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    • 61. 发明申请
    • Low Pulse Rate Cochlear Implant Stimulation In Conjunction With A Separate Representation Of Fundamental Frequencies And Voiced/Unvoiced Distinctions
    • 低脉冲率耳蜗植入刺激与基频和发声/清音区别的独立表示相结合
    • US20110066210A1
    • 2011-03-17
    • US12879159
    • 2010-09-10
    • Blake S. Wilson
    • Blake S. Wilson
    • A61F11/04A61N1/36
    • A61N1/36032A61F11/045A61N1/05A61N1/0541A61N1/056A61N1/36036
    • A method is described for generating stimulus signals for an auditory prosthesis system. A high frequency signal conveys higher frequency audio information including exceptionally low rate band-pass envelope characteristics. This high frequency signal represents at least the upper part if not all of the range of frequencies for speech, music, and other sounds that are audible to listeners with normal hearing. A separate low frequency signal is also provided representing lower audio frequency information including periodicity characteristics (voiced/unvoiced or periodic/aperiodic distinctions) and for periodic sounds, fundamental frequency characteristics. The high frequency signal is applied to the auditory system of a patient by an associated high frequency stimulator, and the low frequency signal is applied to the auditory system of the patient by an associated low frequency signal.
    • 描述了一种用于产生用于听觉假体系统的刺激信号的方法。 高频信号传送包括特别低速带通包络特性的较高频率音频信息。 这个高频信号至少表示在具有正常听觉的听众听到的语音,音乐和其他声音的频率范围中的上部(如果不是全部)。 还提供了一个单独的低频信号,代表包括周期特性(浊音/清音或周期/非周期性区别)以及周期性声音,基频特性的较低音频信息。 通过相关的高频刺激器将高频信号施加到患者的听觉系统,并且通过相关联的低频信号将低频信号施加到患者的听觉系统。
    • 62. 发明授权
    • Adaptive system and method for place-pitch ranking a multi-channel neural stimulator
    • 多通道神经刺激器的放置间距排序的自适应系统和方法
    • US07835799B1
    • 2010-11-16
    • US12334453
    • 2008-12-13
    • Philip A SegelTracey L KrugerLeonid M Litvak
    • Philip A SegelTracey L KrugerLeonid M Litvak
    • A61N1/36A61F11/04A61F11/00
    • A61N1/36036
    • An adaptive place-pitch ranking procedure for use with a cochlear implant or other neural stimulation system provides a systematic method for quantifying the magnitude and direction of errors along the place-pitch continuum. The method may be conducted and completed in a relatively short period of time. In use, the implant user or listener is asked to rank the percepts obtained after a sequential presentation of monopolar stimulation pulses are applied to a selected spatially-defined electrode pair. The spatially-defined electrode pair may be a physical electrode pair or a virtual electrode pair. A virtual electrode pair includes at least one virtual electrode contact. Should the patient's judgment of pitch order be correct for all applied interrogations, then no further testing involving the tested electrode pair (two electrode contacts) is undertaken. However, should there be errors in the place-pitch ranking, which errors evidence perceptual place-confusions, then a search is undertaken for the spread of the perceptual confusion. This search for the spread of confusion continues until no errors are made in all directions. Identified channels wherein pitch confusion exists may be de-selected (not used) during normal operation of the cochlear implant or other neural stimulation system.
