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61. 发明申请

US20060167403A1 Electrokinetic delivery system for self-administration of medicaments and methods therefor 有权
公开(公告)号：US20060167403A1
公开(公告)日：2006-07-27
申请号：US11373301
申请日：2006-03-13
申请人： Julian Henley , Kuo Chang , Joseph Potter , Dennis Goldberg , James Derquin
发明人： Julian Henley , Kuo Chang , Joseph Potter , Dennis Goldberg , James Derquin
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery system for personal use in self-administration of a medicament to a treatment site on an individual includes a device shaped to conform with the shape of a portion of an individual's finger from a tip thereof to a location past the first finger joint. A self-contained power source is carried by the device and a first electrode is carried by the device adjacent a distal end portion thereof and the tip of the individual's finger. The first electrode is in electrical contact with the power source. A second electrode is carried by the device for contact with the individual's finger. The second electrode is in electrical contact with the power source. Upon application of the first electrode over a treatment site with the medicament disposed between the first electrode and the treatment site and completion of an electrical circuit through the individual's body and said electrode, the device applies current for electrokinetically driving the medicament into the treatment site.

62. 发明申请

US20050288621A1 Methods of electrotransport drug delivery 有权
标题翻译：电转运药方法
公开(公告)号：US20050288621A1
公开(公告)日：2005-12-29
申请号：US11214246
申请日：2005-08-29
申请人： Joseph Phipps , Gary Lattin , Larry McNichols , John Badzinski
发明人： Joseph Phipps , Gary Lattin , Larry McNichols , John Badzinski
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： A reservoir and a family of reservoirs are provided which are designed to be used with a single controller to provide a wide range of therapeutic drug delivering regimens while maintaining many of the same reservoir configurations and drug formulations. A method of making a reservoir and a family of reservoirs and incorporating them into an electrotransport system is disclosed.
摘要翻译：提供了储存器和一系列储存器，其设计成与单个控制器一起使用以提供广泛的治疗药物递送方案，同时保持许多相同的储存器构型和药物制剂。公开了一种制造储存器和一系列储存器并将其并入到电输送系统中的方法。

63. 发明申请

US20050287217A1 Transdermal delivery system for water insoluble drugs 有权
标题翻译：用于水不溶性药物的透皮递送系统
公开(公告)号：US20050287217A1
公开(公告)日：2005-12-29
申请号：US11116056
申请日：2005-04-27
申请人： Galit Levin , Meir Stern , Dorit Daniel
发明人： Galit Levin , Meir Stern , Dorit Daniel
IPC分类号： A61K9/14 , A61K31/724 , A61M20060101 , A61N1/30
CPC分类号： A61N1/325 , A61K9/703 , A61K9/7084 , A61N1/044 , A61N1/40
摘要： The present invention provides a system for transdermal delivery of water insoluble drugs and methods using the same. The system includes a pharmaceutical composition of a water insoluble drug and a carrier molecule that enhances the solubility of the drug in aqueous solution, a medical patch containing the same and an apparatus that generates hydrophilic micro-channels in an area of skin of a subject using the composition or patch. The system preferably avoids the use of penetration enhancers and is particularly useful for transdermal delivery of steroids.
摘要翻译：本发明提供了一种用于透皮递送水不溶性药物的方法及使用该系统的方法。该系统包括增加药物在水溶液中的溶解度的水不溶性药物和载体分子的药物组合物，含有该溶液的药物组合物和在受试者皮肤区域中产生亲水性微通道的装置，其使用组成或补丁。该系统优选地避免使用渗透增强剂，并且特别可用于类固醇的透皮递送。

64. 发明申请

US20050267399A1 Device for the transcutaneous administration of substances by means of iontophoresis 失效
标题翻译：通过离子电渗疗法经皮给药物质的装置
公开(公告)号：US20050267399A1
公开(公告)日：2005-12-01
申请号：US10858458
申请日：2004-06-01
申请人： Ezio Tedoldi
发明人： Ezio Tedoldi
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： A device for the transcutaneous administration of substances by means of iontophoresis comprises an operative head (1) provided with an inlet (2) for a fluid transporting substances to be administered, with a dispenser (3) of the fluid which has a part (30) in contact with the skin, with an electrode (4) positioned on a path of the fluid from the inlet (2) to the dispenser (3). The dispenser (3) is made of an electrically conducting material and it is in electrical contact with the electrode (4) only by the action of the fluid. The dispenser (3) and the electrode (4) are arranged in a predetermined relative position which maintains constant over time the geometric shape of the volume of fluid present between them.
摘要翻译：用于通过离子电渗疗法经皮施用物质的装置包括操作头部（1），其具有用于待施用的流体输送物质的入口（2），其具有流体的分配器（3），该分配器具有一部分（30 ），其中电极（4）定位在从入口（2）到分配器（3）的流体路径上。分配器（3）由导电材料制成，并且仅通过流体的作用与电极（4）电接触。分配器（3）和电极（4）被布置在预定的相对位置，其在时间上保持恒定，在它们之间存在的流体的体积的几何形状。

