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61. 发明授权

US4891221A Whole blood antiviral process and composition 失效
标题翻译：全血抗病毒过程及组成
公开(公告)号：US4891221A
公开(公告)日：1990-01-02
申请号：US209161
申请日：1988-12-28
申请人： Edward Shanborm
发明人： Edward Shanborm
IPC分类号： A61K35/14 , A61K35/52 , A61K38/16 , A61L2/00 , A61P7/08 , C07H15/256
CPC分类号： A61L2/0088 , A61K35/52
摘要： The treatment of blood to inactivate or destroy infective viruses found in animal fluids and tissues, such as the cytomegalovirus, by mixing the blood with an effective amount of glycyrrhizic tritepenoid compounds is disclosed.
摘要翻译：公开了通过将血液与有效量的甘草酸三头孢烯化合物混合来治疗血液来灭活或破坏动物流体和组织如巨细胞病毒中发现的感染性病毒。

62. 发明授权

US4804537A Sperm selection process using a salt of hyaluronic acid 失效
标题翻译：使用透明质酸盐的精子选择过程
公开(公告)号：US4804537A
公开(公告)日：1989-02-14
申请号：US60360
申请日：1987-05-22
申请人： Per O. Bergman , Yvonne M. Steen , Bjorn G. Ingelman
发明人： Per O. Bergman , Yvonne M. Steen , Bjorn G. Ingelman
IPC分类号： A61B17/425 , A01N1/02 , A61D19/00 , A61K35/52 , C12N5/00 , C12N5/076 , C12Q1/00 , A61K35/48
CPC分类号： C12N5/0612 , A61K35/52
摘要： The present invention relates to a process and means for separating motile sperm cells in vitro from an aqueous sperm-containing sample by means of contacting said sample with a layer of an aqueous artificial penetration medium for sperm cells, said medium having incorportated therein a water-soluble physiologically acceptable salf of hyaluronic acid, whereby motile sperm cells are caused to migrate into said layer from said sperm-containing sample. The invention also comprises fertilization with sperm cells separated in this manner.
摘要翻译： PCT No.PCT / SE86 / 00484 Sec。 371日期1987年5月22日 102（e）日期1987年5月22日PCT提交1986年10月17日PCT公布。公开号WO87 / 02382 日本1987年4月23日。本发明涉及通过使所述样品与精子细胞的水性人造渗透介质层接触来分离体外活动精子细胞与含水精子样品的方法和装置，所述方法和装置培养基中含有水溶性的生理上可接受的透明质酸盐，由此引起移动精子细胞从所述含精子样品迁移到所述层中。本发明还包括以这种方式分离精子细胞的受精。

63. 发明授权

US4722887A Phase partition separation of sperm based on seminolipid expression 失效
标题翻译：基于硫蛋白表达的精子相分离分离
公开(公告)号：US4722887A
公开(公告)日：1988-02-02
申请号：US943685
申请日：1986-12-19
申请人： Jill D. Fabricant , James D. Willett
发明人： Jill D. Fabricant , James D. Willett
IPC分类号： A01K67/02 , A61K35/52 , B01D15/08 , A01N1/02
CPC分类号： B01D15/30 , A01K67/02 , A61K35/52 , B01D15/3809
摘要： Male- and female-determining sperm are separated by polymeric phase partition chromatography, based on differential expression of a sulfoglycolipid. In a preferred embodiment, a mobile phase comprises a polymer derivatized with a sulfoglycolipid-binding protein, such as an antibody directed against the sulfoglycolipid. The sulfoglycolipid is preferably SGG.
摘要翻译：基于磺酰糖脂的差异表达，通过聚合相分配色谱法分离男性和女性确定的精子。在优选的实施方案中，流动相包含用磺酰糖脂结合蛋白衍生的聚合物，例如针对所述磺酰糖脂的抗体。该磺基糖脂优选为SGG。

