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61. 发明授权

US08778310B2 Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer 有权
标题翻译：荧光氯毒素缀合物和癌症手术中可视化的方法
公开(公告)号：US08778310B2
公开(公告)日：2014-07-15
申请号：US11897721
申请日：2007-08-31
申请人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrik Gabikian , S-Bahram Bahrami
发明人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrik Gabikian , S-Bahram Bahrami
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , A61K38/16 , A61K51/08
CPC分类号： A61B17/22 , A61K38/16 , A61K47/6415 , A61K49/0017 , A61K49/0032 , A61K49/0041 , A61K49/005 , A61K49/0056 , A61K51/08 , C07K14/43522 , G01N33/57492
摘要： A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
摘要翻译：通过荧光成像可检测的氯毒素缀合物，其允许癌组织的术中可视化，包括氯毒素缀合物的组合物，以及使用氯毒素缀合物的方法。

62. 发明授权

US08765097B2 Ligands to radiation-induced molecules 有权
标题翻译：对辐射诱导分子的配体
公开(公告)号：US08765097B2
公开(公告)日：2014-07-01
申请号：US13766310
申请日：2013-02-13
申请人： Dennis E. Hallahan , Shimian Qu , Zhaozhong Han
发明人： Dennis E. Hallahan , Shimian Qu , Zhaozhong Han
IPC分类号： A61K51/00 , A61M36/14 , A61K38/08 , A61K38/03 , A61K49/14 , A61K49/08 , A61K51/08 , C07K7/06
CPC分类号： A61K41/00 , A61K38/03 , A61K38/08 , A61K41/0038 , A61K47/42 , A61K47/48246 , A61K47/48815 , A61K47/64 , A61K47/6911 , A61K49/0002 , A61K49/08 , A61K49/14 , A61K51/08 , A61K51/082 , A61K51/088 , A61K51/1255 , A61N5/10 , C07K2/00 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/44 , C07K2317/622
摘要： A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.
摘要翻译：用于鉴定结合被照射的肿瘤的分子的方法和由此鉴定的分子。在一些实施方案中，该方法包括以下步骤：（a）将肿瘤暴露于电离辐射; （b）向受试者施用不同分子的文库; 和（c）从肿瘤中分离不同分子文库的一个或多个分子，从而鉴定结合照射的肿瘤的分子。还提供了结合照射的肿瘤的靶向配体和使用所公开的靶向配体的治疗和诊断方法。

63. 发明申请

US20140112864A1 Anti-Mucin Antibodies for Early Detection and Treatment of Pancreatic Cancer 有权
标题翻译：抗粘蛋白抗体用于早期检测和治疗胰腺癌
公开(公告)号：US20140112864A1
公开(公告)日：2014-04-24
申请号：US14036765
申请日：2013-09-25
申请人： Immunomedics, Inc.
发明人： David V. Gold , David M. Goldenberg
IPC分类号： A61K51/10 , G01N33/68
CPC分类号： A61K47/486 , A61K47/48569 , A61K47/48746 , A61K47/6851 , A61K47/6859 , A61K47/6897 , A61K51/0406 , A61K51/0491 , A61K51/08 , A61K51/088 , A61K51/1045 , A61K51/1057 , A61K51/109 , A61K51/1096 , A61K2039/505 , A61K2039/507 , B82Y5/00 , B82Y15/00 , C07K16/303 , C07K16/3092 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/76 , G01N33/6854
摘要： Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The antibodies show novel and useful diagnostic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to normal or benign pancreatic tissues and binding to a high percentage of early stage pancreatic cancers. Preferably, the antibodies bind to pancreatic cancer mucins such as MUC1 or MUC5ac and are of use for the detection and diagnosis of early stage pancreatic cancer. In more preferred embodiments, the anti-pancreatic cancer antibodies can be used for immunoassay of serum samples, wherein the immunoassay detects a marker for early stage pancreatic cancer in serum. Most preferably, the serum is extracted with an organic phase, such as butanol, before immunoassay. Alternatively, immunoassay with PAM4 and anti-CA19.9 antibodies may be utilized to improve sensitivity for pancreatic cancer.
摘要翻译：本文描述了使用抗胰腺癌抗体或其片段的组合物和方法，例如鼠，嵌合，人源化或人PAM4抗体。抗体显示出新的和有用的诊断特征，例如对胰腺癌和其他癌症具有高特异性结合，但不对正常或良性胰腺组织结合并结合高百分比的早期胰腺癌。优选地，抗体结合胰腺癌粘蛋白如MUC1或MUC5ac，并且可用于早期胰腺癌的检测和诊断。在更优选的实施方案中，抗胰腺癌抗体可用于血清样品的免疫测定，其中免疫测定检测血清中早期胰腺癌的标志物。最优选地，在免疫测定之前，用有机相如丁醇萃取血清。或者，可以使用具有PAM4和抗CA19.9抗体的免疫测定来提高胰腺癌的敏感性。

