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61. 发明申请

US20030077780A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20030077780A1
公开(公告)日：2003-04-24
申请号：US10123215
申请日：2002-04-15
申请人： Genentech, Inc.
发明人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C12P021/02 , C12N005/06 , G01N033/53 , C07H021/04 , C12N009/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

62. 发明申请

US20030077716A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20030077716A1
公开(公告)日：2003-04-24
申请号：US10131813
申请日：2002-04-24
申请人： Genentech, Inc.
发明人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin l. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

63. 发明申请

US20030073214A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20030073214A1
公开(公告)日：2003-04-17
申请号：US10124822
申请日：2002-04-17
申请人： Genentech, Inc.
发明人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C12P021/02 , C12N005/06 , G01N033/53 , C07H021/04 , C12N009/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

64. 发明申请

US20030059909A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20030059909A1
公开(公告)日：2003-03-27
申请号：US10143032
申请日：2002-05-10
申请人： Genentech, Inc.
发明人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C12P021/02 , C12N005/06 , C07K014/435 , C07H021/04 , C12N009/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

65. 发明申请

US20030021794A1 Heat shock protein-based vaccines and immunotherapies 失效
标题翻译：基于热休克蛋白的疫苗和免疫治疗
公开(公告)号：US20030021794A1
公开(公告)日：2003-01-30
申请号：US09794517
申请日：2001-02-27
发明人： James E. Rothman , F. Ulrich Hartl , Mee H. Hoe , Alan Houghton , Yoshizumi Takechi , Mark Mayhew
IPC分类号： A61K039/00
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y10S530/828
摘要： The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heart shock protein in combination with one or more defined target antigens. These methods and compositions be used in the treatment of infectious diseases and cancers.
摘要翻译：本发明涉及用于在受试者中诱导免疫应答的方法和组合物，其中所述受试者与一种或多种所定义的靶抗原组合施用有效量的至少一种心脏休克蛋白。这些方法和组合物用于治疗感染性疾病和癌症。

66. 发明申请

US20030017563A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 有权
公开(公告)号：US20030017563A1
公开(公告)日：2003-01-23
申请号：US10140808
申请日：2002-05-07
申请人： Genentech, Inc.
发明人： Kevin P. Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Steven Sherwood , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , William I. Wood , Zemin Zhang
IPC分类号： C12P021/02 , C12N005/06 , C07H021/04 , C12N009/00 , C07K014/435
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K1/00 , C07K14/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K14/82 , C07K16/18 , C07K17/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N5/06 , C12N9/00 , C12N9/001 , C12N9/1051 , C12N15/00 , C12N2799/026 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5061 , G01N33/53 , G01N33/574 , G01N33/57484 , G01N33/68 , G01N33/6845 , G01N2800/042 , Y10S530/828 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

67. 发明授权

US06472143B1 Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex and its constituents 有权
标题翻译：人类激肽释放酶2（hK2）和蛋白酶抑制剂-6（PI-6）在前列腺肿瘤组织中的复合物及使用复合物及其成分的方法
公开(公告)号：US06472143B1
公开(公告)日：2002-10-29
申请号：US09667288
申请日：2000-09-22
申请人： Stephen D. Mikolajczyk , Mohammad S. Saedi
发明人： Stephen D. Mikolajczyk , Mohammad S. Saedi
IPC分类号： C12Q100
CPC分类号： C12N9/6445 , C07K14/8121 , Y10S436/803 , Y10S530/828
摘要： The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex and its constituents. The novel complexes of hK2 and PI-6 of the present invention and the PI-6 exist at an elevated level in prostate cancer tissues. PI-6 also exists at an elevated level in other types of cancer cells. Therefore, the hK2-PI6 complexes and PI-6 of the present invention may be used as a serum marker for detecting cancers, particularly prostate cancer. They may also be used as an immunohistological marker to detect prostate cancer tissues. In accordance with the present invention, the hK2-PI6 complexes of the present invention may be detected in patient tissue samples by immunohistochemical and/or in patient fluid samples by in vitro immunoassay procedures. Diagnostic methods for detecting the existence of prostate cancer is also provided.
摘要翻译：本发明提供了hK2和PI-6的新型复合物以及使用该新型复合物及其成分的方法。本发明的hK2和PI-6和PI-6的新型复合物在前列腺癌组织中的升高水平存在。其他类型的癌细胞中PI-6也存在于升高的水平。因此，本发明的hK2-PI6复合物和PI-6可以用作检测癌症，特别是前列腺癌的血清标志物。它们也可以用作检测前列腺癌组织的免疫组织学标记。根据本发明，本发明的hK2-PI6复合物可以通过免疫组织化学和/或在患者流体样品中通过体外免疫测定方法在患者组织样品中检测。还提供了用于检测前列腺癌存在的诊断方法。

68. 发明授权

US06468546B1 Compositions and methods for therapy and diagnosis of ovarian cancer 失效
标题翻译：卵巢癌的治疗和诊断的组成和方法
公开(公告)号：US06468546B1
公开(公告)日：2002-10-22
申请号：US09404879
申请日：1999-09-24
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/70532 , C07K2319/00 , Y02A50/472 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译：公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。

69. 发明申请

US20020150893A1 Prostate-specific polypeptide pamp and encoding nucleic acid molecules 有权
标题翻译：前列腺特异性多肽疫苗和编码核酸分子
公开(公告)号：US20020150893A1
公开(公告)日：2002-10-17
申请号：US09729653
申请日：2000-12-04
发明人： Biaoyang Lin
IPC分类号： C12Q001/68 , G01N033/574 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： C07K14/47 , Y10S530/828
摘要： The present invention relates to novel prostate specific nucleic acid molecules and polypeptides and related methods for diagnosing or predicting susceptibility to a prostate neoplastic condition.
摘要翻译：本发明涉及新的前列腺特异性核酸分子和多肽以及用于诊断或预测对前列腺肿瘤病症易感性的相关方法。

70. 发明授权

US06447781B1 Therapeutic and prophylactic methods using heat shock proteins 失效
标题翻译：使用热休克蛋白的治疗和预防方法
公开(公告)号：US06447781B1
公开(公告)日：2002-09-10
申请号：US09545352
申请日：2000-04-07
申请人： Pramod K. Srivastava
发明人： Pramod K. Srivastava
IPC分类号： A61K39385
CPC分类号： C07K14/47 , A61K38/00 , A61K39/0011 , A61K2039/6043 , A61K2039/622 , Y02A50/403 , Y02A50/41 , Y02A50/466 , Y02A50/478 , Y10S530/82 , Y10S530/822 , Y10S530/823 , Y10S530/824 , Y10S530/825 , Y10S530/826 , Y10S530/827 , Y10S530/828
摘要： The present invention relates to immunogenic complexes of heat shock proteins (hsp) noncovalently bound to exogenous antigenic molecules which when administered to an individual elicit specific immunological responses in the host. Methods of prevention and treatment of cancer and infectious disease are provided.
摘要翻译：本发明涉及非共价结合于外源抗原分子的热休克蛋白（hsp）的免疫原性复合物，其在给予个体时在宿主中引发特异性免疫应答。提供了预防和治疗癌症和传染病的方法。

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