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61. 发明授权

US08158422B2 Erythroid cells producing adult-type β-hemoglobin generated from human embryonic stem cells 有权
标题翻译：由人胚胎干细胞产生的产生成人型和血红蛋白的红细胞
公开(公告)号：US08158422B2
公开(公告)日：2012-04-17
申请号：US11672724
申请日：2007-02-08
申请人： Igor I. Slukvin , James A. Thomson , Maksym A. Vodyanyk , Maryna E. Gumenyuk
发明人： Igor I. Slukvin , James A. Thomson , Maksym A. Vodyanyk , Maryna E. Gumenyuk
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0641 , C12N2500/25 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2501/39 , C12N2502/1394 , C12N2506/02
摘要： Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
摘要翻译：通过在无血清培养条件下培养来自胚胎干细胞的CD31 +，CD31 + / CD34 +或CD34 +细胞产生成人和血红蛋白的红细胞的方法和组合物。

62. 发明申请

US20120083034A1 EX HOST MATURATION OF GERMLINE STEM CELLS 有权
标题翻译： GERMLINE干细胞的主要成熟
公开(公告)号：US20120083034A1
公开(公告)日：2012-04-05
申请号：US12940894
申请日：2010-11-05
申请人： FARIBORZ IZADYAR , JOHNNY YUNG-CHIONG CHOW , CONSTANCE YUEN
发明人： FARIBORZ IZADYAR , JOHNNY YUNG-CHIONG CHOW , CONSTANCE YUEN
IPC分类号： C12N5/076 , C12N5/075
CPC分类号： C12N5/0609 , C12N5/061 , C12N2500/25 , C12N2500/30 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/10 , C12N2501/11 , C12N2501/119 , C12N2501/125 , C12N2501/13 , C12N2501/15 , C12N2501/235 , C12N2501/31 , C12N2501/385 , C12N2501/998 , C12N2509/00 , C12N2533/54 , C12N2533/90
摘要： Methods are provided for the ex host maturation of immature germline cells into haploid gametes for restoration of fertility in patients in need thereof.
摘要翻译：提供了用于将未成熟种系细胞的前宿主成熟成为单倍体配子的方法，用于在有需要的患者中恢复生育力。

63. 发明申请

US20120040458A1 METHOD FOR PRODUCING DENDRITIC CELLS 有权
标题翻译：生产细胞的方法
公开(公告)号：US20120040458A1
公开(公告)日：2012-02-16
申请号：US13127753
申请日：2009-11-13
申请人： Yoshikazu Yonemitsu , Yasuji Ueda , Yui Harada
发明人： Yoshikazu Yonemitsu , Yasuji Ueda , Yui Harada
IPC分类号： C12N5/0784
CPC分类号： C12N5/0639 , A61K39/00 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26
摘要： An objective of the present invention is to provide methods for producing dendritic cells (DCs), which comprise the step of culturing DC precursor cells in the presence of a plurality of cytokines, produced dendritic cells, and uses thereof.The present inventors discovered that dendritic cells with a high IL-12 productivity can be obtained by culturing DC precursor cells in the presence of a plurality of cytokines, followed by about one week of culture in the presence of GM-CSF and IL-4. The present invention enables preparation of a large amount of DCs with a high IL-12 productivity from a small number of DC precursor cells, and therefore makes it easier to increase the number of DCs for administration in DC-based anti-tumor immune therapy, treatment of infections, etc. Thus, the effect of DC vaccines is expected to be enhanced.
摘要翻译：本发明的目的是提供用于制备树突状细胞（DC）的方法，其包括在多种细胞因子，产生的树突状细胞的存在下培养DC前体细胞的步骤及其应用。本发明人发现通过在多种细胞因子的存在下培养DC前体细胞，然后在GM-CSF和IL-4存在下培养约1周，可获得具有高IL-12生产能力的树突状细胞。本发明能够从少量的DC前体细胞制备大量具有高IL-12生产能力的DC，因此可以更容易地增加DC-抗肿瘤免疫治疗中用于给药的DC数量，治疗感染等。因此，预期DC疫苗的效果将得到提高。

