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61. 发明授权

US5597485A Process for separating proteins 失效
标题翻译：分离蛋白质的方法
公开(公告)号：US5597485A
公开(公告)日：1997-01-28
申请号：US365068
申请日：1994-12-27
申请人： Jorge A. Mazza , Pablo Outumuro
发明人： Jorge A. Mazza , Pablo Outumuro
IPC分类号： B01D15/08 , B01J20/26 , B01J20/32 , C09B69/10
CPC分类号： C09B69/10 , B01D15/3804 , B01J20/261 , B01J20/264 , B01J20/28014 , B01J20/286 , B01J20/289 , B01J20/3092 , B01J20/321 , B01J20/3217 , B01J20/3219 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J2220/49 , B01J2220/54 , B01J2220/58
摘要： Disclosed is a process of separating protein using a polymeric composition. The composition includes a polymer formed from at least one monomer containing a polymerizable moiety chemically bonded to an anionic organic dye. The dye has an affinity for the protein to be separated. The process includes retaining the protein on the dye fraction and recovering the protein from the polymer.
摘要翻译：公开了使用聚合物组合物分离蛋白质的方法。该组合物包括由至少一种含有与阴离子有机染料化学键合的可聚合部分的单体形成的聚合物。该染料对于蛋白质具有亲和力被分离。该方法包括将蛋白质保留在染料部分上并从聚合物中回收蛋白质。

62. 发明授权

US5547760A Compositions and processes for separating and concentrating certain ions from mixed ion solutions using ion-binding ligands bonded to membranes 失效
标题翻译：使用与膜结合的离子结合配体将某些离子与混合离子溶液分离和浓缩的组合物和方法
公开(公告)号：US5547760A
公开(公告)日：1996-08-20
申请号：US233640
申请日：1994-04-26
申请人： Bryon J. Tarbet , Ronald L. Bruening , Anthony J. Di Leo , Philip M. Goddard , Louis M. Scarmoutzos
发明人： Bryon J. Tarbet , Ronald L. Bruening , Anthony J. Di Leo , Philip M. Goddard , Louis M. Scarmoutzos
IPC分类号： B01D61/00 , B01D67/00 , B01D69/02 , B01D71/82 , B01J20/32 , B01J39/04 , B01J39/18 , B01J45/00 , C02F1/42 , C08J5/22 , G21F9/04 , B32B27/00
CPC分类号： B01D67/0093 , B01J20/24 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28033 , B01J20/28078 , B01J20/28097 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3251 , B01J20/3282 , B01J45/00 , G21F9/04 , B01D2323/30 , B01J2220/4825 , Y10T428/3154 , Y10T428/31544 , Y10T428/31739 , Y10T428/31913 , Y10T428/31935 , Y10T428/31938 , Y10T428/31971
摘要： A method for removing, separating, and concentrating certain selected ions from a source solution that may contain larger concentrations of other ions comprises bringing the source solution in contact with a composition comprising an ion-binding ligand covalently bonded to a membrane having hydrophilic surface properties. The ligand portion of the composition has affinity for and forms a complex with the selected ions, thereby removing them from the source solution. The selected ions are then removed from the composition through contact with a much smaller volume of a receiving solution in which the selected ions are either soluble or which has greater affinity for the selected ions than does the ligand portion of the composition, thereby quantitatively stripping the complexed ions from the ligand and recovering them in concentrated form in the receiving solution. The concentrated ions thus removed may be further separated and recovered by known methods. The process is useful in the removal of selected ions, including noble metals and other transition metals from a variety of source solutions such as are encountered in semiconductor, nuclear waste cleanup, metals refining, environmental cleanup, providing ultra high purity fluids, electric power, and other industrial enterprises. The invention is also drawn to the ligand-membrane compositions.
摘要翻译：用于从可能含有较大浓度的其它离子的源溶液中去除，分离和浓缩某些选定离子的方法包括使源溶液与包含共价键合到具有亲水表面性质的膜的离子结合配体的组合物接触。组合物的配体部分与所选择的离子具有亲和力并与选择的离子形成复合物，从而将其从源溶液中除去。然后通过与少量体积的接收溶液（其中所选择的离子是可溶的或对组合物的配体部分具有比选择的离子更大的亲和力）与组合物的配体部分接触来从组合物中除去选定的离子，从而定量地剥离从配体中复合离子并将其以浓缩形式在接收溶液中回收。这样除去的浓缩离子可以通过已知的方法进一步分离和回收。该方法可用于从各种源解决方案中去除选定的离子，包括贵金属和其他过渡金属，例如半导体遇到的核废料清理，金属精炼，环境清洁，提供超高纯度流体，电力，等工业企业。本发明还涉及配体 - 膜组合物。

