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61. 发明授权

US07425578B2 Immunoregulatory compounds and derivatives and methods of treating diseases therewith 有权
标题翻译：免疫调节化合物及其治疗疾病的衍生物和方法
公开(公告)号：US07425578B2
公开(公告)日：2008-09-16
申请号：US11470655
申请日：2006-09-07
申请人： Nnochiri N. Ekwuribe , Jennifer Riggs-Sauthier
发明人： Nnochiri N. Ekwuribe , Jennifer Riggs-Sauthier
IPC分类号： A61K31/16 , C07C245/06
CPC分类号： A61K31/195 , A61K31/196 , A61K31/215 , A61K31/24 , C07C229/42 , C07C245/08 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or where R6, R7 and R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and —C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group.
摘要翻译：公开了具有式I结构的化合物：其中R 1，R 3和R 4独立地是氢或C 1 C 1至C 4烷基，R 2是：其中R 5选自氢和C _{C 1至C 4烷基，或其中R 6，R 7和R 8是独立地是氢或C 1至C 4烷基; 或其酯或药理学上可接受的盐。这些化合物可用于预防或治疗各种疾病，特别是GI道的炎性病症。还公开了使用具有下式的化合物治疗胃肠道炎症性疾病如炎症性肠病的方法：其中R 9，R 10和R 11 独立地选自氢和C 1至C 4烷基，R 12选自基团由氢和-C（O）R 13组成，其中R 13是C 1至C 6 - 烷基或芳基。}

62. 发明申请

US20050130051A1 Phenylazomethylene-cyclohexadienone derivatives comprising electron withdrawing group and electrophotographic photoreceptor comprising the derivatives 失效
标题翻译：包含吸电子基团的苯基亚甲基 - 环己二烯酮衍生物和包含该衍生物的电子照相感光体
公开(公告)号：US20050130051A1
公开(公告)日：2005-06-16
申请号：US10964740
申请日：2004-10-15
申请人： Beom-jun Kim , Saburo Yokota , Kyung-yol Yon , Hwan-koo Lee , Seung-ju Kim
发明人： Beom-jun Kim , Saburo Yokota , Kyung-yol Yon , Hwan-koo Lee , Seung-ju Kim
IPC分类号： G03G5/04 , C07C245/06 , G03G5/047 , G03G5/05 , G03G5/06 , G03G5/14 , G03G5/147
CPC分类号： G03G5/0609 , G03G5/0517 , G03G5/0605 , G03G5/0616 , G03G5/0677
摘要： A phenylazomethylene-cyclohexadienone derivative and an electrophotographic photoreceptor include a compound that is represented by the following formula: wherein R1 and R2 are independently selected from the group consisting of a substituted or unsubstituted alkyl group having 1 to 20 carbon atom(s), a substituted or unsubstituted alkoxy group having 1 to 20 carbon atom(s), a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 30 carbon atoms, and a halogen; A is selected from the group consisting of nitro group, cyano group and sulfone group; l is a natural number of 0 to 4; m is a natural number of 0 to 4; and n is a natural number of 1 to 5, and the electrophotographic photoreceptor according to the present invention comprises the phenylazomethylene-cyclohexadienone derivative. An electrophotographic photoreceptor having an improved electrical characteristic and a desirable image quality is provided.
摘要翻译：苯基亚甲基亚甲基 - 环己二烯酮衍生物和电子照相感光体包括由下式表示的化合物：其中R 1和R 2独立地选自取代的或未取代的碳原子数为1〜20的烷基，取代或未取代的碳原子数1〜20的烷氧基，取代或未取代的碳原子数为6〜30的芳基，取代或未取代的芳烷基， 7〜30个碳原子，和卤素; A选自硝基，氰基和砜基; l是0到4的自然数; m是0到4的自然数; n为1〜5的自然数，本发明的电子照相感光体为苯基亚甲基 - 环己二烯酮衍生物。提供具有改善的电特性和期望的图像质量的电子照相感光体。