64. 发明授权

US1835853A Prostate hormone and method of producing the same 失效
标题翻译：前列腺激素及其制备方法
公开(公告)号：US1835853A
公开(公告)日：1931-12-08
申请号：US23038227
申请日：1927-11-01
申请人： REED & CARNRICK
发明人： ELDRED FRANK R
IPC分类号： A61K38/22
CPC分类号： A61K35/52

65. 发明申请

US20180221419A1 Methods to Differentiate Stem Cells into Hormone-Producing Cells 审中-公开
公开(公告)号：US20180221419A1
公开(公告)日：2018-08-09
申请号：US15947304
申请日：2018-04-06
申请人： JangoBio, LLC
发明人： Craig S. Atwood , Sivan Vidakkadath Meethal
IPC分类号： A61K35/545 , A61K35/52 , A61K35/55 , C07K14/59 , A61P5/24 , A61P5/06 , A61K9/00
CPC分类号： A61K35/545 , A61K9/0019 , A61K31/566 , A61K31/568 , A61K31/57 , A61K35/15 , A61K35/52 , A61K35/54 , A61K35/55 , A61P5/06 , A61P5/24 , C07K14/59
摘要： Methods are described for differentiating stem and post-natal cells into sex hormone-producing cells that can be administered to a patient autologously or allogeneically in order to maintain in balance, or rebalance, their hypothalamic-pituitary-gonadal (HPG) axis.

66. 发明申请

US20180200345A1 PROCESS AND COMPOSITION FOR LOW DOSE INSEMINATION 审中-公开
公开(公告)号：US20180200345A1
公开(公告)日：2018-07-19
申请号：US15746495
申请日：2016-07-14
申请人： IMV TECHNOLOGIES
发明人： Eric Schmitt
IPC分类号： A61K38/47 , A61K38/16 , A61K9/00 , A61K35/52 , A61D19/02
CPC分类号： A61K38/47 , A61D19/02 , A61K9/0034 , A61K35/52 , A61K38/168 , C12Y302/01018 , A61K2300/00
摘要： The present invention relates to a composition for use in low dose artificial insemination and to a process for artificial insemination of a female mammal using a dose of sperm originating from a male mammal of the same species that is significantly lower than necessary in the absence of the composition. The preferred female mammal is a sow (sus scrofa), and preferably the composition is for use in artificial uterine insemination, and the process for artificial insemination preferably is uterine insemination.

67. 发明申请

US20170189156A1 System for the preservation of a predetermined dose of liquid-based substance in particular diluted animal semen 审中-公开
公开(公告)号：US20170189156A1
公开(公告)日：2017-07-06
申请号：US15314330
申请日：2015-05-27
申请人： IMV TECHNOLOGIES
发明人： Eric SCHMITT
IPC分类号： A61D19/00 , A01N1/02 , A61D19/02
CPC分类号： A61D19/024 , A01N1/02 , A01N1/0268 , A61D19/00 , A61D19/02 , A61D19/04 , A61K35/52
摘要： The system comprises a straw and a liquid dilution medium. The straw comprises a tube (11) extending between a first end and a second end and comprises a gas-permeable, liquid-tight plug, said plug being arranged in the tube (11) in the vicinity of the first end of same and extending between a first end turned towards the first end of the tube (11) and a second end turned towards the second end of the tube (11). Said plug comprises an element (14) impregnated with a reagent (22) at least in the vicinity of a first end turned towards the second end of the tube (11). The liquid medium is provided to produce, by mixing, in predefined conditions, the liquid substance (21). The reagent (22) and the medium(27) are configured such that, when the substance (21) comes into contact with the first end of the impregnated element (14), it forms a hydrogel.