63. 发明授权

US5514668A Composition for removing or inactivating harmful components in blood or other extracellular body fluids 失效
标题翻译：用于去除或灭活血液或其他细胞外体液中的有害成分的组合物
公开(公告)号：US5514668A
公开(公告)日：1996-05-07
申请号：US205629
申请日：1994-03-04
申请人： Henry M. Christensen , Hans B. Andreasen
发明人： Henry M. Christensen , Hans B. Andreasen
IPC分类号： A61K31/335 , A61K31/00 , A61K31/075 , A61K31/357 , A61K31/715 , A61L2/00 , A61P31/12 , A61P39/02 , B01J20/32 , C07D323/00 , C08B37/02
CPC分类号： C08B37/0021 , A61L2/0088 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B01J2220/4825 , Y10S514/832 , Y10S514/833 , Y10S514/836
摘要： A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crown ether compound substituted on a polysaccharide, preferably dextran. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.
摘要翻译：用于从血液或其它细胞外液体中去除或灭活包括病毒的有害成分的组合物包括在多糖上优选葡聚糖取代的冠醚化合物。该组合物可溶于水，优选用于荚膜内施用，或不溶于体外应用。

64. 发明授权

US5456835A Device and process for removing free hemoglobin from blood 失效
标题翻译：从血液中除去游离血红蛋白的装置和方法
公开(公告)号：US5456835A
公开(公告)日：1995-10-10
申请号：US148883
申请日：1993-11-08
申请人： Franco Castino , Abdul R. M. Azad , Eric K. Lee
发明人： Franco Castino , Abdul R. M. Azad , Eric K. Lee
IPC分类号： A61M1/02 , B01D39/16 , B01D67/00 , B01D69/08 , B01D71/68 , B01D71/82 , B01J20/32 , G01N33/50 , B01D37/00 , B01D15/00 , B01D39/04 , B01D39/08
CPC分类号： B01D67/0093 , B01D39/1623 , B01D69/08 , B01D71/68 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/28014 , B01J20/28023 , B01J20/28028 , B01J20/28033 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3293 , G01N33/5002 , A61M2202/0439 , Y10S530/814 , Y10S530/816 , Y10T436/25375
摘要： A filter and a hollow-fiber or flat-sheet membrane for removing hemoglobin from whole blood or blood fractions are disclosed. The filter comprises a laid textile web which has been modified to attach a ligand for hemoglobin. The membrane comprises a polyethersulfone membrane that has been similarly modified. Methods for removing hemoglobin, cellular components and debris from blood are also disclosed.
摘要翻译：公开了一种用于从全血或血液部分去除血红蛋白的过滤器和中空纤维或平片膜。过滤器包括经修饰以连接血红蛋白配体的铺设的纺织网。膜包括已经类似地改性的聚醚砜膜。还公开了从血液中除去血红蛋白，细胞成分和碎屑的方法。

