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61. 发明授权

US06390291B1 Method and package for storing a pressurized container containing a drug 有权
标题翻译：用于储存含有药物的加压容器的方法和包装
公开(公告)号：US06390291B1
公开(公告)日：2002-05-21
申请号：US09571388
申请日：2000-05-15
申请人： Karl Andrew Garrill , Richard J. Haan , Craig Steven Herman , Richard Ian Walker
发明人： Karl Andrew Garrill , Richard J. Haan , Craig Steven Herman , Richard Ian Walker
IPC分类号： B65D8126
CPC分类号： B65D83/54 , A61M15/00 , A61M15/009 , A61M2202/062 , A61M2209/06 , B65D75/26 , B65D77/003 , B65D81/266 , B65D81/268 , B65D83/75
摘要： A method and package for storing a pressurized container which is filled with a drug formulation at a predetermined pressure. The drug formulation includes a mixture of a drug and a propellant. The package which encloses the pressurized container substantially prevents ingression of water vapor and particulate matter into the package while permitting egression of the propellant which may leak from the pressurized container.
摘要翻译：一种用于储存以预定压力填充药物制剂的加压容器的方法和包装。药物制剂包括药物和推进剂的混合物。包围加压容器的包装件基本上防止水蒸气和颗粒物质进入包装中，同时允许可能从加压容器泄漏的推进剂的流出。

62. 发明申请

US20010037805A1 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 失效
公开(公告)号：US20010037805A1
公开(公告)日：2001-11-08
申请号：US09784861
申请日：2001-02-15
发明人： Igor Gonda , Reid M. Rubsamen , Stephen J. Farr
IPC分类号： A61M011/00 , A62B007/00 , A61M016/00 , F16K031/02
CPC分类号： A61K9/007 , A61J7/0418 , A61J7/0427 , A61J7/0445 , A61K9/0073 , A61K9/0075 , A61K38/28 , A61M11/001 , A61M15/00 , A61M15/0031 , A61M15/0045 , A61M15/0051 , A61M15/0065 , A61M15/0066 , A61M15/008 , A61M15/0085 , A61M15/009 , A61M16/142 , A61M2016/0021 , A61M2016/0036 , A61M2202/062 , A61M2202/064 , A61M2205/50 , A61M2205/8206
摘要： The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved relative to regular insulin. The blood concentration versus time profile is substantially unaffected by specific aspects of the patient's breathing maneuver at delivery. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release.

63. 发明授权

US6131570A Temperature controlling device for aerosol drug delivery 失效
公开(公告)号：US6131570A
公开(公告)日：2000-10-17
申请号：US107306
申请日：1998-06-30
申请人： Jeffrey A. Schuster , Christopher J. Flaim
发明人： Jeffrey A. Schuster , Christopher J. Flaim
IPC分类号： A61M11/04 , A61M15/00 , A61M16/00 , A61M16/10 , A61M16/16
CPC分类号： A61M15/0045 , A61M11/001 , A61M15/00 , A61M15/0051 , A61M16/108 , A61M16/1085 , A61M16/1095 , A61M16/161 , A61M16/1075 , A61M16/16 , A61M2016/0021 , A61M2016/0039 , A61M2202/062 , A61M2205/3368 , A61M2205/52
摘要： A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation is described. Warming the air of an aerosol makes it possible to reduce the size of aerosol particles produced by an aerosol generation device. Additionally, warming the air forces the size of the aerosol particles to be in the range required for systemic drug delivery independent of ambient conditions. Smaller particles can be more precisely targeted to different areas of the respiratory tract.

64. 发明授权

US5884620A Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 失效
公开(公告)号：US5884620A
公开(公告)日：1999-03-23
申请号：US846243
申请日：1997-04-25
申请人： Igor Gonda , Reid M. Rubsamen , Stephen J. Farr
发明人： Igor Gonda , Reid M. Rubsamen , Stephen J. Farr
IPC分类号： A61M11/02 , A61J7/04 , A61K9/00 , A61K38/28 , A61M15/00 , A61M16/00 , A61M16/14 , A61M11/00
CPC分类号： A61K9/007 , A61K38/28 , A61K9/0073 , A61M11/001 , A61M15/00 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0051 , A61M15/0066 , A61M15/008 , A61M16/142 , A61J7/0418 , A61J7/0427 , A61J7/0445 , A61M15/0085 , A61M15/009 , A61M2016/0021 , A61M2016/0036 , A61M2202/062 , A61M2202/064 , A61M2205/50 , A61M2205/8206 , Y10S514/866
摘要： Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