64. 发明授权

US08703098B2 Labelled adrenomedullin derivatives and their use for imaging and therapy 有权
标题翻译：标记的肾上腺髓质素衍生物及其用于成像和治疗
公开(公告)号：US08703098B2
公开(公告)日：2014-04-22
申请号：US11597315
申请日：2005-05-24
申请人： Jocelyn Dupuis , Alain Fournier
发明人： Jocelyn Dupuis , Alain Fournier
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/08 , A61K51/088 , C07K14/575
摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide chelated with at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such us for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic is pulmonary embolus.
摘要翻译：本发明涉及包含与至少一种活性剂螯合的肾上腺髓质肽的肾上腺髓质素衍生物。活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。取决于活性剂中包含的特定元素，放射性剂可用于成像和辐射辐射。纤维蛋白溶解剂主要向特定器官（例如我们的肺）递送允许通过允许局部输送纤维蛋白溶解剂来显着改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险器官。如果器官是肺，则可用纤维蛋白溶解治疗的病理学的非限制性实例是肺栓塞。

65. 发明授权

US08691189B2 Method of colorectal cancer detection by using radiolabeled anti-GRP78 peptide 有权
标题翻译：通过使用放射性标记抗GRP78肽的结肠直肠癌检测方法
公开(公告)号：US08691189B2
公开(公告)日：2014-04-08
申请号：US13026471
申请日：2011-02-14
申请人： Siao-Syun Guan , Chun-Chia Cheng , Shui-Cheng Lee , Hsien-Ming Wu
发明人： Siao-Syun Guan , Chun-Chia Cheng , Shui-Cheng Lee , Hsien-Ming Wu
IPC分类号： A61K49/04 , A61K49/00 , A61K49/14 , A61K38/08 , C07K7/06
CPC分类号： A61K49/0004 , A61K38/08 , A61K49/14 , A61K51/08 , C07K7/06
摘要： The present disclosure describes techniques used for colorectal cancer detection. Position and distribution of colorectal cancer tumor are detected through nuclear imaging. Alternatively, stage of colorectal cancer is identified by shading value in tumor. Thus, the present disclosure provides a safe and noninvasive clinical method for diagnosing and tracing level and distribution of colorectal cancer before and after treatment.
摘要翻译：本公开描述了用于结肠直肠癌检测的技术。通过核成像检测结直肠癌肿瘤的位置和分布。或者，通过肿瘤中的阴影值鉴定结肠直肠癌的阶段。因此，本公开提供了用于诊断和追踪治疗前后结肠直肠癌水平和分布的安全和无创的临床方法。

66. 发明申请

US20140051840A1 ARSENIC COMPLEXES FOR POTENTIAL DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于潜在诊断应用的ARSENIC复合物
公开(公告)号：US20140051840A1
公开(公告)日：2014-02-20
申请号：US13969196
申请日：2013-08-16
申请人： The Curators of the University of Missouri
发明人： Silvia S. Jurisson , Cathy S. Cutler , Donald E. Wycoff , Anthony J. DeGraffenreid
IPC分类号： A61K51/04 , A61K51/10 , A61K51/08
CPC分类号： A61K51/0474 , A61K51/0436 , A61K51/08 , A61K51/10
摘要： The present invention provides radioactive arsenic complex useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.
摘要翻译：本发明提供了可用于诊断和治疗应用的放射性砷络合物和形成这些砷络合物的方法。

