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61. 发明授权

US4805622A Direction-finding system for localization of reflection-causing nterfaces in the human body 失效
标题翻译：人体内反射引起的表面定位的测向系统
公开(公告)号：US4805622A
公开(公告)日：1989-02-21
申请号：US25510
申请日：1987-03-13
申请人： Rainer Riedlinger , Friedrich Ueberle
发明人： Rainer Riedlinger , Friedrich Ueberle
IPC分类号： A61B8/00 , A61B8/08 , A61B17/22 , G01S15/06 , A61B10/00
CPC分类号： G01S15/06 , A61B8/0833 , Y10S977/929
摘要： A direction-finding system for localization of reflection-causing interfaces in the human body, in particular those of concretions, consists of at least one transmitter (18) emitting pulsed ultrasound and at least two ultrasound receivers (2, 3), of gate circuits (25) associated with each receiver, with variable amplifiers (26), and respective storage media (6) for ultrasonic echo signals (22, 21), and of a following device for sweep magnification (7) consisting of signal memories for readout at an adjustable clock frequency, there being provided variations of the delay differences ML and of the amplitude frequency spectra MF adjustable independently of each other. Connected downstream are devices for auditory direction finding (8, 9, 10, 15).
摘要翻译：用于定位人体内的反射界面的方向调查系统，特别是结构的定向系统由至少一个发射脉冲超声波发射器（18）和至少两个超声波接收器（2,3）组成，门极电路（25），具有可变放大器（26）和用于超声波回波信号（22,21）的相应存储介质（6），以及用于扫描放大率（7）的随后装置，其由信号存储器组成，用于在提供了可调节的时钟频率，提供了彼此独立调节的延迟差ML和振幅频谱MF的变化。下游连接是用于听觉方向发现的装置（8,9,10,15）。

62. 发明授权

US08283308B2 Copolymer-stabilized emulsions 有权
标题翻译：共聚物稳定的乳液
公开(公告)号：US08283308B2
公开(公告)日：2012-10-09
申请号：US12391914
申请日：2009-02-24
申请人： Thomas G. Mason , Timothy J. Deming , Jarrod A. Hanson , Connie B. Chang , Sara M. Graves
发明人： Thomas G. Mason , Timothy J. Deming , Jarrod A. Hanson , Connie B. Chang , Sara M. Graves
IPC分类号： A61K38/02
CPC分类号： A61K9/113 , A61K47/183 , A61K47/34 , B01F17/005 , B82Y5/00 , Y02A50/401 , Y10S977/773 , Y10S977/795 , Y10S977/906 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T428/2984
摘要： An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid having an inner surface contained within the outer surface of the outer droplet of the first liquid, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the inner surface of the inner droplet. The block copolymers include a hydrophilic polymer block and a hydrophobic polymer block that act in combination to stabilize the droplet structure, and the first liquid is immiscible in the substantially continuous liquid medium.
摘要翻译：乳液包括基本上连续的液体介质和分散在基本上连续的液体介质内的多个液滴结构。多个液滴结构的每个液滴结构包括具有外表面的第一液体的外滴; 第二液体的内部液滴，其具有包含在第一液体的外部液滴的外表面内的内表面，第二液体在第一液体中不混溶，其中内部和外部液滴在其间具有边界表面区域; 设置在外部液滴的外表面上的嵌段共聚物的外层; 以及设置在内部液滴的内表面上的嵌段共聚物的内层。嵌段共聚物包括亲水聚合物嵌段和疏水性聚合物嵌段，其组合起作用以稳定液滴结构，并且第一液体在基本连续的液体介质中是不混溶的。

63. 发明申请

US20090208548A1 COPOLYMER-STABILIZED EMULSIONS 有权
标题翻译：共聚物稳定乳液
公开(公告)号：US20090208548A1
公开(公告)日：2009-08-20
申请号：US12391914
申请日：2009-02-24
申请人： THOMAS G. MASON , Timothy J. Deming , Jarrod A. Hanson , Connie B. Chang , Sara M. Graves
发明人： THOMAS G. MASON , Timothy J. Deming , Jarrod A. Hanson , Connie B. Chang , Sara M. Graves
IPC分类号： B01F3/08 , H01F1/00 , C09K19/06 , A01N25/04 , A61K9/10 , B32B5/00 , C12N11/02 , C12N5/00 , A61K8/04 , C08L89/00
CPC分类号： A61K9/113 , A61K47/183 , A61K47/34 , B01F17/005 , B82Y5/00 , Y02A50/401 , Y10S977/773 , Y10S977/795 , Y10S977/906 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T428/2984
摘要： An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid having an inner surface contained within the outer surface of the outer droplet of the first liquid, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the inner surface of the inner droplet. The block copolymers include a hydrophilic polymer block and a hydrophobic polymer block that act in combination to stabilize the droplet structure, and the first liquid is immiscible in the substantially continuous liquid medium.
摘要翻译：乳液包括基本上连续的液体介质和分散在基本上连续的液体介质内的多个液滴结构。多个液滴结构的每个液滴结构包括具有外表面的第一液体的外滴; 第二液体的内部液滴，其具有包含在第一液体的外部液滴的外表面内的内表面，第二液体在第一液体中不混溶，其中内部和外部液滴在其间具有边界表面区域; 设置在外部液滴的外表面上的嵌段共聚物的外层; 以及设置在内部液滴的内表面上的嵌段共聚物的内层。嵌段共聚物包括亲水聚合物嵌段和疏水性聚合物嵌段，其组合起作用以稳定液滴结构，并且第一液体在基本连续的液体介质中是不混溶的。