65. 发明授权

US5746227A Dry powder delivery system 失效
标题翻译：干粉输送系统
公开(公告)号：US5746227A
公开(公告)日：1998-05-05
申请号：US483540
申请日：1995-06-07
申请人： Jed E. Rose , Frederique Behm , James Turner
发明人： Jed E. Rose , Frederique Behm , James Turner
IPC分类号： A24F47/00 , A61K9/00 , A61M15/00 , A61M15/06
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A method for delivering dry powder particles through the mouth of a user, in which a suction is created through an opening in a proximal end of an elongated housing for drawing air into a flow path in the housing from an opening in a distal end of the housing, the distal end including an opening in the housing with a ridge surrounding the housing, and through a resistance member in the housing for introducing a controlled pressure drop in the housing and a resistance to the drawing of air into the mouth of the user. A measured amount of dry powder particles having a therapeutic capability, is introduced into the housing so that the particles will travel downstream from the resistance member at a relatively low velocity in a non-agglomerated state, the dry powder particles being sized and coordinated with the controlled pressure drop so that the particles can be drawn into the mouth of the user and inhaled, with the resistance being sufficiently great that the particles are drawn into the mouth of the user to simulate the action of puffing on a cigarette so that at least some of the particles are deposited in the oral cavity and upper respiratory tract of the user after being drawn into the mouth.
摘要翻译：一种用于将干燥粉末颗粒输送通过使用者口腔的方法，其中通过细长壳体的近端中的开口产生吸力，用于从空腔的远端中的开口将空气吸入壳体中的流动路径所述远端包括在所述壳体中的开口，所述开口具有围绕所述壳体的脊，并且通过所述壳体中的阻力构件，用于在所述壳体中引入受控的压降并且阻止将空气抽吸到所述使用者的口中。将测量量的具有治疗能力的干粉颗粒引入壳体中，使得颗粒将以非聚集状态的相对较低的速度从阻力构件下游移动，干粉颗粒的尺寸和配合与控制的压降使得颗粒可以被吸入使用者的嘴中并被吸入，其阻力足够大，使得颗粒被吸入使用者的口中以模拟在香烟上膨化的作用，使得至少一些的颗粒在吸入口腔后沉积在使用者的口腔和上呼吸道中。

66. 发明授权

US5687746A Dry powder delivery system 失效
标题翻译：干粉输送系统
公开(公告)号：US5687746A
公开(公告)日：1997-11-18
申请号：US477562
申请日：1995-06-07
申请人： Jed E. Rose , Frederique Behm , James Turner
发明人： Jed E. Rose , Frederique Behm , James Turner
IPC分类号： A24F47/00 , A61K9/00 , A61M15/00 , A61M15/06 , A24B15/16 , A24D1/00
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A dry powder delivery system having an elongated tube containing a matrix having a measured mount of dry particles of therapeutic compound and a porous element having a desiccant therein is disclosed. The porous element with the desiccant can be combined with the powder-containing matrix or it can be two separate elements. The pressure drop induced by inhalation of the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.
摘要翻译：公开了一种干粉输送系统，其具有包含具有测量的治疗化合物的干颗粒的基质的基质的细长管和其中具有干燥剂的多孔元件。具有干燥剂的多孔元件可以与含粉末的基质组合，或者它可以是两个分开的元素。吸入使用者引起的压降导致空气流过管并与干粉颗粒接触，用于排出用户吸入的颗粒。

67. 发明授权

US5437270A Powder inhaler having a multi-positioned metering cup 失效
标题翻译：具有多位置计量杯的粉末吸入器
公开(公告)号：US5437270A
公开(公告)日：1995-08-01
申请号：US24721
申请日：1993-01-06
申请人： Philip W. Braithwaite
发明人： Philip W. Braithwaite
IPC分类号： A61M13/00 , A61M15/00 , G06M1/24 , A61M15/08 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0065 , A61M15/0068 , A61M15/0075 , G06M1/246 , A61M2202/062 , A61M2202/064
摘要： The inhaler includes a storage chamber for the powder to be delivered and an inhalation passage through which air is drawn via a mouth piece. A metering member having a frusto-conical side wall presents each dose to the inhalation passage in an upwardly open metering cup to be drawn therefrom by the air flow through the passage. A wiping element removed any particles of powder from the dispensing cup as it travels from the inhalation passage to the storage chamber to be refilled, and a chamber containing a moisture-absorbent material dries the empty cup and also dries the powder in the cup prior to inhalation to aid its removal from the cup. A mechanical counter is indexed each time the metering member is indexed to display the number of doses used or remaining.
摘要翻译：吸入器包括用于待输送的粉末的储存室和吸入通道，通过该吸入通道，空气通过口件被抽吸。具有截头圆锥形侧壁的计量构件在向上打开的计量杯中呈现吸入通道的每个剂量，以通过通过该通道的气流从其中抽出。擦拭元件从分配杯从吸入通道行进到储存室以重新填充时，从分配杯中除去任何粉末颗粒，并且含有吸湿材料的室将空杯子干燥并且还将粉末在杯中干燥吸入以帮助其从杯中取出。每当计量构件被索引时，机械计数器被索引，以显示使用或剩余的剂量数量。