65. 发明授权

US5401415A Adsorption material for the selective removal of LDL and/or vLDL and method of using therefor 失效
标题翻译：用于选择性去除LDL和/或vLDL的吸附材料及其使用方法
公开(公告)号：US5401415A
公开(公告)日：1995-03-28
申请号：US955881
申请日：1992-12-11
申请人： Andreas Rauh , Waltraud Sichler , Gudrun Henke , Wolfgang Feller , Gerold Morsch , Susan Koch
发明人： Andreas Rauh , Waltraud Sichler , Gudrun Henke , Wolfgang Feller , Gerold Morsch , Susan Koch
IPC分类号： B01J20/02 , A61M1/36 , B01J20/22 , B01J20/26 , B01J20/281 , B01J20/32 , B01D15/00 , B01D15/08 , C07K3/18 , C07K3/20
CPC分类号： B01J20/28061 , B01J20/28004 , B01J20/28085 , B01J20/286 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J2220/54 , B01J2220/58 , B01J2220/66
摘要： An adsorption material for selectively removing Lp(a) lipoprotein, LDL cholesterol and/or vLDL cholesterol from aqueous liquids, in particular from blood, plasma or serum, consisting of porous glass beads as the solid carrier material whose silanol groups present on its surface carry ligands which are covalently bound and have alkyl residues with 4 to 12 atoms containing at least one ether group and a terminal .alpha.,.beta.-diol group containing alkyl residues with 4 to 12 C atoms and wherein the material has no free silanol groups. Also disclosed is a method of using the adsorption material for selective removal or determination of Lp(a) lipoprotein, LDL cholesterol or/and vLDL cholesterol from aqueous liquids, and a device for use in such methods.
摘要翻译： PCT No.PCT / EP91 / 01086 Sec。 371日期：1992年12月11日 102（e）日期1992年12月11日PCT PCT 1991年6月11日PCT公布。出版物WO91 / 19565 1991年12月26日。用于从含水液体，特别是血液，血浆或血清中选择性除去Lp（a）脂蛋白，LDL胆固醇和/或vLDL胆固醇的吸附材料，由多孔玻璃珠作为固体载体材料组成存在于其表面上的硅烷醇基带有共价结合的配体，具有含有至少一个醚基团的4至12个原子的烷基残基和含有4至12个C原子的具有烷基残基的末端α，β-二醇基团，没有游离硅烷醇基团。还公开了使用吸附材料从水性液体中选择性除去或测定Lp（a）脂蛋白，LDL胆固醇或/和vLDL胆固醇的方法，以及用于这些方法的装置。

66. 发明授权

US5326738A Stable, covalently-bonded supports for chemical separation apparatus made through a hydride intermediate 失效
标题翻译：通过氢化物中间体制备的化学分离装置的稳定的共价键合载体
公开(公告)号：US5326738A
公开(公告)日：1994-07-05
申请号：US838429
申请日：1992-03-09
申请人： Junior E. Sandoval , Joseph J. Pesek
发明人： Junior E. Sandoval , Joseph J. Pesek
IPC分类号： B01D57/02 , B01J20/02 , B01J20/32 , G01N27/447 , B01J20/06 , B01J20/22 , B01J20/30
CPC分类号： G01N27/44747 , B01D57/02 , B01J20/041 , B01J20/06 , B01J20/08 , B01J20/103 , B01J20/28004 , B01J20/28016 , B01J20/28061 , B01J20/28083 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3246 , B01J20/3257 , B01J2220/54 , B01J2220/84 , B01J2220/86
摘要： The present invention produces very stable, covalently bonded separation substrates for separations application such as liquid and gas chromatography as well as capillary zone electrophoresis. An intermediate substrate is prepared which has hydride species on the substrate surface. These hydrides preferably are further derivatized by the catalytic addition of organic compounds bearing a terminal vinyl group. The final surface modification contains closely packed, direct carbon linkages that are stable.
摘要翻译： PCT No.PCT / US90 / 05202 Sec。 371日期：1992年3月9日 102（e）1992年3月9日PCT PCT 1990年9月13日PCT公布。公开号WO91 / 04095 日本1991年4月4日。本发明生产非常稳定的共价键合分离底物，用于液相和气相色谱以及毛细管区带电泳等分离应用。制备在衬底表面上具有氢化物物质的中间衬底。这些氢化物优选通过催化加成带有末端乙烯基的有机化合物进一步进行衍生化。最终的表面改性包含稳定的紧密堆积的直接碳键。