64. 发明申请

US20120014933A1 Method for Producing Platelets 有权
标题翻译：血小板生成方法
公开(公告)号：US20120014933A1
公开(公告)日：2012-01-19
申请号：US13132527
申请日：2009-12-04
申请人： Dominique Baruch , Elisabeth Cramer-Borde , Claire Dunois
发明人： Dominique Baruch , Elisabeth Cramer-Borde , Claire Dunois
IPC分类号： A61K35/14 , A61P7/00 , C12M1/00 , C12N5/078 , C12Q1/02
CPC分类号： C12N5/0644 , A61K2035/124 , C12N2501/125 , C12N2501/145 , C12N2521/00 , C12N2533/50
摘要： The present invention relates to a method for producing platelets from mature megakaryocytes. More particularly, the invention relates to an ex vivo method for producing platelets, from mature megakaryocytes, said method comprising a step of subjecting a suspension of mature megakaryocytes to a flow having a minimal shear rate of 600 s−1 on a solid phase coated with Von Willebrand factor.
摘要翻译：本发明涉及从成熟巨核细胞产生血小板的方法。更具体地，本发明涉及从成熟巨核细胞产生血小板的离体方法，所述方法包括将成熟巨核细胞的悬浮液在涂覆有固体相的固相上经受600s-1最小剪切速率的流动的步骤 Von Willebrand因子

65. 发明申请

US20110293574A1 Hematopoietic stem cell growth factor 审中-公开
标题翻译：造血干细胞生长因子
公开(公告)号：US20110293574A1
公开(公告)日：2011-12-01
申请号：US12998208
申请日：2009-09-28
申请人： John P. Chute , Heather Himburg
发明人： John P. Chute , Heather Himburg
IPC分类号： A61K35/12 , A61K38/18 , A61P7/00 , C12N5/0789
CPC分类号： A61K38/18 , C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2502/28
摘要： The present invention relates, in general, to stem cells and, in particular, to a hematopoietic stem cell (HSC) growth factor and to methods of using same.
摘要翻译：本发明一般涉及干细胞，特别是造血干细胞（HSC）生长因子及其使用方法。

66. 发明申请

US20110236971A2 Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions 审中-公开
标题翻译：在无血清条件下产生克隆间充质祖细胞和间充质干细胞系
公开(公告)号：US20110236971A2
公开(公告)日：2011-09-29
申请号：US12726814
申请日：2010-03-18
申请人： Maksym Vodyanyk , Igor Slukvin
发明人： Maksym Vodyanyk , Igor Slukvin
IPC分类号： C12N5/0775
CPC分类号： C12N5/0662 , C12N5/0647 , C12N5/069 , C12N5/0692 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/135 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/23 , C12N2502/1394 , C12N2506/02 , C12N2506/45 , C12N2533/54 , C12N2533/70 , C12N2533/78
摘要： Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed
摘要翻译：公开了在无血清条件下获得多能Apelin受体阳性外侧板中胚层细胞，间充质干细胞和成血管细胞的方法

67. 发明申请

US20110223668A1 Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) 审中-公开
标题翻译：促进间充质前体细胞（MPC）增殖和/或存活的方法
公开(公告)号：US20110223668A1
公开(公告)日：2011-09-15
申请号：US12924008
申请日：2010-09-16
申请人： Stan Gronthos , Andrew Christopher William Zannettino
发明人： Stan Gronthos , Andrew Christopher William Zannettino
IPC分类号： C12N15/00 , C12N5/077
CPC分类号： C12N5/0652 , C12N5/0663 , C12N2501/125 , C12N2501/135 , C12N2501/22 , C12N2501/2301 , C12N2501/2303 , C12N2501/2306 , C12N2501/25 , C12N2501/999 , C12N2502/13
摘要： The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.
摘要翻译：本发明涉及在体外或体内增强间充质前体细胞（MPC）和/或其衍生的后代的增殖和/或存活的方法，包括将MPC或后代暴露于SDF-1或其类似物。本发明还涉及包含分离的MPC或由其衍生的后代和SDF-1或其类似物的组合物。本发明还涉及使用这些方法和组合物用于哺乳动物体内或体内骨形成。

68. 发明授权

US07985550B2 Methods of isolating methylated CpG islands 失效
标题翻译：分离甲基化CpG岛的方法
公开(公告)号：US07985550B2
公开(公告)日：2011-07-26
申请号：US12350159
申请日：2009-01-07
申请人： Andrew P. Feinberg , Liora Strichman-Almashanu , Shan Jiang
发明人： Andrew P. Feinberg , Liora Strichman-Almashanu , Shan Jiang
IPC分类号： C12Q1/68
CPC分类号： C12N5/0611 , C12N2501/115 , C12N2501/125 , C12N2501/235 , C12N2501/385 , C12N2502/13 , C12N2503/00 , C12N2503/02 , C12N2510/00 , C12N2517/00 , C12Q1/6827 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154
摘要： Provided is a method for isolating methylated CpG islands. The method includes identifying an imprinted gene adjacent to the methylated CpG island, and identifying a disease which is preferentially transmitted by one parent and which is genetically linked to region of genomic DNA which contains the imprinted gene, whereby the imprinted gene is thereby indicated as a candidate gene involved in transmitting the disease.
摘要翻译：提供了分离甲基化CpG岛的方法。该方法包括鉴定与甲基化CpG岛相邻的印迹基因，以及鉴定由一个亲本优先传播并与遗传上连接到含有印迹基因的基因组DNA区域的疾病，从而将印迹基因表示为候选基因涉及传播疾病。