68. 发明申请

US20160309685A1 HYBRID DAIRY CATTLE AND SYSTEMS FOR MAXIMIZING HYBRID ADVANTAGE 审中-公开
标题翻译：混合奶酪和系统，以最大限度地发挥混合优势
公开(公告)号：US20160309685A1
公开(公告)日：2016-10-27
申请号：US15169459
申请日：2016-05-31
申请人： Genus plc
发明人： Jon Lightner , Richard Williams
IPC分类号： A01K67/02 , A61D19/04
CPC分类号： A01K67/02 , A61D19/02 , A61D19/04 , A61K35/52 , A61K35/54
摘要： Systems for selecting, generating, and breeding hybrid dairy cattle are described, as are methods for maintaining herds of hybrid cattle.
摘要翻译：描述了用于选择，产生和繁殖杂交奶牛的系统，以及用于保持杂种牛群的方法。

69. 发明申请

US20140100419A1 ACTIVE VITAMIN D OR ANALOGS THEREOF FOR USE IN IN VIVO OR IN VITRO FERTILIZATION 审中-公开
标题翻译：活体维生素D或其用于体外或体外培养的模拟物
公开(公告)号：US20140100419A1
公开(公告)日：2014-04-10
申请号：US14001754
申请日：2012-01-31
申请人： Martin Blomberg Jensen
发明人： Martin Blomberg Jensen
IPC分类号： A61K31/59 , A61K35/52
CPC分类号： A61K31/59 , A61K35/52 , C12N5/061 , C12N2500/38 , C12N2517/10
摘要： The present invention relates to methods for improving the ability of spermatozoa to fertilize an egg in vitro and/or vivo, said method comprising providing a medium comprising active vitamin D (calcitriol) or analogs thereof, providing a sample of spermatozoa, and incubating said sample of spermatozoa with said medium. In addition, the invention relates to compositions comprising active vitamin D or analogs thereof for use in the treatment of infertility in a male or female subject.
摘要翻译：本发明涉及提高精子在体外和/或体内施肥卵的能力的方法，所述方法包括提供包含活性维生素D（骨化三醇）或其类似物的培养基，提供精子样品，并将所述样品的精子与所述培养基。此外，本发明涉及包含活性维生素D或其类似物的组合物，其用于治疗男性或女性受试者的不育症。

70. 发明申请

US20130164382A1 EJACULUM OF ANIMALS AS MEDICINAL MATERIAL AND USES THEREOF IN MEDICAMENTS FOR TREATMENT OF DISEASES SUCH AS TUMORS, DEPRESSION, ETC 有权
标题翻译：动物作为医学材料的用途及其在治疗疾病的药物中的应用，如肿瘤，肿瘤，ETC
公开(公告)号：US20130164382A1
公开(公告)日：2013-06-27
申请号：US13772055
申请日：2013-02-20
申请人： Yan LI
发明人： Yan LI
IPC分类号： A61K35/52 , A61K9/19
CPC分类号： A61K35/52 , A61K9/19
摘要： Provided are ejaculum of animals as medicinal materials and uses thereof in manufacture of medicaments for treatment of various tumors, depression, senile dementia, and dermatosis. Said tumors include ovarian cancer, uterine cancer, breast cancer, esophageal cancer, stomach cancer, colon cancer, lung cancer, osteocarcinama, etc. The present medicinal material, alone or in combination with additional agents, is similar to cyclophosphamide in antineoplastic effects, which is accepted presently the most potent chemotherapeutic agent. It can inhibit the growth of tumors, not destroying the normal immune system of human. The present medicinal material of ejaculum is powdery crystal prepared by vacuum lyophilization from fresh ejaculum of animals, and it is suitable to a variety of dosage forms such as capsule or oral solution.
摘要翻译：提供动物的动物作为药用材料及其用于制备用于治疗各种肿瘤，抑郁症，老年性痴呆和皮肤病的药物的用途。所述肿瘤包括卵巢癌，子宫癌，乳腺癌，食管癌，胃癌，结肠癌，肺癌，骨癌等。本发明的药物单独或与其他试剂组合，与抗肿瘤作用中的环磷酰胺相似，其中目前是最有效的化疗药物。它可以抑制肿瘤的生长，不破坏人体的正常免疫系统。目前的药用药物是通过从动物的新鲜真菌中真空冻干制备的粉末状晶体，并且适用于各种剂型如胶囊或口服溶液。

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