67. 发明申请

US20140039153A1 CANCER IMAGING AND TREATMENT 审中-公开
标题翻译：癌症成像和治疗
公开(公告)号：US20140039153A1
公开(公告)日：2014-02-06
申请号：US14047846
申请日：2013-10-07
申请人： Technische Universitat Munchen
发明人： Hans-Jurgen Peter Wester , Ingrid Dijkgraaf , Horst Kessler , Oliver Demmer
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K47/55 , A61K51/088
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.
摘要翻译：化合物或其药学上可接受的盐或酯包含以下结构：[（P1-S1j）pL-（S2q-P2）r] t其中：P1和P2可以相同或不同，是环状寡肽部分在环状部分中具有基序B-Arg或B（Me）Arg的P1和P2中的至少一个，其中B是碱性氨基酸，其衍生物或苯丙氨酸或其衍生物; S1和S2是间隔基，其可以相同或不同; L是含有至少两个用于连接环状寡肽或间隔基团的官能团的连接体部分; n和q独立地为0或1; p和r独立地为1或更大的整数; 并且t为1或更大的整数，条件是当t，p或r大于1时，环状寡肽部分，间隔基团和/或j或q的值可以在多个 P1-S1j）部分或多个（S2q-P2）部分。

68. 发明申请

US20140023585A1 177 LUTETIUM-LABELED BOMBESIN ANALOGS FOR RADIOTHERAPY 审中-公开
标题翻译： 177放射性标记的BOMBESIN模拟物
公开(公告)号：US20140023585A1
公开(公告)日：2014-01-23
申请号：US13988629
申请日：2011-11-21
申请人： Sandra Borkowski , Rosalba Mansi , Helmut Macke
发明人： Sandra Borkowski , Rosalba Mansi , Helmut Macke
IPC分类号： A61K51/08
CPC分类号： A61K51/088 , A61K51/08
摘要： The invention is directed to novel Lutetium-177-labeled bombesin analogs for treatment of tumor by radiotherapy.
摘要翻译：本发明涉及通过放射治疗来治疗肿瘤的新型镥-177标记的铃蟾肽类似物。

69. 发明申请

US20140017168A1 Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules 有权
标题翻译：改进的蛋白质，肽和其他分子的F-18标记的方法和组合物
公开(公告)号：US20140017168A1
公开(公告)日：2014-01-16
申请号：US14012582
申请日：2013-08-28
申请人： Immunomedics, Inc.
发明人： Christopher A. D'Souza , William J. McBride , David M. Goldenberg
IPC分类号： A61K51/04
CPC分类号： A61K51/08 , A61B5/055 , A61K47/48746 , A61K47/6897 , A61K49/06 , A61K51/0406 , A61K51/041 , A61K51/044 , A61K51/0482 , A61K51/0491 , A61K51/082 , A61K51/083 , A61K51/088 , A61K51/109 , B82Y5/00 , C07D225/00 , C07F13/005
摘要： The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.
摘要翻译：本申请公开了在PET，SPECT和/或MR成像中合成和使用18F或19F标记的分子的组合物和方法。优选地，18F或19F通过与IIIA族金属形成络合物并将该复合物与双功能螯合剂结合（其可以直接或间接连接到靶向分子）而与靶向分子缀合。在其它实施方案中，18F或19F标记的部分可以包含与靶向疾病相关抗原的双特异性抗体组合使用的可靶向构建体。所公开的方法和组合物允许在30分钟或更短时间内非常高的效率和比活性的分子的简单且可重现的标记。在优选的实施方案中，标记的分子可以在标记后不经纯化用于受试者的成像。

70. 发明授权

US08628750B2 Cancer imaging and treatment 失效
标题翻译：癌症成像和治疗
公开(公告)号：US08628750B2
公开(公告)日：2014-01-14
申请号：US12280829
申请日：2007-02-27
申请人： Hans Jürgen Wester , Norman Koglin , Markus Schwaiger , Horst Kessler , Burkhardt Laufer , Oliver Demmer , Martina Anton
发明人： Hans Jürgen Wester , Norman Koglin , Markus Schwaiger , Horst Kessler , Burkhardt Laufer , Oliver Demmer , Martina Anton
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07K7/64 , A61K51/08 , A61K51/088
摘要： Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a Nα-methyl derivative of a basic amino acid.
摘要翻译：本文提供了可用于诊断成像和/或治疗目的的化合物或缀合物。每种化合物或缀合物包含趋化因子受体CXCR4的配体和可检测的标记。该配体对于CXCR4受体具有结合亲和力，以125nM-CPCR4的存在下的IC 50测定为250nM或更低，并且配体包含具有基序B-Arg或B（Me）Arg的环状寡肽部分环状部分，其中B是碱性氨基酸，其衍生物或苯丙氨酸，条件是当B是碱性氨基酸的Nalpha-甲基衍生物时，基序是B-Arg。

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