63. 发明授权

US5834604A Photographic element containing a coupler capable of releasing a photograpically useful group through a pyrazole group 失效
标题翻译：含有能够通过吡唑基释放摄影有用基团的成色剂的照相元件
公开(公告)号：US5834604A
公开(公告)日：1998-11-10
申请号：US923796
申请日：1997-09-04
申请人： William James Begley , Frank Dino Coms , Teh-Hsuan Chen , Donald Singleton, Jr.
发明人： William James Begley , Frank Dino Coms , Teh-Hsuan Chen , Donald Singleton, Jr.
IPC分类号： C07D403/12 , G03C7/305 , C07C245/06 , C07D231/10 , C07D403/02
CPC分类号： C07D403/12 , G03C7/30576 , Y10S430/156 , Y10S430/158 , Y10S534/02
摘要： A photographic element comprising a support having situated thereon at least one silver halide emulsion layer, the element further comprising a photographic coupler represented by the formula COUP--(T.sup.1).sub.b --T.sup.2 --(T.sup.3).sub.c --PUG wherein the substituents are as defined in the specification.
摘要翻译：一种照相元件，包括一个载体上至少有一个卤化银乳剂层，该元件还包含由式COUP-（T1）b-T2-（T3）c-PUG表示的照相成色剂，其中取代基如说明书中所定义。

64. 发明授权

US5811529A Bis-pyridone compounds 失效
标题翻译：双吡啶酮化合物
公开(公告)号：US5811529A
公开(公告)日：1998-09-22
申请号：US816758
申请日：1997-03-07
申请人： Danette R. Vines , Ronald P. Pedemonte
发明人： Danette R. Vines , Ronald P. Pedemonte
IPC分类号： C09B62/01 , C09B62/25 , C09B62/44 , C09B62/513 , C07C245/06
CPC分类号： C09B62/25 , C09B62/01 , C09B62/4415 , C09B62/513
摘要： A fiber reactive dye having the formula ##STR1## wherein R.sub.1 and R.sub.3 are independently selected from the group consisting of; hydrogen; an alkyl group having from one to four carbon atoms; the foregoing alkyl group further substituted with one or more groups selected from hydroxy; amino; sulfo; halogen; an aryl radical; a heterocyclic radical or combination thereof; where for R.sub.3 said amino group maybe further substituted by a nitrogen heterocyclic fiber reactive group of the series: 1, 3, 5 mono or dichloro triazinyl; 1, 3, 5 mono or difluoro triazinyl; trichloropyrimidinyl; difluoropyrimidinyl; or monochlorodifluoro pyrimidinyl; where the nitrogen heterocycle may be further substituted by an: alkyl; or aryl amino group; wherein B is selected from the group consisting of a C.sub.2 to C.sub.4 alkyl chain; a substituted aryl or a heterocyclic radical; wherein X is selected from the group consisting of SO.sub.3 H; SO.sub.3 Na or a hydroxy group; and wherein Q.sub.1 and Q.sub.2 are independently selected from diazo components.
摘要翻译：一种具有式“IMAGE”的纤维活性染料，其中R 1和R 3独立地选自：氢; 具有1-4个碳原子的烷基; 前述烷基还被一个或多个选自羟基的基团取代; 氨基; 磺基卤素; 芳基; 杂环基或其组合; 对于R3，所述氨基可以进一步被该系列的氮杂环纤维反应性基团取代：1,3,5-单或二氯三嗪基; 1,3,5-单或二氟三嗪基; 三氯嘧啶基; 二氟嘧啶基或一氯二氟嘧啶基; 其中氮杂环可以进一步被烷基取代; 或芳基氨基; 其中B选自C2-C4烷基链; 取代的芳基或杂环基; 其中X选自SO 3 H; SO 3 Na或羟基; 并且其中Q1和Q2独立地选自重氮组分。