68. 发明授权

US5295479A Device intended for measuring a dose of powdered medicament for inhalation 失效
标题翻译：用于测量用于吸入的粉末药物的剂量的装置
公开(公告)号：US5295479A
公开(公告)日：1994-03-22
申请号：US955743
申请日：1993-02-16
申请人： Tapio Lankinen
发明人： Tapio Lankinen
IPC分类号： A61J7/02 , A61M20060101 , A61M13/00 , A61M15/00
CPC分类号： A61M15/0065 , A61M15/0015 , A61M2202/062 , A61M2202/064
摘要： The invention relates to a device intended for measuring a dose of powdered medicament for inhalation, including a medicament container (1), through which extends a shaft (3) provided with at least one dosage recess (5). Container (1) is provided with at least one flap-like sweeper element (4), resting on shaft (3) in alignment with the dosage recess and having one of its ends rotatable around shaft (3), the other end of said flap dragging along the shaft surface, whereafter said shaft (3) is displaceable in this longitudinal direction relative to container (1) so as to bring dosage recess (5), along with a dose of the medicament carried therein, outside container (1). The invention relates also to the measuring of a dose of powdered medicament for inhalation by using the device described above.
摘要翻译： PCT No.PCT / FI91 / 00113 Sec。 371日期：1993年2月16日 102（e）日期1993年2月16日PCT 1991年4月15日PCT PCT。 WO92 / 18188 PCT出版物本发明涉及一种用于测量用于吸入的粉末药物的剂量的装置，包括药物容器（1），通过该药物容器（1）延伸设置有至少一个剂量凹部（5）的轴（3）。容器（1）设置有至少一个襟翼状清扫器元件（4），其与所述剂量凹部对准地搁置在轴（3）上，并且其端部中的一个端部可围绕轴（3）旋转，所述翼片的另一端沿着轴表面拖动，此后所述轴（3）可相对于容器（1）在该纵向方向上移位，以便将剂量凹槽（5）与其中携带的药物的剂量一起放置在容器（1）的外部。本发明还涉及通过使用上述装置测量用于吸入的粉末药物的剂量。

69. 发明授权

US2693805A Apparatus for administering therapeutic agents 失效
标题翻译：用于施用治疗剂的装置
公开(公告)号：US2693805A
公开(公告)日：1954-11-09
申请号：US12962449
申请日：1949-11-26
申请人： TAPLIN GEORGE V , BRYAN FREDERICK A
发明人： TAPLIN GEORGE V , BRYAN FREDERICK A
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61M2202/062 , A61M2202/064

70. 发明授权

US11986597B2 Nitric oxide generating systems for inhalation 有权
公开(公告)号：US11986597B2
公开(公告)日：2024-05-21
申请号：US17182868
申请日：2021-02-23
申请人： NOTA Laboratories, LLC
发明人： Glenn Martin , Andrew P. Hunt , Maria Kim , Mark E. Meyerhoff , Malcolm Kahn
IPC分类号： A61M16/14 , A61K9/00 , A61K31/16 , A61K33/00 , A61K47/02 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , A61M16/06 , C01B21/24
CPC分类号： A61M16/14 , A61K9/0073 , A61K31/16 , A61K33/00 , A61K47/02 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/24 , A61M16/06 , C01B21/24 , A61M2202/0275 , A61M2202/062
摘要： A moisture or hydrating liquid activatable solid formulation for nitric oxide (NO) generation includes a nitrite source; a copper (I) or copper (II) catalyst; an NO generation accelerant; and a solid pH buffer. The nitrite source is to generate NO when exposed to an effective amount of moisture or a hydrating liquid. The pH buffer is present in an amount sufficient to render a pH of the moisture or hydrating liquid activatable solid formulation from greater than 4 to about 9.0.

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