64. 发明授权

US07530940B2 Methods of enhancing radiation effects with metal nanoparticles 有权
标题翻译：用金属纳米粒子增强辐射效应的方法
公开(公告)号：US07530940B2
公开(公告)日：2009-05-12
申请号：US10705614
申请日：2003-11-10
申请人： James F. Hainfeld , Daniel N. Slatkin
发明人： James F. Hainfeld , Daniel N. Slatkin
IPC分类号： A61N5/00
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
摘要翻译：本发明提供使用直径为0.5-400nm的金属纳米粒子的方法，以增强X射线或其它类型辐射在消融诸如肿瘤的靶组织的治疗方案中的剂量和效力。金属纳米颗粒可以静脉内，动脉内或局部施用，以实现靶组织内和周围的特异性负载。金属纳米颗粒也可以连接到特异性结合靶组织的化学和/或生物化学部分。增强的辐射方法也可用于离体消融不需要的组织或细胞。

65. 发明申请

US20050256360A1 Methods of enhancing radiation effects with metal nanoparticles 有权
公开(公告)号：US20050256360A1
公开(公告)日：2005-11-17
申请号：US11186675
申请日：2005-07-21
申请人： James Hainfeld , Daniel Slatkin
发明人： James Hainfeld , Daniel Slatkin
IPC分类号： A61B6/00 , A61K41/00 , A61K47/48 , A61K49/22 , A61N1/40 , A61N5/00 , A61N5/06 , A61N5/10
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

66. 发明申请

US20050202064A1 Product of heat treatment of uronic acid, food, drink or drug including the product 审中-公开
标题翻译：产品的糖醛酸，食品，饮料或药物包括产品的热处理
公开(公告)号：US20050202064A1
公开(公告)日：2005-09-15
申请号：US11114071
申请日：2005-04-26
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
IPC分类号： A23L3/3562 , A61K8/60 , A61K31/19 , A61K31/70 , A61K31/7012 , A61K31/715 , A61K31/727 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/737 , A61K35/00 , A61K35/12 , A61K35/74 , A61K36/00 , A61L2/16 , A61P35/00 , A61Q11/00 , C07H7/033 , C08B37/00
CPC分类号： C07H7/033 , A61K8/60 , A61Q11/00 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.
摘要翻译：通过加热至少一种选自以下（a），（b）和（c）的物质而得到的产物。（a）糖醛酸或糖醛酸衍生物; （b）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质; 以及食品，饮料或药剂，其特征在于含有上述热处理产品。

67. 发明授权

US06613306B1 Ultrasound contrast agents and methods of making and using them 失效
标题翻译：超声造影剂及其使用方法
公开(公告)号：US06613306B1
公开(公告)日：2003-09-02
申请号：US09401838
申请日：1999-09-22
申请人： Michel Schneider , Feng Yan , Pascal Grenier , Jerome Puginier , Marie-Bernadette Barrau , Philippe Bussat , Eva Hybl , Daniel Bichon
发明人： Michel Schneider , Feng Yan , Pascal Grenier , Jerome Puginier , Marie-Bernadette Barrau , Philippe Bussat , Eva Hybl , Daniel Bichon
IPC分类号： A61B800
CPC分类号： A61K49/223 , Y10S977/929
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
摘要翻译：在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。它们含有表面活性剂和任选的亲水稳定剂。表面活性剂可以是脂质体的形式。通过在与水相混合之前或之后将表面活性剂暴露于空气或气体中来获得悬浮液。通过使用作为填充气体的填充气体，其在水中的溶解度，以标准条件下以升水表示的水分数除以平方根，可以赋予在超声波回波造影中用作造影剂的这些充气微泡的压力下突出的抵抗压力崩溃的抵抗力的分子量不超过0.003。还公开了具有特定气体混合物的对比剂，其具有有利的性质。