65. 发明授权

US5438123A Insecticidal phenylhydrazine derivatives 失效
标题翻译：杀虫剂苯肼衍生物
公开(公告)号：US5438123A
公开(公告)日：1995-08-01
申请号：US286738
申请日：1994-08-05
申请人： Mark A. Dekeyser , Paul T. McDonald
发明人： Mark A. Dekeyser , Paul T. McDonald
IPC分类号： A01N37/28 , A01N37/30 , A01N37/42 , A01N43/08 , A01N43/10 , A01N47/02 , A01N47/24 , A01N47/34 , A01N57/30 , A01P5/00 , A01P7/02 , A01P7/04 , C07C243/28 , C07C281/02 , C07C281/06 , C07C311/49 , C07C337/02 , C07C337/06 , C07D307/91 , C07F9/24 , C07C245/06
CPC分类号： C07D307/91 , A01N37/28 , A01N37/30 , A01N47/02 , A01N47/24 , A01N47/34 , A01N57/30 , C07C243/28 , C07C281/02 , C07C281/06 , C07C311/49 , C07C337/02 , C07F9/2491 , C07C2101/14
摘要： Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes, rice planthopper, tobacco budworm, and southern corn rootworm. Methods for making these compounds are also set forth.
摘要翻译：公开了具有结构式为其中X，Y，R和Z在本说明书中定义的结构式（I）的化合物（II）。本发明的化合物可有效控制螨虫，线虫，稻虱，烟芽夜蛾和南方玉米根虫。还阐述了制备这些化合物的方法。

66. 发明授权

US5053073A Thiophene derivatives useful as fungicidal, insecticidal or plant growth regulating agents 失效
标题翻译：有害作为杀真菌剂，杀虫剂或植物生长调节剂的噻吩衍生物
公开(公告)号：US5053073A
公开(公告)日：1991-10-01
申请号：US378076
申请日：1989-07-11
申请人： Vivienne M. Anthony , John M. Clough , Paul deFraine , Christopher R. A. Godfrey , Kevin Beautement
发明人： Vivienne M. Anthony , John M. Clough , Paul deFraine , Christopher R. A. Godfrey , Kevin Beautement
IPC分类号： C07C241/00 , A01N37/36 , A01N37/42 , A01N37/44 , A01N37/48 , A01N43/06 , A01N43/08 , A01N43/10 , A01N43/36 , A01N43/38 , A01N43/58 , C07C67/00 , C07C69/734 , C07C201/00 , C07C205/56 , C07C229/64 , C07C233/58 , C07C239/00 , C07C245/06 , C07C251/02 , C07C251/44 , C07C253/00 , C07C255/57 , C07C255/59 , C07C309/63 , C07C313/00 , C07C323/54 , C07D207/32 , C07D207/337 , C07D207/34 , C07D209/18 , C07D307/42 , C07D307/54 , C07D307/79 , C07D333/24 , C07D333/32 , C07D333/34 , C07D333/38 , C07D333/60 , C07F7/18
CPC分类号： C07D207/337 , A01N43/06 , A01N43/36 , A01N43/38 , A01N43/58 , C07D209/18 , C07D307/54 , C07D307/79 , C07D333/24 , C07D333/60
摘要： Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein W is R.sup.1 O.sub.2 C--C.dbd.CH--ZR.sup.2, wherein R.sup.1 and R.sup.2, which are the same or different, are alkyl or fluoroalkyl groups, and Z is either an oxygen or sulphur atom; A is an oxygen or sulphur atom, --NR.sup.3 --, or --CR.sup.4 R.sup.5 --; X, Y and Z.sup.1, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkoxy, optionally substituted arylalkoxy, optionally substituted aryloxy, optionally substituted heteraryloxy, optionally substituted acyloxy, optionally substituted amino, optionally substituted acylamino, optionally substituted arylazo, nitro, cyano, --CO.sub.2 R.sup.6, --CONR.sup.7 R.sup.8, --COR.sup.9 --CR.dbd.NR.sup.10, --CR.dbd.NOR.sup.10 or --N.dbd.CR.sup.11 R.sup.12 groups; or the groups X and Y, when they are in adjacent positions on the ring, optionally join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and R, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, and R.sup.12, which are the same or different, are hydrogen atoms (provided that R.sup.4 and R.sup.5 are not hydrogen) or optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heterarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted heteroaryl groups; and metal complexes thereof.The compounds are useful in agriculture, especially as fungicides but also as insecticides and plant growth regulators.

