyl, polyhydroxyalkyl, monocarbamylalkyl, dicarbamylalkyl, aminoalkyl, acyl, alkoxycarbonyl, carbamyl or monoalkylcarbamyl radical of 1 to 6 carbon atoms; R'.sub.1, R'.sub.2, R'.sub.3 and R'.sub.4, which are identical or different, represent a hydrogen atom, a halogen atom or an alkyl, hydroxyalkyl, alkoxy or hydroxyalkoxy radical, of 1 to 6 carbon atoms; and Y represents OH or NR'.sub.5 R'.sub.6, wherein R'.sub.5 and R'.sub.6, which are identical or different, represent a hydrogen atom or an alkyl, monohydroxyalkyl, polyhydroxyalkyl, carbamylalkyl, mesylaminoalkyl or methoxy alkyl radical of 1 to 6 carbon atoms are disclosed, together with a process for their preparation, hair-dyeing compositions containing them and a hair dyeing process.
摘要翻译：新的吲哚苯胺和式（I）的靛酚化合物：其中Z代表具有1至6个碳原子的单羟基化或多羟基化烃基，或式IMA图形的氨基烷基，其中n是1的整数至6和相同或不同的R 1和R 2表示氢原子或具有1至4个碳原子的烷基，羟烷基或酰基; R代表1到6个碳原子的氢原子或烷基，羟基烷基，多羟基烷基，单链烷基烷基，二氨基烷基，氨基烷基，酰基，烷氧基羰基，氨基甲酰基或单烷基氨基甲酰基; R'1，R'2，R'3和R'4相同或不同，表示1至6个碳原子的氢原子，卤素原子或烷基，羟基烷基，烷氧基或羟基烷氧基; Y表示OH或NR'5R'6，其中R'5和R'6相同或不同，表示氢原子或1至6个碳原子的烷基，单羟基烷基，多羟基烷基，氨基甲酰基烷基，甲磺酰氨基烷基或甲氧基烷基公开了原料及其制备方法，含有它们的染发组合物和染发方法。

66. 发明授权

US4496590A Benzyl alcohol derivatives, their preparation and use 失效
标题翻译：苄醇衍生物，其制备和用途
公开(公告)号：US4496590A
公开(公告)日：1985-01-29
申请号：US485936
申请日：1983-04-18
申请人： Donald C. Schlegel , Malcolm R. Bell
发明人： Donald C. Schlegel , Malcolm R. Bell
IPC分类号： A61K31/135 , A61P11/00 , C07C67/00 , C07C213/00 , C07C215/82 , C07C241/00 , C07C251/20 , A01N33/02 , A61K31/335 , C07C50/10 , C07C97/10
CPC分类号： A61K31/135 , C07C215/82 , Y10S514/826
摘要： Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Y is C.sub.n H.sub.2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein --Y--OH is replaced by --COCH.sub.3.
摘要翻译：可用作止喘剂的新型羟基苯基氨基苯烷醇具有下式：其中R是氢，低级烷基，低级烷氧基或卤素; R'是氢或低级烷基; R“是氢，低级烷基或卤素; Y为C n H 2n，n为1-2。该化合物通过相应的苯酚烷基或苄基醚的脱醚化来制备; 通过还原相应的苯甲酸或其酯; 或通过还原其中-Y-OH被-COCH 3替代的酮。

67. 发明授权

US3879469A Process for preparing 6,9-dioxo-3,8-dihydroxy-2-substituted-bicyclo-3,3,1-nonenes-7 失效
标题翻译：制备6,9-二氧代-3,8-二羟基-2-取代 - 双环-3,3,1-壬烯-7的方法
公开(公告)号：US3879469A
公开(公告)日：1975-04-22
申请号：US33287173
申请日：1973-02-15
申请人： ZYMA SA
发明人： VALENZA ANDRE , HORVATH ERNO , COURBAT PIERRE , ALBERT ALBAN
IPC分类号： C07C49/587 , A61K31/12 , C07C45/00 , C07C49/623 , C07C51/00 , C07C62/38 , C07C67/00 , C07C225/20 , C07C241/00 , C07C251/20 , C07C325/00 , C07C49/80 , C07C49/82
CPC分类号： A61K31/12 , C07C45/57 , C07C49/747 , Y10S514/893
摘要： Novel bicyclic compunds of formula:

WHEREIN N IS AN INTEGER HAVING AT LEAST THE VALUE 1, A'' is O, S or NB, B is hydrogen, or a substituted or unsubstituted alkyl group, or substituted or unsubstituted acyl or aryl, Q is hydrogen, a halogen, or an -OH group, or an alkyl, alkoxy, aryl, or carboxyl group, T is a halogen, or a hydroxyl, alkoxy, or substituted or unsubstituted aryl, W is hydrogen, or a halogen, or a hydroxyl, alkyl, alkoxy, substituted or unsubstituted aryl, or carboxyl group, X is a hydroxyl, alkoxy, substituted aryl, or a substituted or unsubstituted amino group, Y is hydrogen, or a halogen, or a hydroxyl, alkyl, alkoxy, substituted or unsubstituted aryl, or carboxyl group, Z'' is O or NB; these compounds are prepared by reacting a compound of formula:

WHEREIN A is -O-, -S- or NB, and Z is -OH or -NHB, with an alkali in an at least partially aqueous medium. The novel compounds thus obtained are useful against circulation and hepatic diseases.
摘要翻译：新型双环配方：

68. 发明授权

US3835191A Aldimines and ketimines containing hydroxymethyl groups and preparation thereof 失效
标题翻译：含有羟基甲基的组合物及其制备及其制备
公开(公告)号：US3835191A
公开(公告)日：1974-09-10
申请号：US88042069
申请日：1969-11-26
申请人： BAYER AG
发明人： WAGNER K , HAJEK M
IPC分类号： C07C255/61 , C07C67/00 , C07C241/00 , C07C251/02 , C07C251/20 , C07C253/00 , C08G18/10 , C08G18/32 , C08G18/65 , C07C119/00
CPC分类号： C08G18/6535 , C08G18/10 , C08G18/3296
摘要： Novel aldimines and ketimines which contain hydroxy methyl groups are provided. These new compounds are prepared by reacting Schiff''s bases which have active hydrogen atoms in Alpha position to the C N-group with formaldehyde or formaldehyde yielding compounds. The new compounds can, e.g., be used as plasticizing chain lengthening agents for the preparation of polyurethane plastics.

69. 发明授权

US3803234A Tricyclic imines 失效
标题翻译： TRICYCLIC IMINES
公开(公告)号：US3803234A
公开(公告)日：1974-04-09
申请号：US18490171
申请日：1971-09-29
申请人： HOFFMANN LA ROCHE
发明人： DOSTERT P , KYBURZ E
IPC分类号： C07C251/20 , C07C65/36 , C07C249/02 , C07C251/50 , C07D313/12 , C07D337/12 , C07C119/00
CPC分类号： C07C65/36 , C07D313/12 , C07D337/12
摘要： TRICYCLIC IMINES OF THE FORMULA

R2-N(-R3)-(CH(-R4))N-N=C
1,2-PHENYLENE)-)

WHEREIN R1, R2, R3, R4, X, M AND N ARE AS HEREINAFTER. DESCRIBED, PREPARED FROM THE CORRESPONDING KETONES OF THE FORMULA

O=C
WHEREIN R1, X AND M ARE AS HEREINAFTER DESCRIBED, ARE DISCLOSED. THE COMPOUNDS OF FORMULA 1 ARE USEFUL AS ANTIDEPRESSANTS, AS WELL AS ANTICONVULSANTS AND AGENTS FOR THE TREATMENT OF PARKINSONISM.

70. 发明公开

US20240190814A1 Novel Intermediates 审中-公开
公开(公告)号：US20240190814A1
公开(公告)日：2024-06-13
申请号：US18551292
申请日：2022-03-23
申请人： Syngenta Crop Protection AG
发明人： George Robert Hodges , Martin Charles Bowden
IPC分类号： C07C251/20 , C07C251/08
CPC分类号： C07C251/20 , C07C251/08
摘要： A compound:

and double bond regioisomers thereof.

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