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61. 发明授权

US09650436B2 Antibody based reagents that specifically recognize toxic oligomeric forms of tau 有权
公开(公告)号：US09650436B2
公开(公告)日：2017-05-16
申请号：US14434742
申请日：2013-10-15
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： Michael Sierks , Huilai Tian
IPC分类号： C07K16/18 , G01N33/68 , C07K16/00 , C12N15/10 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/30 , C07K2317/62 , C07K2317/622 , C07K2317/76 , C12N15/1037 , G01N33/6896 , G01N2333/47 , G01N2333/4703 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/7047
摘要： The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomelic tau, fibrillar tau or non-disease associated forms of tau.

62. 发明授权

US09631191B2 System for production of antibodies and their derivatives 有权
公开(公告)号：US09631191B2
公开(公告)日：2017-04-25
申请号：US14094109
申请日：2013-12-02
申请人： Alexey Gennadievich Zdanovsky
发明人： Alexey Gennadievich Zdanovsky
IPC分类号： C12N5/10 , C12N15/13 , C12N15/85 , C12P21/04 , C12P21/08 , C12N15/10 , C12Q1/66 , G01N33/68 , C07K16/12
CPC分类号： C12N15/1037 , C07K16/1282 , C12Q1/66 , G01N33/6845 , G01N33/6854 , G01N2333/33
摘要： The present disclosure provides methods and compositions for the production of chimeric antibodies that specifically bind an antigen of interest.

63. 发明授权

US09587237B2 Compositions, methods, and computer systems related to making and administering modified T cells 有权
标题翻译：与制备和施用修饰的T细胞相关的组合物，方法和计算机系统
公开(公告)号：US09587237B2
公开(公告)日：2017-03-07
申请号：US13804224
申请日：2013-03-14
申请人： Elwha LLC
发明人： Roderick A. Hyde , Wayne R. Kindsvogel , Gary L. McKnight
IPC分类号： C12N15/10
CPC分类号： C12N15/1037 , C12N15/1093
摘要： Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.
摘要翻译：本文描述的实施例涉及用于推导T CAR图书馆（通用主题或个人主题）的方法，装置和计算机系统，用于个体化治疗受试者的疾病。在某些实施方案中，利用正常和患病组织表达数据的差异筛选来确定疾病特异性抗原，从而产生对这种抗原反应的T CAR细胞以形成疾病特异性文库。在某些实施方案中，来自疾病特异性文库的最有效的T CAR克隆的测定是基于受试者自己的疾病特异性抗原。在某些实施方案中，用治疗有效量的T CAR克隆治疗受试者。

64. 发明申请

US20170058275A1 PLATFORM AND METHOD FOR IDENTIFYING PAST EXPOSURE TO CHEMICAL AGENTS OR HEAVY METALS 有权
标题翻译：用于识别化学试剂或重金属的过度曝光的平台和方法
公开(公告)号：US20170058275A1
公开(公告)日：2017-03-02
申请号：US15249842
申请日：2016-08-29
申请人： The Johns Hopkins University
发明人： Mekbib Astatke
IPC分类号： C12N15/10 , G01N33/68 , C12Q1/68 , G01N33/543 , G01N33/564
CPC分类号： C12N15/1037 , C12N15/1065 , C12Q1/6804 , C12Q1/6883 , G01N33/6845 , G01N2800/42
摘要： A method for determining past exposure to chemical agents or heavy metals may include coating a capture material with a capture reagent. The capture reagent may be selected based on an ability of the capture reagent to bind with a target antibody, and the target antibody may be an indicator associated with a particular chemical agent or heavy metal. The method may further include interrogating a clinical sample associated with an individual by forming a mixture of the capture material and the clinical sample, and determining an exposure status of the individual to the particular chemical agent or heavy metal based on whether the capture material demonstrates capture of the indicator.
摘要翻译：用于确定过去暴露于化学试剂或重金属的方法可以包括用捕获试剂涂覆捕获材料。可以基于捕获试剂与靶抗体结合的能力来选择捕获试剂，并且靶抗体可以是与特定化学试剂或重金属相关联的指示剂。该方法还可以包括通过形成捕获材料和临床样品的混合物来询问与个体相关的临床样品，以及基于捕获材料是否显示捕获来确定个体对特定化学试剂或重金属的暴露状态的指标。