67. 发明授权

US5314878A Composition for removing or inactivating harmful components in blood or other extracellular body fluids 失效
标题翻译：用于去除或灭活血液或其他细胞外体液中的有害成分的组合物
公开(公告)号：US5314878A
公开(公告)日：1994-05-24
申请号：US806206
申请日：1991-12-13
申请人： Henry M. Christensen , Hans B. Andreasen
发明人： Henry M. Christensen , Hans B. Andreasen
IPC分类号： A61K31/335 , A61K31/00 , A61K31/075 , A61K31/357 , A61K31/715 , A61L2/00 , A61P31/12 , A61P39/02 , B01J20/32 , C07D323/00 , C08B37/02 , C07D321/00 , C07D321/10 , C08B31/10
CPC分类号： C08B37/0021 , A61L2/0088 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B01J2220/4825 , Y10S514/832 , Y10S514/833 , Y10S514/836
摘要： A composition for removing or inactivating harmful components including virus from blood or other extracellular liquids comprises a crownether compound substituted on a polysaccharide, preferably dextrane. The composition may be soluble in water, preferably for intraveneous application, or insoluble for extracorporeal application.
摘要翻译：用于从血液或其他细胞外液体中除去或灭活包括病毒的有害成分的组合物包括在多糖上取代的冠醚化合物，优选为葡聚糖。该组合物可溶于水，优选用于荚膜内施用，或不溶于体外应用。

68. 发明授权

US5274167A Polymeriable optically active (meth) acrylic acid derivatives 失效
标题翻译：可聚合光学活性（甲基）丙烯酸衍生物
公开(公告)号：US5274167A
公开(公告)日：1993-12-28
申请号：US835169
申请日：1992-02-13
申请人： Walter Lange , Bruno Bomer , Rolf Grosser , Dieter Arlt
发明人： Walter Lange , Bruno Bomer , Rolf Grosser , Dieter Arlt
IPC分类号： B01J20/26 , B01J20/32 , C07C233/49 , C07C237/22 , C07C271/22 , C07D207/16 , C07D295/185 , C08F20/54 , C07C229/00
CPC分类号： B01J20/286 , B01J20/26 , B01J20/261 , B01J20/265 , B01J20/267 , B01J20/285 , B01J20/29 , B01J20/3204 , B01J20/3217 , B01J20/327 , B01J20/328 , C07C233/49 , C07C237/22 , C07C271/22 , C07D207/16 , C07D295/185 , C08F20/54 , B01J2220/54 , C07C2101/14 , C07C2102/28 , C07C2102/42
摘要： An optically active N-(meth)acryloyl amino acid amide of the formula ##STR1## in which R is hydrogen or methyl,R.sub.1 represents an optionally substituted alkyl, cycloalkyl, aralkyl, aryl or heteroaryl radical,R.sub.3 represents hydrogen or denotes together with R.sub.1 a tri- or tetramethylene group;X denotes oxygen or a NR.sub.4 -group wherein R.sub.4 represents hydrogen or alkyl or denotes together with R.sub.2 and the nitrogen atom a 5- to 7-membered ring which ring is optionally substituted by the group COO-alkyl (1-6 carbon atoms) or by one or two alkyl radicals (1-4 carbon atoms) andR.sub.2 denotes a strongly space-filling hydrocarbon radical.The amide is polymerized and optionally bound to a support such as silica, and can then be used for the chromatographic separation of racemic mixtures of pharmacologically active compounds.
摘要翻译：式（I）的光学活性N-（甲基）丙烯酰氨基酸酰胺，其中R是氢或甲基，R 1表示任选取代的烷基，环烷基，芳烷基，芳基或杂芳基，R 3表示氢或表示与R1一起是三亚甲基或四亚甲基; X表示氧或NR4-基团，其中R4表示氢或烷基或与R2和氮原子一起表示5-7元环，该环任选被COO-烷基（1-6个碳原子）或通过一个或两个烷基（1-4个碳原子），R 2表示强空间填充烃基。酰胺聚合并任选地结合到载体如二氧化硅上，然后可用于色谱分离药理活性化合物的外消旋混合物。