68. 发明授权

US06517869B1 Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake 有权
标题翻译：用于通过组织和细胞摄取递送生物活性剂的带正电荷的聚（α-（ω-氨基烷基）柠檬酸）
公开(公告)号：US06517869B1
公开(公告)日：2003-02-11
申请号：US09595691
申请日：2000-06-16
申请人： Jong-Sang Park , Min-Hyo Seo
发明人： Jong-Sang Park , Min-Hyo Seo
IPC分类号： A61K914
CPC分类号： A61K9/1647 , A61K47/34 , A61K47/593 , A61K47/60 , C08G63/6852 , C08L67/04 , Y10S977/724 , Y10S977/775 , Y10S977/788 , Y10S977/792 , Y10S977/793 , Y10S977/907 , Y10S977/915 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A biodegradable, positively-charged aminoalkyl polyester polymer for the delivery of bioactive agents, such as DNA, RNA, oligonucleotides is disclosed. Biologically active moieties, such as drugs, ligands, and the like, can be coupled to the free amino groups of the polymer.
摘要翻译：公开了用于递送生物活性剂如DNA，RNA，寡核苷酸的可生物降解的带正电荷的氨基烷基聚酯聚合物。生物活性部分，例如药物，配体等可以与聚合物的游离氨基偶联。

69. 发明申请

US20020061280A1 DIAGNOSTIC IMAGING OF LYMPH STRUCTURES 失效
标题翻译： LYMPH结构的诊断成像
公开(公告)号：US20020061280A1
公开(公告)日：2002-05-23
申请号：US09245828
申请日：1999-02-05
发明人： ROBERT F. MATTREY
IPC分类号： A61B005/055 , A61B008/00 , A61B008/12 , A61B008/14
CPC分类号： A61K49/223 , A61K49/225 , Y10S977/928 , Y10S977/929
摘要： In accordance with the present invention, there are provided methods for identifying the sentinel lymph node in a drainage field for a tissue or organ in a subject. In select embodiments, the invention allows for the identification of the first or sentinel lymph node that drains the tissue or organ, particularly those tissues associated with neoplastic or infectious diseases and disorders, and within the pertinent lymph drainage basin. Once the drainage basin from the tissue or organ, i.e., the sentinel lymph node, is identified, a pre-operative or intraoperative mapping of the affected lymphatic structure can be carried out with a contrast agent. Identification of the first or sentinel lymph node, on the most direct drainage pathway in the drainage field, can be accomplished by a variety of imaging techniques, including ultrasound, MRI, CT, nuclear and others. Moreover, once the lymphatic structure is identified as being associated with neoplastic or infectious diseases and disorders, the affected lymphatic structure can be removed surgically or by a suitable minimally invasive procedure to allow pathological analysis to be performed to determine whether certain diseases or disorders exist, without resort to more radical lymphadenectomy. Further, the agent can be made to carry diagnostic or therapeutic probes to be activated and/or delivered to the injection site or any part of the lymphatic pathway downstream from the injection site.
摘要翻译：根据本发明，提供了用于鉴定受试者中组织或器官的排水区域中的前哨淋巴结的方法。在选择的实施方案中，本发明允许鉴定排出组织或器官的第一或前哨淋巴结，特别是与肿瘤或感染性疾病和病症相关的那些组织以及相关的淋巴引流盆内。一旦从组织或器官即前哨淋巴结中排出流域，就可以用造影剂进行受影响的淋巴结构的术前或术中的映射。在排水领域最直接的排水路径上识别第一个或前哨淋巴结，可以通过各种成像技术，包括超声，MRI，CT，核等等来实现。此外，一旦淋巴结构被鉴定为与肿瘤或感染性疾病和病症相关，则可以通过手术或通过合适的微创手术来移除受影响的淋巴结构，以允许进行病理分析以确定是否存在某些疾病或病症，而不需要更根本的淋巴结清扫术。此外，可以使试剂携带要被激活和/或递送至注射部位的下游的注射部位或淋巴管道的任何部分的诊断或治疗探针。

70. 发明授权

US06375931B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US06375931B2
公开(公告)日：2002-04-23
申请号：US09291277
申请日：1999-04-14
申请人： Jonny Østensen , Morten Eriksen , Sigmund Frigstad , Pål Rongved
发明人： Jonny Østensen , Morten Eriksen , Sigmund Frigstad , Pål Rongved
IPC分类号： A61B800
CPC分类号： A61K49/223 , Y10S977/928 , Y10S977/929
摘要： Ultrasonic visualization of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.
摘要翻译：使用新型含气体的造影剂制剂，使用受试者的超声波可视化，特别是心肌和其他组织中的灌注进行，其在给药后在体内促进气相的可控和临时生长，因此可用作沉积的灌注示踪剂。制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

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