65. 发明授权

US09567373B2 Methods of constructing and screening libraries of peptide structures 有权
标题翻译：构建和筛选肽结构文库的方法
公开(公告)号：US09567373B2
公开(公告)日：2017-02-14
申请号：US14038660
申请日：2013-09-26
申请人： Phylogica Limited
发明人： Paul Michael Watt , Roland Dunbrack
IPC分类号： C40B40/10 , C07K14/00 , C07K1/04 , C12N15/10 , C40B30/02 , C07K1/00 , C07K7/08
CPC分类号： C07K1/047 , C07K1/00 , C07K7/08 , C07K14/001 , C12N15/1037 , C12N15/1072 , C12N15/1089 , C12Q1/18 , C40B30/02 , C40B40/10 , G01N33/6824 , G01N33/6845 , G01N2500/10 , G06F19/18 , G06F19/22
摘要： The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
摘要翻译：本发明提供用于生产用于药物筛选应用的肽结构库的方法，其能够独立于衍生自其的蛋白质中的人造支架或侧翼序列折叠或假定其天然构象。图书馆可以是高度多样化的，因为它们代表了自然界中存在的蛋白质结构的所有组成部分。这些库也可以是非冗余的或归一化的，使得存在于源数据集中和/或本质上的特定结构的偏移被删除。在特别优选的实施方案中，本发明提供了通过该方法制备的30,000个独立折叠结构。本发明还提供计算机可读介质和包含与肽库相关的结构数据的系统，以及显示和筛选文库的方法。

66. 发明申请

US20170029812A1 GENETICALLY ENGINEERED POLYMER LIBRARIES AND METHODS OF USING THEM 审中-公开
标题翻译：遗传工程聚合物图书馆及其使用方法
公开(公告)号：US20170029812A1
公开(公告)日：2017-02-02
申请号：US15115212
申请日：2015-01-28
申请人： LOS ALAMOS NATIONAL SECURITY, LLC
发明人： Jennifer S. Martinez , Devin W. Close , Antonietta M. Lillo , Eva Rose Murdock Balog , Csaba Kiss , Reginaldo C. Rocha , Andrew R.M. Bradbury , Koushik Ghosh , Prakash Sista , Hsing-Lin Wang , Charlie E. Strauss
IPC分类号： C12N15/10 , C07K7/06 , C07K1/04 , C07K7/08
CPC分类号： C12N15/1037 , C07K1/047 , C07K7/06 , C07K7/08 , C07K2319/00 , G01N33/6845
摘要： Disclosed herein are methods of identifying polymers having particular biological or physical characteristics from in vivo generated libraries of polymers. Methods of generating in vivo polymer libraries are also described. Polymers identified using the methods of the invention are also described.
摘要翻译：本文公开了从体内产生的聚合物文库鉴定具有特定生物或物理特征的聚合物的方法。还描述了产生体内聚合物文库的方法。还描述了使用本发明的方法鉴定的聚合物。