69. 发明申请

US20110151554A1 METHOD FOR CULTURING AND SUBCULTURING PRIMATE EMBRYONIC STEM CELL, AS WELL AS METHOD FOR INDUCING DIFFERENTIATION THEREOF 审中-公开
标题翻译：用于培养和再培养原始胚胎干细胞的方法，作为诱导其差异的方法
公开(公告)号：US20110151554A1
公开(公告)日：2011-06-23
申请号：US12514207
申请日：2007-11-09
申请人： Akira Yuo , Kumiko Tobe , Koichi Saeki , Masako Nakahara , Naoko Nakamura , Yoshiko Yogisashi , Satoko Matsuyama , Asako Yoneda
发明人： Akira Yuo , Kumiko Tobe , Koichi Saeki , Masako Nakahara , Naoko Nakamura , Yoshiko Yogisashi , Satoko Matsuyama , Asako Yoneda
IPC分类号： C12N5/0735 , C12N5/078 , C12N5/071 , C12N5/0789
CPC分类号： C12N5/0606 , C12N5/0634 , C12N2500/84 , C12N2501/105 , C12N2501/115 , C12N2501/125 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2506/02 , C12N2509/00 , C12N2533/90
摘要： The present invention provides a method for subculturing primate embryonic stem cells, and a method for inducing differentiation of the same cell into a vascular endothelial cell and a blood cell. The present invention provides a method comprising culturing primate embryonic stem cells in a medium containing a protein component without using feeder cells and cytokines in a container coated with an extracellular matrix, detaching colonies of the resulting embryonic stem cells in the presence of a cytodetachment agent, and plating the colonies in the similar medium, and a method comprising culturing primate embryonic stem cells in a serum-containing or not containing medium in the presence of cytokine, adhesion-culturing the resulting embryoid body or embroyid body-analogous cellular aggregate in the presence of a cytokine to obtain specific precursor cells, and separating non-adherent cells and adherent cells from the specific precursor cells to obtain blood cells and vascular endothelial precursor cells.
摘要翻译：本发明提供了用于传代培养灵长类动物胚胎干细胞的方法，以及诱导将相同细胞分化成血管内皮细胞和血细胞的方法。本发明提供了一种方法，其包括在含有蛋白质组分的培养基中培养灵长类动物胚胎干细胞，而不在包被细胞外基质的容器中使用饲养细胞和细胞因子，在细胞分析剂存在下分离所得胚胎干细胞的集落，并将菌落电镀在相似的培养基中，以及包括在存在细胞因子的情况下在含有血清的或不含有培养基中培养灵长类动物胚胎干细胞的方法，在存在的情况下粘附培养所得到的类胚体或刺激体类似的细胞聚集体的细胞因子以获得特异性前体细胞，并从特异性前体细胞分离非贴壁细胞和贴壁细胞以获得血细胞和血管内皮前体细胞。

70. 发明申请

US20110136230A1 Cultured Hematopoietic Stem Cells and Method for Expansion and Analysis Thereof 失效
标题翻译：培养造血干细胞及其扩增和分析方法
公开(公告)号：US20110136230A1
公开(公告)日：2011-06-09
申请号：US12830709
申请日：2010-07-06
申请人： Chengcheng Zhang , Harvey Lodish
发明人： Chengcheng Zhang , Harvey Lodish
IPC分类号： C12N5/00
CPC分类号： C12N5/0647 , A61K2035/124 , C12N2500/90 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/91
摘要： Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor(IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said cells. Methods for identifying expanded hematopoeitc stem cells and kits for ex vivo expansion of hematopoietic stem cells are also provided.
摘要翻译：提供造血干细胞和造血干细胞离体扩增的方法。所述方法包括在足以扩展所述细胞的条件下在含有有效量胰岛素样生长因子（IGF），成纤维细胞生长因子（FGF），血小板生成素（TPO）和干细胞因子（SCF））的培养基中培养细胞。还提供了用于鉴定扩大造血干细胞的方法和用于造血干细胞离体扩增的试剂盒。

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