65. 发明申请

US20050234389A1 Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds 有权
标题翻译：哌嗪基-2（3H） - 苯并恶唑酮化合物的透皮离子电渗递送
公开(公告)号：US20050234389A1
公开(公告)日：2005-10-20
申请号：US11088880
申请日：2005-03-25
申请人： Johanna Bouwstra , Dirk-Jan van den Berg , Frederik Verbaan , Rajkumar Conjeevaram , Ajay Banga , Viswatej Vemulapalli
发明人： Johanna Bouwstra , Dirk-Jan van den Berg , Frederik Verbaan , Rajkumar Conjeevaram , Ajay Banga , Viswatej Vemulapalli
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/325 , A61N1/0436 , A61N1/044
摘要： The invention is related to an iontophoretic method for the delivery of a compound of the formula wherein R is defined herein, and pharmaceutically acceptable salts and prodrugs thereof; and, wherein the method comprises: (a) applying a transdermal device to the skin of a living body, wherein the transdermal device has a reservoir containing the compound of formula I or a composition thereof and optionally a pharmaceutically acceptable electrolyte; (b) causing current to flow through the skin so as to iontophoretically deliver the compound of formula 1. The invention is further related to iontophoretic systems and to kits containing the iontophoretic system combined with one or more cartridges containing a compound of formula I, and to cartridges containing a compound of formula I.
摘要翻译：本发明涉及用于递送下式化合物的离子电渗法：其中R如本文所定义，及其药学上可接受的盐和前药; 并且其中所述方法包括：（a）将透皮装置施加到活体的皮肤，其中所述透皮装置具有含有式I化合物或其组合物和任选的药学上可接受的电解质的储库; （b）引起电流流过皮肤，以离子电渗方式递送式1的化合物。本发明还涉及离子电渗疗法系统以及与含有式I化合物的一种或多种药筒组合的离子电渗疗法系统的试剂盒，以及包含式I化合物的药筒。

66. 发明申请

US20050228335A1 Physical, structural, mechanical, electrical and electromechanical features for use in association with electrically assisted delivery devices and systems 审中-公开
标题翻译：物理，结构，机械，电气和机电特征，用于与电气辅助输送装置和系统相关联
公开(公告)号：US20050228335A1
公开(公告)日：2005-10-13
申请号：US10820346
申请日：2004-04-07
申请人： Vilambi Reddy , Preston Keusch , Robert Strowe , Jeffrey Kapec , Kazuna Tanaka
发明人： Vilambi Reddy , Preston Keusch , Robert Strowe , Jeffrey Kapec , Kazuna Tanaka
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.
摘要翻译：提供了集成电极装置，组件和系统的各种实施例，其被构造为与被配置为将组合物递送到膜的电辅助输送装置相关联地使用。集成电极装置，组件和系统包括各种结构，物理，机械，电和机电增强中的一种或多种。

67. 发明申请

US20050182351A1 Electrokinetic delivery of medicaments 审中-公开
标题翻译：药物电动输送
公开(公告)号：US20050182351A1
公开(公告)日：2005-08-18
申请号：US11104568
申请日：2005-04-13
申请人： Julian Henley , Kuo Chang , Joseph Potter , Dennis Goldberg
发明人： Julian Henley , Kuo Chang , Joseph Potter , Dennis Goldberg
IPC分类号： A61M37/00 , A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.
摘要翻译：提供了一种用于个人使用的电动输送或诊断装置以及药物自动施用于治疗部位。该装置包括容纳电源，第一有源电极和接地触觉电极的壳体。涂抹器包括用于容纳用于覆盖装置的第一电极的药物的垫。使用者可以将药物施用于包含在垫内的垫或包含在垫内的可破裂胶囊中，以及如果需要赋予导电性的水凝胶，由此当将施用器施加到治疗部位时，药物是电动运输到治疗部位。在另一种形式中，施用器是独立的，具有电源，与衬垫相重叠的第一电极和接地电极，其中个体将衬垫压在治疗部位上以完成电路和电动驱使药物进入治疗部位。