    • 用于耳蜗植入物或其他神经刺激系统的自适应放置间距分级程序提供了一种用于量化沿着位置 - 俯仰连续体的误差的大小和方向的系统方法。 该方法可以在相当短的时间内进行和完成。 在使用中,要求植入用户或收听者将单极刺激脉冲的顺序呈现施加到所选择的空间限定电极对之后获得的感知进行排名。 空间限定的电极对可以是物理电极对或虚拟电极对。 虚拟电极对包括至少一个虚拟电极触点。 如果患者对所有应用询问的音调顺序的判断是正确的,则不进行涉及被测电极对(两个电极接触)的进一步测试。 然而,如果地方间距排序有错误,哪些错误证据感知地点混淆,那么就会对感知混乱的扩散进行搜索。 这种寻求混乱的传播继续下去,直到在所有方向没有错误。 在耳蜗植入物或其他神经刺激系统的正常操作期间,存在音高混乱存在的识别的通道可被取消选择(未使用)。
    • 63. 发明申请
    • MULTI-ELECTRODE CHANNEL CONFIGURATIONS
    • 多电极通道配置
    • US20100198301A1
    • 2010-08-05
    • US12366510
    • 2009-02-05
    • Zachary M. Smith
    • Zachary M. Smith
    • A61F11/04A61N1/08
    • A61N1/0541A61N1/36036
    • An apparatus and method optimizing complex channel configurations to produce minimal channel interactions is provided. The method includes selecting multiple channels from a channel configuration including a plurality of channels, each of the plurality of channels includes multiple electrodes. The method also includes measuring an interaction between selected channels and determining a significance of the measured interaction. The method further includes adjusting a focus of the channel configuration based on the significance of measured interaction, wherein the focus of the channel configuration is not adjusted if the interaction between the selected channels determined to be insignificant. The measuring, determining and adjusting is repeated until the interaction between the selected channels is determined to be insignificant or the magnitude of the interaction is determined to be minimized, thereby optimizing the channel configuration for the selected channels. Another set of channels from the channel configuration is selected and the measuring, determining, adjusting and repeating is performed for each set until full channel configuration is optimized.
    • 提供了优化复杂信道配置以产生最小信道交互的装置和方法。 该方法包括从包括多个信道的信道配置中选择多个信道,多个信道中的每一个包括多个电极。 该方法还包括测量所选通道之间的相互作用并确定所测量的相互作用的重要性。 该方法还包括基于测量的交互的重要性来调整频道配置的焦点,其中如果所选择的频道之间的交互被确定为不重要,则不调整频道配置的焦点。 重复测量,确定和调整,直到所选择的通道之间的相互作用被确定为不重要,或确定相互作用的大小被最小化,从而优化所选择的通道的通道配置。 选择来自通道配置的另一组通道,并且对每组进行测量,确定,调整和重复,直到完全通道配置被优化。
    • 67. 发明申请
    • PHARMACEUTICAL INTERVENTION FOR MODULATION OF NEURAL PLASTICITY
    • 神经胶质调节药物干预
    • US20100030130A1
    • 2010-02-04
    • US12415812
    • 2009-03-31
    • John L. ParkerDusan MilojevicClaudia Tasche
    • John L. ParkerDusan MilojevicClaudia Tasche
    • A61F11/04A61N1/36A61M37/00
    • A61N1/36036A61F11/00A61M5/14276A61M2205/05A61M2210/0662A61N1/0541
    • A stimulating medical device. The stimulating medical device comprises: a stimulating assembly implantable proximate to a recipient's neural system, the assembly having at least one agent delivery port and a plurality of electrical contacts; an electrical stimulation controller configured to generate electrical stimulation signals for application the neural system via one or more of the plurality of electrical contacts; a pharmaceutical agent source configured to provide a plasticity modulating agent to the at least one delivery port for application to the neural system; and a pharmaceutical agent controller configured to control one or more of the pharmaceutical agent source and the at least one delivery port to cause selective application of the plasticity modulating agent to the neural system to at least one of reinforce and activate one or more neural pathways within the system.
    • 刺激性医疗器械。 刺激性医疗装置包括:可接近接收者的神经系统植入的刺激组件,所述组件具有至少一个药剂输送口和多个电触头; 电刺激控制器,被配置为产生电刺激信号,用于经由所述多个电触点中的一个或多个施加所述神经系统; 药剂源,被配置为向所述至少一个递送端口提供可塑性调节剂以供应用于所述神经系统; 以及药剂控制器,其被配置为控制所述药剂源和所述至少一个递送端口中的一个或多个,以引起对所述神经系统的所述可塑性调节剂的选择性应用至少一种以增强和激活所述神经系统内的一个或多个神经通路 系统。