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61. 发明授权

US07682629B1 Floating pharmaceutical composition comprising an active phase and a non-active phase 失效
标题翻译：包含活性相和非活性相的浮动药物组合物
公开(公告)号：US07682629B1
公开(公告)日：2010-03-23
申请号：US10048459
申请日：2000-08-02
申请人： Jerome Besse
发明人： Jerome Besse
IPC分类号： A61K9/20 , A61K9/22 , A61K9/24
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/2086
摘要： The invention concerns a floating pharmaceutical composition consisting of at least a first phase comprising at least a high dose active principle combined with one or several carriers and at least a second phase comprising at least a gas-generating system. The invention also concerns tablets comprising such a pharmaceutical composition and a method for preparing such tablets.
摘要翻译：本发明涉及一种浮动药物组合物，其由至少包含与一种或多种载体组合的至少高剂量活性成分和至少包含至少一种气体发生系统的第二相的至少第一相组成。本发明还涉及包含这种药物组合物的片剂和制备这种片剂的方法。

62. 发明申请

US20100021393A1 Pharmaceutical Compositions Comprising Effervescent Agents and Fenofibrate 审中-公开
标题翻译：包含泡腾剂和非诺贝特的药物组合物
公开(公告)号：US20100021393A1
公开(公告)日：2010-01-28
申请号：US12573302
申请日：2009-10-05
申请人： Yisheng Chen , Yihong Qiu , Thomas L. Reiland
发明人： Yisheng Chen , Yihong Qiu , Thomas L. Reiland
IPC分类号： A61K9/12 , A61P9/10 , A61P3/06
CPC分类号： A61K9/0007 , A61K9/485 , A61K9/4866 , A61K31/216
摘要： A pharmaceutical composition comprising at least one effervescent agent and a fibrate and a process for making such composition. The fibrate is fenofibrate and the effervescent agent are in a dosage form. The dosage form increases dissolution and absorption of fenofibrate in biological conditions where the form contacts acidic gastric fluid after oral administration.
摘要翻译：包含至少一种泡腾剂和贝特类的药物组合物和制备该组合物的方法。贝特类是非诺贝特，泡腾剂是剂型。该剂型增加了非诺贝特在口服给药后接触酸性胃液的生物学条件下的溶解和吸收。

63. 发明申请

US20090004270A1 METHOD OF USING GUAVA EXTRACT 审中-公开
标题翻译：使用GUAVA提取物的方法
公开(公告)号：US20090004270A1
公开(公告)日：2009-01-01
申请号：US12170972
申请日：2008-07-10
申请人： Fred Wehling , Mary Aldritt , GeMing Lui
发明人： Fred Wehling , Mary Aldritt , GeMing Lui
IPC分类号： A61K9/46 , A61K36/61 , A61P25/00
CPC分类号： A61K9/0007 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K9/0058 , A61K9/0095 , A61K36/61 , A23V2250/21 , A23V2200/32 , A23V2200/30
摘要： A method of using guava extract is disclosed that includes administering guava extract to a mammal to inhibit, prevent or alleviate at least one of a headache, nausea, dry mouth, lack of appetite, shakiness, and fatigue. A composition is also disclosed that includes a pharmaceutically acceptable carrier and guava extract.
摘要翻译：公开了一种使用番石榴提取物的方法，其包括向哺乳动物施用番石榴提取物以抑制，预防或缓解头痛，恶心，口干，食欲不振，抖动和疲劳中的至少一种。还公开了包含药学上可接受的载体和番石榴提取物的组合物。

64. 发明申请

US20080279935A1 Composition Comprising a Powder Containing Microencapsulated Polyunsaturated Long-Chain Esterified Fatty Acids Distributed in an Effervescent Base 审中-公开
标题翻译：包含分散在泡腾基质中的包含微囊化多不饱和长链酯化脂肪酸的粉末的组合物
公开(公告)号：US20080279935A1
公开(公告)日：2008-11-13
申请号：US11814643
申请日：2006-02-17
申请人： Robert Wahren , Bjorn Skjaevestad
发明人： Robert Wahren , Bjorn Skjaevestad
IPC分类号： A61K9/46 , A61K9/50 , A61P43/00 , A61K31/20
CPC分类号： A61K9/0007 , A23L2/395 , A23L2/40 , A23L33/12 , A23V2002/00 , A61K9/2081 , A23V2250/1882 , A23V2200/22 , A23V2200/224 , A23V2200/32 , A23V2250/642 , A23V2250/2482 , A23V2250/5114 , A23V2250/032 , A23V2250/242 , A23V2250/056
摘要： The invention relates to a composition being substantially free from water comprising a powder containing microencapsulated polyunsaturated long-chain esterified fatty acids (PUFA), wherein said PUPA content of said powder is from about 5 to about 50% (w/w), said powder being homogenously distributed in an effervescent base, wherein said effervescent base is from about 20 to about 75% (w/w) of said composition. The invention also relates to a process for the production of said composition as well as tablets, granules and powders comprising said composition and does unites as well as containers comprising said composition, tablet, granules or powders and the use of said products.
摘要翻译：本发明涉及一种基本上不含水的组合物，其包含含有微囊化多不饱和长链酯化脂肪酸（PUFA）的粉末，其中所述粉末的所述PUPA含量为约5至约50％（w / w），所述粉末均匀分布在泡腾基质中，其中所述泡腾碱为所述组合物的约20至约75％（w / w）。本发明还涉及生产所述组合物的方法以及包含所述组合物的片剂，颗粒剂和粉剂，以及包含所述组合物，片剂，颗粒或粉末的容器以及所述产品的用途。