67. 发明授权

US4939287A Chiral esters of mesogenic carboxylic acids 失效
标题翻译：介晶羧酸的手性酯
公开(公告)号：US4939287A
公开(公告)日：1990-07-03
申请号：US912790
申请日：1986-09-26
申请人： Christian Bahr , Gerd Heppke , Detlef Lotzsch , Feodor Oestreicher
发明人： Christian Bahr , Gerd Heppke , Detlef Lotzsch , Feodor Oestreicher
IPC分类号： C07C69/76 , C07C67/00 , C07C69/767 , C07C69/773 , C07C69/92 , C07C241/00 , C07C245/06 , C07C251/18 , C07C251/24 , C07C253/00 , C07C255/55 , C07C255/57 , C07C291/08 , C09K19/58 , G02F1/13
CPC分类号： C09K19/58 , C09K19/586
摘要： The novel esters of a chiral alcohol and a mesogenic carboxylic acid are characterized by the general formula (I) ##STR1## in which the symbols have the following meanings: n denotes 0 or 1,R.sup.1 denotes a straight-chain or branched (C.sub.1 -C.sub.4)alkyl which is unsubstituted or substituted by halogen, in particular fluorine,R.sup.2 denotes unsubstituted or substituted (C.sub.6 -C.sub.18)aryl, cyclo(C.sub.5 -C.sub.12)alkyl or mononuclear or binuclear heteroaryl possessing a five-membered and/or six-membered ring, andMC denotes a molecular radical of a mesogenic monocarboxylic acid MC-OH after elimination of an OH group where n=0, and denotes a molecular radical of a mesogenic dicarboxylic acid HO-MC-OH after elimination of two OH groups where n=1, with the exception of compounds in which n denotes 0, R.sup.1 denotes CH.sub.3, R.sup.2 denotes phenyl and MC denotes ##STR2## These esters are preferably used as admixtures in twistable liquid crystal phases, in which they produce temperature compensation and a large twist.
摘要翻译：手性醇和介晶羧酸的新酯由通式（I）表示，其中符号具有以下含义：n表示0或1，R1表示直链或支链（C 1 -C 18）烷基，其未被取代或被卤素，特别是氟取代，R 2表示未取代或取代的（C 6 -C 18）芳基，环（C 5 -C 12）烷基或单核或双核杂芳基，其具有五元和/ 六元环，MC表示在消除n = 0的OH基团后的介晶一元羧酸MC-OH的分子量，表示消除两个OH后的介晶二羧酸HO-MC-OH的分子量其中n = 1的基团，除了其中n表示0的化合物，R1表示CH3，R2表示苯基，MC表示这些酯优选用作可扭曲液晶相中的混合物，其中它们产生温度补偿和一个大的扭曲。

68. 发明授权

US4920222A Preparation of 3,3-diarylacrylic acid amides 失效
标题翻译：制备3,3-二芳基丙烯酸酰胺
公开(公告)号：US4920222A
公开(公告)日：1990-04-24
申请号：US302938
申请日：1989-01-30
申请人： Jurgen Curtze , Ludwig Schroder , Paul H. Briner
发明人： Jurgen Curtze , Ludwig Schroder , Paul H. Briner
IPC分类号： C07D295/18 , B01J37/02 , C07B43/06 , C07B61/00 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/11 , C07C235/34 , C07C237/20 , C07C241/00 , C07C245/06 , C07C315/04 , C07C317/44 , C07C317/46 , C07C319/20 , C07C323/60 , C07C323/62 , C07D295/182
CPC分类号： C07D295/182 , C07C231/12
摘要： 3,3-Diarylacrylic acid amides are prepared by the reaction of a benzophenone with an acetamide in the presence of a base characterized in that a sodium alcoholate is used as the base.

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