68. 发明申请

US20050010161A1 Methods of treating acne and rosacea with galvanic generated electricity 有权
标题翻译：用电生电处理痤疮和酒渣鼻的方法
公开(公告)号：US20050010161A1
公开(公告)日：2005-01-13
申请号：US10874917
申请日：2004-06-23
申请人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Jeannette Chantalat , Aliya Omer
发明人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Jeannette Chantalat , Aliya Omer
IPC分类号： A61N1/20 , A61N1/30 , A61N1/32
CPC分类号： A61N1/0492 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/205 , A61N1/325
摘要： The present invention features a method of treating acne or rosacea on the skin by applying electricity to skin in need of such treatment wherein said electricity is generated by a first conductive electrode in electric communication with a second conductive electrode, wherein both the first conductive electrode and the second conductive electrode are in ionic communication with the skin, wherein the difference of the standard potentials of the first conductive electrode and the second conductive electrode is at least 0.2 V and wherein the electrons that pass between the first conductive electrode and the second conductive electrode are generated as a result of such difference of the standard potentials.
摘要翻译：本发明的特征在于一种通过向需要这种治疗的皮肤施加电力来治疗皮肤上的痤疮或红斑痤的方法，其中所述电由与第二导电电极电连通的第一导电电极产生，其中第一导电电极和所述第二导电电极与皮肤离子连通，其中所述第一导电电极和所述第二导电电极的标准电位的差异为至少0.2V，并且其中在所述第一导电电极和所述第二导电电极之间通过的电子是由于这些标准电位的差异而产生的。

69. 发明申请

US20040267283A1 Method, device and kit for body decoration 审中-公开
标题翻译：身体装饰的方法，装置和工具包
公开(公告)号：US20040267283A1
公开(公告)日：2004-12-30
申请号：US10821966
申请日：2004-04-12
发明人： Daniela Mavor , Zvi Nitzan , Nurit Harel , Michal Shahar , Giora Arbel , Yosef Gross , Dalia Jayes , Dov Tamarkin
IPC分类号： A61B017/00
CPC分类号： B44C1/16 , A61N1/0432 , A61N1/044 , A61N1/325
摘要： A method, device and kit for body decoration. Embodiments of the kit include an ink suitable for body decoration, means for applying the ink to a desired body area, and an electrically powered patch detachably coupled to the application means to promote penetration of the ink into the body area. Embodiments of the device include a fully integrated patch device. The patch device integrates the elements of a kit (i.e., a color formulation, a means for applying, and a patch) into a stand-alone patch. Embodiments of the method include contacting the desired body area with a means for applying, applying ink through the means for applying, and promoting penetration of the ink into the body area with the patch by applying electric current to the ink application. Exemplary applications include temporary and permanent tattooing, applying semi-permanent cosmetics, animal tattooing, and administering therapeutic treatments.
摘要翻译：身体装饰的方法，装置和工具包。试剂盒的实施方案包括适用于身体装饰的油墨，将油墨施加到所需身体区域的装置，以及可拆卸地联接到施加装置上以促进油墨渗入体内区域的电动贴剂。该设备的实施例包括完全集成的补丁设备。贴片装置将试剂盒的元件（即，颜色制剂，施用装置和贴剂）整合到独立贴片中。该方法的实施例包括使所需的身体区域与用于施加墨水的装置接触，通过用于施加的装置施加墨水，并通过向墨水施加电流来促进墨水通过贴片渗透到身体区域中。示例性应用包括临时和永久纹身，应用半永久化妆品，动物纹身和施用治疗疗法。

70. 发明申请

US20040186417A1 Electrotransport agent delivery apparatus 有权
标题翻译：电子输送装置
公开(公告)号：US20040186417A1
公开(公告)日：2004-09-23
申请号：US10778748
申请日：2004-02-12
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N001/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein the length of the applied current pulses is at least 5 msec and preferably at least 10 msec. Most preferably, the current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中所施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。最优选地，电流脉冲具有高于临界水平（Ic）的量值，在该临界水平（Ic）下，皮肤转化为更高的电转运递送效率（E）状态。

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