65. 发明申请

US20080268081A1 METHOD OF USING GUAVA EXTRACT AND COMPOSITION INCLUDING GUAVA EXTRACT 审中-公开
标题翻译：使用GUAVA提取物和组合物的方法，包括GUAVA提取物
公开(公告)号：US20080268081A1
公开(公告)日：2008-10-30
申请号：US12170946
申请日：2008-07-10
申请人： Fred Wehling , Mary Aldritt , GeMing Lui
发明人： Fred Wehling , Mary Aldritt , GeMing Lui
IPC分类号： A61K36/61 , A61P29/00
CPC分类号： A61K36/61 , A23L2/40 , A23L33/105 , A61K9/0007 , A61K9/0058 , A61K9/0095
摘要： A method of using guava extract is disclosed that includes administering alcohol to a mammal, and administering guava extract within no greater than about 12 hours of administering of the alcohol. A composition is also disclosed that includes a pharmaceutically acceptable carrier and guava extract.
摘要翻译：公开了一种使用番石榴提取物的方法，其包括向哺乳动物施用酒精，并在施用酒精不超过约12小时内施用番石榴提取物。还公开了包含药学上可接受的载体和番石榴提取物的组合物。

66. 发明申请

US20080026080A1 Method for manufacturing calcium gluconolactate compositions processes and uses 有权
标题翻译：葡萄糖酸钙组合物的制备方法和用途
公开(公告)号：US20080026080A1
公开(公告)日：2008-01-31
申请号：US11728728
申请日：2007-03-26
申请人： Manuel Buendia
发明人： Manuel Buendia
IPC分类号： A61K33/10 , A61P19/00 , C07H15/00
CPC分类号： C07C51/412 , A61K9/0007 , A61K31/19 , A61K31/22 , A61K33/06 , C07C59/08 , C07C59/105
摘要： A method to manufacture calcium gluconolactate as a single molecule, compositions formed thereby, and uses therefor are disclosed and described. In one embodiment, a method of manufacturing calcium gluconolactate by reacting a gluconic acid reaction or an equivalent thereof, such as glucono delta lactone with lactic acid in the presence of calcium hydroxide and water to obtain a calcium gluconolactate molecule having the formula CH2OH—(CHOH)4—COOCaCOO—CH(OH)—CH3 with molecular weight of 324.2994 is presented.
摘要翻译：公开和描述了一种制造葡萄糖酸乳糖酸酯作为单一分子的方法，由此形成的组合物及其用途。在一个实施方案中，通过在氢氧化钙和水的存在下使葡萄糖酸反应或其等同物（例如葡萄糖酸内酯）与乳酸反应来制备葡糖酸钙酸钙的方法，以获得具有式CH 提供分子量为324.2994的2个OH-（CHOH）4 -COOCaCOO-CH（OH）-CH 3 3。

67. 发明申请

US20080003289A1 Method for the Production of Effervescent Granules in a Vacuum 有权
标题翻译：在真空中生产泡腾颗粒的方法
公开(公告)号：US20080003289A1
公开(公告)日：2008-01-03
申请号：US10568712
申请日：2004-08-07
申请人： Irmgard Gergely , Thomas Gergely , Stefan Gergely
发明人： Irmgard Gergely , Thomas Gergely , Stefan Gergely
IPC分类号： A61K9/14 , B32B5/16
CPC分类号： A61K9/0007 , A61K47/02 , A61K47/12 , Y10S514/951 , Y10T428/2982
摘要： The invention relates to a method for producing effervescent granules, in which the reaction partners edible, organic acid components and alkaline effervescent components separating carbon dioxide are reacted with each other in a vacuum under the effect of gas in a container that can be evacuated. The container is evacuated to a first vacuum value within a vacuum range of 200-900 mbar, whereupon the pressure inside the container is increased to a second vacuum value as a result of the gases produced during the reaction. The steps are cyclically repeated while the reaction continues. A maximum number of cycles, a maximum reaction time, and optionally, a maximum load for the stirring apparatus are defined before the reaction begins, and the reaction is terminated after reaching the first of the maximums. In an alternative embodiment, the invention also relates to a method for improving the shelf life of effervescent granules by a treatment with carbon dioxide during and/or following the production of the effervescent granules, and effervescent particles treated in this manner.
摘要翻译：本发明涉及一种生产泡腾颗粒的方法，其中反应配对物可食用，有机酸组分和分离二氧化碳的碱性泡腾成分在气体作用下在真空中彼此反应，在可抽出的容器中。容器在200-900mbar的真空范围内抽真空至第一真空值，由此在反应期间产生的气体，容器内的压力增加到第二真空度。反应继续时，循环重复步骤。在反应开始之前定义最大循环次数，最大反应时间和任选的搅拌装置的最大负荷，并且在达到第一个最大值后终止反应。在另一个实施方案中，本发明还涉及通过在生产泡腾颗粒期间和/或之后用二氧化碳处理来改善泡腾颗粒的保质期的方法，以及以这种方式处理的泡腾颗粒。