69. 发明授权

US5250188A Process of removing and concentrating desired molecules from solutions 失效
标题翻译：从溶液中去除和浓缩所需分子的过程
公开(公告)号：US5250188A
公开(公告)日：1993-10-05
申请号：US401670
申请日：1989-09-01
申请人： Ronald L. Bruening , Reed M. Izatt , Bryon J. Tarbet , Jerald S. Bradshaw
发明人： Ronald L. Bruening , Reed M. Izatt , Bryon J. Tarbet , Jerald S. Bradshaw
IPC分类号： B01D15/08 , B01J20/32 , B01J45/00 , C02F1/42 , C02F1/68
CPC分类号： B01J45/00 , B01D15/363 , B01J20/06 , B01J20/08 , B01J20/103 , B01J20/223 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3246 , B01J20/3257 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3265 , C02F1/683 , C22B3/42 , B01J2220/49 , B01J2220/58 , Y02P10/234
摘要： A method is disclosed for the quantitative removal and concentration of desired molecules or ions, such as gases, anions and amino acids, from a source solution which may contain larger concentrations of other molecules. The method comprises bringing the source solution into contact with a solid cation-ligand-matrix consisting of a cation complexed to a ligand molecule covalently bonded to a matrix consisting of an organic spacer bonded to a solid inorganic support through a silicon atom. The cation has an affinity for the desired molecules to form a complex between the desired molecules and the cation portion of the solid cation-ligand-matrix at binding sites initially held by H.sub.2 O or other weakly coordinated ligands or via ion pairing. The desired molecule complex is broken releasing either the desired molecules or desired molecules complexed with the cation by contacting the solid cation-ligand-matrix-desired molecule complex with a much smaller volume of a receiving solution in which said desired molecules are soluble. The concentrated ions or molecules thus removed may be analyzed and/or recovered by known methods. The process is useful in measuring the concentrations of molecules originally present at parts per billion levels; in the removal of low levels of toxic molecules such as ammonia or anions such as chromate from potable and saline water; in the preparation of ultrapure salts and gases; and in the recovery of valuable molecules present in low concentrations as in the separation of amino acids, etc.
摘要翻译：公开了用于从可能含有较大浓度的其它分子的源溶液定量除去和浓缩所需分子或离子（例如气体，阴离子和氨基酸）的方法。该方法包括使源溶液与固体阳离子 - 配体基质接触，所述固体阳离子 - 配位体基质与与通过硅原子键合到固体无机载体的有机间隔共价键合的配位体分子络合的阳离子形成。该阳离子对所需分子具有亲和性，以在最初由H 2 O或其它弱配位配体或通过离子配对保持的结合位点处形成所需分子与固体阳离子 - 配体 - 基质的阳离子部分之间的复合物。通过使固体阳离子 - 配体 - 基质 - 需要的分子复合物与其中所述所需分子可溶的接收溶液的体积更小的体积接触，所需的分子复合物被破坏释放所需的分子或与阳离子络合的所需分子。可以通过已知方法分析和/或回收由此除去的浓缩离子或分子。该方法可用于测量最初以十亿分之几的水平存在的分子的浓度; 在从饮用水和盐水中除去低含量的有毒分子如氨或阴离子如铬酸盐; 在制备超纯盐和气体时; 以及在分离氨基酸等方面回收低浓度有价值的分子。

70. 发明授权

US5203991A Packing material for liquid chromatography 失效
标题翻译：液相色谱填充材料
公开(公告)号：US5203991A
公开(公告)日：1993-04-20
申请号：US778357
申请日：1991-10-17
申请人： Hiroshi Kutsuna , Yoshihiro Shiojima , Tsuneo Suhara , Hiroshi Fukui , Yutaka Ohtsu , Michihiro Yamaguchi
发明人： Hiroshi Kutsuna , Yoshihiro Shiojima , Tsuneo Suhara , Hiroshi Fukui , Yutaka Ohtsu , Michihiro Yamaguchi
IPC分类号： B01J20/286 , B01D15/08 , B01J20/281 , B01J20/32 , G01N30/88
CPC分类号： B01D15/08 , B01J20/262 , B01J20/267 , B01J20/28078 , B01J20/289 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3272 , B01J20/3282 , B01J20/3289 , B01J2220/54 , B01J2220/58
摘要： A packing material for liquid chromatography bears a polyalkylene polyamine moiety linked through a spacer moiety as the pendant group to a porous silica gel coated with a silicone polymer, and optionally is crosslinked by a crosslinking agent on two or more amino group of the different polyalkylene polyamine moieties, and a process for production thereof. Such a packing material is especially useful in the analysis of sugars.
摘要翻译：用于液相色谱的包装材料具有通过作为侧基的间隔部分连接到被硅氧烷聚合物涂覆的多孔硅胶上的聚亚烷基多胺部分，并且任选地通过交联剂在不同聚亚烷基多胺的两个或更多个氨基上交联部分及其生产方法。这种包装材料在糖的分析中特别有用。

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