67. 发明授权

US09546359B2 Method for engineering proteases and protein kinases 有权
标题翻译：蛋白酶和蛋白激酶的工程方法
公开(公告)号：US09546359B2
公开(公告)日：2017-01-17
申请号：US14576766
申请日：2014-12-19
申请人： Research Development Foundation
发明人： Brent Iverson , George Georgiou , Joseph M. Taft , Li Yi
IPC分类号： C12N15/81 , C12N9/50 , C12N15/10 , C12N9/12
CPC分类号： C12N9/50 , C12N9/12 , C12N15/1037 , C12N15/1058 , C12N15/81 , C12N2800/60 , C12N2810/40
摘要： Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects, TEV proteases with altered substrate specificity, potency, and/or efficiency are provided.
摘要翻译：提供蛋白质工程的方法，如工程蛋白酶或激酶。该方法可以利用蛋白质或底物的酵母显示和/或ER螯合。在一些方面，提供具有改变的底物特异性，效力和/或效率的TEV蛋白酶。

68. 发明申请

US20160362683A1 Recombinant Fusion Proteins and Libraries from Immune Cell Repertoires 审中-公开
公开(公告)号：US20160362683A1
公开(公告)日：2016-12-15
申请号：US15156226
申请日：2016-05-16
申请人： Gigagen, Inc.
发明人： David Scott Johnson , Adam Adler , Rena Mizrahi
IPC分类号： C12N15/10 , C07K16/00 , C12Q1/68
CPC分类号： C12N15/1037 , C07K14/7051 , C07K16/00 , C07K2317/14 , C07K2317/622 , C12N15/1075 , C12N15/1093 , C12Q1/6876 , C40B50/06
摘要： Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.

69. 发明申请

US20160362476A1 METHODS AND COMPOSITIONS FOR PRODUCING A CHIMERIC POLYPEPTIDE 有权
标题翻译：用于生产半固化多肽的方法和组合物
公开(公告)号：US20160362476A1
公开(公告)日：2016-12-15
申请号：US15175739
申请日：2016-06-07
申请人： AxioMx, Inc.
发明人： Michael WEINER , Margaret KISS , Melissa BATONICK
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/35 , C07K2317/51 , C07K2317/515 , C07K2317/622 , C07K2319/00 , C12N15/1037 , C12N15/63
摘要： The present invention provides methods and compositions for converting a first polypeptide into a chimeric polypeptide. The invention includes two vectors: a first vector including the sequence of the first polypeptide and a second vector including a second polypeptide. The vectors include complementary site-specific recombination motifs such that site-specific recombination between the two vectors results in the generation of a chimeric polypeptide including at least a portion of the first polypeptide and at least a portion of the second polypeptide. A site-specific recombination motif may be positioned within an intron or within a coding sequence on the first or second vector.
摘要翻译：本发明提供了将第一多肽转化为嵌合多肽的方法和组合物。本发明包括两个载体：包含第一多肽的序列的第一载体和包含第二多肽的第二载体。载体包括互补位点特异性重组基序，使得两个载体之间的位点特异性重组导致产生嵌合多肽，其包括第一多肽的至少一部分和第二多肽的至少一部分。位点特异性重组基序可以位于第一或第二载体的内含子内或编码序列内。

70. 发明申请

US20160348096A1 NEGATIVE SELECTION AND STRINGENCY MODULATION IN CONTINUOUS EVOLUTION SYSTEMS 审中-公开
标题翻译：连续演化系统中的负选择和码率调制
公开(公告)号：US20160348096A1
公开(公告)日：2016-12-01
申请号：US15112759
申请日：2015-01-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： David R. Liu , Jacob Charles Carlson , Ahmed Hussein Badran , Kevin Michael Esvelt
IPC分类号： C12N15/10
CPC分类号： C12N15/1058 , C12N7/00 , C12N15/01 , C12N15/1024 , C12N15/1037 , C12N15/64 , C12N15/70 , C12N2795/14121 , C12N2795/14152 , C40B10/00 , C40B50/06
摘要： Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and/or positive selection of desired properties.
摘要翻译：本文提供了用于噬菌体辅助连续进化的策略，系统，方法，试剂和试剂盒。这些包括策略，系统，方法，试剂和试剂盒，允许进行严格调节以产生弱活性或非活性生物分子变体，阴性选择不期望的性质和/或所需性质的正选择。

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