68. 发明申请

US20070281014A1 Prednisolone salt formulations 审中-公开
标题翻译：泼尼松龙盐配方
公开(公告)号：US20070281014A1
公开(公告)日：2007-12-06
申请号：US11638260
申请日：2006-12-13
申请人： Walid Habib , Bhaveshkumar Kothari
发明人： Walid Habib , Bhaveshkumar Kothari
IPC分类号： A61K9/46
CPC分类号： A61K9/2081 , A61K9/0007 , A61K9/0056 , A61K31/573
摘要： The present invention relates to tablets containing prednisolone salts and in particular prednisolone sodium phosphates. The tablets include ODTs and non-ODTs, effervescent tablets and noneffervescent tablets and tablets meeting certain performance criteria.
摘要翻译：本发明涉及含泼尼松龙盐，特别是泼尼松龙磷酸钠的片剂。片剂包括ODT和非ODT，泡腾片和满足某些性能标准的无泡片剂和片剂。

69. 再颁专利

USRE39892E1 Pharmaceutical compositions containing lactobacilli for treatment of vaginal infections and related method 失效
标题翻译：含有乳酸杆菌治疗阴道感染的药物组合物及相关方法
公开(公告)号：USRE39892E1
公开(公告)日：2007-10-23
申请号：US11484028
申请日：2006-07-11
申请人： Claudio De Simone
发明人： Claudio De Simone
IPC分类号： C12N1/20
CPC分类号： A61K9/0034 , A61K9/0007 , A61K9/2054 , A61K9/209 , A61K35/747 , A61K2300/00
摘要： Use of an association of lactobacilli for preparation of a pharmaceutical composition for treatment of vaginosis and vaginitis. Said bacteria association comprises the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, possibly in combination with one or more species selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri.A pharmaceutical composition comprising said association of lactobacilli adapted for treatment of vaginosis and vaginitis.A method of treating vaginosis and vaginitis based on administration of said pharmaceutical composition.
摘要翻译：使用乳杆菌联合制备用于治疗阴道炎和阴道炎的药物组合物。所述细菌结合物包括短乳杆菌（Lactobacillus brevis）和唾液乳杆菌（Lactobacillus salivarius）。 salicinius物种，可能与选自唾液乳杆菌的一种或多种物质组合。唾液乳杆菌，绞肉芽孢杆菌（Lactobacillus jensenii），嗜酸乳杆菌（Lactobacillus catenaforme），乳杆菌（Lactobacillus minutus）和加氏乳杆菌（Lactobacillus gasseri）。一种药物组合物，其包含适于治疗阴道炎和阴道炎的乳酸杆菌结合物。一种基于施用所述药物组合物治疗阴道炎和阴道炎的方法。

70. 发明申请

US20070224268A1 Process for preparing oral calcium compositions 有权
标题翻译：制备口服钙组合物的方法
公开(公告)号：US20070224268A1
公开(公告)日：2007-09-27
申请号：US11798519
申请日：2007-05-15
申请人： Jan Piene , Dina Schmidt
发明人： Jan Piene , Dina Schmidt
IPC分类号： A61K9/28 , A61K9/16 , A61K9/46 , A61K9/20
CPC分类号： A61K9/0007 , A61K9/0056 , A61K9/0095 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2077 , Y10S514/819
摘要： A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range 3 to 40 μm, having a crystalline structure and having a surface area of 0.1 to 1.2 m2/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and drying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.
摘要翻译：一种制备可口服给药的钙组合物的方法，包括以下步骤：（i）获得平均粒度在3-40μm范围内的具有晶体结构且表面积为0.1的生理上可耐受的颗粒状钙化合物至1.2m 2 / g; （ii）将钙化合物与水溶性稀释剂和水溶性粘合剂的水溶液混合在流化床造粒装置中并干燥得到的混合物以产生第一颗粒; （iii）任选地将第一颗粒与一种或多种其它组分混合以产生第二颗粒; 和（iv）任选地压缩第一或第二颗粒以形成片剂。

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